CN102357220B - Traditional Chinese medicine composition for treating early-stage lower limb thrombotic deep phlebitis - Google Patents
Traditional Chinese medicine composition for treating early-stage lower limb thrombotic deep phlebitis Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and especially discloses a traditional Chinese medicine composition for treating early-stage lower limb thrombotic deep phlebitis. The composition is prepared by the following raw material herbs by weight: 10-60 parts of radix astragali, 5-10 parts of rhizoma atractylodis, 5-10 parts of phellodendron, 2-5 parts of scorpions, 5-10 parts of lumbricus, 3-10 parts of long-nosed pit viper, 3-10 parts of ground beetle, 1.5-3 parts of leeches, 3-10 parts of pangolins, 3-15 parts of rhizoma sparganii, 3-10 parts of frankincense, 3-10 parts of safflowers, 6-15 parts of radix cyathulae, 5-10 parts of menispermaceae, 5-10 parts of grifola, 10-15 parts of plantain seeds, 10-15 parts of poria cocos, and 5-10 parts of alisma orientale. The composition of the invention has the efficacy of clearing heat and drying damp, inducing diuresis and alleviating edema, tonifying qi and invigorating blood, dissolving stasis and dissipating binds, relaxing vein and relieving pain. The composition is used to treat symptoms such as unilateral lower limb sudden and generalized hypertrophy, edema, distending pain, walking difficulty with low fever caused by limb qi-blood running unsmoothness, qi-blood stagnation, blood stasis flowing into lower limbs, vein-collateral obstruction, ying blood backflow obstruction, body fluid overflow due to blood vessel injury, long-lying qi damage, or qi deficiency and blood stasis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese medicine composition for the treatment of early stage Lower Limb Thrombosis deep phlebitis.
Background technology
The Lower Limb Thrombosis deep phlebitis belongs to motherland's medical science " thigh is swollen " category.The Tang Rong of the Qing Dynasty points out in " treatise on blood trouble " in the river: " multiple abscess due to blood stasis is also swelled swollen, is the card that blood becomes water." clear Golden Mirror of Medicine that Wu Qian shows says: " swollen person is done in sprain and contusion in puerperal, blood stasis, and blood stasis is for a long time stagnant in meridians, neglects the firmly not red slight fever of wood." its pathogenesis is: blood vessels damage or excessive rest on bed impairing QI or blood stasis due to qi deficiency, cause the limbs QI-blood circulation not smooth, coagulation of QI-blood, multiple abscess due to blood stasis are in lower limb, and venation blocks obstructed, the nutrient blood backflow obstruction, water Tianjin is excessive, and sends out primary disease.Clinical with: single lower limb is sudden, popularity is slightly swollen, and distending pain is walked unfavorable, can accompany low grade fever.Superficial vein expansion, varicose can appear in the later stage, the slight edema of limbs, and the shank pigmentation, and dermatitis, ecthyma, prolonged do not heal etc. are primary symptom.
The Lower Limb Thrombosis deep phlebitis shows as because the slow and high blood coagulation state of blood flow causes venous thrombosis: suffer from limb swelling, pain, local skin temperature rise and superficial vein anger such as open at the disease.And use merely the Western medicine symptomatic treatment, and poor effect, because the thromboembolism treatment Best Times is 1 ~ 2 hour, maximum duration should not be over 12 hours.Most of patients has lost thrombolytic opportunity clinically, and anticoagulant therapy can only prevent the stretching, extension of existing thrombosis, but can not dissolve existing thrombosis.Primary disease directly affects patient's health and work, and easily causes the severe complication such as pulmonary infarction, brings very large burden for society and family.
Summary of the invention
For overcoming the deficiencies in the prior art part, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of early stage Lower Limb Thrombosis deep phlebitis.Said composition has the effect of heat clearing and damp drying, inducing diuresis to remove edema, benefiting QI for activating blood circulation, blood stasis-eliminating and stagnation-dissipating, removing obstruction in the collateral to relieve pain.
For achieving the above object, the technical scheme taked of the present invention is as follows:
A kind of Chinese medicine composition for the treatment of early stage Lower Limb Thrombosis deep phlebitis is made by each crude drug of following portions by weight: 10 ~ 60 parts of the Radixs Astragali, 5 ~ 10 parts of Rhizoma Atractylodis, 5 ~ 10 parts of Cortex Phellodendris, 2 ~ 5 parts of Scorpios, 5 ~ 10 parts of Pheretimas, 3 ~ 10 parts of Agkistrodons, 3 ~ 10 parts of Eupolyphaga Seu Steleophagas, 1.5 ~ 3 parts of Hirudos, 3 ~ 10 parts of Squama Maniss, 3 ~ 15 parts of rhizoma sparganic, 3 ~ 10 parts of Olibanums, 3 ~ 10 parts, Flos Carthami, 6 ~ 15 parts of Radix Cyathulaes, 5 ~ 10 parts of Radix Stephaniae Tetrandrae, 5 ~ 10 parts of Polyporus, 10 ~ 15 parts of Semen Plantaginiss, 10 ~ 15 parts, Poria, 5 ~ 10 parts of Rhizoma Alismatis.
Further, the parts by weight of described each crude drug are preferably: 30 parts of the Radixs Astragali, 10 parts of Rhizoma Atractylodis, 10 parts of Cortex Phellodendris, 5 parts of Scorpios, 10 parts of Pheretimas, 6 parts of Agkistrodons, 10 parts of Eupolyphaga Seu Steleophagas, 3 parts of Hirudos, 10 parts of Squama Maniss, 10 parts of rhizoma sparganic, 6 parts of Olibanums, 10 parts, Flos Carthami, 10 parts of Radix Cyathulaes, 10 parts of Radix Stephaniae Tetrandrae, 10 parts of Polyporus, 15 parts of Semen Plantaginiss, 10 parts, Poria, 10 parts of Rhizoma Alismatis.
Preferably, Eupolyphaga Seu Steleophaga is Eupolyphaga (parched), and Squama Manis is Squama Manis preparata, and Olibanum is Olibanum (processed).
Make according to a conventional method any acceptable preparation clinically, such as can be decoct, pill, capsule, granule or concentrated pill.Can according to the needs of different preparations, choose and add corresponding conventional adjuvant.
Preparation method and using method:
the progression of disease phase: 1. in weight/volume, take the Radix Astragali 10 ~ 60g, Rhizoma Atractylodis 5 ~ 10g, Cortex Phellodendri 5 ~ 10g, Scorpio 2 ~ 5g, Pheretima 5 ~ 10g, Agkistrodon 3 ~ 10g, Eupolyphaga Seu Steleophaga 3 ~ 10g, Hirudo 1.5 ~ 3g, Squama Manis 3 ~ 10g, rhizoma sparganic 3 ~ 15g, Olibanum 3 ~ 10g, Flos Carthami 3 ~ 10g, Radix Cyathulae 6 ~ 15g, Radix Stephaniae Tetrandrae 5 ~ 10g, Polyporus 5 ~ 10g, Semen Plantaginis 10 ~ 15g, Poria 10 ~ 15g, Rhizoma Alismatis 5 ~ 10g, then this 18 flavor crude drug is put into marmite, first fries in shallow oil and adds water 600ml and soaked 30 minutes, after first boiling with high heat, used instead again 30 minutes at a simmer, taking liquid is 350ml approximately, second fries in shallow oil and adds water 500ml, uses instead 25 minutes at a simmer after first boiling with high heat again, and taking liquid is 350ml approximately, boiling medicine two takes after liquid mixes at twice, morning and evening service once, decoction being taken warmly.Or, 2. the present invention's 18 flavor crude drug are utilized the agent of prior art granulation, be distributed into bag, every bag of 10g each serving 1 bag, takes warm boiled water every day three times.
the stable disease phase: by weight ratio, take the Radix Astragali 10 ~ 60g, Rhizoma Atractylodis 5 ~ 10g, Cortex Phellodendri 5 ~ 10g, Scorpio 2 ~ 5g, Pheretima 5 ~ 10g, Agkistrodon 3 ~ 10g, Eupolyphaga Seu Steleophaga 3 ~ 10g, Hirudo 1.5 ~ 3g, Squama Manis 3 ~ 10g, rhizoma sparganic 3 ~ 15g, Olibanum 3 ~ 10g, Flos Carthami 3 ~ 10g, Radix Cyathulae 6 ~ 15g, Radix Stephaniae Tetrandrae 5 ~ 10g, Polyporus 5 ~ 10g, Semen Plantaginis 10 ~ 15g, Poria 10 ~ 15g, Rhizoma Alismatis 5 ~ 10g, then cross 120 mesh sieves after this 18 flavor Chinese medicine being pulverized, after making superfine medicated powder: 1. medicated powder and honey are made honeyed pill by the 1:1.5 mass ratio, every ball 3g, each serving 6g, take every day three times, warm boiled water, or, the Capsules of 2. medicated powder being packed into, every 0.3g, each serving 6, every day three times, warm boiled water, or, 3. utilize prior art to make concentrated pill the present invention's 18 flavor crude drug, each serving 6g, take warm boiled water every day three times.
Pharmacology of the present invention:
The Radix Astragali, the sweet in the mouth tepor is returned spleen, lung meridian, has the effect that tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening, enriched blood and invigorate blood circulation.This product is good at invigorating the spleen and replenishing QI.Can QI invigorating with promoting the circulation of blood, certain merit of invigorating blood circulation is arranged again.Therefore multiplex in the stagnant all diseases of the treatment blood vessels stasis of blood.Again because of the energy inducing diuresis to remove edema of holding concurrently, therefore be also the key medicine of deficiency of vital energy edema.Control the wet edema oliguria person who loses fortune of insufficiency of the spleen water.This product can invigorating the spleen and replenishing QI to effect a permanent cure, again can inducing diuresis to remove edema to take stopgap measures." treatise on blood trouble ": " blood stasis water also floods swollen, be disorders of blood and hold concurrently water also ", if stagnation of blood stasis, damage three warmers water channel often can make the edema stubbornness not heal." Radix Astragali can not only pass through QI invigorating, makes gas prosperous in promoting the circulation of blood, and the good merit of invigorating blood circulation is arranged, " blood water is also gone simultaneously." modern experimentation proves: this product truly has the good merit of invigorating blood circulation, and can reduce whole blood contrast viscosity and plasma viscosity, shortens erythrocyte electrophoretic time, reduces packed cell volume, improves hemorheological property, can obviously reduce the platelet cofactor Ⅰ procoagulant activity.And coronary artery and peripheral blood vessel there are direct dilating effect, coronary flow is increased.The effect of remarkable anti-experimental character thrombosis is separately arranged, energy anticoagulant etc.
Rhizoma Atractylodis: acrid in the mouth bitterness temperature, return spleen, stomach warp, have effect drying damp and strengthening spleen, wind-damp dispelling.This product is hot loose bitter dry, and kind dry spleen is wet, the disease for the treatment of retention of dampness in middle-JIAO, dysfunction of the spleen in transportation.And be longer than damp eliminating, wet victor is especially suitable for arthromyodynia, more can be used for damp and hot flaccidity of feet with lamenness, bottom turbid damp leukorrhagia, eczema, eczema etc.
Cortex Phellodendri: bitter in the mouth is cold in nature, returns kidney, bladder, large intestine channel, has heat clearing and damp drying, eliminating fire and detoxication, brings down a fever except the effect of steaming.The sedimentation of this product bitter cold, heat clearing and damp drying is longer than and is rushed down clearly damp-heat in lower-JIAO, is used for damp invasion of lower energizer, beriberi flaccidity of feet with lamenness, sufficient swelling and pain in knee etc.; This product again can eliminating fire and detoxication, controls sore swollen toxin, eczema, eczema etc.
Scorpio: acrid in the mouth is flat, returns Liver Channel, has the functions such as endogenous wind stopping relieving convulsion, resolving mass and removing the obstruction of the collateral.This product has the good effect of expel wind to dredge collateral.With the passing of time do not heal with controlling anemofrigid-damp arthralgia, the contracture of muscle arteries and veins, brothers' erectile problem, very the insensitive impediment of joint deformity, act on rather good." beautiful Chinese catalpa medicine solution ": " wearing muscle deep, by the wet wind that removes ".Modern pharmacological research proves: Scorpio has antithrombotic to form, and reduces platelet adhesion rate, delays hemagglutinative function.
Pheretima: salty in the mouth is cold in nature, enters liver, spleen, urinary bladder channel, has the effects such as endogenous wind stopping relieving convulsion, collateral dredging.Kind control that blood stagnancy due to deficiency of QI after apoplexy, muscle arteries and veins lose and support, the unfavorable all diseases of meridians and rheumatism with the passing of time, Yu Xue Bi resistance passages through which vital energy circulates, podomere or the whole body.The kind current meridians of this product.Modern pharmacological research proves: the Pheretima decoct has anti thrombotic action, and the thrombolytic composition is protease, energy direct hydrolysis fibrin, and have the activation of plasminogen.By anticoagulant, anticoagulation, reduction blood viscosity, thereby stop thrombosis, promote thromboembolism.
Agkistrodon: sweet-salty is warm in nature, enters Liver Channel, has the effects such as wind-damp dispelling, the meridian dredging.This product has the property of walking to alter, and collateral dredging warm in nature is walked internal organs in energy, reaches the flesh table outward and the deep wind of searching is the wind-damp dispelling key medicine; Again can collateral dredging, all rheumatic Bi syndromes without unsuitable it, outstanding kind rheumatoid arthritis stubborn of curing the disease deeply with the passing of time, the Compendium of Material Medica such as blockage of main and collateral channels, numbness contracture.Modern pharmacological research proves: this product has significant hypotensive effect, and its water extract can activate fibrinolytic system, the effect that has stronger prevention artery and vein thrombosis to form.
Eupolyphaga Seu Steleophaga: salty in the mouth, cold in nature, slightly poisonous, return Liver Channel, have the effect of removing blood stasis, reunion of fractured tendons and bones.This product is salty-cold enters blood, mainly enters Liver Channel, and property is apt to away alter, and can invigorate blood circulation and cure the wound, and reunion of fractured tendons and bones is the traumatology key medicine.But single is ground into powder to transfer and is applied, and is used for traumatic injury, injury of tendon and muscle fracture, pain caused by ecchymoma.This product again can the removing blood stasis collateral dredging, is used for the disease of blood stasis retardance meridians." Changsha medicine solution ": " this product is apt to Removing Blood Stasis, mends most and damages medicine ".
Hirudo: salty in the mouth is bitter, and property is flat, and is slightly poisonous, enters Liver Channel, has the effect of removing blood stasis, Xiao wei.The salty hardship of this product enters blood system, and merit is arrogated to oneself removing blood stasis, and the high effect of its power is grand.Hot loose slightly poisonous because of this product again, thus the energy treating the poisonous disease with poisonous drugs, dispersing swelling and dissipating binds.Shennong's Herbal: " master pursues stagnant blood, blood stasis, removing blood stasis abdominal mass, gathers ... "." treatise on blood trouble " pointed out: " blood stasis water also floods swollen." hematogenous blockage is described, must cause the operation of water liquid to be obstructed, disturbance in water passage is edema and send out.The Hirudo removing blood stasis makes the water channel tonneau and brings into play its row water effect, and diuresis is namely arranged.Its chemical composition: mainly contain protein, heparin, antithrombase, contain a kind of anticoagulative substance-hirudin in fresh Hirudo saliva.In addition, still contain the various trace elements such as sodium, potassium, calcium.Modern pharmacological research proves: this product has anti thrombotic action, can not only prevent the formation of tampon, can also thrombus, can suppress Fibrinogen and be converted into fibrin, and the activity of energy factor anticoagulant and the platelet response of thrombin induction, very strong anticoagulation is arranged.Can reduce surface activity of blood platelet; anticoagulant; can improve hemorheology; can reduce blood fat, the atheromatous plaque that disappears increases the Nutritional myocardium blood flow amount; alleviate surrounding tissue inflammatory reaction and edema; improve blood circulation, the protection cerebral tissue promotes the effects such as neurological functional recovery.
Squama Manis: the salty in the mouth cold nature, return liver, stomach warp, have the Xiao of invigorating blood circulation wei, stimulate the menstrual flow, the function such as detumescence and apocenosis.This moral character is apt to away alter, and the stasis of blood of can promoting the circulation of blood dividing is stagnant, in reach the internal organs meridians, can blood circulation promoting and blood stasis dispelling, the promoting flow of QI and blood wei that disappears is long-pending, qualcomm meridian.The disease that is used for the treatment of the stagnation of QI-blood meridians.And the eliminating carbuncle of invigorating blood circulation, detumescence and apocenosis, can make pus not the one-tenth person dissipate, person's speed is burst to have become pus, is the key medicine that the treatment skin infection swells and ache, and is used for the treatment of the chronic ulcer of the lower limb of the meridian qi and blood stasis of blood due to the stagnant disease such as do not close up for a long time." Records of Tradition Chinese and Western Medicine in Combination ": " Squama Manis, lightly seasoned property is flat, gas raw meat and altering, the property that it walks to alter, very careful, therefore can declare logical internal organs, implement meridians, thoroughly reach the pass key, all blood clotting blood is poly-is disease, all can open it ".Modern pharmacological research proves: this product can significantly increase femoral artery blood flow, reduces Peripheral resistance, and blood vessel wall is had direct dilating effect, can obviously extend clotting time, reduces blood viscosity.
Rhizoma sparganic: bitter in the mouth is hot, and property is flat, returns liver, spleen channel, has the effect of removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.The hot loose hardship of this product is let out, can removing blood stasis, again can promoting the circulation of QI to relieve pain, and removing blood stasis power is stronger, is the key medicine of Removing Blood Stasis, and the effect of eliminating carbuncle eliminating stagnation is arranged.Wang Haogu: " Liver Channel blood system medicine also for rhizoma sparganic, the gas in removing blood stasis.Rhizoma sparganic is controlled the long-pending hard person of piece skin ulcer, be hard person disappear also." modern pharmacological research proves: this product can anticoagulant and antithrombotic form; extend fibrinous pool time, the outer thrombosis of extension body shortens thrombosis length; thrombus weight alleviates; remarkable anticoagulant, reduces platelet count, suppresses platelet function; suppress inside and outside coagulation function; reduce whole blood viscosity, promote fibrinolytic etc., external thrombus is formed with inhibitory action.
Olibanum: acrid in the mouth bitterness temperature, return Liver Channel and the heart, spleen channel, have the effect of blood-activating and qi-promoting pain relieving, detumescence and promoting granulation.The hot loose temperature of this product is logical, and internal energy a surname lead to internal organs, and external enwergy reaches meridians thoroughly, can blood circulation promoting and blood stasis dispelling, can manage it again the stagnant gas that falls apart, and the merit of pain relieving is more outstanding.Can " decide pain of all warps " " pearl sac ": the kind pain of controlling stagnation of QI and blood, and this product is partial to circulation of qi promoting, is stretched muscle.Can promoting blood circulation and detumescence, again can promoting tissue regeneration and ulcer healing; Both oral administrations, but also external are external wounds key medicine commonly used, are used for controlling that stagnation of QI-blood swells and ache and anemofrigid-damp arthralgia, and limbs pain is numb waits disease.
Flos Carthami: acrid in the mouth is warm in nature, and GUIXIN, Liver Channel have the effect of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.This product energy blood circulation promoting and blood stasis dispelling, Xiao wei, unobstructed blood vessels, reducing swelling and alleviating pain.The disease that is used for the treatment of blood vessels stasis of blood stagnate-closed plug.Modern pharmacological research proves: this product energy blood vessel dilating, increase the effect of coronary flow and Nutritional myocardium blood flow amount, and improve microcirculation, treatment cerebral thrombosis and thromboangiitis obliterans, phlebitis etc.
Radix Cyathulae: bitter in the mouth, sweet, sour, property is flat, enters liver, kidney channel, has promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, (blood) descending effect of igniting.This product blood circulation promoting and blood stasis dispelling can be used for the disease of multiple blood stasis.Kind descending because of property, be longer than promoting blood circulation to restore menstrual flow, therefore the outstanding multiplex disease of stagnating in the traumatology blood stasis.Again can invigorating the liver and kidney, bone and muscle strengthening, the waist and leg ache of controlling caused by liver and kidney deficiency and the weak and damp and hot one-tenth flaccidity of lingering arthralgia soreness of waist and knee joint, the soft person of sufficient knee joint flaccidity.And this moral character is kind descending, can conducting blood to flow downwards, again can relieving stranguria by diuresis, and be used for the diseases such as edema and dysuria." Records of Tradition Chinese and Western Medicine in Combination ": " kind bleed blood is made a bet, and is to want its lower passerby with medication, permanent take as tying-in, the Gu Shanzhi lumbago and skelalgia of suffering from a deficiency of the kidney, or the knee joint pain can not be bent and stretched or the lower limb flaccidity can not appoint ground.Kind controlling drenched pain again, tonneau urine, all the kind descending effect of its power is also for this ".Modern pharmacological research proves: this product can reduce rat whole blood viscosity, packed cell volume, erythrocyte aggregation index, and anticoagulation is arranged.The effects such as blood fat reducing, slight diuresis are still arranged.
Radix Stephaniae Tetrandrae: the bitter in the mouth suffering is cold in nature, returns bladder, kidney, spleen channel, has the effect of wind-damp dispelling pain relieving, inducing diuresis to remove edema.This product hardship can be fallen and be let out, be apt to away descending, can clearing away damp-heat, diuresis is good at the burnt damp-heat in the urinary bladder of diarrhea especially.Be used for controlling damp and hot heap soil or fertilizer over and around the roots contain due to the diseases such as edema, dysuria and eczema sore." book on Chinese herbal medicine is looked for the truth ": " property danger and be good for was apt to away descendingly, is longer than dehumidifying Radix Stephaniae Tetrandrae, arduous Great Cold, and sensible Li Dao can rush down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system damp and hot, and treatment edema due to wind pathogen key medicine ".Modern pharmacological research proves: " Radix Stephaniae Tetrandrae can obviously increase voided volume, and obviously anticoagulant, can also promote fibrinolysis, the Blood Coagulation Process that Trombin inhibiting causes ".
Polyporus: slightly sweet flavor, property is flat, returns kidney, urinary bladder channel, has the effect of promoting diuresis to eliminate damp pathogen, detumescence.This product sweet light ooze let out, diuresis is stronger, is used for the various edema of retention of water-damp, it is desirable effect that single is used.Modern pharmacological research proves: the Polyporus water decoction has stronger diuresis, and its diuresis mechanism is mainly to suppress renal tubules to water and electrolyte particularly due to the heavily absorption of potassium, sodium, chlorine.
Semen Plantaginis: the sweet in the mouth cold nature, return kidney, bladder, liver, lung meridian, have the effect of inducing diuresis for treating stranguria syndrome, eliminating dampness by diuresis antidiarrheal, removing heat from the lung and dissipating phlegm, liver heat removing and eyesight improving.The sweet cold sliding profit of this product, has the merit of inducing diuresis for treating stranguria syndrome at kind tonneau water channel, clear bladder accumulation of heat.Edema, dysuria, odynuria person to the retention of water-damp due to damp invasion of lower energizer are particularly suitable.Shennong's Herbal: " dredging water passages urine is except arthralgia chiefly caused by damp pathogen for main stranguria due to disorder of QI, pain relieving ".
Poria: slightly sweet flavor, property are put down, and GUIXIN, spleen, kidney channel have the effect of promoting diuresis to eliminate damp pathogen, spleen invigorating, mind tranquilizing and the heart calming.This product can eliminating dampness and diuresis with eliminating evil, again can spleen invigorating with righting, the property of medicine is gentle, mend and not high, profit and not violent, diuretic and do not hinder healthy energy is the key medicine of inducing diuresis to remove edema, can be used for controlling the edema of all kinds.Join the product of the air making-up and spleen enlivening diuretic such as the Radix Astragali, control edema due to deficiency of the spleen especially suitable." generation mend vegetarian medical book ": " Poria simply, for controlling the expectorant principal agent, expectorant this, water also, Poria can be gone water; Expectorant is moving, wets also, and Poria can be gone again wet ".
Rhizoma Alismatis: slightly sweet flavor is cold in nature, returns kidney, urinary bladder channel, the effect of have promoting diuresis to eliminate damp pathogen, purging heat.This product promoting diuresis with drugs of tasteless flavour, its diuretic effect is strong than Poria.Normal and Poria, Polyporus mutual reinforcement between are use, to strengthen the effect of eliminating dampness and diuresis.And cold in naturely can let out the damp and hot of kidney and bladder, the damp-heat in lower-JIAO person is particularly suitable.The diseases such as wet edema of stopping holding, dysuria are used for harnessing the river.
Above all medicine compatibilities, the effect of playing altogether heat clearing and damp drying, inducing diuresis to remove edema, benefiting QI for activating blood circulation, blood stasis-eliminating and stagnation-dissipating, removing obstruction in the collateral to relieve pain.Be used for the treatment of because of blood vessels damage or excessive rest on bed impairing QI or blood stasis due to qi deficiency, cause the limbs QI-blood circulation not smooth, coagulation of QI-blood, multiple abscess due to blood stasis are in lower limb, and venation blocks obstructed, the nutrient blood backflow obstruction, water Tianjin is excessive, and causes that single lower limb is sudden, popularity is slightly swollen, distending pain, walk unfavorable, can accompany the early stage Lower Limb Thrombosis deep phlebitis of the diseases such as low grade fever.And the slight edema of superficial vein expansion, varicose, limbs, the shank pigmentation that can occur the later stage, and the therapeutic effect of the ecthyma that heals of dermatitis and prolonged difficulty is also better.
The Lower Limb Thrombosis deep phlebitis use merely the Western medicine thrombolytic or the anticoagulant therapy curative effect not good enough, even can not effectively stop the progress of the state of an illness to worsen.And bolt easily occurs to form in operation and interventional therapy again, therefore all the year round can not be from medicine.But utilize effectively relief of symptoms of the present composition, delay or control the progress of disease, clinical effectiveness is remarkable, has made up the simple drawback that can not effectively stop disease progression with Western medicine, for the treatment of primary disease provides another new effective way.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is done to introduce in detail further, but protection scope of the present invention is not limited to this.
Embodiment 1
Radix Astragali 10g, Rhizoma Atractylodis 7.5g, Cortex Phellodendri 5g, Scorpio 3g, Pheretima 5g, Agkistrodon 10g, Eupolyphaga (parched) 3g, Hirudo 2g, Squama Manis preparata 3g, rhizoma sparganic 15g, Olibanum (processed) 3g, Flos Carthami 7.5g, Radix Cyathulae 15g, Radix Stephaniae Tetrandrae 5g, Polyporus 7.5g, Semen Plantaginis 13g, Poria 10g, Rhizoma Alismatis 5g.
Preparation method and using method:
The progression of disease phase: 1. above-mentioned 18 flavor crude drug are put into marmite, first fries in shallow oil and adds water 600ml and soaked 30 minutes, after first boiling with high heat, then uses instead 30 minutes at a simmer, and taking liquid is 350ml approximately; Second fries in shallow oil and adds water 500ml, uses instead 25 minutes at a simmer after first boiling with high heat again, and taking liquid is 350ml approximately; Boiling medicine two takes after liquid mixes at twice, morning and evening service once, decoction being taken warmly.Or, 2. above-mentioned 18 flavor crude drug are utilized the agent of prior art granulation, be distributed into bag, every bag of 10g each serving 1 bag, takes warm boiled water every day three times.
The stable disease phase: will be above-mentioned 18 flavor Chinese medicines cross 120 mesh sieves after pulverizing, after making superfine medicated powder: 1. medicated powder and honey are made honeyed pill by the 1:1.5 mass ratio, every ball 3g, each serving taking 6g, every day three times, warm boiled water; Or, the Capsules of 2. medicated powder being packed into, every 0.3g, each serving 6, every day three times, warm boiled water; Or, 3. utilize prior art to make concentrated pill the present invention's 18 flavor crude drug, each serving 6g, take warm boiled water every day three times.
Embodiment 2
Radix Astragali 30g, Rhizoma Atractylodis 10g, Cortex Phellodendri 10g, Scorpio 5g, Pheretima 10g, Agkistrodon 6g, Eupolyphaga (parched) 10g, Hirudo 3g, Squama Manis preparata 10g, rhizoma sparganic 10g, Olibanum (processed) 6g, Flos Carthami 10g, Radix Cyathulae 10g, Radix Stephaniae Tetrandrae 10g, Polyporus 10g, Semen Plantaginis 15g, Poria 10g, Rhizoma Alismatis 10g.
Preparation method and using method are with embodiment 1.
Embodiment 3
Radix Astragali 60g, Rhizoma Atractylodis 5g, Cortex Phellodendri 7.5g, Scorpio 2g, Pheretima 7.5g, Agkistrodon 3g, Eupolyphaga (parched) 7.5g, Hirudo 1.5g, Squama Manis preparata 7.5g, rhizoma sparganic 3g, Olibanum (processed) 10g, Flos Carthami 3g, Radix Cyathulae 6g, Radix Stephaniae Tetrandrae 7.5g, Polyporus 5g, Semen Plantaginis 10g, Poria 15g, Rhizoma Alismatis 7.5g.
Preparation method and using method are with embodiment 1.
Clinical trial
1.1 physical data
From year August in May, 2002 to 2011, accept early stage Lower Limb Thrombosis deep phlebitis patient 78 examples for medical treatment, all cases is all made a definite diagnosis through multiple inspections such as health check-up and the ultrasonic figure inspection of Doppler's blood vessel or dark phlebographies, and be not in the mood for, liver, the serious dysfunction of kidney and late period serious Lower Limb Thrombosis deep phlebitis complications.Be divided at random treatment group 39 examples, male 22 examples wherein, female's 17 examples, 26 ~ 69 years old age, 56 years old mean age, high blood viscosity 29 examples, hyperlipidemia 27 examples, diabetes 18 examples, 3 examples after operation, puerperal 2 example.Matched group 39 examples, male 23 examples wherein, female's 16 examples, 27 ~ 70 years old age, 57 years old mean age, high blood viscosity 26 examples, hyperlipidemia 25 examples, diabetes 16 examples, 3 examples after operation, puerperal 3 example.Two groups at aspects such as sex, age, the state of an illness all without significant difference (P〉0.05), have comparability, see table 1 for details.
1.2 diagnostic criteria
1. have that the venous blood stasis of blood is stagnant, high blood coagulation state or wall of vein damage medical history; 2. get involved vein place's tenderness and tractive pain, suffer from that limb swelling, pitting edema, local skin temperature raise, the Superficial veins expansion, the later stage: the expansion of Superficial veins severe, graniphyric cyanosis, severe patient occur and often be the limb necrosis tendency; When 3. the ultrasonic figure of Doppler's blood vessel checked, the deep vein lumen of getting involved is aobvious to be weakened or disappears; 4. dark phlebography can show that obstructive position degree, scope and side prop up loop condition.
1.3 Therapeutic Method
Matched group: adopt to suffer from that limb is had a rest, raised, hot compress, super early stage thrombolytic urokinase, anticoagulant therapy is first used heparin, keeps treatment, other employing symptomatic treatment measure with oral anticoagulation warfarin etc. afterwards.
Treatment group: be to adopt routine of western medicine to treat on the basis at matched group to add the embodiment of the present invention 2 prescriptions and preparation method thereof, using method.
Two groups treated respectively for 8 weeks after, observe clinical symptoms, the ultrasonic figure inspection of Doppler's blood vessel and dark phlebography etc. and check number of cases and improvement rate.
1.4 therapeutic evaluation
Produce effects: the vein place's tenderness disappearance of getting involved, suffering from limb swelling substantially disappears or disappears, it is normal that the local skin temperature is recovered, the Superficial veins expansion is basic to disappear or disappears, the ultrasonic diagram of Doppler's blood vessel: the deep vein of getting involved stream obviously strengthens before, and dark phlebography shows: thrombosis obviously reduces before or is logical again.
Effectively: the vein place tenderness of getting involved substantially disappears or alleviates, suffer from limb swelling and obviously alleviate, the local skin temperature is recovered normally substantially, and the Superficial veins expansion obviously alleviates, the ultrasonic diagram of Doppler's blood vessel: the deep vein of getting involved stream strengthens before, and dark phlebography shows: thrombosis reduces before to some extent.
Invalid: before and after treatment, clinical symptoms, the ultrasonic figure of Doppler's blood vessel and dark phlebography check result are without improvement.
1.5 statistical method
Data represent with rate, adopt X
2Check has statistical significance take P＜0.05 as difference.
1.6 result
1.6.1 before and after treatment, two groups of doing well,improving situations relatively
Treatment group is treated on the basis with routine of western medicine at matched group and is added Chinese medicine composition of the present invention, and clinical symptoms improvement rate (94.6%) obviously is better than matched group merely with clinical symptoms improvement rate (57.3%) after the routine of western medicine treatment, sees table 2 for details.
1.6.2 treatment two groups of the front and back ultrasonic figure inspections of Doppler's blood vessel improve number of cases with dark phlebography and the improvement rate compares
After treatment group is treated with routine of western medicine at matched group and is added Chinese medicine composition of the present invention on the basis, the deep vein of getting involved stream strengthens and obviously is better than matched group with thromboembolism degree improvement rate (96.5%) and uses merely the deep vein stream of getting involved after the routine of western medicine treatment to strengthen and thromboembolism degree improvement rate (51.7%) (P＜0.05), sees table 3 for details.
1.6.2 untoward reaction
Matched group has 5 examples subcutaneous purpura to occur, has 2 examples conjunctival congestion to occur.Untoward reaction does not appear in treatment group.
Model case
Case 1
Lee so-and-so, the man, 56 years old, the porter was western Shao Xiang west Shao Ji people from village, on July 12nd, 2002, comes the inventor to locate to go to a doctor with " left lower extremity thrombotic deep phlebitis ".The patient indulges in excessive drinking usually, has a liking for food delicious food savoury, occurs the inboard pain of left lower extremity thigh after 2 all cause fatigues, then swelling rapidly, once arrived Puyang the People's Hospital's diagnosis and treatment, by " thrombotic deep phlebitis " treatment first quarter moon (medication is not quite clear), curative effect is not good enough, changes afterwards the inventor place over to.Disease is seen: left lower extremity is slightly swollen, and the part slightly generates heat, distending pain, swells and ache after activity and increases the weight of; Red tongue, yellow and greasy fur, stringy and rolling pulse.Outer court's doppler ultrasound diagram: left lower extremity femoral vein blood flow rate obviously weakens.
Dialectical Analyses: eating and drinking without temperance, insufficiency of the spleen mistake fortune, damp resistance network, for a long time and heat-transformation, damp and hot long-pending poison is made a bet in arteries and veins, therefore see slightly swollen, local pyrexia of left lower extremity, distending pain.After movable, QI-blood circulation is accelerated, and the stasis of blood is stagnant to be increased the weight of because the passages through which vital energy circulates of getting involved does not freely cause, therefore swell and ache very.Red tongue, yellow and greasy fur, stringy and rolling pulse are the disease of retention of damp-heat in the interior.
Diagnosis: strand swollen (damp invasion of lower energizer).
The rule for the treatment of: heat clearing and damp drying, inducing diuresis to remove edema, benefiting QI for activating blood circulation, blood stasis-eliminating and stagnation-dissipating, removing obstruction in the collateral to relieve pain.
Side's medicine: the embodiment of the present invention 2 prescriptions and preparation method thereof, using method.
Western medicine: rest, lifting affected limb, anticoagulant warfarin, other symptomatic treatment.
After treating for 8 weeks, left lower extremity swelling disappears substantially, and heating and distending pain disappear, and it is normal that body of the tongue and tongue fur recover, the ultrasonic diagram of check Doppler's blood vessel: left lower extremity femoral vein blood flow rate is front obviously to be strengthened.Advise and continue to take the made honey pill agent of the embodiment of the present invention 2 prescriptions, each 6g, every day three times, after serveing on 6 months, clinical symptoms and sign are all recovered normally, and by repeatedly following up a case by regular visits to, stable disease is without recurrence.
Case 2
Zhang, the man, 60 years old, the builder was nearly De Gu township Radix Et Rhizoma Rhei seven people from village, on May 18th, 2008, comes the inventor to locate to go to a doctor with " right lower extremity thrombotic deep phlebitis ".The patient because fatigue is subjected to cold and coolly afterwards again, right lower extremity swelling occurred before half a year, once treated to county people's hospital, and effect is not good enough.Then go the diagnosis and treatment of Beijing 301 Hospital, treat month remaining (medication is not quite clear) by " thrombotic deep phlebitis ", effect is also not obvious, the expert advice operative treatment, and the patient be unwilling to accept, and locates therefore change the inventor over to.Disease is seen: right lower extremity is swollen very, color of the leather is purple secretly, blue veins exposes, burst inboard lower limb root tenderness; Dark tongue quality, tongue are white, stringy pulse.Outer court's phlebography shows: right iliofemoral vein thrombosis.
Dialectical Analyses: bear a heavy burden for a long time, stand, the hyperamization arteries and veins is impaired, stagnant blood stays and interior, stagnantly do not fall apart, makes QI-blood circulation to be obstructed, therefore see: right lower extremity is swollen very, skin purple dark, blue veins exposes, burst inboard lower limb root pain.Dark tongue quality, tongue are white, stringy pulse is resembling of blood-vessel obstructive.
Diagnosis: strand swollen (blood-vessel obstructive).
The rule for the treatment of: benefiting QI for activating blood circulation, blood stasis-eliminating and stagnation-dissipating, inducing diuresis to remove edema, removing obstruction in the collateral to relieve pain.
Side's medicine: the embodiment of the present invention 3 prescriptions and preparation method thereof, using method.
Western medicine: rest, lifting affected limb, anticoagulant therapy warfarin, other symptomatic treatment.
After treating for 8 weeks, right lower extremity swelling disappears substantially, and it is normal that skin color recovers, and the blue veins that appears disappears with burst inboard shank pain, and it is normal that body of the tongue and tongue fur recover.Phlebography shows: the iliofemoral vein thrombosis disappears.Advise and continue to take the made honey pill agent of the embodiment of the present invention 3 prescriptions, each 6g takes 6 months every day three times, transference cure, and by repeatedly following up a case by regular visits to, stable disease is without recurrence.
Case 3
Yin so-and-so, the female, 55 years old, the workman was the Nanyue County worker of power administration, in JIUYUE in 2005 28 days, came the inventor to locate to go to a doctor with " right lower extremity thrombotic deep phlebitis ".The patient has cerebral thrombosis to cause the right side limbs disturbance approximately 11 years, and occurs suddenly again right lower extremity pain, swelling before half a year.Once arrived the Puyang the People's Hospitals by " thrombotic deep phlebitis " treatment, effect is not good enough, therefore change the inventor place over to.Disease is seen: the right side limbs disturbance, right lower extremity swelling, heavy towards light dusk, the aggravation of swelling and ache after activity, have a rest and raise right lower extremity after swelling alleviate, color of the leather is slightly dark, blue veins exposure, fatigue and weakness, pale tongue, white and thin fur, deep pulse.Outer court's doppler ultrasound diagram: right lower extremity femoral vein blood flow rate obviously weakens.
Dialectical Analyses: the prolonged illness deficiency of vital energy, blood are slow, venation is smooth, blood stasis stops amassing, therefore see right lower extremity swelling, color of the leather is dark, and blue veins exposes, fatigue and weakness.Towards the time YANG QI being flourishing, when dusk decline of YANG QI, heavy towards light dusk, labor is felt frustrated, therefore the aggravation of swelling and ache after activity.Pale tongue, white and thin fur, deep pulse are the disease of the wet resistance of deficiency of vital energy blood stasis.
Diagnosis: strand swollen (the wet resistance of the deficiency of vital energy).
The rule for the treatment of: benefiting QI for activating blood circulation, blood stasis-eliminating and stagnation-dissipating, inducing diuresis to remove edema, removing obstruction in the collateral to relieve pain.
Side's medicine: the embodiment of the present invention 1 prescription and preparation method thereof, using method.
Western medicine: rest, lifting affected limb, anticoagulant therapy warfarin, other symptomatic treatment.
After treating for 8 weeks, right lower extremity swelling and pain disappear substantially, and the color of the leather recovery is normal, and the blue veins that appears disappears, and fatigue and weakness disappears, and it is ruddy that body of the tongue turns, the ultrasonic diagram of check Doppler's blood vessel: right lower extremity femoral vein blood flow rate is front obviously to be strengthened.Advise and continue to take the made honeyed pill of the embodiment of the present invention 1 prescription, each 6g, every day three times, after serveing on 6 months, clinical symptoms and sign disappear, and through repeatedly following up a case by regular visits to, stable disease is without recurrence.
Claims (8)
1. a Chinese medicine composition for the treatment of early stage Lower Limb Thrombosis deep phlebitis, is characterized in that being made by each crude drug of following portions by weight: 10 ~ 60 parts of the Radixs Astragali, 5 ~ 10 parts of Rhizoma Atractylodis, 5 ~ 10 parts of Cortex Phellodendris, 2 ~ 5 parts of Scorpios, 5 ~ 10 parts of Pheretimas, 3 ~ 10 parts of Agkistrodons, 3 ~ 10 parts of Eupolyphaga Seu Steleophagas, 1.5 ~ 3 parts of Hirudos, 3 ~ 10 parts of Squama Maniss, 3 ~ 15 parts of rhizoma sparganic, 3 ~ 10 parts of Olibanums, 3 ~ 10 parts, Flos Carthami, 6 ~ 15 parts of Radix Cyathulaes, 5 ~ 10 parts of Radix Stephaniae Tetrandrae, 5 ~ 10 parts of Polyporus, 10 ~ 15 parts of Semen Plantaginiss, 10 ~ 15 parts, Poria, 5 ~ 10 parts of Rhizoma Alismatis.
2. the Chinese medicine composition of the early stage Lower Limb Thrombosis deep phlebitis for the treatment of as claimed in claim 1, is characterized in that being made by each crude drug of following portions by weight: 30 parts of the Radixs Astragali, 10 parts of Rhizoma Atractylodis, 10 parts of Cortex Phellodendris, 5 parts of Scorpios, 10 parts of Pheretimas, 6 parts of Agkistrodons, 10 parts of Eupolyphaga Seu Steleophagas, 3 parts of Hirudos, 10 parts of Squama Maniss, 10 parts of rhizoma sparganic, 6 parts of Olibanums, 10 parts, Flos Carthami, 10 parts of Radix Cyathulaes, 10 parts of Radix Stephaniae Tetrandrae, 10 parts of Polyporus, 15 parts of Semen Plantaginiss, 10 parts, Poria, 10 parts of Rhizoma Alismatis.
3. the Chinese medicine composition of the early stage Lower Limb Thrombosis deep phlebitis for the treatment of as claimed in claim 1 or 2, it is characterized in that: Eupolyphaga Seu Steleophaga is Eupolyphaga (parched).
4. the Chinese medicine composition of the early stage Lower Limb Thrombosis deep phlebitis for the treatment of as claimed in claim 1 or 2, it is characterized in that: Squama Manis is Squama Manis preparata.
5. the Chinese medicine composition of the early stage Lower Limb Thrombosis deep phlebitis for the treatment of as claimed in claim 1 or 2, it is characterized in that: Olibanum is Olibanum (processed).
6. the Chinese medicine composition of the early stage Lower Limb Thrombosis deep phlebitis for the treatment of as claimed in claim 1 or 2, is characterized in that: make according to a conventional method any acceptable preparation clinically.
7. the Chinese medicine composition of the early stage Lower Limb Thrombosis deep phlebitis for the treatment of as claimed in claim 6, it is characterized in that: described preparation is decoct, pill, capsule or granule.
8. the Chinese medicine composition of the early stage Lower Limb Thrombosis deep phlebitis for the treatment of as claimed in claim 7, it is characterized in that: described preparation is concentrated pill.
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| CN103656417B (en) * | 2013-12-15 | 2016-01-20 | 丁飞 | For preventing the Chinese medicine preparation of hip replacement deep vein thrombosis of lower extremity |
| CN105596976A (en) * | 2015-11-16 | 2016-05-25 | 孙绪连 | Traditional Chinese medicine decoction for treating thrombophlebitis |
| CN105477596A (en) * | 2015-12-16 | 2016-04-13 | 昝世永 | Traditional Chinese medicinal composition for treating extremity superficial thrombophlebitis |
| CN106177029A (en) * | 2016-08-31 | 2016-12-07 | 王志军 | Medicine of a kind ofization thrombosis and preparation method thereof |
| CN108079233A (en) * | 2017-12-22 | 2018-05-29 | 天津顺兴捷科技有限责任公司 | A kind of external use plaster for treating phlebitis |
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