CN103462834A - Room-temperature volatile natural plant essential oil mosquito repelling gel - Google Patents

Room-temperature volatile natural plant essential oil mosquito repelling gel Download PDF

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CN103462834A
CN103462834A CN2013103587198A CN201310358719A CN103462834A CN 103462834 A CN103462834 A CN 103462834A CN 2013103587198 A CN2013103587198 A CN 2013103587198A CN 201310358719 A CN201310358719 A CN 201310358719A CN 103462834 A CN103462834 A CN 103462834A
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parts
natural plant
plant essential
essential oils
anophelifuge
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CN103462834B (en
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苏毅生
欧祥平
许春晖
张利春
黄丽凤
张会琴
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to the field of mosquito repellent technology, and provides a room-temperature volatile natural plant essential oil mosquito repelling gel which is green and environmentally friendly, is harmless to human bodies, can volatilize at the room temperature without being heated, can emit a pleasant odor, has good mosquito repelling effect, has no irritation to skin, does not contain any pesticide raw materials, and is safe. The mosquito repelling gel comprises the following components in parts by weight: 5-30 parts of natural plant essential oils, 5-30 parts of a solubilizing agent, 0.5-10 parts of auxiliary agents, and 20-80 parts of purified water. The natural plant essential oils comprise at least two of the following four essential oils in parts by weight: 0.1-15 parts of lavender oil, 0.1-15 parts of eucalyptus oil, 0.1-15 parts of citronella oil and 0.1-15 parts of blumea oil.

Description

Room temperature volatile-type natural plant essential oils anophelifuge gel
Technical field
The present invention relates to the anophelifuge technical field, relate in particular to room temperature volatile-type natural plant essential oils anophelifuge gel.
Background technology
Mosquito stings the thorn people, inhales human blood, also propagates various diseases, has a strong impact on the mankind's life and health.Anophelifuge and anophelifuge product are very ripe through development for many years, and product on the market mainly contains insect aerosol, electric heating or needs igniting mosquito-repellent incense product, floral water etc.Insect aerosol, electric heating or to need the igniting mosquito-repellent incense product be mainly that waving of chemical composition (being generally pesticide) by having certain toxicity is loose, may cause discomfort or certain healthy hidden danger to part population (as infant), in addition electric heating and the potential safety hazard of lighting the product existence consumption energy or initiation fire; The anophelifuge product that directly acts on skin also likely causes the discomfort of human body to reach the safe zest problem to skin.
Chinese Patent Application No. 201210195806.1 discloses a kind of anophelifuge gel and preparation method, by anophelifuge effective ingredient and gel carrier, formed, gel agent composition consists of the component of following mass percent: mosquito-repellent (R2) 5 %~20 %, substrate 0.5 %~1.5 %, neutralization bases 0.8 %~2 %, wetting agent 5 %~16 %, antiseptic 0.2 %~0.4 %, appropriate essence, all the other are deionized water, amount to 100%, described mosquito-repellent is hydroxycitronellal 1, the 2-propylene glycol acetal, this anophelifuge gel is the slow setting dosage form, mosquito component can slowly discharge, thereby make the anophelifuge time be extended, but contain hydroxycitronellal 1 in this anophelifuge gel, the 2-propylene glycol acetal, there is certain toxicity, dangerous, environmental protection not.
Harmless to human-body safety while therefore developing a kind of use, environmental protection, to the non-irritating mosquito repellent product of human body skin, there is huge society and economic implications.
Summary of the invention
Therefore, for above content, the invention provides a kind of environmental protection, harmless, do not need heating at room temperature volatilizable, can distribute joyful abnormal smells from the patient, repelling effect good, to the skin nonirritant, containing the room temperature volatile-type natural plant essential oils anophelifuge gel of any pesticide raw material, safety.
For achieving the above object, the present invention is achieved by the following technical solutions: room temperature volatile-type natural plant essential oils anophelifuge gel is characterized in that, each component that comprises following weight portion: 5~30 parts of natural plant essential oils, 5~30 parts of solubilizing agents, 0.5~10 part of adjuvant, 20~80 parts of purified water; Described natural plant essential oils comprises: in four kinds of Oleum lavandula angustifolias, eucalyptus oil, citronella oil, Oleum Folium Artemisiae Argyi at least two kinds, the parts by weight of described four kinds of quintessence oils are: 0.1~15 part of Oleum lavandula angustifolia, 0.1~15 part of eucalyptus oil, 0.1~15 part of citronella oil, Oleum Folium Artemisiae Argyi 0.1~15.
Further improve and be: described solubilizing agent be in nonyl phenol polyethers-10, Cremophor RH40, oleth-20, laureth-9 any one or two or more with arbitrarily than the mixture mixed.
Further improve and be: described adjuvant comprises gel, acid-base modifier, antiseptic and spice.
Further improve and be: described gel is any one in carbomer, xanthan gum, dehydrogenation xanthan gum, hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, agar, carrageenan, and described acid-base modifier is triethanolamine or citric acid; Described spice is Isolongifolenone.
Further improve and be: the weight portion of described each material is: 0.1~1 part of carbomer, 0.1~2 part of xanthan gum, 0.1~2 part of dehydrogenation xanthan gum, 0.1~2 part of hydroxypropyl emthylcellulose, 0.1~2 part of hydroxyethyl-cellulose, 0.1~5 part, agar, 0.1~5 part of carrageenan; Acid-base modifier: 0~1 part of triethanolamine, 0~4 part of citric acid; Antiseptic: 0.1~0.5 part of DMDM hydantoin, 0.05~0.1 part of methylchloroisothiazandnone; Spice: 0.1~4 part of Isolongifolenone.
Further improve and be: described purified water is distilled water or deionized water.
By adopting the aforementioned techniques scheme, the invention has the beneficial effects as follows:
1, anophelifuge gel mosquito repellent function primary raw material quintessence oil of the present invention derives from plant, nontoxic, human body is had no adverse effects, and environmental protection, repelling effect is stable.
2, use described plants essential oil and solubilizing agent to optimize proportioning, preparation anophelifuge gel, make the present invention both have obvious repelling effect, has again the effect in pure and fresh delicate fragrance room.
3, anophelifuge gel repelling effect of the present invention is outstanding, and described natural plant essential oils all has obvious mosquito-repelling function, and result of the test of the present invention shows, two kinds and above essential oil compound have obvious repellent action to Anopheles sinensis, Culex quinquefasciatus, Aedes albopictus.
4, in the present invention, natural plant essential oils is used for to the anophelifuge gel, 120 grams dress effective anophelifuge times of product were higher than 720 hours.
5, in the present invention, the anophelifuge gel is transparent or opaque colloid, fragrant odour, and sealing is placed and is had good stability half a year.Place 24h in-5 ℃~-1 ℃ refrigerator, take out while recovering room temperature and wad a quilt with cotton with solidifying without layering, abnormal smells from the patient is constant; Place 24h in the calorstat of (40 ± 1) ℃, take out and observe not stratifiedly, abnormal smells from the patient is constant.
6, anophelifuge gel of the present invention, through the rabbit irritation test, is observed 48 hours, and result is smeared position without any untoward reaction, illustrates that product of the present invention is to skin nonirritant and anaphylaxis; Reality use in the simulation room is randomly drawed Healthy People and is entered and evaluate and test, and fragrant odour with fresh air in the sensory effects room, make the people joyful.
The specific embodiment
Describe embodiments of the present invention in detail below with reference to specific embodiment, to the present invention, how the application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
If do not specialize, the conventional means that the technological means adopted in embodiment is well known to those skilled in the art, but the reagent adopted and product also are the business acquisition.The source of agents useful for same, trade name and be necessary to list its constituent person are all indicated when occurring first.
Embodiment mono-
Room temperature volatile-type natural plant essential oils anophelifuge gel, each component that comprises following weight portion: 7 parts of Oleum lavandula angustifolias, 1 part, 20 parts oleth-20 of eucalyptus oil, 0.5 part of carbomer, 0.5 part of triethanolamine, 0.3 part of DMDM hydantoin, 3.7 parts of Isolongifolenones, 67 parts of distilled water.
Embodiment bis-
Room temperature volatile-type natural plant essential oils anophelifuge gel, comprise each component of following weight portion: 6 parts of Oleum lavandula angustifolias, 2 parts of eucalyptus oils, 2 parts, 25 parts nonyl phenol polyethers-10 of Oleum Folium Artemisiae Argyi, 1 part of hydroxypropyl emthylcellulose, 0.3 part of DMDM hydantoin, 0.7 part of Isolongifolenone, 63 parts of deionized waters.
Embodiment tri-
Room temperature volatile-type natural plant essential oils anophelifuge gel comprises each component of following weight portion: 0.4 part of 0.1 part of 0.5 part of 1 part of Cremophor RH40, hydroxyethyl-cellulose, xanthan gum, methylchloroisothiazandnone, Isolongifolenone, 64 parts of the distilled water of the nonyl phenol polyethers-10,7 of the laureth-9,7 of 6 parts of Oleum lavandula angustifolias, 2 parts of eucalyptus oils, 2 parts of Oleum Folium Artemisiae Argyis, 2 parts, 8 parts of citronella oil part part.
Embodiment tetra-
Room temperature volatile-type natural plant essential oils anophelifuge gel, comprise each component of following weight portion: 5 parts of eucalyptus oils, 5 parts of Oleum Folium Artemisiae Argyis, 3 parts, 8 parts laureth-9,8 of citronella oil part nonyl phenol polyethers-10,8 part Cremophor RH40,1 part of dehydrogenation xanthan gum, 0.1 part of methylchloroisothiazandnone, 0.9 part of Isolongifolenone, 61 parts of deionized waters.
Embodiment five
Room temperature volatile-type natural plant essential oils anophelifuge gel, comprise each component of following weight portion: 4 parts of eucalyptus oils, 5 parts of Oleum Folium Artemisiae Argyis, 6 parts of citronella oil, 25 parts of Cremophor RH40s, 1 part of carrageenan, 0.1 part of methylchloroisothiazandnone, 0.9 part of Isolongifolenone, 58 parts of distilled water.
Embodiment six
Room temperature volatile-type natural plant essential oils anophelifuge gel, comprise each component of following weight portion: 3 parts of Oleum lavandula angustifolias, 3 parts of eucalyptus oils, 2 parts of Oleum Folium Artemisiae Argyis, 2 parts of citronella oil, 20 parts of Cremophor RH40s, 1 part, agar, 0.1 part of methylchloroisothiazandnone, 0.9 part of Isolongifolenone, 68 parts of deionized waters.
Embodiment seven:
Room temperature volatile-type natural plant essential oils anophelifuge gel, comprise each component of following weight portion: 12 parts of Oleum lavandula angustifolias, 1 part of eucalyptus oil, 1 part of Oleum Folium Artemisiae Argyi, 6 parts of citronella oil, 28 parts of Cremophor RH40s, 1.5 parts, agar, 0.1 part of methylchloroisothiazandnone, 0.4 part of Isolongifolenone, 50 parts of distilled water.
The anophelifuge rate test result of each embodiment of table 1
Embodiment/anophelifuge rate Anopheles sinensis Culex quinquefasciatus Aedes albopictus
Embodiment 1 96.8 89.3 91.6
Embodiment 2 97.5 89.3 93.1
Embodiment 3 96.3 90.4 93.2
Embodiment 4 98.1 90.1 92.3
Embodiment 5 99.2 89.8 95.4
Embodiment 6 96.3 93.1 94.6
Embodiment 7 98.6 92.7 95.2
From table one, anophelifuge gel repelling effect of the present invention is outstanding, and the room temperature volatile-type natural plant essential oils anophelifuge gel of described embodiment mono-to seven configuration all has obvious mosquito-repelling function.Result of the test of the present invention shows, two kinds and above essential oil compound have obvious repellent action to Anopheles sinensis, Culex quinquefasciatus, Aedes albopictus, anophelifuge gel mosquito repellent function primary raw material quintessence oil of the present invention derives from plant, nontoxic, human body is had no adverse effects, environmental protection, repelling effect is stable.Use described plants essential oil and solubilizing agent to optimize proportioning, preparation anophelifuge gel, make the present invention both have obvious repelling effect, has again the effect in pure and fresh delicate fragrance room.In the present invention, natural plant essential oils is used for to the anophelifuge gel, 120 grams dress effective anophelifuge times of product were higher than 720 hours.In the present invention, the anophelifuge gel is transparent or opaque colloid, fragrant odour, and sealing is placed and is had good stability half a year.Place 24h in-5 ℃~-1 ℃ refrigerator, take out while recovering room temperature and wad a quilt with cotton with solidifying without layering, abnormal smells from the patient is constant; Place 24h in the calorstat of (40 ± 1) ℃, take out and observe not stratifiedly, abnormal smells from the patient is constant.Anophelifuge gel of the present invention, through the rabbit irritation test, is observed 48 hours, and result is smeared position without any untoward reaction, illustrates that product of the present invention is to skin nonirritant and anaphylaxis; Reality use in the simulation room is randomly drawed Healthy People and is entered and evaluate and test, and fragrant odour with fresh air in the sensory effects room, make the people joyful.
Wherein, described Oleum lavandula angustifolia, eucalyptus oil, citronella oil, Oleum Folium Artemisiae Argyi are natural plant essential oils, and Oleum lavandula angustifolia is at 0.1~15 part, eucalyptus oil is at 0.1~15 part, citronella oil is at 0.1~15 part, Oleum Folium Artemisiae Argyi is 0.1~15, and natural plant essential oils is two or more composite the forming of said components, and its overall control is at 5~30 parts; Described nonyl phenol polyethers-10, Cremophor RH40, oleth-20, laureth-9 are solubilizing agent, solubilizing agent can for above-described any one or two or more with arbitrarily than the mixture mixed, its overall control is at 5~30 parts, gel, acid-base modifier, antiseptic and spice are adjuvant, in described carbomer, xanthan gum, dehydrogenation xanthan gum, hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, agar, carrageenan, be gel, triethanolamine or citric acid are acid-base modifier; Described Isolongifolenone is spice, the weight portion of described each material: 0.1~1 part of carbomer, 0.1~2 part of xanthan gum, 0.1~2 part of dehydrogenation xanthan gum, 0.1~2 part of hydroxypropyl emthylcellulose, 0.1~2 part of hydroxyethyl-cellulose, 0.1~5 part, agar, 0.1~5 part of carrageenan; Acid-base modifier: 0~1 part of triethanolamine, 0~4 part of citric acid; Antiseptic: 0.1~0.5 part of DMDM hydantoin, 0.05~0.1 part of methylchloroisothiazandnone; Spice: 0.1~4 part of Isolongifolenone, the overall control of described adjuvant is at 0.5~10 part; Described is that distilled water or deionized water are purified water, and its consumption is at 20~80 parts.All can realize purpose of the present invention in above parameter area.
The above record, only, for utilizing the embodiment of this origination techniques content, modification, variation that any those skilled in the art use this creation to do, all belong to the scope of the claims that this creation is advocated, and be not limited to those disclosed embodiments.

Claims (6)

1. room temperature volatile-type natural plant essential oils anophelifuge gel, is characterized in that, comprises each component of following weight portion: 5~30 parts of natural plant essential oils, 5~30 parts of solubilizing agents, 0.5~10 part of adjuvant, 20~80 parts of purified water; Described natural plant essential oils comprises: in four kinds of Oleum lavandula angustifolias, eucalyptus oil, citronella oil, Oleum Folium Artemisiae Argyi at least two kinds, the parts by weight of described four kinds of quintessence oils are: 0.1~15 part of Oleum lavandula angustifolia, 0.1~15 part of eucalyptus oil, 0.1~15 part of citronella oil, Oleum Folium Artemisiae Argyi 0.1~15.
2. room temperature volatile-type natural plant essential oils anophelifuge gel according to claim 1 is characterized in that: described solubilizing agent be in nonyl phenol polyethers-10, Cremophor RH40, oleth-20, laureth-9 any one or two or more with arbitrarily than the mixture mixed.
3. room temperature volatile-type natural plant essential oils anophelifuge gel according to claim 1 and 2, it is characterized in that: described adjuvant comprises gel, acid-base modifier, antiseptic and spice.
4. room temperature volatile-type natural plant essential oils anophelifuge gel according to claim 3, it is characterized in that: described gel is any one in carbomer, xanthan gum, dehydrogenation xanthan gum, hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, agar, carrageenan, and described acid-base modifier is triethanolamine or citric acid; Described spice is Isolongifolenone.
5. room temperature volatile-type natural plant essential oils anophelifuge gel according to claim 4, it is characterized in that: the weight portion of described each material is: 0.1~1 part of carbomer, 0.1~2 part of xanthan gum, 0.1~2 part of dehydrogenation xanthan gum, 0.1~2 part of hydroxypropyl emthylcellulose, 0.1~2 part of hydroxyethyl-cellulose, 0.1~5 part, agar, 0.1~5 part of carrageenan; Acid-base modifier: 0~1 part of triethanolamine, 0~4 part of citric acid; Antiseptic: 0.1~0.5 part of DMDM hydantoin, 0.05~0.1 part of methylchloroisothiazandnone; Spice: 0.1~4 part of Isolongifolenone.
6. according to claim 1 or 2 or 4 or 5 described room temperature volatile-type natural plant essential oils anophelifuge gels, it is characterized in that: described purified water is distilled water or deionized water.
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CN104042448A (en) * 2014-05-20 2014-09-17 上海天晟医疗器材有限公司 Mosquito-preventing plaster and preparation method thereof
CN104255824A (en) * 2014-09-29 2015-01-07 福建师范大学 Method for preparing cockroach insecticide tablets by Sichuan pepper essential oil
CN104274848A (en) * 2014-05-25 2015-01-14 许春晖 Air freshener with aldehyde removing effect
CN104304338A (en) * 2014-09-29 2015-01-28 福建师范大学 Method for preparing cockroach repellent tablet by extracting xanthoxylin with carbon dioxide supercritical method
CN104940055A (en) * 2015-05-29 2015-09-30 佛山薇薇秘密商贸有限公司 Whitening lavender mask and use method thereof
CN105497957A (en) * 2015-12-28 2016-04-20 上海市第十人民医院 Air freshening gel and preparation and application thereof
CN105851092A (en) * 2016-04-26 2016-08-17 江苏耐雀生物工程技术有限公司 Environment-friendly toxin-free solid-sate essential oil preparation as well as preparation method and application thereof
CN106070300A (en) * 2016-06-10 2016-11-09 孙爱华 A kind of anophelifuge and preparation method thereof
CN106417268A (en) * 2016-08-22 2017-02-22 广州暨南生物医药研究开发基地有限公司 Mosquito repelling gel containing folium artemisiae argyi essential oil and preparation method thereof
LU92879B1 (en) * 2015-11-05 2017-06-21 Loen Holding S A R L Repellent accessories against fleas, mites and insects
CN107343861A (en) * 2017-07-28 2017-11-14 厦门琥珀日化科技股份有限公司 Long-acting mosquito-driving and antimicrobial spray containing natural plant essential oils and preparation method thereof
CN107372685A (en) * 2017-08-01 2017-11-24 然晟(上海)实业发展有限公司 A kind of plants essential oil solid mosquito repelling agent and preparation method thereof
CN107802523A (en) * 2017-12-11 2018-03-16 亳州职业技术学院 A kind of essential oil rod for eliminating bite by mosquitos sufferings and its preparation method and application
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CN104042448A (en) * 2014-05-20 2014-09-17 上海天晟医疗器材有限公司 Mosquito-preventing plaster and preparation method thereof
CN104274848A (en) * 2014-05-25 2015-01-14 许春晖 Air freshener with aldehyde removing effect
CN104255824A (en) * 2014-09-29 2015-01-07 福建师范大学 Method for preparing cockroach insecticide tablets by Sichuan pepper essential oil
CN104304338A (en) * 2014-09-29 2015-01-28 福建师范大学 Method for preparing cockroach repellent tablet by extracting xanthoxylin with carbon dioxide supercritical method
CN104940055A (en) * 2015-05-29 2015-09-30 佛山薇薇秘密商贸有限公司 Whitening lavender mask and use method thereof
LU92879B1 (en) * 2015-11-05 2017-06-21 Loen Holding S A R L Repellent accessories against fleas, mites and insects
CN105497957A (en) * 2015-12-28 2016-04-20 上海市第十人民医院 Air freshening gel and preparation and application thereof
CN105851092A (en) * 2016-04-26 2016-08-17 江苏耐雀生物工程技术有限公司 Environment-friendly toxin-free solid-sate essential oil preparation as well as preparation method and application thereof
CN106070300A (en) * 2016-06-10 2016-11-09 孙爱华 A kind of anophelifuge and preparation method thereof
CN106417268A (en) * 2016-08-22 2017-02-22 广州暨南生物医药研究开发基地有限公司 Mosquito repelling gel containing folium artemisiae argyi essential oil and preparation method thereof
CN110461152A (en) * 2017-03-22 2019-11-15 Xeda国际有限公司 Utilize the killing of at least one moderate volatile bio and/or processing method, respective handling component and the storage assembly of plant protection products
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CN107372685A (en) * 2017-08-01 2017-11-24 然晟(上海)实业发展有限公司 A kind of plants essential oil solid mosquito repelling agent and preparation method thereof
CN107802523A (en) * 2017-12-11 2018-03-16 亳州职业技术学院 A kind of essential oil rod for eliminating bite by mosquitos sufferings and its preparation method and application
CN108378081A (en) * 2018-04-28 2018-08-10 湖北民族学院 A kind of natural Chinese medicinal herb mosquito repellent gelling agent and preparation method thereof
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CN111281646A (en) * 2020-03-28 2020-06-16 广州市赛迪药业科技有限公司 Production process of medical cold compress patch
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