CN103417580B - 菲牛蛭中高活性抗凝剂粗品的制备方法 - Google Patents
菲牛蛭中高活性抗凝剂粗品的制备方法 Download PDFInfo
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- CN103417580B CN103417580B CN201310397030.6A CN201310397030A CN103417580B CN 103417580 B CN103417580 B CN 103417580B CN 201310397030 A CN201310397030 A CN 201310397030A CN 103417580 B CN103417580 B CN 103417580B
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- Prior art keywords
- crude product
- anticoagulant
- hirudinaria manillensis
- high activity
- manillensis
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000500851 Poecilobdella manillensis Species 0.000 title claims abstract description 76
- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 43
- 229940127219 anticoagulant drug Drugs 0.000 title claims abstract description 43
- 230000000694 effects Effects 0.000 title claims abstract description 43
- 239000012043 crude product Substances 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title abstract description 24
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 4
- 208000026106 cerebrovascular disease Diseases 0.000 claims abstract description 4
- 230000002526 effect on cardiovascular system Effects 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 46
- 239000002002 slurry Substances 0.000 claims description 27
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 26
- 239000002994 raw material Substances 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 16
- 239000011780 sodium chloride Substances 0.000 claims description 13
- 238000004108 freeze drying Methods 0.000 claims description 12
- 238000003801 milling Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 210000003079 salivary gland Anatomy 0.000 claims description 9
- 239000004019 antithrombin Substances 0.000 claims description 3
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 239000002775 capsule Substances 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 208000007536 Thrombosis Diseases 0.000 abstract description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract description 2
- 239000000835 fiber Substances 0.000 abstract description 2
- 230000004089 microcirculation Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 229940116269 uric acid Drugs 0.000 abstract description 2
- 241000545744 Hirudinea Species 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000010100 anticoagulation Effects 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
- 238000004448 titration Methods 0.000 abstract 1
- 241000237903 Hirudo Species 0.000 description 13
- 108010072035 antithrombin III-protease complex Proteins 0.000 description 8
- 239000000701 coagulant Substances 0.000 description 7
- 238000010298 pulverizing process Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 2
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201310397030.6A CN103417580B (zh) | 2013-09-04 | 2013-09-04 | 菲牛蛭中高活性抗凝剂粗品的制备方法 |
Applications Claiming Priority (1)
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CN201310397030.6A CN103417580B (zh) | 2013-09-04 | 2013-09-04 | 菲牛蛭中高活性抗凝剂粗品的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN103417580A CN103417580A (zh) | 2013-12-04 |
CN103417580B true CN103417580B (zh) | 2015-07-22 |
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CN201310397030.6A Active CN103417580B (zh) | 2013-09-04 | 2013-09-04 | 菲牛蛭中高活性抗凝剂粗品的制备方法 |
Country Status (1)
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CN (1) | CN103417580B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105125588B (zh) * | 2015-07-31 | 2019-05-10 | 云南海瑞迪生物药业有限公司 | 利用酵母发酵降低菲牛蛭冻干粉腥味的方法 |
CN106581075A (zh) * | 2015-10-19 | 2017-04-26 | 云南云域瑞达生物药业有限公司 | 红花或其提取物用于药材脱腥的应用 |
CN107998385A (zh) * | 2017-12-08 | 2018-05-08 | 广西卫生职业技术学院 | 水蛭素作为防治高尿酸血症药物的用途 |
CN108653336A (zh) * | 2018-07-30 | 2018-10-16 | 北京卫仁中药饮片厂 | 一种菲牛蛭的炮制方法 |
CN110075127A (zh) * | 2019-05-10 | 2019-08-02 | 云南晟招制药有限公司 | 一种菲牛蛭的炮制方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1082409A (zh) * | 1992-07-28 | 1994-02-23 | 胡维明 | 医用天然水蛭素的提取方法 |
CN1452986A (zh) * | 2002-04-28 | 2003-11-05 | 康强 | 一种水蛭提取物及其生产方法和用途 |
CN101230086A (zh) * | 2007-01-22 | 2008-07-30 | 广东海洋大学 | 一种以菲牛蛭唾液为原材料的水蛭素生产工艺 |
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2013
- 2013-09-04 CN CN201310397030.6A patent/CN103417580B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1082409A (zh) * | 1992-07-28 | 1994-02-23 | 胡维明 | 医用天然水蛭素的提取方法 |
CN1452986A (zh) * | 2002-04-28 | 2003-11-05 | 康强 | 一种水蛭提取物及其生产方法和用途 |
CN101230086A (zh) * | 2007-01-22 | 2008-07-30 | 广东海洋大学 | 一种以菲牛蛭唾液为原材料的水蛭素生产工艺 |
Non-Patent Citations (2)
Title |
---|
水蛭抗凝活性成分的研究;李瑞海;《中国优秀硕士学位论文全文数据库》;20031231;第E057-9页 * |
菲牛蛭成分与急性毒性试验研究;吴志军等;《中成药》;20061130;第28卷(第11期);第1625-1627页 * |
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Effective date of registration: 20220527 Address after: 111000 No. 67, unit 2, No. 82-10, Weiguo Road, Baita District, Liaoyang City, Liaoning Province Patentee after: An Tange Address before: 530007 No. 210, block B, building 2, No. 23, Chuangxin Road, high tech Zone, Nanning, Guangxi Zhuang Autonomous Region Patentee before: NANNING JINGXUEHUANG BIOENGINEERING Co.,Ltd. |