CN102949639A - Medicinal composition of external lotion for treating vaginitis and preparation method thereof - Google Patents
Medicinal composition of external lotion for treating vaginitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal composition of external lotion for treating vaginitis and a preparation method thereof, and belongs to the technical field of medicines. The medicinal composition is prepared from the following raw materials: golden thread, golden cypress, sophora flavescens, stemona, cortex dictamni, selinum japenious seed, belvedere fruit, mint, pepper and the like, and has the effects of clearing heat and removing toxicity, and removing dampness and destroying parasites. The medicinal composition is used for treating various vaginitis.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of colpitic external wash liquid, have heat-clearing and toxic substances removing, the effect of removing dampness and killing parasites; Clinically be used for the treatment of various vaginitiss.The invention still further relates to the preparation method of this pharmaceutical composition, belong to medical technical field.
Background technology
Vaginitis is the common disease of gynecological, for pathogen enters vagina, makes vaginal mucosa production inflammation.Vaginitis belongs to the category of TCM Gynecology " leukorrheal diseases ", " pudendal pruritus ", clinical common trichomonal vaginitis, colpitis mycotica, bacterial vaginitis and senile vaginitis Four types.Wherein trichomonal vaginitis is a kind of vagina that produces take trichomonal vaginitis as pathogen, and sickness rate is high and treat very obstinate.Except making us itching bitterly unbearably, trichomonal vaginitis also can consume or engulf ground glycogen in the vaginal epithelial cell, hinders lactic acid and generates, and not only destroys the weak acid environment of vagina, also might cause vaginal cell abnormal development, brings out pathological changes pre-cancer.Infusorian not only parasitizes vagina, also often invades urethra or paraurethral gland, even bladder, renal pelvis, thereby causes urethritis, cystitis, pyelitis etc.
Particularly Candida albicans is as a kind of vagina of main pathogens take candidiasis during colpitis mycotica, so be called monilial vaginitis, its incidence probability has been higher than trichomonal vaginitis now.Colpitis mycotica patient's main manifestations is leucorrhoea grow in quantity, pudendum, pruritus of vagina, burning sensation, and painful urination, Chang Fahong, edema, epidermis change varied around the pudendum; Very shallow vesicle, pimple can occur; It is rotten to the corn also can to form the eczema shape, can cause individually small white pustule, and ulcer occurs when serious.
Vaginitis has brought very large misery and inconvenient to the patient; Gynaecologic washing lotion directly acts on the focus quick result, and easy to use, is numerous vagina patients' first-selection.
Fructus Cnidii temperature in the medicine of the present invention, kidney and enhancing body, killing parasites for relieving itching has the effect of the trichomonas vaginitis killed.The Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide, diuresis, Rhizoma Coptidis, Cortex Phellodendri can be strengthened the effect of heat-clearing and toxic substances removing parasite killing, Pericarpium Zanthoxyli parasite killing dispelling wind for relieving itching, the Herba Menthae heat-clearing and toxic substances removing is antipruritic.All medicines share, and leukorrhagia is controlled in the parasite killing dehumidifying, heat-clearing and toxic substances removing, and the only pudendal pruritus of dispeling the wind has good therapeutical effect to vaginitis.
Through the retrieval prior art, finding has with the similar prior art of patent of the present invention: Dong Li the present invention a kind of external used medicine for the treatment of various gynecological diseases---Fuyanyu.No. 1 powder and capsule cures mainly the multiple gynecologicals diseases such as vulvitis, vaginitis, cervical erosion, cervicitis.Comprise Chinese medicine: Rhizoma Pinelliae, float the Rhizoma Pinelliae, Herba Andrographis, Radix Sophorae Tonkinensis, Radix Arnebiae (Radix Lithospermi), Herba Senecionis Scandentis, Rhizoma Polygoni Cuspidati, Herba Solani Nigri, Fructus Cnidii, dried Alumen, Borneolum Syntheticum.No. 2 capsule for suppository cures mainly the early metaphase cervical cancer, comprises Chinese medicine: Herba Crotalariae sessiliflorae, rhizoma sparganic, Rhizoma Curcumae, Pseudobulbus cremastrae seu pleiones, process arsenic, Realgar, Fructus Cnidii, Borax, Moschus, dried Alumen, Borneolum Syntheticum, Endothelium Corneum Gigeriae Galli.(application (patent) number: CN97112812.X).But compare with medicine of the present invention, drug prescription taste of Chinese medicine of the present invention is few, and is conventional medicine, low price; Preparation technology is simple, and production cost is low, has alleviated patient economy burden.
The colpitic medicine for the treatment of is main mainly with the chemical medicine composition on the existing market, though therapeutic effect is better, produces easily the untoward reaction such as drug dependence and heavy damage vagina internal medium even the vagina inner skin of burning; Medicine of the present invention is pure Chinese medicinal preparation, have no adverse reaction, clinical practice for many years, successful.
Summary of the invention
Purpose of the present invention just provides a kind of pharmaceutical composition for the treatment of colpitic external wash liquid, and this pharmaceutical composition has heat-clearing and toxic substances removing, the effect of removing dampness and killing parasites, clinical practice treatment vaginitis.
Another object of the present invention provides the preparation method of this pharmaceutical composition.
For achieving the above object, the pharmaceutical composition of the colpitic external wash liquid for the treatment of provided by the invention is prepared from by the processing of the crude drug of following weight parts:
Rhizoma Coptidis 15-25 part Cortex Phellodendri 15-25 part Radix Sophorae Flavescentis 10-20 part Radix Stemonae 20-30 part
Cortex Dictamni 10-20 part Fructus Cnidii 5-15 part Fructus Kochiae 8-15 part Pericarpium Zanthoxyli 5-15 part
Herba Menthae 12-18 part.
Preferred plan is prepared from by the processing of the crude drug of following weight parts:
25 parts of 15 parts of Radixs Stemonae of 20 parts of Radix Sophorae Flavescentiss of 18 portions of Cortex Phellodendris of Rhizoma Coptidis
12 parts in 15 portions of Pericarpium Zanthoxylies of 12 parts of Fructus Kochiae of 15 parts of Fructus Cnidiis of Cortex Dictamni
15 parts of Herba Menthaes.
The present invention treats colpitic pharmaceutical composition, and preparation is external wash liquid.
Described weight portion can be the weight metering units such as gram, two, jin, kilogram, ton.
Pharmaceutical composition of the present invention can adopt the ingredients of conventional method in will writing out a prescription to carry out in proportion compatibility, makes various clinical applicable dosage forms by existing preparation process, and used ingredients is the Chinese crude drug that commercially available process is up to the standards.
The preparation method that the present invention relates to is as follows:
(1) it is for subsequent use to get above-mentioned qualified Chinese crude drug;
(2) Pericarpium Zanthoxyli, Herba Menthae are extracted volatile oil with vapor distillation;
(3) the seven flavor medicine materials such as the medicinal residues after the distillation and medicinal liquid and all the other Rhizoma Coptidis decoct 2 times, add 3-6 times of water gaging for the first time, decoct 1-3 hour, add 2-4 times of water gaging for the second time, decoct 1 hour;
(4) collecting decoction filters, and filtrate is condensed into the relative density of measuring in the time of 60 ℃ be 1.05～1.10 clear paste, adds equivalent 75% ethanol, stirs evenly, and left standstill 24 hours, filters, and filtrate recycling ethanol is to distinguishing the flavor of without ethanol;
(5) the above-mentioned volatile oil of adding stirs evenly and gets final product.
Pharmaceutical composition ingredients modern pharmacological research of the present invention shows:
1. Rhizoma Coptidis: hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, the conjunctival congestion acid regurgitation, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.
Rhizoma Coptidis main component berberine hydrochloride has anti-trichomonal, anti-leishmania donovani, anti-trypanosomicide, kill the effect such as paramecium.
2. Cortex Phellodendri: hardship, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging is except steaming, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
3. Radix Sophorae Flavescentis: hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
The matrine that Radix Sophorae Flavescentis contains has active anticancer, oxymatrine has effect in increasing leukocyte, oxymatrine can obviously resist the exudative inflammation that Oleum Tiglii, carrageenin (rat) and glacial acetic acid (mice) bring out, all there is antibacterial action the matrine inside and outside, action intensity is suitable with chloromycetin in the body, the alcohol leaching mastic has the anti-trichomonal effect outward, and its intensity and hops are close.
4. the Radix Stemonae: sweet, bitter, tepor.Return lung meridian.Nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Be used for new chronic cough and cough lung impairment and cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus disease.
5. Cortex Dictamni: hardship, cold.Return spleen, stomach, urinary bladder channel.Heat clearing and damp drying, the detoxifcation of dispeling the wind.Be used for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, jaundice dark coloured urine.
6. Fructus Cnidii: hot, bitter, temperature; Slightly poisonous.Return kidney channel.Warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago, external treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis.
The xanthotoxol that Fructus Cnidii contains has significant antifungal effect, and Fructus Cnidii also has anti-trichomonal effect, gonadotropic Effect, local anesthetic action, and osthole can suppress the mice passive cutaneous anaphylaxis, PCA strongly.
7. the Fructus Kochiae: hot, bitter, cold.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Be used for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
8. Pericarpium Zanthoxyli: suffering, temperature.Return spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching.Be used for coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.Pericarpium Zanthoxyli is to 10 kinds of gram positive bacterias such as anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, lemon yellow and Staphylococcus albus, bacillus subtilis, and the enteral pathogenic bacterium such as escherichia coli, Song Nei Shi dysentery bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have obvious inhibitory action.
9. Herba Menthae: suffering, cold.Return lung, Liver Channel.Dispelling wind-heat.The refresh oneself, rash.Be used for anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.
Drug therapy 90 routine vaginitis patients of the present invention, trichomonal vaginitis 30 examples wherein, colpitis mycotica 33 examples and other vaginitiss are totally 27 examples.The external wash liquid of medicine of the present invention carries out washout with it, and every day 2 times, a week is a course for the treatment of.Cure altogether patient's 72 examples (wherein infusorian and colpitis mycotica 65 examples) in the course for the treatment of, 10 examples that take a turn for the better, invalid 8 examples.That is to say that medicine of the present invention is 80.0% to colpitic cure rate, total effective rate can reach 91.1%, and can reach 72.2% to the cure rate of trichomonal vaginitis and colpitis mycotica.
The specific embodiment
Below with embodiment the pharmaceutical composition of the colpitic external wash liquid for the treatment of of the present invention is further described; this will help the present invention and effect thereof are further understood; embodiment does not limit protection scope of the present invention, and its protection domain is decided by claim.
Embodiment 1
Treat the pharmaceutical composition of colpitic external wash liquid, formed by the Chinese crude drug of following weight parts: Rhizoma Coptidis 150g, Cortex Phellodendri 150g, Radix Sophorae Flavescentis 100g, Radix Stemonae 200g, Cortex Dictamni 100g, Fructus Cnidii 50g, Fructus Kochiae 80g, Pericarpium Zanthoxyli 50g, Herba Menthae 120g;
Preparation method: get Pericarpium Zanthoxyli, Herba Menthae is extracted volatile oil with vapor distillation; The seven flavor medicine materials such as the medicinal residues after the distillation and medicinal liquid and all the other Rhizoma Coptidis decoct 2 times, add 3 times of water gagings for the first time, decoct 1 hour, add 2 times of water gagings for the second time, decoct 1 hour; Collecting decoction filters, and filtrate is condensed into the relative density of measuring in the time of 60 ℃ be 1.05 clear paste, adds equivalent 75% ethanol, stirs evenly, and left standstill 24 hours, filters, and filtrate recycling ethanol is to distinguishing the flavor of without ethanol; Add above-mentioned volatile oil and an amount of distilled water and stir evenly and get final product, make 10000ml.
Embodiment 2
Treat the pharmaceutical composition of colpitic external wash liquid, formed by the Chinese crude drug of following weight parts: Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Radix Sophorae Flavescentis 200g, Radix Stemonae 300g, Cortex Dictamni 200g, Fructus Cnidii 150g, Fructus Kochiae 150g, Pericarpium Zanthoxyli 150g, Herba Menthae 150g;
Preparation method: get Pericarpium Zanthoxyli, Herba Menthae is extracted volatile oil with vapor distillation; The seven flavor medicine materials such as the medicinal residues after the distillation and medicinal liquid and all the other Rhizoma Coptidis decoct 2 times, add 6 times of water gagings for the first time, decoct 3 hours, add 4 times of water gagings for the second time, decoct 1 hour; Collecting decoction filters, and filtrate is condensed into the relative density of measuring in the time of 60 ℃ be 1.10 clear paste, adds equivalent 75% ethanol, stirs evenly, and left standstill 24 hours, filters, and filtrate recycling ethanol is to distinguishing the flavor of without ethanol; Add above-mentioned volatile oil and an amount of distilled water and stir evenly and get final product, make 10000ml.
Embodiment 3
Treat the pharmaceutical composition of colpitic external wash liquid, formed by the Chinese crude drug of following weight parts: Rhizoma Coptidis 180g, Cortex Phellodendri 200g, Radix Sophorae Flavescentis 150g, Radix Stemonae 250g, Cortex Dictamni 150g, Fructus Cnidii 120g, Fructus Kochiae 150g, Pericarpium Zanthoxyli 120g, Herba Menthae 150g;
Preparation method: get Pericarpium Zanthoxyli, Herba Menthae is extracted volatile oil with vapor distillation; The seven flavor medicine materials such as the medicinal residues after the distillation and medicinal liquid and all the other Rhizoma Coptidis decoct 2 times, add 4 times of water gagings for the first time, decoct 2 hours, add 3 times of water gagings for the second time, decoct 1 hour; Collecting decoction filters, and filtrate is condensed into the relative density of measuring in the time of 60 ℃ be 1.10 clear paste, adds equivalent 75% ethanol, stirs evenly, and left standstill 24 hours, filters, and filtrate recycling ethanol is to distinguishing the flavor of without ethanol; Add above-mentioned volatile oil and an amount of distilled water and stir evenly and get final product, make 10000ml.
Below in conjunction with concrete case to drug effect further instruction of the present invention.
Case 1: Lee, the woman, 31 years old, 09 year summer conscious pruritus vulvae, gynaecological examination finds that vaginal wall is congested, the surface is covered with white films sample thing, vaginal secretions is the yellow-white of thickness, is diagnosed as colpitis mycotica.The prescription of embodiment 1 with it, one day washout or demibain 2-3 time, after the week, recovery from illness.
Case 2: Zhang, the woman, 38 years old, conscious pruritus vulvae when examining, and with diseases such as frequent micturition, urgent micturitions.Gynaecological examination finds that vaginal mucosa is congested, and vaginal secretions is the bean curd scoriform, is diagnosed as colpitis mycotica.With the prescription of embodiment 2, washout was 2-3 time in one day, each 10ml, and after the week, recovery from illness.
Case 3: the Wang, the woman, 28 years old, summer and autumn conscious pruritus vulvae, the vagina formicant itching is difficult to restrain oneself.The visible vagina of gynaecological examination has the petechia, many places, and vaginal secretions is the foam sample, is diagnosed as trichomonal vaginitis.With the prescription of embodiment 3, washout was 2-3 time in one day, each 10ml, and after 10 days, recovery from illness.
Claims (4)
1. pharmaceutical composition for the treatment of colpitic external wash liquid is characterized in that being prepared from by the crude drug processing of following weight parts:
Rhizoma Coptidis 15-25 part Cortex Phellodendri 15-25 part Radix Sophorae Flavescentis 10-20 part Radix Stemonae 20-30 part
Cortex Dictamni 10-20 part Fructus Cnidii 5-15 part Fructus Kochiae 8-15 part Pericarpium Zanthoxyli 5-15 part
Herba Menthae 12-18 part.
2. a kind of pharmaceutical composition for the treatment of colpitic external wash liquid according to claim 1 is characterized in that being prepared from by the crude drug processing of following weight parts:
25 parts of 15 parts of Radixs Stemonae of 20 parts of Radix Sophorae Flavescentiss of 18 portions of Cortex Phellodendris of Rhizoma Coptidis
12 parts in 15 portions of Pericarpium Zanthoxylies of 12 parts of Fructus Kochiae of 15 parts of Fructus Cnidiis of Cortex Dictamni
15 parts of Herba Menthaes.
3. one of them described a kind of pharmaceutical composition for the treatment of colpitic external wash liquid according to claim 1 and 2 is characterized in that preparation is external wash liquid.
4. according to claim 1 to 2 described a kind of preparation methoies for the treatment of the pharmaceutical composition of colpitic external wash liquid, it is characterized in that comprising the steps:
(1) it is for subsequent use to get above-mentioned qualified Chinese crude drug;
(2) Pericarpium Zanthoxyli, Herba Menthae are extracted volatile oil with vapor distillation;
(3) the seven flavor medicine materials such as the medicinal residues after the distillation and medicinal liquid and all the other Rhizoma Coptidis decoct 2 times, add 3-6 times of water gaging for the first time, decoct 1-3 hour, add 2-4 times of water gaging for the second time, decoct 1 hour;
(4) collecting decoction filters, and filtrate is condensed into the relative density of measuring in the time of 60 ℃ be 1.05～1.10 clear paste, adds equivalent 75% ethanol, stirs evenly, and left standstill 24 hours, filters, and filtrate recycling ethanol is to distinguishing the flavor of without ethanol;
(5) the above-mentioned volatile oil of adding stirs evenly and gets final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209794A (en) * | 2022-01-11 | 2022-03-22 | 曾志安 | Medicine for treating female vaginal infection and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209794A (en) * | 2022-01-11 | 2022-03-22 | 曾志安 | Medicine for treating female vaginal infection and preparation method thereof |
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Application publication date: 20130306 |