CN103443079B - 可用作抗菌剂的氟吡啶酮衍生物 - Google Patents
可用作抗菌剂的氟吡啶酮衍生物 Download PDFInfo
- Publication number
- CN103443079B CN103443079B CN201280012230.9A CN201280012230A CN103443079B CN 103443079 B CN103443079 B CN 103443079B CN 201280012230 A CN201280012230 A CN 201280012230A CN 103443079 B CN103443079 B CN 103443079B
- Authority
- CN
- China
- Prior art keywords
- fluoro
- methyl
- methylsulfonyl
- butanamide
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HVHKMDCJPVXKPB-UHFFFAOYSA-N CC(CCN(C=C(C(I)=C1)F)C1=O)(C(NOC1OCCCC1)=O)S(C)(=O)=O Chemical compound CC(CCN(C=C(C(I)=C1)F)C1=O)(C(NOC1OCCCC1)=O)S(C)(=O)=O HVHKMDCJPVXKPB-UHFFFAOYSA-N 0.000 description 1
- UKYCSJLHQGNGLM-DGJGDDIISA-N CO/C(/C(/F)=C/C(C(F)=CN1CC[C@H](C(NO)O)S(C)(=O)=O)=CC1O)=C/C=C Chemical compound CO/C(/C(/F)=C/C(C(F)=CN1CC[C@H](C(NO)O)S(C)(=O)=O)=CC1O)=C/C=C UKYCSJLHQGNGLM-DGJGDDIISA-N 0.000 description 1
- LKEPPVHFBXHFGX-GOSISDBHSA-N C[C@@](CCN(C=C(C(c(c(F)c1)ccc1OC)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(C=C(C(c(c(F)c1)ccc1OC)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O LKEPPVHFBXHFGX-GOSISDBHSA-N 0.000 description 1
- QDXBMOPOGFARAY-HXUWFJFHSA-N C[C@@](CCN(C=C(C(c(cc1)cc(C)c1-[n]1nccn1)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(C=C(C(c(cc1)cc(C)c1-[n]1nccn1)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O QDXBMOPOGFARAY-HXUWFJFHSA-N 0.000 description 1
- CNNISRAIKTVRMR-GOSISDBHSA-N C[C@@](CCN(C=C(C(c(cc1)cc(C)c1F)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(C=C(C(c(cc1)cc(C)c1F)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O CNNISRAIKTVRMR-GOSISDBHSA-N 0.000 description 1
- KXGQAIKJVAOOEL-JOCHJYFZSA-N C[C@@](CCN(C=C(C(c(cc1)ccc1-c(nc1)ncc1OC)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(C=C(C(c(cc1)ccc1-c(nc1)ncc1OC)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O KXGQAIKJVAOOEL-JOCHJYFZSA-N 0.000 description 1
- BRBWTINHVJRGQL-BUKPSGGLSA-N C[C@@](CCN(C=C(C(c(cc1)ccc1OC[C@H](CC1)CC[C@@H]1O)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(C=C(C(c(cc1)ccc1OC[C@H](CC1)CC[C@@H]1O)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O BRBWTINHVJRGQL-BUKPSGGLSA-N 0.000 description 1
- UQWQBGXSQVCNRW-QGZVFWFLSA-N C[C@@](CCN(C=C(C(c1ccc(C)cc1)=C1)F)C1=O)(C(NO)=O)S Chemical compound C[C@@](CCN(C=C(C(c1ccc(C)cc1)=C1)F)C1=O)(C(NO)=O)S UQWQBGXSQVCNRW-QGZVFWFLSA-N 0.000 description 1
- JVXLIWKTSPIRPE-GOSISDBHSA-N C[C@@](CCN(C=C(C(c1cccc(C)c1)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(C=C(C(c1cccc(C)c1)=C1)F)C1=O)(C(NO)=O)S(C)(=O)=O JVXLIWKTSPIRPE-GOSISDBHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449825P | 2011-03-07 | 2011-03-07 | |
| US61/449,825 | 2011-03-07 | ||
| PCT/IB2012/050812 WO2012120397A1 (en) | 2011-03-07 | 2012-02-22 | Fluoro-pyridinone derivatives useful as antibacterial agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410611970.5A Division CN104529883A (zh) | 2011-03-07 | 2012-02-22 | 可用作抗菌剂的氟吡啶酮衍生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103443079A CN103443079A (zh) | 2013-12-11 |
| CN103443079B true CN103443079B (zh) | 2015-06-03 |
Family
ID=45841548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280012230.9A Active CN103443079B (zh) | 2011-03-07 | 2012-02-22 | 可用作抗菌剂的氟吡啶酮衍生物 |
| CN201410611970.5A Pending CN104529883A (zh) | 2011-03-07 | 2012-02-22 | 可用作抗菌剂的氟吡啶酮衍生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410611970.5A Pending CN104529883A (zh) | 2011-03-07 | 2012-02-22 | 可用作抗菌剂的氟吡啶酮衍生物 |
Country Status (34)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| PL2512474T3 (pl) | 2009-12-16 | 2015-03-31 | Pfizer | N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne |
| GEP20156370B (en) | 2011-03-07 | 2015-09-25 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| EP2694488B1 (en) | 2011-04-08 | 2014-11-12 | Pfizer Inc | Isoxazole derivatives useful as antibacterial agents |
| EP2694481B1 (en) * | 2011-04-08 | 2015-12-30 | Pfizer Inc | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| WO2015085238A1 (en) * | 2013-12-05 | 2015-06-11 | The Regents Of The University Of California, A California Corporation | Inhibitors of lpxc |
| JP6407288B2 (ja) | 2013-12-19 | 2018-10-17 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性１ｈ−インダゾール及び１ｈ−インドール誘導体 |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| EP3134401B1 (en) | 2014-04-22 | 2018-06-13 | Novartis AG | Isoxazoline hydroxamic acid derivatives as lpxc inhibitors |
| EP3143007B1 (en) | 2014-05-16 | 2018-07-11 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| JP6195684B2 (ja) | 2014-06-03 | 2017-09-13 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ピラゾール化合物及びｔ型カルシウムチャンネルブロッカーとしてのそれらの使用 |
| WO2016079688A1 (en) | 2014-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Antibacterial benzothiazole derivatives |
| CU24443B1 (es) | 2014-12-16 | 2019-10-04 | Novartis Ag | COMPUESTOS DE ISOXAZOL DE ÁCIDO HIDROXÁMICO COMO INHIBIDORES DE LpxC |
| CN104876883B (zh) * | 2015-06-05 | 2017-11-28 | 安徽联创生物医药股份有限公司 | 抗失眠药物苏沃雷生中间体的合成方法 |
| AR105646A1 (es) * | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| HRP20201524T1 (hr) | 2016-06-14 | 2021-03-05 | Novartis Ag | Kristalni oblik (r)-4-(5-(ciklopropiletinil) izoksazol-3 -il)-n-hidroksi-2-metil-2-(metilsufonil) butanamid kao antibakterijsko sredstvo |
| LT3554490T (lt) | 2016-12-16 | 2022-04-25 | Idorsia Pharmaceuticals Ltd | Farmacinis derinys, apimantis t tipo kalcio kanalo blokatorių |
| CA3050348A1 (en) | 2017-02-06 | 2018-08-09 | Idorsia Pharmaceuticals Ltd | A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes |
| MX2020009584A (es) * | 2018-03-15 | 2020-10-05 | Pfizer | Fosfatos y boronatos de piridinona y pirimidinona utiles como agentes antibacterianos. |
| US11981696B2 (en) | 2018-03-15 | 2024-05-14 | Pfizer Inc. | Fluoro-pyridinone phosphates and boronates useful as antibacterial agents |
| CN110699312B (zh) * | 2019-11-28 | 2022-08-12 | 西北农林科技大学 | 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用 |
Citations (4)
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| WO2007069020A2 (en) * | 2005-12-15 | 2007-06-21 | Vicuron Pharmaceuticals Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| CN101239978A (zh) * | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
| WO2010017060A1 (en) * | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
| WO2011073845A1 (en) * | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
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| US4769461A (en) | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
| US5110831A (en) | 1990-11-30 | 1992-05-05 | Du Pont Merck Pharmaceutical Company | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors |
| CN1298299A (zh) | 1998-02-07 | 2001-06-06 | 英国生物技术药物有限公司 | 抗菌剂 |
| GB9925470D0 (en) | 1999-10-27 | 1999-12-29 | Smithkline Beecham Plc | Novel compounds |
| JPWO2002074298A1 (ja) | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| ES2180456B1 (es) | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| ES2334990T3 (es) * | 2002-02-14 | 2010-03-18 | Pharmacia Corporation | Piridinonas sustituidas como moduladores de p38 map quinasa. |
| SG159388A1 (en) | 2003-01-08 | 2010-03-30 | Chiron Corp | Antibacterial agents |
| GB0302431D0 (en) | 2003-01-30 | 2003-03-05 | Glaxo Group Ltd | Novel compounds |
| WO2006063281A2 (en) | 2004-12-10 | 2006-06-15 | Emory University | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
| WO2006118155A1 (ja) | 2005-04-27 | 2006-11-09 | Ishihara Sangyo Kaisha, Ltd. | ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤 |
| WO2006124897A2 (en) | 2005-05-13 | 2006-11-23 | Lexicon Genetics Incorporated | Methods and compositions for improving cognition |
| WO2008045671A1 (en) | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica, N.V. | Matrix metalloprotease inhibitors |
| US7879911B2 (en) | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| JP5227304B2 (ja) | 2007-02-28 | 2013-07-03 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| WO2008115262A2 (en) | 2007-03-20 | 2008-09-25 | Curis, Inc. | Hsp90 inhibitors containing a zinc binding moiety |
| JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2010147975A1 (en) * | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147969A2 (en) * | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| GEP20156370B (en) | 2011-03-07 | 2015-09-25 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| EP2694488B1 (en) | 2011-04-08 | 2014-11-12 | Pfizer Inc | Isoxazole derivatives useful as antibacterial agents |
| EP2694481B1 (en) | 2011-04-08 | 2015-12-30 | Pfizer Inc | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
-
2012
- 2012-02-22 GE GEAP201213215A patent/GEP20156370B/en unknown
- 2012-02-22 CN CN201280012230.9A patent/CN103443079B/zh active Active
- 2012-02-22 WO PCT/IB2012/050812 patent/WO2012120397A1/en not_active Ceased
- 2012-02-22 KR KR1020137026034A patent/KR101593288B1/ko not_active Expired - Fee Related
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| WO2007069020A2 (en) * | 2005-12-15 | 2007-06-21 | Vicuron Pharmaceuticals Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| CN101239978A (zh) * | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
| WO2010017060A1 (en) * | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
| WO2011073845A1 (en) * | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
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