CN103479536B - Clove mouthrinse solution - Google Patents
Clove mouthrinse solution Download PDFInfo
- Publication number
- CN103479536B CN103479536B CN201310412823.0A CN201310412823A CN103479536B CN 103479536 B CN103479536 B CN 103479536B CN 201310412823 A CN201310412823 A CN 201310412823A CN 103479536 B CN103479536 B CN 103479536B
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- CN
- China
- Prior art keywords
- clove
- mouthrinse solution
- mouthrinse
- solution
- present
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Links
- 235000016639 Syzygium aromaticum Nutrition 0.000 title claims abstract description 14
- 239000002324 mouth wash Substances 0.000 title claims abstract description 14
- 239000000243 solution Substances 0.000 title claims abstract description 14
- 244000061408 Eugenia caryophyllata Species 0.000 title abstract description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 244000223014 Syzygium aromaticum Species 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- -1 propyl amide amine Chemical class 0.000 claims abstract description 5
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 5
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 5
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 5
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 6
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 claims description 6
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 6
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 claims description 5
- 239000004378 Glycyrrhizin Substances 0.000 claims description 5
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 5
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 5
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 5
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 5
- 229940052490 naringin Drugs 0.000 claims description 5
- 229930019673 naringin Natural products 0.000 claims description 5
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 5
- 235000012141 vanillin Nutrition 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 3
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 abstract description 3
- 238000000855 fermentation Methods 0.000 abstract description 3
- 230000004151 fermentation Effects 0.000 abstract description 3
- 206010006326 Breath odour Diseases 0.000 abstract description 2
- 208000032139 Halitosis Diseases 0.000 abstract description 2
- 244000005700 microbiome Species 0.000 abstract description 2
- 210000000214 mouth Anatomy 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000006558 Dental Calculus Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940117960 vanillin Drugs 0.000 description 1
Landscapes
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of clove mouthrinse solution, be made up of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, surplus are water.Clove mouthrinse solution of the present invention, clean oral cavity, suppresses the microorganism and the fermentation activity that produce stench, eliminates halitosis.
Description
Technical field
The present invention relates to a kind of gargarism, be specifically related to a kind of clove mouthrinse solution.
Background technology
Gargarism, also referred to as collutory, collutory etc.Gargarism is easy to use, saves time, and does not need special apparatus, is very effective oral hygiene appliance.
Can the antibacterial, tartar, dental calculus, food debris etc. of residual harmful on oral mucosa and tooth, can stench be produced through corrupt, fermentation.Very usual and necessary during the use of therefore gargarism.
Summary of the invention
A kind of clove mouthrinse solution, is made up of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, surplus are water.
Preferably,
A kind of clove mouthrinse solution, is made up of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, biological antibiosis agent 0.4-0.6%, surplus are water.
Described biological antibiosis agent is one in naringin, glycyrrhizin and vanillin or its mixture.Preferably described biological antibiosis agent, is made up of by weight following component: naringin 50-70 part, glycyrrhizin 10-30 part and vanillin 10-30 part.Wherein, naringin, CAS accession number: 10236-47-2.Glycyrrhizin, CAS accession number: 1405-86-3.Vanillin, CAS accession number: 121-33-5.
Clove mouthrinse solution of the present invention, via common process, is carried out manufacture by mixed above-mentioned each raw material and is formed.
Clove mouthrinse solution of the present invention, clean oral cavity, suppresses the microorganism and the fermentation activity that produce stench, eliminates halitosis.
Detailed description of the invention
Embodiment 1-4
Composition of raw materials list position: kilogram
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| Oleum Caryophylli | 0.8 | 0.8 | 0.8 | 0.8 |
| Africa hesperidium element | 0.2 | 0.2 | 0.2 | 0.2 |
| Propylene glycol | 14 | 14 | 14 | 14 |
| Zinc sulfate | 0.2 | 0.2 | 0.2 | 0.2 |
| Ethanol | 10 | 10 | 10 | 10 |
| Cocamidopropyl propyl amide amine oxide | 0.3 | 0.3 | 0.3 | 0.3 |
| Naringin | 0.5 | / | / | 0.3 |
| Glycyrrhizin | / | 0.5 | / | 0.1 |
| Vanillin | / | / | 0.5 | 0.1 |
| Water | To 100 | To 100 | To 100 | To 100 |
In each embodiment, raw material gross weight is 100 kilograms, and wherein the addition of water deducts other raw material weights by 100 kilograms and determines.
Clove mouthrinse solution of the present invention can adopt the conventional method of this area to prepare completely, as " detergent compositions workshop manual ", (Xu Baocai etc. write, Chemical Industry Press, chemistry and applied chemistry publishing centre, January in 2006 the 1st edition) gargarism production technology disclosed in 700-717 page is prepared.Namely via common process, carry out manufacture by mixed above-mentioned each raw material and form.Obviously, the preparation method of gargarism is prior art in the present invention, not special character, and main improvement of the present invention is just the difference of formula.
Test case
Clove mouthrinse solution respectively obtained by Example 1-4 directly carries out the evaluating and measuring of fungistatic effect without dilution, bacteriostatic test is carried out according to QB/T3738 " evaluation methodology of daily chemical products antibacterial bacteriostatic effect ", 1 minute action time, activity is 100% clove mouthrinse solution, and test strain is: staphylococcus aureus and escherichia coli.
Fungistatic effect test chart
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| Bacteriostasis rate (staphylococcus aureus), % | 90.1 | 89.5 | 89.2 | 91.2 |
| Bacteriostasis rate (escherichia coli), % | 88.6 | 89.3 | 89.1 | 90.4 |
From upper table data, the clove mouthrinse solution obtained by embodiment 1-4 has good antibacterial bacteriostatic effect.
Claims (1)
1. a clove mouthrinse solution, it is characterized in that, be made up of following compositions in weight percentage: Oleum Caryophylli 0.6-1.0%, African hesperidium element 0.1-0.3%, propylene glycol 12-16%, zinc sulfate 0.1-0.3%, ethanol 8-12%, cocamidopropyl propyl amide amine oxide 0.2-0.4%, biological antibiosis agent 0.4-0.6%, surplus are water;
Described biological antibiosis agent is made up of by weight following component: naringin 50-70 part, glycyrrhizin 10-30 part and vanillin 10-30 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310412823.0A CN103479536B (en) | 2013-09-11 | 2013-09-11 | Clove mouthrinse solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310412823.0A CN103479536B (en) | 2013-09-11 | 2013-09-11 | Clove mouthrinse solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103479536A CN103479536A (en) | 2014-01-01 |
| CN103479536B true CN103479536B (en) | 2015-10-28 |
Family
ID=49820366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310412823.0A Expired - Fee Related CN103479536B (en) | 2013-09-11 | 2013-09-11 | Clove mouthrinse solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103479536B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112773848B (en) * | 2021-02-03 | 2022-04-08 | 安徽中医药大学 | Traditional Chinese medicine formula freeze-dried quick-release tablet for treating halitosis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191039A (en) * | 2013-04-10 | 2013-07-10 | 江苏华生安颐生物科技有限公司 | Mouthwash as well as preparation method and application thereof |
-
2013
- 2013-09-11 CN CN201310412823.0A patent/CN103479536B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191039A (en) * | 2013-04-10 | 2013-07-10 | 江苏华生安颐生物科技有限公司 | Mouthwash as well as preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中药提取物及其化学成分抑菌作用的研究进展;黄秀凤;《中国药物与临床》;20070531;第7卷(第5期);第370-371页 * |
| 柚皮苷在口腔护理用品中的应用研究;覃青云等;《牙膏工业》;20090630;第19卷(第2期);第25-29页 * |
| 甘草甜素的用途;吴天祥等;《现代化工》;19961231(第5期);第49-50页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103479536A (en) | 2014-01-01 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Weiping Inventor before: Song Fanhua |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170810 Address after: Baiyun District of Guangzhou City, Guangdong province 510550 Zhongluotan town Anle South six lane 18, one of the 101 room Patentee after: Guangzhou long day Chemical Co.,Ltd. Address before: 201107 Shanghai city Minhang District Minhang Road 88 Lane No. 1-30 building twenty-second room T159 Patentee before: SHANGHAI FANGMU FINE CHEMICAL Co.,Ltd. |
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| TR01 | Transfer of patent right |
Effective date of registration: 20180628 Address after: 510000 503, room 399, three road, Yuncheng south, Baiyun District, Guangzhou, Guangdong, China Patentee after: Guangzhou Induced Love Biotechnology Co.,Ltd. Address before: 510550 Room 101, 18 Lane six lane, Zhong lountan Town, Baiyun District, Guangzhou, Guangdong Patentee before: Guangzhou long day Chemical Co.,Ltd. |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191202 Address after: 510000 Room 302, building K, No. 46, Wanggang shangsheng East Street, Jiahe street, Baiyun District, Guangzhou City, Guangdong Province (self declaration) Patentee after: Guangzhou Kanglida Health Technology Co.,Ltd. Address before: 510000 503, room 399, three road, Yuncheng south, Baiyun District, Guangzhou, Guangdong, China Patentee before: Guangzhou Induced Love Biotechnology Co.,Ltd. |
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| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151028 Termination date: 20210911 |
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| CF01 | Termination of patent right due to non-payment of annual fee |