CA2828337C - Fluoro-pyridinone derivatives useful as antibacterial agents - Google Patents

Fluoro-pyridinone derivatives useful as antibacterial agents Download PDF

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Publication number
CA2828337C
CA2828337C CA2828337A CA2828337A CA2828337C CA 2828337 C CA2828337 C CA 2828337C CA 2828337 A CA2828337 A CA 2828337A CA 2828337 A CA2828337 A CA 2828337A CA 2828337 C CA2828337 C CA 2828337C
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CA
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Prior art keywords
fluoro
butanamide
methy1
methylsulfonyl
hydroxy
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CA2828337A
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English (en)
French (fr)
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CA2828337A1 (en
Inventor
Mathew Frank BROWN
Ye Che
Michael Joseph Melnick
Justin Ian Montgomery
Mark Stephen Plummer
Loren Michael PRICE
Usa Reilly
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Pfizer Corp SRL
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Pfizer Corp SRL
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Publication of CA2828337A1 publication Critical patent/CA2828337A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2828337A 2011-03-07 2012-02-22 Fluoro-pyridinone derivatives useful as antibacterial agents Active CA2828337C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449825P 2011-03-07 2011-03-07
US61/449,825 2011-03-07
PCT/IB2012/050812 WO2012120397A1 (en) 2011-03-07 2012-02-22 Fluoro-pyridinone derivatives useful as antibacterial agents

Publications (2)

Publication Number Publication Date
CA2828337A1 CA2828337A1 (en) 2012-09-13
CA2828337C true CA2828337C (en) 2016-05-03

Family

ID=45841548

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2828337A Active CA2828337C (en) 2011-03-07 2012-02-22 Fluoro-pyridinone derivatives useful as antibacterial agents

Country Status (34)

Country Link
US (2) US8624034B2 (enExample)
EP (1) EP2683689B1 (enExample)
JP (1) JP5620020B2 (enExample)
KR (1) KR101593288B1 (enExample)
CN (2) CN104529883A (enExample)
AP (1) AP3336A (enExample)
AR (1) AR085615A1 (enExample)
AU (1) AU2012226473B8 (enExample)
BR (1) BR112013022536B1 (enExample)
CA (1) CA2828337C (enExample)
CL (1) CL2013002417A1 (enExample)
CO (1) CO6761338A2 (enExample)
CR (1) CR20130403A (enExample)
CU (1) CU20130117A7 (enExample)
DO (1) DOP2013000200A (enExample)
EA (1) EA024782B1 (enExample)
EC (1) ECSP13012928A (enExample)
ES (1) ES2626457T3 (enExample)
GE (1) GEP20156370B (enExample)
GT (1) GT201300213A (enExample)
HK (1) HK1209734A1 (enExample)
IL (1) IL228100A0 (enExample)
MA (1) MA34963B1 (enExample)
MX (1) MX341977B (enExample)
NI (1) NI201300077A (enExample)
PE (1) PE20140397A1 (enExample)
PH (1) PH12013501780A1 (enExample)
SG (1) SG192766A1 (enExample)
TN (1) TN2013000353A1 (enExample)
TW (1) TWI453197B (enExample)
UA (1) UA107423C2 (enExample)
UY (1) UY33936A (enExample)
WO (1) WO2012120397A1 (enExample)
ZA (1) ZA201306515B (enExample)

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CN103492368A (zh) 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物
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AU2012238374B2 (en) 2011-04-08 2015-04-02 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
CN103492368A (zh) 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物

Also Published As

Publication number Publication date
JP5620020B2 (ja) 2014-11-05
TN2013000353A1 (fr) 2015-01-20
TW201249798A (en) 2012-12-16
NZ614205A (en) 2014-06-27
CN103443079A (zh) 2013-12-11
HK1191951A1 (en) 2014-08-08
HK1209734A1 (en) 2016-04-08
GT201300213A (es) 2014-06-06
AU2012226473A1 (en) 2013-09-05
CO6761338A2 (es) 2013-09-30
DOP2013000200A (es) 2014-06-15
TWI453197B (zh) 2014-09-21
NI201300077A (es) 2014-01-07
ES2626457T3 (es) 2017-07-25
MX341977B (es) 2016-09-07
WO2012120397A1 (en) 2012-09-13
MA34963B1 (fr) 2014-03-01
US8779148B2 (en) 2014-07-15
CL2013002417A1 (es) 2013-12-13
CN103443079B (zh) 2015-06-03
BR112013022536A2 (pt) 2016-11-29
AP2013007074A0 (en) 2013-08-31
UY33936A (es) 2012-10-31
KR101593288B1 (ko) 2016-02-11
ZA201306515B (en) 2014-05-28
IL228100A0 (en) 2013-09-30
AU2012226473B8 (en) 2015-10-15
EA201391072A1 (ru) 2014-02-28
CR20130403A (es) 2013-09-18
MX2013010276A (es) 2013-10-01
EP2683689A1 (en) 2014-01-15
PH12013501780A1 (en) 2019-07-03
AP3336A (en) 2015-07-31
UA107423C2 (en) 2014-12-25
GEP20156370B (en) 2015-09-25
AR085615A1 (es) 2013-10-16
US20140057919A1 (en) 2014-02-27
CN104529883A (zh) 2015-04-22
AU2012226473B2 (en) 2015-06-11
EA024782B1 (ru) 2016-10-31
PE20140397A1 (es) 2014-03-28
JP2014507464A (ja) 2014-03-27
SG192766A1 (en) 2013-09-30
EP2683689B1 (en) 2017-04-12
KR20130131459A (ko) 2013-12-03
US20120232083A1 (en) 2012-09-13
BR112013022536B1 (pt) 2020-05-26
US8624034B2 (en) 2014-01-07
CU20130117A7 (es) 2013-10-29
ECSP13012928A (es) 2013-11-29
CA2828337A1 (en) 2012-09-13

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