CN1034864C - 咪唑烷-4-酮和噻唑烷-4-酮的衍生物的制备方法 - Google Patents

咪唑烷-4-酮和噻唑烷-4-酮的衍生物的制备方法 Download PDF

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CN1034864C
CN1034864C CN92110177A CN92110177A CN1034864C CN 1034864 C CN1034864 C CN 1034864C CN 92110177 A CN92110177 A CN 92110177A CN 92110177 A CN92110177 A CN 92110177A CN 1034864 C CN1034864 C CN 1034864C
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compound
low
phenyl
formula
reaction
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Expired - Fee Related
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CN92110177A
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Chinese (zh)
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CN1069728A (zh
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宫启介
安井凡平
本山晶章
石川伸太郎
安村贡一
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN92110177A 1991-08-27 1992-08-27 咪唑烷-4-酮和噻唑烷-4-酮的衍生物的制备方法 Expired - Fee Related CN1034864C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21562191 1991-08-27
JP215621/91 1991-08-27

Publications (2)

Publication Number Publication Date
CN1069728A CN1069728A (zh) 1993-03-10
CN1034864C true CN1034864C (zh) 1997-05-14

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CN92110177A Expired - Fee Related CN1034864C (zh) 1991-08-27 1992-08-27 咪唑烷-4-酮和噻唑烷-4-酮的衍生物的制备方法

Country Status (7)

Country Link
US (1) US5422360A (en:Method)
EP (1) EP0531812A1 (en:Method)
KR (1) KR930004286A (en:Method)
CN (1) CN1034864C (en:Method)
AU (1) AU649158B2 (en:Method)
CA (1) CA2077032A1 (en:Method)
TW (1) TW221689B (en:Method)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ286632B6 (cs) * 1992-09-29 2000-05-17 Inhale Therapeutic Systems Farmaceutický prostředek
DK0638075T3 (da) * 1993-02-26 2002-02-18 Otsuka Pharma Co Ltd Thiazol- eller imidazolderivater som Maillard-reaktionsinhibitorer
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
KR100419037B1 (ko) 1994-03-07 2004-06-12 넥타르 테라퓨틱스 폐를통한인슐린의전달방법및그조성물
GB2288732B (en) * 1994-04-13 1998-04-29 Quadrant Holdings Cambridge Pharmaceutical compositions
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
WO1997044324A1 (en) 1996-05-21 1997-11-27 Pharmacia & Upjohn Company Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus
AU6518598A (en) * 1997-03-28 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Age production inhibitory composition comprising a maillard reaction inhibitor and vitamin b6
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
CA2382133C (en) 2000-05-10 2010-11-23 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
SI1689726T1 (sl) 2003-11-21 2011-01-31 Actelion Pharmaceuticals Ltd Derivati 5-(benz-(z)-iliden)-tiazolidin-4-ona kot imunosupresivna sredstva
CN103087004A (zh) * 2006-11-23 2013-05-08 埃科特莱茵药品有限公司 一种制备2-亚氨基-四氢噻唑-4-酮衍生物的新方法
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
RS60408B1 (sr) 2012-08-17 2020-07-31 Actelion Pharmaceuticals Ltd Postupak za pripremanje (2z,5z)-5-(3-hloro-4-((r)-2,3-dihidroksipropoksi)benziliden)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona i međujedinjenja upotrebljena u pomenutom postupku
CN106620745B (zh) * 2015-11-02 2019-10-11 中国石油化工股份有限公司 一种降低培养基灭菌过程中的美拉德反应的方法
CN107522311A (zh) * 2017-10-19 2017-12-29 王云龙 一种净水机
CN114315753B (zh) * 2020-09-30 2023-11-21 烟台药物研究所 一种化合物、其合成方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402964A (en) * 1981-11-16 1983-09-06 Mcneilab, Inc. N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for the treatment of epilepsy
US4657922A (en) * 1985-05-24 1987-04-14 Mcneilab, Inc. Anxiolytic 4,5-dihydro-4-oxo-1H-imidazol-2-yl urea derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB132914A (en:Method) *
DE185346C (en:Method) *
DE381628C (de) * 1923-09-22 Gegauf & Co Nadelkluppe fuer Handstickmaschinen
GB181779A (en) * 1921-02-19 1922-06-19 Henry Ramsden Improvements in covers or gaiters for laminated vehicle springs
DE929549C (de) * 1951-11-29 1955-08-01 Hoechst Ag Verfahren zur Herstellung substituierter Pseudothiohydantoine und ihrer Hydrohalogenide
DE932674C (de) * 1952-12-06 1955-09-05 Hoechst Ag Verfahren zur Herstellung von N-Alkoxyphenyl-pseudothiohydantoinen
US2739971A (en) * 1954-03-29 1956-03-27 Eastman Kodak Co 5-benzal-3-n-cetyl-2-phenylimino-4-thiazolidone
DE1038050B (de) * 1955-11-17 1958-09-04 Farmaceutici Italia S A Soc Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen
FR1548312A (en:Method) * 1967-06-06 1968-12-06
US3641019A (en) * 1968-08-30 1972-02-08 Dow Chemical Co Thiazolo-as-triazines
AR204619A1 (es) * 1973-02-13 1976-02-20 Ciba Geigy Ag Procedimiento para la elaboracion de un nuevo derivado de 2,2-azina-2,4-tiazolidindiona
DE3146299A1 (de) * 1981-11-17 1983-06-01 Schering Ag, 1000 Berlin Und 4619 Bergkamen Thiazolo- und (1,3)thiazino(2,3-c)(1,2,4)triazinone mit selektiver herbizider wirkung sowie verfahren zur herstellung dieser verbindungen
DE3302413A1 (de) * 1983-01-21 1984-07-26 Schering AG, 1000 Berlin und 4709 Bergkamen Triazinone, verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel mit selektiver herbizider wirkung
GB8311443D0 (en) * 1983-04-27 1983-06-02 Smith Kline French Lab Chemical compounds
US4908446A (en) * 1985-11-14 1990-03-13 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US4758583A (en) * 1984-03-19 1988-07-19 The Rockefeller University Method and agents for inhibiting protein aging
DE3446812A1 (de) * 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
JPS6456614A (en) * 1987-08-27 1989-03-03 Ono Pharmaceutical Co Maillard reaction inhibitor
JPS6483059A (en) * 1987-09-25 1989-03-28 Ono Pharmaceutical Co Guanidine derivative, its production and maillard reaction inhibitor containing said derivative as active component
DE3841879A1 (de) * 1988-12-13 1990-06-21 Boehringer Mannheim Gmbh Neue imidazolidin-derivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US4957936A (en) * 1989-02-01 1990-09-18 Nippon Zoki Pharmaceutical Co., Ltd. Glycocyamidine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402964A (en) * 1981-11-16 1983-09-06 Mcneilab, Inc. N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for the treatment of epilepsy
US4657922A (en) * 1985-05-24 1987-04-14 Mcneilab, Inc. Anxiolytic 4,5-dihydro-4-oxo-1H-imidazol-2-yl urea derivatives

Also Published As

Publication number Publication date
TW221689B (en:Method) 1994-03-11
US5422360A (en) 1995-06-06
CA2077032A1 (en) 1993-02-28
KR930004286A (ko) 1993-03-22
EP0531812A1 (en) 1993-03-17
AU2131192A (en) 1993-03-04
CN1069728A (zh) 1993-03-10
AU649158B2 (en) 1994-05-12

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