CN102357125A - Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis - Google Patents
Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis Download PDFInfo
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Abstract
The invention belongs to the medicine category, and in particular discloses a Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis. The composition comprises the following raw material drugs in parts by weight: 10-60 parts of astragalus mongholicus, 5-30 parts of ginseng, 3-10 parts of cassia twig, 5-10 parts of lumbricus, 2-5 parts of scorpion, 1.5-3 parts of leech, 3-10 parts of pangolin scales, 6-15 parts of medicinal cyathula root, 3-10 parts of long-noded pit viper, 3-10 parts of safflower carthamus, 3-10 parts of frankincense and 3-10 parts of rhizoma corydalis. The composition disclosed by the invention has the effects of supplementing qi and activating blood, breaking blood stasis, dredging collaterals and relieving pain; according to composition disclosed by the invention, blood circulation of lower limbs can be effectively improved, limbs pain is obviously relieved or effectively eliminated, intermittent claudication is relieved or eliminated, skin is changed to normal skin color from black brown, lower limb crural muscular atrophy can be retarded or controlled, healing effect of later-stage toe, foot or crural ulcer is promoted, the disadvantage of not effectively preventing disease process from gradually developing and deteriorating which is caused owing to merely using western medicine to carry out symptomatic treatment is solved, and an effective treatment measure is provided for a new subject.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of atherosis Chinese medicine composition of early stage occlusive peripheral arterial of treating.
Background technology
The category of the occlusive peripheral arterial is atherosis genus motherland's medical science " passages through which vital energy circulates " pathological changes and " vascular " pathological changes.So peripheral vascular disease is referred to as " vascular disorders ".Its pathogenesis is: diseases caused by exogenous pathogenic factor six climate exopathogens, tobacco poisoning, wound or diet delicious food, feelings will internal injury, internal organs meridian function are lacked of proper care, the hyperamization arteries and veins stasis of bloods such as impairment caused by overstrain is deficient, blood stasis, phlegm retention stagnate, blood operation is obstructed; Cause that lower limb send out cold, numbness, pain, raise that pain increases the weight of when suffering from limb, intermittent claudication, also pain during rest when serious; Increase the weight of night; Skin color becomes pitchy, amyotrophy, and the later stage can produce ulcer or the dry gangrene of toe, foot or shank etc. and be primary symptom.
The occlusive peripheral arterial is atherosis, is the new subject that just grows up in recent years, and everybody is stranger to this, and misdiagnosis rate is higher.Lose valuable opportunity if can not get correct treatment in early days, some patient has just lost limbs becomes lifelong deformity, even threat to life.And when using the western medicine primary disease merely, can only adopt supporting treatment to the ill, effect is relatively poor, can not effectively stop the deterioration of the state of an illness.
Summary of the invention
For overcoming the weak point that exists in the prior art, the object of the present invention is to provide a kind of atherosis Chinese medicine composition of early stage occlusive peripheral arterial of treating.Said composition has the effect of benefiting QI for activating blood circulation, removing blood stasis with potent drugs collateral dredging, pain relieving, and its clinical efficacy is remarkable.
For realizing above-mentioned purpose, the technical scheme that the present invention takes is following:
A kind of atherosis Chinese medicine composition of early stage occlusive peripheral arterial of treating is processed by each crude drug of following portions by weight: 10 ~ 60 parts of the Radixs Astragali, 5 ~ 30 parts of Radix Ginsengs, 3 ~ 10 parts of Ramulus Cinnamomi, 5 ~ 10 parts of Pheretimas, 2 ~ 5 parts of Scorpios, 1.5 ~ 3 parts of Hirudos, 3 ~ 10 parts of Squama Maniss, 6 ~ 15 parts of Radix Cyathulaes, 3 ~ 10 parts of Agkistrodons, 3 ~ 10 parts on Flos Carthami, 3 ~ 10 parts of Olibanums, 3 ~ 10 parts of Rhizoma Corydalis.
Further, the parts by weight of said each crude drug are preferably: 30 parts of the Radixs Astragali, 15 parts of Radix Ginsengs, 10 parts of Ramulus Cinnamomi, 10 parts of Pheretimas, 5 parts of Scorpios, 2 parts of Hirudos, 6 parts of Squama Maniss, 10 parts of Radix Cyathulaes, 9 parts of Agkistrodons, 9 parts on Flos Carthami, 6 parts of Olibanums, 10 parts of Rhizoma Corydalis.
Preferably, Squama Manis is a Squama Manis preparata, and Olibanum is an Olibanum (processed).
Process any acceptable clinically preparation by conventional method, such as can be decoct, pill, capsule, granule or concentrated pill.Can choose and add corresponding conventional adjuvant according to the needs of different preparations.
Method for preparing and method for using:
The PD phase: 1. in by weight/volume; Take by weighing the Radix Astragali 10 ~ 60g, Radix Ginseng 5 ~ 30g, Ramulus Cinnamomi 3 ~ 10g, Pheretima 5 ~ 10g, Scorpio 2 ~ 5g, Hirudo 1.5 ~ 3g, Squama Manis 3 ~ 10g, Radix Cyathulae 6 ~ 15g, Agkistrodon 3 ~ 10g, Flos Carthami 3 ~ 10g, Olibanum 3 ~ 10g, Rhizoma Corydalis 3 ~ 10g; Then this 12 flavor crude drug is put into marmite, first fries in shallow oil and adds water 600ml and soaked 30 minutes, after boiling with high heat earlier; Used the about 350ml of taking liquid again instead 30 minutes at a simmer; Second fries in shallow oil and adds water 500ml, uses the about 350ml of taking liquid again instead 25 minutes at a simmer after boiling with high heat earlier; Two boil medicine liquid mix after clothes at twice, early, evening each clothes once, decoction being taken warmly.Or, 2. utilize prior art to process granule the present invention's 12 flavor crude drug, divide the bag of packing into, every bag of 10g obeys 1 bag at every turn, obeys warm boiled water every day three times.
The stable disease phase: by weight ratio; Take by weighing the Radix Astragali 10 ~ 60g, Radix Ginseng 5 ~ 30g, Ramulus Cinnamomi 3 ~ 10g, Pheretima 5 ~ 10g, Scorpio 2 ~ 5g, Hirudo 1.5 ~ 3g, Squama Manis 3 ~ 10g, Radix Cyathulae 6 ~ 15g, Agkistrodon 3 ~ 10g, Flos Carthami 3 ~ 10g, Olibanum 3 ~ 10g, Rhizoma Corydalis 3 ~ 10g, then this 12 flavor Chinese medicine pulverized the back and cross 120 mesh sieves, process superfine medicated powder after: 1. medicated powder and honey are processed honeyed pill by the 1:1.5 mass ratio; Every ball 3g; Each clothes 6g obeys warm boiled water every day three times; Or, 2. with the medicated powder Capsules of packing into, every 0.3g, obey 6, every day three times, warm boiled water at every turn; Or, 3. utilize prior art to process concentrated pill the present invention's 12 flavor crude drug, obey 6g at every turn, obey warm boiled water every day three times.
Pharmacology of the present invention:
The Radix Astragali: sweet in the mouth, slightly warm in nature is gone into spleen, lung meridian, has effects such as benefiting QI for activating blood circulation, promoting pus discharge and tissue regeneration strengthening." Mingyi Bielu " called these article " by stagnant blood between the five internal organs ".Modern pharmacological research proves: these article truly have the good merit of invigorating blood circulation, and can reduce whole blood contrast viscosity and plasma viscosity, shorten erythrocyte electrophoretic time, reduce packed cell volume, improve hemorheological property.Can obviously reduce the platelet cofactor procoagulant activity.And coronary artery and peripheral blood vessel there are direct dilating effect, CF is increased.Other has the effect of remarkable anti-experimental character thrombosis, ability anticoagulant etc.Be widely used in the stagnant person of the multiple blood vessels stasis of bloods such as artery thrombosis, coronary heart disease, cerebral thrombosis for many years clinically especially.This shows that the Radix Astragali can not only make gas prosperous in promoting the circulation of blood through QI invigorating, and the good merit of invigorating blood circulation is arranged.
Radix Ginseng: sweet in the mouth, slightly warm in nature is gone into lung, spleen, the heart, kidney channel, has strongly invigorating primordial QI, functions such as enriching blood and promoting secretion of body fluid.These article are for saving danger emergency treatment of collapse key medicine, and the merit of its strongly invigorating primordial QI does not have medicine can generation, are suitable for most because of vigour fictitious pole due to losing blood greatly etc. and desire to take off the critical disease of faint pulse being about to disappear.These article can QI invigorating with hemopoietic, certain merit of enriching blood is arranged again; Can QI invigorating with promoting the circulation of blood, certain merit of invigorating blood circulation is arranged, so availablely control blood deficiency disease and the blood vessels stasis of blood all diseases that stagnates again.In recent years the diseases that are used to treat multiple blood-vessel obstructives such as cardiovascular and cerebrovascular disease and peripheral arterial thrombosis more.Pharmacological research proves: Radix Ginseng has the peripheral vascular resistance of reduction and blood pressure lowering, anti-hypoxia and protection cardiac muscle, improves hemorheology and antithrombotic formation, atherosclerosis, anti-stress, raising immunologic function, strengthens effects such as hemopoietic function, cholesterol regulating metabolism, blood fat reducing, blood sugar lowering.
Ramulus Cinnamomi: acrid-sweet flavor, warm in nature, go into lung, kidney, the heart, spleen channel, have the effect of warm promoting blood circulation, warm aid yang qi.Can temperature loose cold coagulation in the blood can be declared again and lead blood circulation promoting medicine, to be strengthened the effect that blood stasis dispelling is promoted blood circulation.The clinical heart arteries and veins stasis of blood resistance that is usually used in due to the flaccidity of the heart-yang, and because of the arthromyodynia due to the rheumatism.Other has clinical report: Ramulus Cinnamomi also can be used for controlling Raynaud disease etc.
Pheretima: salty in the mouth is cold in nature, goes into liver, spleen, urinary bladder channel, has effects such as endogenous wind stopping relieving convulsion, collateral dredging.Kind control that blood stagnancy due to deficiency of QI after the apoplexy, muscle arteries and veins lose and support, the unfavorable all diseases of meridians and rheumatism with the passing of time, blood stasis numbness resistance passages through which vital energy circulates, podomere or the whole body.The kind current meridians of Pheretima, pharmacological research proves: the Pheretima decoct has anti thrombotic action, and the thrombolytic composition is a protease, ability direct hydrolysis fibrin, and have the activation of plasminogen.Through anticoagulant, anticoagulation, reduction blood viscosity, thereby stop thrombosis, promote thromboembolism.
Scorpio: acrid in the mouth property is flat, returns Liver Channel, has functions such as endogenous wind stopping relieving convulsion, resolving mass and removing the obstruction of the collateral.These article have the good of expel wind to dredge collateral to imitate.With the passing of time do not heal with controlling anemofrigid-damp arthralgia, the contracture of muscle arteries and veins, brothers' erectile problem, very then the insensitive impediment effect of joint deformity is rather good." beautiful Chinese catalpa medicine is separated ": " it is deep to wear muscle, by the wet wind that removes ".Modern pharmacological research confirms: these article have antithrombotic to form, reduce platelet adhesion rate, delay hemagglutinative function.
Hirudo: salty in the mouth is bitter, and property is flat, goes into Liver Channel, goes into blood, removing blood stasis power is strong, can cure the wound by the meridian dredging ， Xiao wei.Shennong's Herbal: " master pursues stagnant blood, blood stasis, removing blood stasis abdominal mass, gathers ... ".These article mainly contain in protein, heparin, antithrombase, the fresh Hirudo saliva and contain a kind of anticoagulative substance-hirudin.In addition, still contain various trace elements such as sodium, potassium, calcium.Pharmacological research proves: these article have anti thrombotic action; Can not only prevent the formation of tampon, can also thrombus, can suppress Fibrinogen and be converted into fibrin; And the activity of ability factor anticoagulant and the platelet response of thrombin induction, very strong anticoagulation is arranged.Can reduce surface activity of blood platelet, anticoagulant can improve hemorheology; The ability blood fat reducing, the atheromatous plaque that disappears alleviates the surrounding tissue inflammatory reaction; Improve local blood circulation, the protection cerebral tissue increases effects such as myocardial nutrition property blood flow and promotion neurological functional recovery.
Squama Manis: the salty in the mouth cold nature, go into liver, stomach warp, have functions such as the Xiao of invigorating blood circulation wei, dredge the meridian passage.This moral character is apt to away scurry, can promoting the circulation of blood the stagnant and wei that disappears of the stasis of blood of branchs, dredge the meridian passage.Be used to control the chronic ulcer of the lower limb stagnant disease of meridian stasis such as do not close up for a long time.Modern pharmacological research confirms: these article can significantly increase FABF, reduce Peripheral resistance, and blood vessel wall is had direct dilating effect.Can obviously prolong clotting time, blood viscosity lowering." Records of Tradition Chinese and Western Medicine in Combination ": " Squama Manis, lightly seasoned property is flat, gas raw meat and scurrying, the property that it walks to scurry, very careful, lead to internal organs so can declare, implement meridians, reach the pass key thoroughly, all blood clotting blood gathers and is disease, all can open it ".
Radix Cyathulae: bitter in the mouth, sweet, sour, property is flat, goes into liver, kidney channel, has effects such as promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards.These article are longer than promoting blood circulation to restore menstrual flow, clinical disease and the damp and hot one-tenth flaccidity that is used for multiple blood stasis, the soft person of sufficient knee joint flaccidity." Records of Tradition Chinese and Western Medicine in Combination ": " kind bleed blood is made a bet, and is to desire its passerby down with medication, permanent be tying-in, so control the lumbago and skelalgia of suffering from a deficiency of the kidney, or knee joint ache can not bend and stretch or the lower limb flaccidity can not be appointed ground ".Pharmacological research proves: these article can reduce the rat WBV, packed cell volume, erythrocyte aggregation index, and anticoagulation is arranged.In addition, effects such as blood fat reducing, blood sugar lowering, antiinflammatory, raise immunity are still arranged." Chinese pharmacopoeia (version in 2000) record: Radix Cyathulae " eliminating blood stasis and inducing menstruation, easing joint movement ... be used for arthralgia, flaccidity of the lower limbs clonic spasm of the muscle ... ".
Agkistrodon: sweet-salty is warm in nature, goes into Liver Channel, has effects such as wind-damp dispelling, the meridian dredging.These article have the property of walking to scurry, and collateral dredging warm in nature is walked internal organs in the ability, reach the flesh table outward and the deep wind of searching is the wind-damp dispelling key medicine; Again can collateral dredging, all rheumatic Bi syndromes do not have unsuitable it, outstanding kind rheumatoid arthritis stubborn of curing the disease deeply with the passing of time, blockage of main and collateral channels, numbness contracture etc.Compendium of Material Medica: " can the deep wind of searching, cut and frightenedly jerk surely, for migratory arthralgia, frightenedly jerk, favus, malignant boil key medicine.Get and walk internal organs in it, outer thorough skin is nowhere less than also ".Modern pharmacological research confirms: these article have significant hypotensive effect, and its water extract can activate fibrinolytic system, and the stronger thrombotic effect of prevention artery and vein is arranged.
Flos Carthami: acrid in the mouth is warm in nature, and GUIXIN, Liver Channel have the effect of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.The hot temperature of loosing of these article is logical, specially goes into blood system, is the key medicine of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Can blood circulation promoting and blood stasis dispelling, the stasis of blood is gone new life, and warm venting QI-blood is used to control that meridian stasis stagnates swells and ache diseases such as traumatic injury." book on Chinese herbal medicine converges and says ": " Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.”
Olibanum: acrid in the mouth bitterness temperature, return liver, the heart, spleen channel, have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving, detumescence and promoting granulation.The hot temperature of loosing of these article is logical, can the blood-activating and qi-promoting pain relieving, again can blood stasis dispelling, stretch muscle, and exempt from numbness, so diseases such as the limbs pain due to dispelling the wind and dampness pathogens arthralgia pain and the stagnation of blood stasis, numbnesses.And internal energy a surname of these article is led to internal organs, and external enwergy reaches meridians thoroughly, can blood circulation promoting and blood stasis dispelling, can manage it the gas that stagnates that looses again, and the merit of pain relieving is more outstanding.Can " decide pain of all warps " " pearl sac ", the kind pain of controlling stagnation of QI and blood." property of medicine is cut usefulness ": " relaxing muscles and tendons to promote blood circulation, wind-expelling pain-stopping is for controlling the active special medicine of numbness ".
Olibanum: acrid in the mouth bitterness temperature, return liver, the heart, spleen channel, have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving, detumescence and promoting granulation.The hot temperature of loosing of these article is logical, can the blood-activating and qi-promoting pain relieving, again can blood stasis dispelling, stretch muscle, and exempt from numbness, so diseases such as the limbs pain due to dispelling the wind and dampness pathogens arthralgia pain and the stagnation of blood stasis, numbnesses.And internal energy a surname of these article is led to internal organs, and external enwergy reaches meridians thoroughly, can blood circulation promoting and blood stasis dispelling, can manage it the gas that stagnates that looses again, and the merit of pain relieving is more outstanding.Can " decide pain of all warps " " pearl sac ", the kind pain of controlling stagnation of QI and blood." property of medicine is cut usefulness ": " relaxing muscles and tendons to promote blood circulation, wind-expelling pain-stopping is for controlling the active special medicine of numbness ".
Rhizoma Corydalis: acrid in the mouth bitterness temperature, return liver, spleen, heart channel, have invigorate blood circulation, the effect of promoting the circulation of QI to relieve pain.The hot temperature of loosing of these article is logical, and " stagnation of QI in the promoting the circulation of blood, stasis in the gas is so specially control all up and down all over the body pain Compendium of Material Medica for ability.These article are the pain relieving key medicine, which kind of pain disease no matter, but all compatibility is used, and especially qi depression to blood stasis person is better.
More than all medicine compatibilities, play the effect of benefiting QI for activating blood circulation, removing blood stasis with potent drugs collateral dredging, pain relieving altogether.Be used to treat that the hyperamization arteries and veins stasis of bloods such as, blood stasis deficient because of diseases caused by exogenous pathogenic factor six climate exopathogens, tobacco poisoning, wound or diet delicious food, feelings will internal injury, the imbalance of internal organs meridian function, impairment caused by overstrain, phlegm retention stagnate, blood operation is obstructed that the lower limb that cause send out cold, numbness, pain, raise that pain increases the weight of when suffering from limb; Intermittent claudication; Also pain during rest when serious; Increase the weight of night, and skin color becomes pitchy, and the early stage occlusive peripheral arterial of diseases such as amyotrophy is atherosis.
The present composition has the effect of benefiting QI for activating blood circulation, removing blood stasis with potent drugs removing obstruction in the collateral to relieve pain; Can improve the blood circulation of lower limb effectively, significantly alleviate or effectively eliminate limbs pain, alleviate or eliminate intermittent claudication; Make skin gradually transfer the normal colour of skin to by pitchy; Can delay or control the atrophy of lower limb muscle of leg, and treatment more early, curative effect is just remarkable more.Chinese medicine composition of the present invention can impel toe in late period, foot or calf ulcer healing, has remedied the simple Western medicine symptomatic treatment of using, the drawback that can not effectively stop the state of an illness to be made progress gradually to worsen, and an efficacious therapy approach is provided for this new subject.
The specific embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is done to introduce in detail further, but protection scope of the present invention is not limited thereto.
Embodiment 1
Radix Astragali 10g, Radix Ginseng 30g, Ramulus Cinnamomi 3g, Pheretima 7g, Scorpio 2g, Hirudo 3g, Squama Manis preparata 3g, Radix Cyathulae 15g, Agkistrodon 3g, Flos Carthami 7g, Olibanum (processed) 10g, Rhizoma Corydalis 3g.
Method for preparing and method for using:
The PD phase: 1. above-mentioned 12 flavor crude drug are put into marmite, first fries in shallow oil and adds water 600ml and soaked 30 minutes, after boiling with high heat earlier, uses the about 350ml of taking liquid again instead 30 minutes at a simmer; Second fries in shallow oil and adds water 500ml, uses the about 350ml of taking liquid again instead 25 minutes at a simmer after boiling with high heat earlier; Two boil medicine liquid mix after clothes at twice, early, evening each clothes once, decoction being taken warmly.Or, 2. utilize prior art to process granule above-mentioned 12 flavor crude drug, divide the bag of packing into, every bag of 10g obeys 1 bag at every turn, obeys warm boiled water every day three times.
The stable disease phase: above-mentioned 12 flavor Chinese medicines are pulverized the back cross 120 mesh sieves, process superfine medicated powder after: 1. medicated powder and honey are processed honeyed pill by the 1:1.5 mass ratio, every ball 3g obeys 6g, every day at every turn and obeys warm boiled water three times; Or, 2. with the medicated powder Capsules of packing into, every 0.3g, obey 6, every day three times, warm boiled water at every turn; Or, 3. utilize prior art to process concentrated pill the present invention's 12 flavor crude drug, obey 6g at every turn, obey warm boiled water every day three times.
Embodiment 2
Radix Astragali 30g, Radix Ginseng 15g, Ramulus Cinnamomi 10g, Pheretima 10g, Scorpio 5g, Hirudo 2g, Squama Manis preparata 6g, Radix Cyathulae 10g, Agkistrodon 9g, Flos Carthami 9g, Olibanum (processed) 6g, Rhizoma Corydalis 10g.
Method for preparing and method for using are with embodiment 1.
Embodiment 3
Radix Astragali 60g, Radix Ginseng 5g, Ramulus Cinnamomi 7g, Pheretima 5g, Scorpio 3g, Hirudo 1.5g, Squama Manis preparata 10g, Radix Cyathulae 6g, Agkistrodon 6g, Flos Carthami 3g, Olibanum (processed) 3g, Rhizoma Corydalis 7g.
Method for preparing and method for using are with embodiment 1.
Clinical trial
1.1 physical data
From year August in January, 2005 to 2011, accept atherosis patient's 120 examples of early stage occlusive peripheral arterial for medical treatment.All cases are all through health check-up, the intensity that the inspection dorsal artery of foot is beaten, the test of finger pressure nail matrix, survey the ankle SAP and multiple inspections such as brachial artery systolic pressure ratio and laboratory auxiliary examination are made a definite diagnosis, and it is bad not have severe cardiac, liver, renal function.Be divided into treatment at random and organize 60 examples, wherein male 39 examples, women 21 examples, 36 ~ 65 years old age, 55 years old mean age, suffer from diabetes 33 examples, suffer from hypertension 60 examples, suffer from hyperlipemia 60 examples.Matched group 60 examples, wherein male 40 examples, women 20 examples, 38 ~ 67 years old age, 56 years old mean age, suffer from diabetes 32 examples, suffer from hypertension 60 examples, suffer from hyperlipemia 60 examples.Two groups are not all had significant difference (P>0.05) at aspects such as sex, age, the state of an illness, have comparability, see table 1 for details.
1.2 diagnostic criteria
Diagnostic criteria with reference to 367 pages of the internal medicine of 8 years systems of confession of Wang Jiyao chief editor and 7 years professional usefulness such as system clinical medicine is formulated.
1. the age is many more than 50 years old; 2. hyperlipemia, diabetes or hypertension history are arranged; 3. intermittent claudication, acroesthesia companion artery of lower extremity beat weaken, disappearance, asymmetric, ankle/brachial artery systolic pressure index < 1.0; 4. Doppler checks the positive.
1.3 Therapeutic Method
Matched group: adopt the routine of western medicine treatment: the control blood fat is with simvastatin or fenofibrate; Blood sugar control is with glipizide or insulin; Controlling blood pressure is improved the blood samples of patients circulation and is used low molecular dextran with enalapril, Nifedipine sustained release tablets, and other takes symptomatic treatment.
Treatment group: on the basis of matched group, add the embodiment of the invention 2 prescriptions and preparation method thereof, method for using with the routine of western medicine treatment.
Two groups treated for 8 weeks respectively after, observe improvement situation such as clinical symptoms and each item auxiliary examination.
1.4 therapeutic evaluation
Produce effects: clinical symptom disappearance, finger pressure nail matrix capillary filling time shortens, and survey ankle/upper arm index is approaching or equal 1; Dorsal artery of foot is beaten near normal or normal; The blood fat and blood pressure glycemic control is normal.
Effectively: clinical symptoms disappears basically, and finger pressure nail matrix capillary filling time prolongs slightly or near normal, surveys ankle/upper arm index greater than more than 0.7; Dorsal artery of foot is beaten near normal; Blood fat and blood pressure blood glucose all is controlled near normal.
Invalid: clinical symptoms and finger pressure nail matrix capillary filling time all do not have obvious improvement, survey ankle/upper arm index below 0.5; Dorsal artery of foot is beaten and is weakened or disappear.
1.5 statistical method
Data are represented with rate, adopt X
2Check is with P<0.05 for difference has statistical significance.
1.6 result
1.6.1 two groups of doing well,improving situation relatively before and after the treatment
The treatment group is treated on the basis with routine of western medicine at matched group and is added Chinese medicine composition of the present invention, and clinical symptoms improvement rate (91.5%) significantly is superior to matched group merely with routine of western medicine treatment back clinical symptoms improvement rate (49.8%), sees table 2 for details.
1.6.2 two groups of auxiliary examination results improve comparison before and after the treatment
The treatment group is after matched group adds Chinese medicine composition of the present invention on routine of western medicine treatment basis; Dorsal artery of foot beat strengthen improvement rate (86.6%), with finger compressing nail matrix capillary filling time shorten improvement rate (91.6%), survey ankle/brachial artery systolic pressure index improvement rate (83.3%), after blood glucose improvement rate (90.9%), blood pressure improvement rate (95%), blood fat and improving rate (96.6%) significantly be superior to matched group and treat with routine of western medicine merely; Dorsal artery of foot is beaten and is strengthened improvement rate (65%); With finger compressing nail matrix capillary filling time improvement rate (68.3%); Survey ankle/brachial artery systolic pressure index improvement rate (65%); Blood glucose improvement rate (84.3%), blood pressure improvement rate (60%), blood fat and improving rate (53.3%) see table 3 for details.
1.6.2 untoward reaction
Matched group has 7 examples dry cough to occur, and there have 3 examples hypoglycemia to occur to be dizzy.The treatment group is not seen obvious adverse reaction.
Model case
Case 1
Feng so-and-so, the man, 52 years old, the peasant was East St people from village, area just outside a city gate town, on August 16th, 2007, came the inventor to locate to go to a doctor with " the occlusive peripheral arterial is atherosis ".The patient has surplus the hypertension history 10 year.Two lower limb pains occur in 2 years causes back of suffering from cold, once the treatment back of taking medicine is alleviated in the locality, occurs tired back two lower limb pains then, alleviate slightly after the rest, and pruritus causes before the two shank shins because of scratching and inboard ulcer, merge in blocks.More not and change the treatment of Puyang the People's Hospital,, with the external of many sulfonic acid mucopolysaccharide emulsifiable paste, heavy when light when festering, outbreak is repeatedly located for asking further treatment to change the inventor over to through county people's hospital treatment.Disease is seen: the slight atrophy of two lower limb muscles, and the colour of skin is purple dark, reaches two medial legs before the shin and festers, and merges in flakes, and the skin ulcer face oozes out; Pain, the activity postemphasis also bitterly, is tucked and is comforted foot, shallow complexion during rest; Lip is purple dark, and purplish tongue is dark, and tongue is white, thready pulse without strength, and finger pressure nail matrix capillary filling time prolongs; Survey ankle/upper arm index 0.6, T:37.6 ℃, P:86 time/minute, R:20 time/minute; BP:160/95mmHg, blood glucose 4.6mmol/L, blood fat: triglyceride 2.9 mmol/L, cholesterol 6.1 mmol/L, surplus (-).
Dialectical analysis: prolonged illness is felt frustrated, the deficiency of vital energy does not have mechanical resistance blood operation, and hyperamization liquid stasis of blood resistance passages through which vital energy circulates, limbs lose and support, so sallow, purple dark, the two lower limb muscles atrophy of lip of meeting color, purple dark, the pain of the colour of skin, tucks and comforts foot.Overexertion leading to consumption of QI, the movable back of event pain increase the weight of.Because of scratching the damage skin, multiple sense poison is evil, so shin is anterior and two medial legs fester, merges in flakes gradually, and the skin ulcer face oozes out.Purplish tongue is dark, and tongue is greasy in vain, and thready and weak pulse without strength is resembling of blood stasis due to qi deficiency.
Diagnosis: vascular disorders (blood stasis due to qi deficiency)
The rule of treatment: benefiting QI for activating blood circulation, removing blood stasis with potent drugs removing obstruction in the collateral to relieve pain.
Side's medicine: the embodiment of the invention 2 prescriptions and preparation method thereof, method for using.
Western medicine: controlling blood pressure is with Nifedipine sustained release tablets, enalapril, and the control blood fat is used fenofibrate, and microcirculation improvement is used low molecular dextran, other symptomatic treatment.
After 8 weeks of treatment, the two lower limb pains of patient disappear, and it is normal that the colour of skin is gradually recovered; Form a scab with inboard rotten position before the two shank shins, and the healing that comes off gradually, finger pressure nail matrix capillary filling time transfers to normally; Surveying ankle/upper arm index is 1, and blood pressure, blood fat, blood glucose all are controlled within normal range.Advise the capsule preparations 6 months that continues to take the embodiment of the invention 2 prescriptions, after the drug withdrawal,, do not have recurrence so far through repeatedly following up a case by regular visits to.
Case 2
Pay so-and-so, the man, 60 years old, the cadre was first villages and small towns Shi Gu people from village, on June 19th, 2008, came the inventor to locate to go to a doctor with " the occlusive peripheral arterial is atherosis ".The patient has surplus hypertension and coronary heart disease, the atrial fibrillation medical history 30 year, often medication.Occur two lower limb over nearly 3 years and send out cold, numbness, movable back pain.Once in county people's hospital's treatment, effect was not good enough, changeed Puyang the People's Hospital's diagnosis and treatment, did not still have to be clearly better, and changed the inventor place over to.Disease is seen: two lower limb pains, and the activity postemphasis, light slightly after the rest, the colour of skin is purple dark, two Calf muscle atrophys; Festering of diameter 3cm arranged before the left leg shin, and wound surface depression is oozed out, and has palpitation, breathes hard, asthenia, dim complexion, dark, the irregularly intermittent and regularly intermittent pulse of light red tongue, and finger pressure nail matrix capillary filling time prolongs; Survey ankle/upper arm index 0.5, T:37 ℃, P:90 time/minute, R:22 time/minute; BP:170/95mmHg, blood glucose 5.0mmol/L, blood fat: triglyceride 1.2mmol/L, cholesterol 6.7 mmol/L, surplus (-).
Dialectical analysis: the prolonged illness QI and blood is two to be lost, and causes the qi and blood stagnation passages through which vital energy circulates, and limbs lose supports, so see two Calf muscle atrophys, the colour of skin is purple dark.Stagnation of QI-blood can not be gone up flourish in face, so the meeting color is dark and gloomy.Impaired because of the wound skin, multiple sense poison is evil, thus fester before the left leg shin, Qi and blood deficiency of a specified duration, then the wound surface depression is oozed out.Insufficiency of vital energy and blood, the heart is become homeless foster, so see nervously, breathes hard asthenia.Light red tongue is dark, and irregularly intermittent and regularly intermittent pulse is deficiency of qi and blood, the stagnant disease of the passages through which vital energy circulates stasis of blood.
Diagnosis: vascular disorders (deficiency of qi and blood, the passages through which vital energy circulates stasis of blood stagnates)
The rule of treatment: QI replenishing and blood tonifying, removing blood stasis with potent drugs removing obstruction in the collateral to relieve pain.
Side's medicine: the embodiment of the invention 3 prescriptions and preparation method thereof, method for using.
Western medicine: controlling blood pressure is with Nifedipine sustained release tablets, valsartan, and the control blood fat is used simvastatin, improves blood circulation and uses low molecular dextran, and other adopts symptomatic treatment.
After 8 weeks of treatment, patient's two lower limb pains disappear, and the left leg rotten position heals; Calf muscle is plentiful before, and the colour of skin gradually transfers to normally, the alleviation of having palpitation, breathe hard; Finger pressure nail matrix capillary filling time shortens, and surveys ankle/upper arm index 0.9, and blood pressure, blood fat, blood glucose all are controlled in normal range.Advise the made capsule of the continuation clothes embodiment of the invention 3 prescriptions to consolidate curative effect in 6 months,, do not have recurrence so far through repeatedly following up a case by regular visits to.
Case 3
The field so-and-so, the woman, 67 years old, the peasant was Gu Jin Lou Xiang Pingyi people from village, on JIUYUE 28th, 2006, came the inventor to locate to go to a doctor with " the occlusive peripheral arterial is atherosis ".The patient two lower limb pains occur in 3 years causes back of catching cold, and once in county people's hospital's diagnosis and treatment commentariess on classics of not getting better, arrives the Puyang the People's Hospital then and treats, and leaves hospital after making pain relief.In nearly March, two lower limb pains increase the weight of and change the inventor over to and locate.Disease is seen: two lower limb have an intense pain, and tuck and comfort foot, and skin is pitchy, two Calf muscle atrophys, asthenia, poor appetite, have palpitation, breathe hard, pale tongue with white fur, weak pulse be unable.T:36.8 ℃, P:80 time/minute, R:22 time/minute, BP:160/90mmHg.Two dorsal artery of foot are beaten and are weakened, and finger pressure nail matrix capillary filling time prolongs, and survey ankle/upper arm index 0.6, blood glucose 9.2mmol/L, blood fat: triglyceride 3.2mmol/L, cholesterol 5.3 mmol/L, surplus (-).
Dialectical analysis: the cold-evil stagnates, and makes blood-vessel obstructive obstructed, and again because of prolonged illness causes deficiency of qi and blood, limbs lose supports, and, also can not alleviate amyotrophy, skin darkish complexion during rest so two lower limb have an intense pain.Insufficiency of vital energy and blood, heart arteries and veins lose to be supported, so see nervously, breathe hard.Pale tongue with white fur, weak pulse is unable, is resembling of blood stasis due to qi deficiency.
Diagnosis: vascular disorders (blood stasis due to qi deficiency)
The rule of treatment: benefiting QI for activating blood circulation, removing blood stasis with potent drugs, pain relieving.
Side's medicine: the embodiment of the invention 1 prescription and preparation method thereof, method for using.
Western medicine: controlling blood pressure is with Nifedipine sustained release tablets, enalapril, and blood sugar control is used glipizide, and the control blood fat is used fenofibrate, improves blood circulation and uses low molecular dextran, and other adopts symptomatic treatment.
After 8 weeks of treatment, patient's two lower limb pains disappear, and skin color is near normal, and two Calf muscles are plentiful gradually, diet still can, the alleviation of having palpitation, breathe hard.Blood pressure, blood glucose, blood fat etc. all are controlled within normal range.Advise and continue the surplus drug withdrawal in 6 months of the clothes made capsule of the embodiment of the invention 1 prescription,, do not have recurrence so far through repeatedly following up a case by regular visits to.
Claims (6)
1. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial of treatment is characterized in that being processed by each crude drug of following portions by weight: 10 ~ 60 parts of the Radixs Astragali, 5 ~ 30 parts of Radix Ginsengs, 3 ~ 10 parts of Ramulus Cinnamomi, 5 ~ 10 parts of Pheretimas, 2 ~ 5 parts of Scorpios, 1.5 ~ 3 parts of Hirudos, 3 ~ 10 parts of Squama Maniss, 6 ~ 15 parts of Radix Cyathulaes, 3 ~ 10 parts of Agkistrodons, 3 ~ 10 parts on Flos Carthami, 3 ~ 10 parts of Olibanums, 3 ~ 10 parts of Rhizoma Corydalis.
2. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial of treatment as claimed in claim 1 is characterized in that being processed by each crude drug of following portions by weight: 30 parts of the Radixs Astragali, 15 parts of Radix Ginsengs, 10 parts of Ramulus Cinnamomi, 10 parts of Pheretimas, 5 parts of Scorpios, 2 parts of Hirudos, 6 parts of Squama Maniss, 10 parts of Radix Cyathulaes, 9 parts of Agkistrodons, 9 parts on Flos Carthami, 6 parts of Olibanums, 10 parts of Rhizoma Corydalis.
3. according to claim 1 or claim 2 the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial of treatment, it is characterized in that: Squama Manis is a Squama Manis preparata.
4. according to claim 1 or claim 2 the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial of treatment, it is characterized in that: Olibanum is an Olibanum (processed).
5. according to claim 1 or claim 2 the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial of treatment is characterized in that: process any acceptable clinically preparation by conventional method.
6. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial of treatment as claimed in claim 5, it is characterized in that: said preparation is decoct, pill, capsule, granule or concentrated pill.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435449A (en) * | 2014-12-23 | 2015-03-25 | 青岛市市立医院 | Pharmaceutical composition for resisting atherosclerosis and application of pharmaceutical composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1347709A (en) * | 2000-10-09 | 2002-05-08 | 王学勇 | Cardiac and cerebral vascular disease treating medicine |
| CN101020034A (en) * | 2007-04-02 | 2007-08-22 | 李宏良 | Prepn process of medicine for treating cerebral apoplexy and its sequela |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1347709A (en) * | 2000-10-09 | 2002-05-08 | 王学勇 | Cardiac and cerebral vascular disease treating medicine |
| CN101020034A (en) * | 2007-04-02 | 2007-08-22 | 李宏良 | Prepn process of medicine for treating cerebral apoplexy and its sequela |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435449A (en) * | 2014-12-23 | 2015-03-25 | 青岛市市立医院 | Pharmaceutical composition for resisting atherosclerosis and application of pharmaceutical composition |
| CN104435449B (en) * | 2014-12-23 | 2018-09-07 | 青岛市市立医院 | A kind of pharmaceutical composition of antiatherosclerosis and its application |
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