CN102525862A - Mosquito repellent gel containing sedum sarmentosum and mint oil and preparation method thereof - Google Patents

Abstract

The invention relates to a mosquito repellent gel containing sedum sarmentosum and mint oil and a preparation method thereof, belonging to the field of pharmaceutics. Based on the combination of sedum sarmentosum with detoxifying, swelling reducing, antibacterial and insect repelling effects and mint oil with cooling and itching and pain relieving effects, the invention provides a gel and the preparation method and production technology of the gel. The preparation method comprises the following steps of sedum sarmentosum filtered juice preparation, uniform mixing, matrix preparation, pH value regulation, sterilizing and finished product preparation and the like. The gel has mosquito repelling, itching relieving and antibacterial functions, is natural, safe, harmless and portable, can be absorbed quickly, has stable and long-lasting pesticide effect; the utilization rate of medical materials is improved, medical demands are met and the clinic application of the medical materials is widened.

Description

A kind of Herba Sedi Oleum menthae anophelifuge gel and preparation method thereof

 

Technical field

This invention relates to a kind of method of utilizing Herba Sedi, Oleum menthae to prepare anophelifuge, belongs to the pharmaceutics field.

Background technology

Mosquito is one of four pests, is again viral portable object.Along with the development of society, the human living standard does not improve constantly, and also in continuous increase, various mosquito repellent products arise at the historic moment people in succession to the consciousness of healthy and sense of self-protection.Mosquito repellent product in the market is a lot, mainly concentrates on coiled mosquito-repellent incense, the sheet that kindles mosquito repellent incense, aerosol mosquitocide, floral water, mosquito-dispelling cream, cis-3,6-endomethylene-.DELTA.4-tetrahydrophthalic acid dimethyl ester, heating mosquito incense liquid etc.These mosquito repellent product majorities are to rely on pesticide or chemical constituent to reach repelling effect, and having only minority is to play mosquito-repelling function with natural harmless composition.And mostly this part product is liquid, solid, and liquid repellent agent carries inconvenience and is subject to the influence of extraneous factors such as temperature, pressure, and solid mosquito repelling agent need be lighted and use inconvenience, so the both has certain weak point.

Herba Sedi Sedum sarmentosum Bunge. is the Crassulaceae herbaceos perennial, slightly sweet flavor cool in nature, and fresh or dry all herbal medicine is the medical herbs commonly used of treatment carbuncle sore among the people and snake bite and insect sting.The Herba Sedi using fresh herb smash apply or extracting juice be coated with outward have detoxifcation, detumescence, antibiotic drug effect, be used for that the honeybee class is stung, snake bite and insect sting, carbuncle skin infection, itchy skin eruption etc.And Oleum menthae has refrigerant, antipruritic, analgesic effect used with the Herba Sedi compatibility and to be had well collaborative mosquito-expelling and antipruritic effect.

Gel is a kind of conventional Chinese medicine dosage form, has to be coated with lubricated comfortable, and is splendid with the skin coupling effect, be prone to clean, absorb fast, easy to use, the characteristics of stable in properties.The present invention is prepared into gel with Herba Sedi, Oleum menthae; Said preparation tool anophelifuge, antipruritic, antimicrobial effect; Have simultaneously natural, safe, harmless, easy to carry, absorb fast, the persistent advantage of efficacy stability; Both improve the utilization rate of herb resource, satisfied needs of medical treatment, reached the purpose that enlarges its clinical practice again.

 

Summary of the invention

The present invention unites use with refrigerant, antipruritic, the pain relieving effect of the detoxifcation of Herba Sedi, detumescence, antibiotic, anthelminthic effect and Oleum menthae, and preparation of a kind of gel and preparation method thereof is provided.Technical problem to be solved by this invention is design one cover technological process, selects for use suitable adjuvant to process to have anophelifuge, the Herba Sedi Oleum menthae gel of antipruritic, antibacterial action.To the technical problem that will solve, the present invention realizes through following technical scheme.

Gel of the present invention is to be prepared from Herba Sedi, Oleum menthae and suitable adjuvant.

A kind of Herba Sedi Oleum menthae anophelifuge gel is formed by the feedstock production of following parts by weight:

Herba Sedi 400-1200 part;

Peppermint Oil 50-150 part;

Acritamer 940 5-15 part;

Distilled water 500-1500 part;

Glycerol 5-15 part;

Propylene glycol 5-10 part;

Ethyl hydroxybenzoate 5-15 part;

PH regulator agent triethanolamine transfers pH to use in right amount.

A kind of method for preparing of Herba Sedi Oleum menthae anophelifuge gel, carry out according to following step:

1. preparation Herba Sedi filtered juice: take seven, the August, the plump fresh emerald green Herba Sedi 400-1200 part of the food value of leaf, through cleaning, dry after, smashing juice, to filter Herba Sedi juice 100-300 part subsequent use;

2. mixing: 50-150 part Oleum menthae is added in the Herba Sedi juice that makes, subsequent use after the mixing and stirring;

3. preparation substrate: 5-15 part Acritamer 940 is soaked in 500-1500 part distilled water, and adding 5-15 part glycerol adds 5-10 part propylene glycol through after grinding evenly, and placement a period of time to the substrate that stirs once more profit rises fully;

4. adjust pH: ready Herba Sedi mint oil mixtures before adding, add pH regulator agent triethanolamine again, stir, the control pH value is 5-7;

5. finished product: all solution are mixed add 5-15 part ethyl hydroxybenzoate at last, mixing, fully stir, sterilization, clear gel, finished product is processed in encapsulation.

It is of the present invention that to have a repelling effect obvious, have simultaneously natural, safe, harmless, easy to carry, absorb fast, the persistent advantage of efficacy stability.

The specific embodiment

Below further specify technical process of the present invention through concrete embodiment:

Embodiment 1

1. preparation Herba Sedi filtered juice: take seven, the August, plump fresh emerald green Herba Sedi 400 g of the food value of leaf, through cleaning, dry after, smashing juice, to filter Herba Sedi juice 100 g subsequent use;

2. mixing: 150 g Oleum menthae are added in the Herba Sedi juice that makes, subsequent use after the mixing and stirring;

3. preparation substrate: 5 g Acritamer 940s are soaked in the 500 ml distilled water, add 15 g glycerol through after grinding evenly, add 10 g propylene glycol, placement a period of time to the substrate that stirs once more profit rises fully;

4. adjust pH: ready Herba Sedi mint oil mixtures before adding, add pH regulator agent triethanolamine again, the control pH value that stirs is 5;

5. finished product: all solution are mixed add 5 g ethyl hydroxybenzoates at last, mixing, fully stir, sterilization, clear gel, finished product is processed in encapsulation.

Embodiment 2

1. preparation Herba Sedi filtered juice: take seven, the August, plump fresh emerald green Herba Sedi 800 g of the food value of leaf, through cleaning, dry after, smashing juice, to filter Herba Sedi juice 200 g subsequent use;

2. mixing: 100 g Oleum menthae are added in the Herba Sedi juice that makes, subsequent use after the mixing and stirring;

3. preparation substrate: 10 g Acritamer 940s are soaked in the 1000 ml distilled water, add 10 g glycerol through after grinding evenly, add 5 g propylene glycol, placement a period of time to the substrate that stirs once more profit rises fully;

4. transfer pH: ready Herba Sedi mint oil mixtures before adding, add pH regulator agent triethanolamine again, the control pH value that stirs is 6;

5. finished product: all solution are mixed add 10 g ethyl hydroxybenzoates at last, mixing, fully stir, sterilization, clear gel, finished product is processed in encapsulation.

Embodiment 3

1. preparation Herba Sedi filtered juice: take seven, the August, plump fresh emerald green Herba Sedi 1200 g of the food value of leaf, through cleaning, dry after, smashing juice, to filter Herba Sedi juice 300 g subsequent use;

2. mixing: 50 g Oleum menthae are added in the Herba Sedi juice that makes, subsequent use after the mixing and stirring;

3. preparation substrate: 15 g Acritamer 940s are soaked in the 1500 ml distilled water, add 5 g glycerol through after grinding evenly, add 7.5 g propylene glycol, placement a period of time to the substrate that stirs once more profit rises fully;

4. transfer pH: ready Herba Sedi mint oil mixtures before adding, add pH regulator agent triethanolamine again, the control pH value that stirs is 7;

5. finished product: all solution are mixed add 15 g ethyl hydroxybenzoates at last, mixing, fully stir, sterilization, clear gel, finished product is processed in encapsulation.

Test the mosquito-repelling function of 1 Herba Sedi Oleum menthae anophelifuge gel

Method is carried out the repelling effect test among the employing GB/17322.10-1988.

Mosquito attack test: growing * wide * height is respectively in the mosquito cage of 40cm * 30cm * 30cm and puts 300 mosquitoes, and experimenter's arm exposes 4cm * 4cm skin area, and remainder covers.Arm stretched in the mosquito cage place 2min, the mosquito number that record comes to stop falling is that attack is qualified greater than 30 persons, and this testing crew and this cage mosquito can be used for walking quickly and keeping away experiment.

Walk quickly and keep away test: select the qualified experimenter of attack; As described abovely respectively expose 4cm * 4cm skin area at its both hands arm; Wherein an arm is set to blank, does not do any smearing, and another arm expose portion is evenly smeared the anophelifuge gel by the dosage of 1.5mg/ cm2.After smearing 2 h, arm is stretched into 2min in the qualified mosquito cage of attack, observation has or not mosquito to come to suck blood, and per hour tests afterwards 1 time, judges that promptly repellant lost efficacy as long as there is mosquito to come to suck blood, the effective protecting time (h) of record repellant.Prescription repetition 10 times.

Effective Vate of Protection (%)=[(matched group is on average stung thorn number-experimental group and on average stung the thorn number)/matched group is on average stung the thorn number] * 100

Experimental result, anophelifuge gel Effective Vate of Protection of the present invention are greater than 85%, and average repelling effect is at 10 h.Explain that anophelifuge gel provided by the invention has very good repelling effect.

Claims (2)

1. Herba Sedi Oleum menthae anophelifuge gel is characterized in that being formed by the feedstock production of following parts by weight:

Herba Sedi 400-1200 part;

Peppermint Oil 50-150 part;

Acritamer 940 5-15 part;

Distilled water 500-1500 part;

Glycerol 5-15 part;

Propylene glycol 5-10 part;

Ethyl hydroxybenzoate 5-15 part;

PH regulator agent triethanolamine transfers pH to use in right amount.

2. the method for preparing of the described a kind of Herba Sedi Oleum menthae anophelifuge gel of claim 1 is characterized in that carrying out according to following step:

1. preparation Herba Sedi filtered juice: take seven, the August, the plump fresh emerald green Herba Sedi 400-1200 part of the food value of leaf, through cleaning, dry after, smashing juice, to filter Herba Sedi juice 100-300 part subsequent use;

2. mixing: 50-150 part Oleum menthae is added in the Herba Sedi juice that makes, subsequent use after the mixing and stirring;

3. preparation substrate: 5-15 part Acritamer 940 is soaked in 500-1500 part distilled water, and adding 5-15 part glycerol adds 5-10 part propylene glycol through after grinding evenly, and placement a period of time to the substrate that stirs once more profit rises fully;

4. adjust pH: ready Herba Sedi mint oil mixtures before adding, add pH regulator agent triethanolamine again, stir, the control pH value is 5-7;

5. finished product: all solution are mixed add 5-15 part ethyl hydroxybenzoate at last, mixing, fully stir, sterilization, clear gel, finished product is processed in encapsulation.