CN103479536A - Clove mouthrinse solution - Google Patents
Clove mouthrinse solution Download PDFInfo
- Publication number
- CN103479536A CN103479536A CN201310412823.0A CN201310412823A CN103479536A CN 103479536 A CN103479536 A CN 103479536A CN 201310412823 A CN201310412823 A CN 201310412823A CN 103479536 A CN103479536 A CN 103479536A
- Authority
- CN
- China
- Prior art keywords
- gargarism
- flos caryophylli
- clove
- caryophylli
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000016639 Syzygium aromaticum Nutrition 0.000 title abstract 3
- 239000002324 mouth wash Substances 0.000 title abstract 3
- 239000000243 solution Substances 0.000 title abstract 3
- 244000061408 Eugenia caryophyllata Species 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 6
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 6
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 6
- 241000628997 Flos Species 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 8
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 7
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 claims description 7
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 7
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 claims description 6
- 239000004378 Glycyrrhizin Substances 0.000 claims description 6
- 230000003115 biocidal effect Effects 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 6
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 6
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 6
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 6
- 229940052490 naringin Drugs 0.000 claims description 6
- 229930019673 naringin Natural products 0.000 claims description 6
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 6
- 235000012141 vanillin Nutrition 0.000 claims description 6
- -1 propyl amide amine Chemical class 0.000 claims description 5
- 229940117960 vanillin Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000000855 fermentation Methods 0.000 abstract description 3
- 230000004151 fermentation Effects 0.000 abstract description 3
- 206010006326 Breath odour Diseases 0.000 abstract description 2
- 208000032139 Halitosis Diseases 0.000 abstract description 2
- 230000005764 inhibitory process Effects 0.000 abstract description 2
- 244000005700 microbiome Species 0.000 abstract description 2
- 244000223014 Syzygium aromaticum Species 0.000 abstract 2
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000010634 clove oil Substances 0.000 abstract 1
- 229940031728 cocamidopropylamine oxide Drugs 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000006558 Dental Calculus Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
Abstract
The present invention relates to a clove mouthrinse solution, which comprises, by weight, 0.6-1.0% of clove oil, 0.1-0.3% of thaumathin, 12-16% of propylene glycol, 0.1-0.3% of zinc sulfate, 8-12% of ethanol, 0.2-0.4% of cocamidopropylamine oxide, and the balance of water. The clove mouthrinse solution has effects of mouth cleaning, inhibition of odor production microorganisms and fermentation activity, and halitosis elimination.
Description
Technical field
The present invention relates to a kind of gargarism, be specifically related to a kind of Flos Caryophylli gargarism.
Background technology
Gargarism, also referred to as collutory, collutory etc.Gargarism is easy to use, saves time, and does not need special apparatus, is very effective oral hygiene appliance.
On oral mucosa and tooth, the antibacterial of meeting residual harmful, tartar, dental calculus, food debris etc., can produce stench through corrupt, fermentation.Therefore very usual and necessary during the use of gargarism.
Summary of the invention
A kind of Flos Caryophylli gargarism is comprised of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, surplus are water.
Preferably,
A kind of Flos Caryophylli gargarism is comprised of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, biological antibiosis agent 0.4-0.6%, surplus are water.
Described biological antibiosis agent is a kind of or its mixture in naringin, glycyrrhizin and vanillin.Preferably described biological antibiosis agent, consist of by weight following component: naringin 50-70 part, glycyrrhizin 10-30 part and vanillin 10-30 part.Wherein, naringin, CAS accession number: 10236-47-2.Glycyrrhizin, CAS accession number: 1405-86-3.Vanillin, CAS accession number: 121-33-5.
Flos Caryophylli gargarism of the present invention, via common process, forms by mixed above-mentioned each raw material manufacture.
Flos Caryophylli gargarism of the present invention, clean oral cavity, inhibition produces microorganism and the fermentation activity of stench, eliminates halitosis.
The specific embodiment
Embodiment 1-4
Composition of raw materials list position: kilogram
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Oleum Caryophylli | 0.8 | 0.8 | 0.8 | 0.8 |
| Africa hesperidium element | 0.2 | 0.2 | 0.2 | 0.2 |
| Propylene glycol | 14 | 14 | 14 | 14 |
| Zinc sulfate | 0.2 | 0.2 | 0.2 | 0.2 |
| Ethanol | 10 | 10 | 10 | 10 |
| The cocamidopropyl propyl amide amine oxide | 0.3 | 0.3 | 0.3 | 0.3 |
| Naringin | 0.5 | / | / | 0.3 |
| Glycyrrhizin | / | 0.5 | / | 0.1 |
| Vanillin | / | / | 0.5 | 0.1 |
| Water | To 100 | To 100 | To 100 | To 100 |
In each embodiment, the raw material gross weight is 100 kilograms, and wherein the addition of water deducts other raw material weights by 100 kilograms and determines.
Flos Caryophylli gargarism of the present invention can adopt the conventional method preparation of this area fully, as " detergent compositions workshop manual ", (Xu Baocai etc. write, Chemical Industry Press, chemistry and applied chemistry publishing centre, January in 2006 the 1st edition) the disclosed gargarism production technology of 700-717 page is prepared.Via common process, by mixed above-mentioned each raw material manufacture, form.Obviously, the preparation method of gargarism is prior art in the present invention, does not have special character, and main improvement of the present invention just is the difference of formula.
Test case
Get respectively the prepared Flos Caryophylli gargarism of embodiment 1-4 and directly carry out the evaluating and measuring of fungistatic effect without dilution, carry out bacteriostatic test according to QB/T3738 " evaluation methodology of daily chemical products antibacterial bacteriostatic effect ", 1 minute action time, activity is 100% Flos Caryophylli gargarism, and test strain is: staphylococcus aureus and escherichia coli.
The fungistatic effect test chart
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Bacteriostasis rate (staphylococcus aureus), % | 90.1 | 89.5 | 89.2 | 91.2 |
| Bacteriostasis rate (escherichia coli), % | 88.6 | 89.3 | 89.1 | 90.4 |
From upper table data, the prepared Flos Caryophylli gargarism of embodiment 1-4 has antibacterial bacteriostatic effect preferably.
Claims (4)
1. a Flos Caryophylli gargarism, it is characterized in that, be comprised of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, surplus are water.
2. a Flos Caryophylli gargarism, it is characterized in that, be comprised of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, biological antibiosis agent 0.4-0.6%, surplus are water.
3. Flos Caryophylli gargarism as claimed in claim 2, is characterized in that, described biological antibiosis agent is a kind of or its mixture in naringin, glycyrrhizin and vanillin.
4. Flos Caryophylli gargarism as claimed in claim 3, is characterized in that, described biological antibiosis agent consists of by weight following component: naringin 50-70 part, glycyrrhizin 10-30 part and vanillin 10-30 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310412823.0A CN103479536B (en) | 2013-09-11 | 2013-09-11 | Clove mouthrinse solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310412823.0A CN103479536B (en) | 2013-09-11 | 2013-09-11 | Clove mouthrinse solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103479536A true CN103479536A (en) | 2014-01-01 |
| CN103479536B CN103479536B (en) | 2015-10-28 |
Family
ID=49820366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310412823.0A Expired - Fee Related CN103479536B (en) | 2013-09-11 | 2013-09-11 | Clove mouthrinse solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103479536B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112773848A (en) * | 2021-02-03 | 2021-05-11 | 安徽中医药大学 | Traditional Chinese medicine formula freeze-dried quick-release tablet for treating halitosis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191039A (en) * | 2013-04-10 | 2013-07-10 | 江苏华生安颐生物科技有限公司 | Mouthwash as well as preparation method and application thereof |
-
2013
- 2013-09-11 CN CN201310412823.0A patent/CN103479536B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191039A (en) * | 2013-04-10 | 2013-07-10 | 江苏华生安颐生物科技有限公司 | Mouthwash as well as preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 吴天祥等: "甘草甜素的用途", 《现代化工》 * |
| 覃青云等: "柚皮苷在口腔护理用品中的应用研究", 《牙膏工业》 * |
| 黄秀凤: "中药提取物及其化学成分抑菌作用的研究进展", 《中国药物与临床》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112773848A (en) * | 2021-02-03 | 2021-05-11 | 安徽中医药大学 | Traditional Chinese medicine formula freeze-dried quick-release tablet for treating halitosis and preparation method thereof |
| CN112773848B (en) * | 2021-02-03 | 2022-04-08 | 安徽中医药大学 | Traditional Chinese medicine formula freeze-dried quick-release tablet for treating halitosis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103479536B (en) | 2015-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Weiping Inventor before: Song Fanhua |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20170810 Address after: Baiyun District of Guangzhou City, Guangdong province 510550 Zhongluotan town Anle South six lane 18, one of the 101 room Patentee after: Guangzhou long day Chemical Co.,Ltd. Address before: 201107 Shanghai city Minhang District Minhang Road 88 Lane No. 1-30 building twenty-second room T159 Patentee before: SHANGHAI FANGMU FINE CHEMICAL Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180628 Address after: 510000 503, room 399, three road, Yuncheng south, Baiyun District, Guangzhou, Guangdong, China Patentee after: Guangzhou Induced Love Biotechnology Co.,Ltd. Address before: 510550 Room 101, 18 Lane six lane, Zhong lountan Town, Baiyun District, Guangzhou, Guangdong Patentee before: Guangzhou long day Chemical Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191202 Address after: 510000 Room 302, building K, No. 46, Wanggang shangsheng East Street, Jiahe street, Baiyun District, Guangzhou City, Guangdong Province (self declaration) Patentee after: Guangzhou Kanglida Health Technology Co.,Ltd. Address before: 510000 503, room 399, three road, Yuncheng south, Baiyun District, Guangzhou, Guangdong, China Patentee before: Guangzhou Induced Love Biotechnology Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151028 Termination date: 20210911 |