CN102114113B - 一种白头翁汤颗粒剂的制备方法 - Google Patents
一种白头翁汤颗粒剂的制备方法 Download PDFInfo
- Publication number
- CN102114113B CN102114113B CN201010028013A CN201010028013A CN102114113B CN 102114113 B CN102114113 B CN 102114113B CN 201010028013 A CN201010028013 A CN 201010028013A CN 201010028013 A CN201010028013 A CN 201010028013A CN 102114113 B CN102114113 B CN 102114113B
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- Prior art keywords
- extraction
- granule
- radix pulsatillae
- water
- decoction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008187 granular material Substances 0.000 title claims abstract description 16
- 241000206469 Pulsatilla Species 0.000 title claims abstract description 5
- 238000002360 preparation method Methods 0.000 title claims description 7
- 238000000605 extraction Methods 0.000 claims abstract description 26
- 239000000284 extract Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 25
- 239000009806 pulsatillae Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000008589 Cortex Fraxini Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000003809 water extraction Methods 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 235000021050 feed intake Nutrition 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000009835 boiling Methods 0.000 abstract description 9
- 239000004615 ingredient Substances 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000005520 cutting process Methods 0.000 abstract description 2
- 241000099774 Cuscuta salina Species 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 239000012567 medical material Substances 0.000 description 10
- 239000012141 concentrate Substances 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
提取方法 | 药材浸膏收率% | 浸膏中白头翁B4的含量 | 浸膏中盐酸小糪碱的含量 |
沸腾煎煮方法 | 25% | 42mg/g | 30mg/g |
低温循环动态提取 | 18% | 60mg/g | 42mg/g |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010028013A CN102114113B (zh) | 2010-01-05 | 2010-01-05 | 一种白头翁汤颗粒剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010028013A CN102114113B (zh) | 2010-01-05 | 2010-01-05 | 一种白头翁汤颗粒剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102114113A CN102114113A (zh) | 2011-07-06 |
CN102114113B true CN102114113B (zh) | 2012-09-12 |
Family
ID=44213113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201010028013A Expired - Fee Related CN102114113B (zh) | 2010-01-05 | 2010-01-05 | 一种白头翁汤颗粒剂的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN102114113B (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102526302A (zh) * | 2011-12-31 | 2012-07-04 | 郑州后羿制药有限公司 | 一种抑制仔猪细菌性痢疾的中药微生态制剂及其制备方法 |
CN102697930A (zh) * | 2012-06-15 | 2012-10-03 | 李良 | 治疗痢疾的凤尾草中药汤剂及制备方法 |
CN102973702B (zh) * | 2012-08-23 | 2014-12-17 | 郑州后羿制药有限公司 | 一种用于治疗仔猪黄白痢的复方中药组合物及其制备方法 |
CN104257826B (zh) * | 2014-09-24 | 2017-07-04 | 河南亚卫动物药业有限公司 | 一种畜禽用中药白头翁发酵颗粒及其制备方法 |
CN104922636B (zh) * | 2015-06-16 | 2018-11-30 | 黑龙江中医药大学 | 一种地黄饮子颗粒 |
CN113884587B (zh) * | 2021-08-25 | 2023-03-21 | 广西中医药大学 | 一种白头翁汤多组分化学成分含量测定方法 |
-
2010
- 2010-01-05 CN CN201010028013A patent/CN102114113B/zh not_active Expired - Fee Related
Non-Patent Citations (2)
Title |
---|
时维静,等.白头翁汤提取工艺试验研究.《中国实验方剂学杂志》.2006,第12卷(第5期),第1-3页. * |
时维静,等.综合评分法优化白头翁汤提取工艺.《中国中医药科技》.2009,第16卷(第1期),第44-45页. * |
Also Published As
Publication number | Publication date |
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CN102114113A (zh) | 2011-07-06 |
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Date | Code | Title | Description |
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C06 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB02 | Change of applicant information |
Address after: 610041, No. 3, No. 6, building A, building 1, high tech incubator Park, South Tianfu Road, Chengdu hi tech Zone, Sichuan, China Applicant after: Sichuan Dihon Medical Development Co., Ltd. Co-applicant after: Dihon Pharmaceutical Group Co., Ltd. Co-applicant after: Yunnan Dihon Pharmaceutical Co., Ltd. Address before: 610041, No. 3, No. 6, building A, building 1, high tech incubator Park, South Tianfu Road, Chengdu hi tech Zone, Sichuan, China Applicant before: Sichuan Dihon Medical Development Co., Ltd. Co-applicant before: Kuning Dianhong Pharmaceutical Co., Ltd. Co-applicant before: Yunnan Dihon Pharmaceutical Group Co., Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: DIHON PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER OWNER: DIHON PHARMACEUTICAL GROUP CO., LTD. YUNNAN DIHON PHARMACEUTICAL CO., LTD. Effective date: 20130220 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20130220 Address after: 610041, No. 3, No. 6, building A, building 1, high tech incubator Park, South Tianfu Road, Chengdu hi tech Zone, Sichuan, China Patentee after: Sichuan Dihon Medical Development Co., Ltd. Patentee after: Dihon Pharmaceutical Group Co., Ltd. Address before: 610041, No. 3, No. 6, building A, building 1, high tech incubator Park, South Tianfu Road, Chengdu hi tech Zone, Sichuan, China Patentee before: Sichuan Dihon Medical Development Co., Ltd. Patentee before: Dihon Pharmaceutical Group Co., Ltd. Patentee before: Yunnan Dihon Pharmaceutical Co., Ltd. |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160720 Address after: 650106 Kunming science and Technology Development Zone, Yunnan Province Road No. 45 Patentee after: Dihon Pharmaceutical Group Co., Ltd. Address before: 610041, No. 3, No. 6, building A, building 1, high tech incubator Park, South Tianfu Road, Chengdu hi tech Zone, Sichuan, China Patentee before: Sichuan Dihon Medical Development Co., Ltd. Patentee before: Dihon Pharmaceutical Group Co., Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120912 Termination date: 20190105 |
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CF01 | Termination of patent right due to non-payment of annual fee |