CN103533995B - 提纯米卡芬净的方法 - Google Patents

提纯米卡芬净的方法 Download PDF

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Publication number
CN103533995B
CN103533995B CN201280019379.XA CN201280019379A CN103533995B CN 103533995 B CN103533995 B CN 103533995B CN 201280019379 A CN201280019379 A CN 201280019379A CN 103533995 B CN103533995 B CN 103533995B
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mfg
salt
water
organic solvent
aqueous solution
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Chinese (zh)
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CN103533995A (zh
Inventor
丽娜·阿斯维
艾丽·卡莉·德尔
佛里德约夫·艾斯本·汉森
迈德赫尔·卡杰斯迪·艾德
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Xellia Pharmaceuticals ApS
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Xellia Pharmaceuticals ApS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Photolithography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CN201280019379.XA 2011-04-20 2012-04-13 提纯米卡芬净的方法 Active CN103533995B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477190P 2011-04-20 2011-04-20
US61/477,190 2011-04-20
PCT/EP2012/056768 WO2012143293A1 (en) 2011-04-20 2012-04-13 Method for purification of micafungin

Publications (2)

Publication Number Publication Date
CN103533995A CN103533995A (zh) 2014-01-22
CN103533995B true CN103533995B (zh) 2016-03-02

Family

ID=45953151

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280019379.XA Active CN103533995B (zh) 2011-04-20 2012-04-13 提纯米卡芬净的方法

Country Status (18)

Country Link
US (1) US9132163B2 (ru)
EP (2) EP2918324A1 (ru)
JP (1) JP5992507B2 (ru)
KR (1) KR101944512B1 (ru)
CN (1) CN103533995B (ru)
AU (1) AU2012244435B2 (ru)
BR (1) BR112013026420A2 (ru)
CA (1) CA2832145C (ru)
DK (1) DK2699327T3 (ru)
ES (1) ES2547827T3 (ru)
HR (1) HRP20151033T1 (ru)
HU (1) HUE027806T2 (ru)
IL (1) IL228913A (ru)
PL (1) PL2699327T3 (ru)
RS (1) RS54240B1 (ru)
RU (1) RU2583262C2 (ru)
SI (1) SI2699327T1 (ru)
WO (1) WO2012143293A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS54240B1 (en) * 2011-04-20 2015-12-31 Xellia Pharmaceuticals Aps PROCEDURE FOR PURIFICATION OF MIKAFUNGIN
CN102775476B (zh) * 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
CN105254721B (zh) * 2014-05-13 2021-05-18 江苏豪森药业集团有限公司 米卡芬净的纯化转盐方法
US10183973B2 (en) * 2014-05-29 2019-01-22 Shanghai Techwell Biopharmaceutical Co., Ltd. Solvate of cyclic peptide compound, preparation method for same, and uses thereof
EP3150624A4 (en) * 2014-05-29 2017-12-20 Shanghai Techwell Biopharmaceutical Co., Ltd Crystal of cyclic peptide compound, preparation method for same, and uses thereof
CN105693824A (zh) * 2015-08-27 2016-06-22 博瑞生物医药（苏州）股份有限公司 一种降低米卡芬净钠原料药溶剂残留量的方法
KR101880179B1 (ko) * 2016-11-03 2018-07-20 한국생명공학연구원 미카펀진(micafungin) 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 항바이러스용 약학적 조성물
CN108250274A (zh) * 2016-12-28 2018-07-06 浙江华谱新创科技有限公司 米卡芬净高效分离纯化方法
EP3485873A1 (en) * 2017-11-17 2019-05-22 Cadila Healthcare Limited Stable pharmaceutical injectable compositions of micafungin
CN113087775B (zh) * 2018-05-31 2022-07-08 杭州中美华东制药有限公司 米卡芬净钠新晶型ii及其制备方法
CN111909244A (zh) * 2020-08-14 2020-11-10 卓和药业集团有限公司 一种高纯度米卡芬净前体fr901379的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
CN1337968A (zh) * 1998-12-09 2002-02-27 伊莱利利公司 蓝刺菌素环肽化合物的纯化
EP2236513A1 (en) * 2009-03-24 2010-10-06 Cadila Healthcare Limited An improved purification process for lipopeptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901379A (fr) 1943-09-10 1945-07-25 Télégraphie par variations de fréquence
IE912046A1 (en) 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
EP0788511B1 (en) 1994-10-07 2002-12-11 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides having antibiotic activity
US6227164B1 (en) 1998-04-24 2001-05-08 Cooper Automotive Products, Inc. Insulator shield for spark plug
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
US7199248B2 (en) 2002-08-08 2007-04-03 Astellas Pharma Inc. Process
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
CN106397543A (zh) * 2010-09-28 2017-02-15 中化帝斯曼制药有限公司荷兰公司 用于分离环六肽的方法
AU2011307731B2 (en) * 2010-09-29 2016-02-18 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclic lipopeptide compounds or salts thereof
RS54240B1 (en) * 2011-04-20 2015-12-31 Xellia Pharmaceuticals Aps PROCEDURE FOR PURIFICATION OF MIKAFUNGIN

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
CN1337968A (zh) * 1998-12-09 2002-02-27 伊莱利利公司 蓝刺菌素环肽化合物的纯化
EP2236513A1 (en) * 2009-03-24 2010-10-06 Cadila Healthcare Limited An improved purification process for lipopeptides

Also Published As

Publication number Publication date
ES2547827T3 (es) 2015-10-08
EP2699327B1 (en) 2015-07-01
DK2699327T3 (en) 2015-10-05
AU2012244435A1 (en) 2013-10-24
EP2699327A1 (en) 2014-02-26
SI2699327T1 (sl) 2015-11-30
IL228913A0 (en) 2013-12-31
ES2547827T8 (es) 2015-10-21
US9132163B2 (en) 2015-09-15
JP2014511886A (ja) 2014-05-19
BR112013026420A2 (pt) 2020-11-03
AU2012244435B2 (en) 2017-06-15
RU2013150600A (ru) 2015-05-27
CN103533995A (zh) 2014-01-22
WO2012143293A1 (en) 2012-10-26
RU2583262C2 (ru) 2016-05-10
CA2832145C (en) 2020-10-20
HRP20151033T1 (hr) 2015-11-06
RS54240B1 (en) 2015-12-31
US20140371423A1 (en) 2014-12-18
EP2918324A1 (en) 2015-09-16
PL2699327T3 (pl) 2015-12-31
IL228913A (en) 2017-03-30
HUE027806T2 (en) 2016-11-28
KR101944512B1 (ko) 2019-01-31
JP5992507B2 (ja) 2016-09-14
CA2832145A1 (en) 2012-10-26
KR20140029453A (ko) 2014-03-10

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