CN105395784A - External traditional Chinese medicinal composition for treating mosquito bites and preparation method of traditional Chinese medicinal composition - Google Patents
External traditional Chinese medicinal composition for treating mosquito bites and preparation method of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses an external traditional Chinese medicinal composition for treating pruritus caused by mosquito bites, wherein active ingredients constituting the traditional Chinese medicinal composition mainly include the following raw materials: rhizoma paridis, centipede, dried toad skin, humifuse euphorbia herb, herba sedi, peppermint and borneol. The invention also discloses a preparation method of the traditional Chinese medicinal composition. The external traditional Chinese medicinal composition for relieving itching provided by the invention is simple in preparation method, low in treatment cost, natural in source, scientific in compatibility, rapid to take effect, good in curative effect and free from remarkable toxic and side effects; and the traditional Chinese medicinal composition is mainly used for treating pruritus caused by various mosquito bites.
Description
Technical field
The present invention relates to a kind of external medicine composition, particularly a kind ofly treat the external medicine composition that mosquito bite causes pruritus.The invention still further relates to the preparation method of this external medicine composition.
Background technology
During summer, mosquito wreaks havoc, and people often suffer mosquito bite in daily life, field work, there will be the phenomenons such as pruritus, redness, blister, affect routine work and rest after being subject to mosquito bite.The scratching lasting due to pruritus, gently then causes skin ulceration hemorrhage, and heavy then infection is festered, left scar or occur anaphylaxis and even threat to life.Therefore, the emphasis that various skin pruritus, redness that mosquito bite causes are diseases prevention and treatment in summer is solved.Show about the research of itching at present, the pathway of itching comprises the tickle and itch of histamine dependence and the tickle and itch of non-histamine dependence, the clinical treatment taking antihistamine, anti-inflammatory analgetic for these prurituss of doctor trained in Western medicine more, but this kind of medicine mostly is synthetics, common disadvantage is not resistance, easily causes body Drug resistance, and use inconvenience, life-time service can cause damage to skin, such as the symptom such as pigmentation, allergy, strengthens patient's burden.
The main basic research such as formation, nerve conduction being engaged in tickle and itch in preclinical medicine institute of Nanjing University of Traditional Chinese Medicine during doctor applicant, in conjunction with the viewpoint of differentiation of tcm, applicant selects suitable plant and animal species always in Chinese medicine, carrying out treatment mosquito bite causes the Related product of pruritus to be studied, and achieves certain achievement.The present invention's long-term practice that is applicant on the basis of research treatment histamine dependency and histamine dependent/non-dependent pruritus and updating.
Summary of the invention
A kind of external use anti pruritic Chinese medicine composition, is characterized in that forming Rhizoma Paridis 12 ~ 20g, Scolopendra 1 ~ 3g, dry maxima skin 1 ~ 3g, Herba Euphorbiae Humifusae 6 ~ 15g, Herba Sedi 8 ~ 15g, Herba Menthae 3 ~ 8g, Borneolum Syntheticum 0.5 ~ 2g by the raw material of following weight.
Preferably, be made up of the raw material of following weight: Rhizoma Paridis 15g, Scolopendra 2g, dry maxima skin 2g, Herba Euphorbiae Humifusae 10g, Herba Sedi 10g, Herba Menthae 5g, Borneolum Syntheticum 1g.
Above-described Herba Sedi is fresh Herba Sedi stem and leaf.
Treat the manufacture method that mosquito bite causes the external medicine composition of pruritus, its concrete steps are:
(1) Rhizoma Paridis, Scolopendra, dry maxima skin, Herba Euphorbiae Humifusae, Herba Sedi, Herba Menthae are pulverized, add the deionized water of 8 ~ 10 times amount of drug weight, after moderate heat boils, little fire decocts 1 ~ 2 hour, filtration obtains extracting solution, adds the deionized water of 8 ~ 10 times amount of filtering residue weight, repeats decoction 3 times;
(2) extracting solution decocted 3 times merges, and carries out rotary evaporation in vacuo, be concentrated into certain volume under 40 ~ 45 DEG C of conditions;
(3) by borneol and grinding, add the anhydrous alcohol solution of drug weight 2 ~ 3 times, mix, be settled to 50mL with deionized water with (2), the mosquito bite that obtains medical treatment causes the external medicine composition of pruritus.
Rhizoma Paridis, bitter, be slightly cold, slightly poisonous.Function with cure mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the arresting convulsion of cool liver.For furuncle carbuncle, laryngopharynx swelling and pain, snake bite and insect sting, fall and flutter the pain of injury, convulsion with spasms.
Scolopendra, pungent, warm, poisonous.Function with cure mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain., hemiplegia, tetanus, rheumatoid arthritis stubborn askew for skin infection, scrofula, venom, infantile convulsion, tic spasm, middle air port.
Dry maxima skin, pungent, cool, micro-poison; Function with cure mainly: heat-clearing and toxic substances removing, diuretic relieving distension.For carbuncle, toxic swelling, scrofula, tumor, infantile malnutrition abdominal distention, chronic tracheitis.
Herba Euphorbiae Humifusae, pungent, flat; Return liver, large intestine channel; Function with cure mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For furuncle carbuncle, dysentery, have loose bowels, hemoptysis, hematuria, have blood in stool, metrorrhagia.
Herba Sedi is sweet, light, cool; Return liver, gallbladder, small intestine meridian; Function cures mainly: eliminating damp-heat, removing toxic substances.For jaundice due to damp-heat, dysuria, carbuncle skin infection, acute hepatitis, chronic hepatitis.
Herba Menthae is pungent, cool; Return lung, Liver Channel; Function cures mainly: dispelling wind-heat, refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.
Borneolum Syntheticum, pungent, bitter, be slightly cold; GUIXIN, spleen, lung meridian; Function cures mainly: refreshment of having one's ideas straightened out, the loose poison of heat clearing away.For calentura coma, faint from fear, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Advantage of the present invention is: provided by the inventionly a kind ofly treat the external medicine composition that mosquito bite causes pruritus, and preparation method is simple, and medical expense is low, originates natural, and compatibility science is rapid-action, evident in efficacy, not repeatedly.
Toxicologic study result shows, treatment mosquito bite provided by the invention causes the external application Chinese medicine of pruritus without overt toxicity reaction, without obvious sensitization, without obvious irritation, has antipruritic, the pain that disappears effect.Medication of the present invention is convenient, only needs Chinese medicine composition to clean affected part, and can repetitive cycling utilize, and can save medical expense, reduce the waste of natural resources of Chinese medicinal materials.Zoopery shows, gives Chinese medicine composition, and the pruritus (pruritus that histamine relies on and the pruritus that non-histamine relies on) caused for histamine, chloroquine has significant therapeutic effect.Anemia of pregnant woman is cautious use of.
Accompanying drawing explanation
Fig. 1 is the external use anti pruritic Chinese medicine composition prepared in the embodiment of the present invention 1 causes mice scratching inhibitory action design sketch to histamine.
Fig. 2 is the external use anti pruritic Chinese medicine composition prepared in the embodiment of the present invention 1 causes mice scratching inhibitory action design sketch to chloroquine.
Detailed description of the invention
The embodiment provided below is only and further illustrates the present invention, description is below only to make those skilled in the art better understand the present invention, but they do not constitute any limitation the present invention.
Embodiment 1
A kind of external use anti pruritic Chinese medicine composition, is characterized in that being made up of the raw material of following weight: Rhizoma Paridis 15g, Scolopendra 2g, dry maxima skin 2g, Herba Euphorbiae Humifusae 10g, Herba Sedi 10g, Herba Menthae 5g, Borneolum Syntheticum 1g.
Above-described Herba Sedi is fresh Herba Sedi stem and leaf.
Treat the manufacture method that mosquito bite causes the external medicine composition of pruritus, its concrete steps are:
(1) Rhizoma Paridis, Scolopendra, dry maxima skin, Herba Euphorbiae Humifusae, Herba Sedi, Herba Menthae are pulverized, add the deionized water of 8 times amount of drug weight, after moderate heat boils, little fire decocts 1 hour, filtration obtains extracting solution, adds the deionized water of 8 times amount of filtering residue weight, repeats decoction 3 times;
(2) extracting solution decocted 3 times merges, and carries out rotary evaporation in vacuo, be concentrated into certain volume under 45 DEG C of conditions;
(3) by borneol and grinding, add the anhydrous alcohol solution of drug weight 2 times, mix, be settled to 50mL with deionized water with (2), the mosquito bite that obtains medical treatment causes the external medicine composition of pruritus.
Embodiment 2
A kind of external use anti pruritic Chinese medicine composition, is characterized in that being made up of the raw material of following weight: Rhizoma Paridis 18g, Scolopendra 3g, dry maxima skin 3g, Herba Euphorbiae Humifusae 6g, Herba Sedi 15g, Herba Menthae 8g, Borneolum Syntheticum 2g.
Above-described Herba Sedi is fresh Herba Sedi stem and leaf.
Preparation method is with embodiment 1
The experiment that embodiment 3 inventor does
This research adopts histamine, chloroquine to stimulate B6 mice as the animal experimental model of pruritus, carries out pharmacodynamic observation to antipruritic Chinese medicine composition of the present invention.
1 material
Male B6 mice 120, body weight 25 ~ 30g, is provided by Nanjing University of Traditional Chinese Medicine's Experimental Animal Center; Chloroquine, histamine all come from Sigma company.Positive drug is jidesheng sheyao tablets.
Medicine of the present invention is the antipruritic external medicine composition that embodiment 1 obtains; Video camera is Sony HDR-CX405.
2 methods
2.1 experiments 1
B6 mice, to the therapeutical effect of the tickle and itch that histamine relies on, is divided into normal group, modeling group, positive drug treatment group, medicine group of the present invention by the antipruritic external medicine composition of the present invention, 4 groups altogether, often organizes 10.With shaver, mice cervical region is rejected by hair, and adapt in experimental situation after 3 days for experiment.Experimental day normal group subcutaneous injection 50 μ L normal saline, injecting normal saline 50 μ L after 30min; Modeling group subcutaneous injection 50 μ L normal saline, injects the histamine 50 μ L of 100 μMs after 30min; Positive drug ultrasonic dissolution is in 2mL ultra-pure water, and centrifuging and taking supernatant is for subsequent use, and during the experiment of positive drug group, subcutaneous injection 50 μ L positive drug aqueous solution, injects the histamine 50 μ L of 100 μMs after 30min; Subcutaneous injection 50 μ L antipruritic Chinese medicine composition aqueous solution during medicine group experiment of the present invention, injects the histamine 50 μ L of 100 μMs after 30min; After the injection of all animal second time, mice is positioned in transparent plastic pail and carries out animal behavioral study, use camera record 30min, adopt computer for analysis scratching number of times.More often organize the mean of mice scratching, and carry out statistical procedures.
2.2 experiments 2
B6 mice, to the therapeutical effect of the tickle and itch that non-histamine relies on, is divided into normal group, modeling group, positive drug treatment group, medicine group of the present invention by the antipruritic external medicine composition of the present invention, 4 groups altogether, often organizes 10.With shaver, mice cervical region is rejected by hair, and adapt in experimental situation after 3 days for experiment.Experimental day normal group subcutaneous injection 50 μ L normal saline, injecting normal saline 50 μ L after 30min; Modeling group subcutaneous injection 50 μ L normal saline, injects the chloroquine 50 μ L of 8mM after 30min; Positive drug ultrasonic dissolution is in 2mL ultra-pure water, and centrifuging and taking supernatant is for subsequent use, and during the experiment of positive drug group, subcutaneous injection 50 μ L positive drug aqueous solution, injects the chloroquine 50 μ L of 8mM after 30min; During medicine group experiment of the present invention, the antipruritic Chinese medicine composition aqueous solution of subcutaneous injection 50 μ L, injects the chloroquine 50 μ L of 8mM after 30min; After the injection of all animal second time, mice is positioned in transparent plastic pail and carries out animal behavioral study, use camera record 30min, adopt computer for analysis scratching number of times.More often organize the mean of mice scratching, and carry out statistical procedures.
3 results
3.1 experiments 1
Experimental result is shown in Fig. 1.
Fig. 1 shows, after injection histamine, modeling group mice scratching number of times is significantly higher than normal group, two groups are compared and have significant difference (P < 0.05), and after giving positive drug and Chinese medicine composition group, histamine causes the scratching number of times of mice significantly to reduce (P < 0.05).
3.2 experiments 2
Experimental result is shown in Fig. 2.
Fig. 2 shows, after injection chloroquine, modeling group mice scratching number of times is significantly higher than normal group, two groups are compared and have significant difference (P < 0.05), and after giving positive drug and Chinese medicine composition group, the scratching number of times that chloroquine causes significantly reduces (P < 0.05).
4 conclusions and discussion
At present focus mostly on the tickle and itch path relied on non-histamine that relies at histamine about the research of pruritus, therefore universally acknowledged two kinds of this experimental selection cause material histamine of itching (histamine dependence) and chloroquine (non-histamine dependence) as the tool drug manufacturing pruritus model, and whether investigate antipruritic external medicine composition in the present invention has therapeutical effect to itching of two kinds of paths.This experimental study results which prove, Chinese medicine composition significantly can suppress the mice scratching reaction caused by histamine, chloroquine, has significant itching-relieving efficacies.The active drug JIDESHENGSHEYAO of the treatment mosquito bite that this experimental selection is commonly used summer is as positive control, and compare observation with medicine of the present invention, result proves, Chinese medicine composition of the present invention is consistent with JIDESHENGSHEYAO curative effect, and in dosage form, be better than JIDESHENGSHEYAO (tablet), there is determined curative effect, feature easy to use.
Embodiment 4
A kind of external use anti pruritic Chinese medicine composition, is characterized in that being made up of the raw material of following weight: Rhizoma Paridis 12g, Scolopendra 1g, dry maxima skin 1g, Herba Euphorbiae Humifusae 6g, Herba Sedi 9g, Herba Menthae 3g, Borneolum Syntheticum 0.5g.
Above-described Herba Sedi is fresh Herba Sedi stem and leaf.
Preparation method is with embodiment 1
Concrete case:
Ma, female, 35 years old, operation in the wild throughout the year, on August 12nd, 2015, red and swollen by local skin heating after mosquito bite, very itch hard to bear.Pick the prepared antipruritic Chinese medicine composition obtained of 2mL embodiment 4 with cotton swab, be applied in skin pruritus place, smeared 1 time every 1 hour, smear 3 times altogether.After medication 1 time, pruritus obviously alleviates, and lump disappears gradually, and the red and swollen symptom of heating alleviates gradually, and without obvious scratchiness after medication 3 times, local skin returns to normal color.
Zhang, man, 29 years old, field was walked by mosquito bite in thick grass, and local is red and swollen, acute pruritus, and scratching is to occurring blood stain.Pick the prepared antipruritic Chinese medicine composition obtained of 2mL embodiment 4 with cotton swab, be applied in skin pruritus place, smeared 1 time every 1 hour, smear 3 times altogether.After medication 1 time, pruritus obviously alleviates, and without obvious scratchiness after medication 3 times, local skin redness disappears.
Claims (3)
1. an external use anti pruritic Chinese medicine composition, is characterized in that forming Rhizoma Paridis 12 ~ 20g, Scolopendra 1 ~ 3g, dry maxima skin 1 ~ 3g, Herba Euphorbiae Humifusae 6 ~ 15g, Herba Sedi 8 ~ 15g, Herba Menthae 3 ~ 8g and Borneolum Syntheticum 0.5 ~ 2g by the raw material of following weight.
2. a kind of external use anti pruritic Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the raw material of following weight: Rhizoma Paridis 15g, Scolopendra 2g, dry maxima skin 2g, Herba Euphorbiae Humifusae 10g, Herba Sedi 10g, Herba Menthae 5g, Borneolum Syntheticum 1g.
3. the preparation method of a kind of external use anti pruritic Chinese medicine composition as claimed in claim 1, is characterized in that, comprise the following steps:
(1) Rhizoma Paridis, Scolopendra, dry maxima skin, Herba Euphorbiae Humifusae, Herba Sedi, Herba Menthae are pulverized, add the deionized water of 8 ~ 10 times amount of drug weight, after moderate heat boils, little fire decocts 1 ~ 2 hour, filtration obtains extracting solution, adds the deionized water of 8 ~ 10 times amount of filtering residue weight, repeats decoction 3 times;
(2) extracting solution decocted 3 times merges, and carries out rotary evaporation in vacuo, be concentrated into certain volume under 40 ~ 45 DEG C of conditions;
(3) by borneol and grinding, add the anhydrous alcohol solution of drug weight 2 ~ 3 times, mix, be settled to 50mL with deionized water with (2), the mosquito bite that obtains medical treatment causes the external medicine composition of pruritus.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110917275A (en) * | 2019-12-30 | 2020-03-27 | 王托资 | Traditional Chinese medicine for treating mosquito bites and preparation method thereof |
| CN116870090A (en) * | 2023-08-04 | 2023-10-13 | 精华制药集团股份有限公司 | Application of Jide Sheng medicine composition or preparation thereof in preparation of medicine for relieving, auxiliary treating or treating diabetic foot |
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| CN102525862A (en) * | 2012-02-28 | 2012-07-04 | 江苏大学 | Mosquito repellent gel containing sedum sarmentosum and mint oil and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102525862A (en) * | 2012-02-28 | 2012-07-04 | 江苏大学 | Mosquito repellent gel containing sedum sarmentosum and mint oil and preparation method thereof |
Non-Patent Citations (3)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917275A (en) * | 2019-12-30 | 2020-03-27 | 王托资 | Traditional Chinese medicine for treating mosquito bites and preparation method thereof |
| CN116870090A (en) * | 2023-08-04 | 2023-10-13 | 精华制药集团股份有限公司 | Application of Jide Sheng medicine composition or preparation thereof in preparation of medicine for relieving, auxiliary treating or treating diabetic foot |
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