CN103408626A - 卤米松的多晶型及其制备方法 - Google Patents
卤米松的多晶型及其制备方法 Download PDFInfo
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- CN103408626A CN103408626A CN2013103162959A CN201310316295A CN103408626A CN 103408626 A CN103408626 A CN 103408626A CN 2013103162959 A CN2013103162959 A CN 2013103162959A CN 201310316295 A CN201310316295 A CN 201310316295A CN 103408626 A CN103408626 A CN 103408626A
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- halometasone
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- GGXMRPUKBWXVHE-MIHLVHIWSA-N halometasone Chemical compound C1([C@@H](F)C2)=CC(=O)C(Cl)=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O GGXMRPUKBWXVHE-MIHLVHIWSA-N 0.000 title claims abstract description 51
- 229960002475 halometasone Drugs 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000013078 crystal Substances 0.000 claims abstract description 70
- 230000015572 biosynthetic process Effects 0.000 claims description 19
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 19
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 4
- 238000001953 recrystallisation Methods 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 3
- 238000001757 thermogravimetry curve Methods 0.000 claims description 3
- 239000012046 mixed solvent Substances 0.000 claims description 2
- 150000004682 monohydrates Chemical class 0.000 claims 2
- 229960000795 halometasone monohydrate Drugs 0.000 description 21
- 238000005755 formation reaction Methods 0.000 description 17
- 238000002411 thermogravimetry Methods 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000007787 solid Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010014201 Eczema nummular Diseases 0.000 description 1
- 201000009053 Neurodermatitis Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 229940082666 cortifoam Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
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CN201310316295.9A CN103408626B (zh) | 2013-07-25 | 2013-07-25 | 卤米松的多晶型及其制备方法 |
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CN201310316295.9A CN103408626B (zh) | 2013-07-25 | 2013-07-25 | 卤米松的多晶型及其制备方法 |
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CN103408626A true CN103408626A (zh) | 2013-11-27 |
CN103408626B CN103408626B (zh) | 2015-06-03 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104370987A (zh) * | 2014-10-22 | 2015-02-25 | 湖南明瑞制药有限公司 | 一种卤米松的精制方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102079767A (zh) * | 2009-11-26 | 2011-06-01 | 天津金耀集团有限公司 | 卤甲松单水合物的制备方法 |
CN102827229A (zh) * | 2011-06-17 | 2012-12-19 | 重庆华邦胜凯制药有限公司 | 一种纯化卤米松羧酸酯的方法 |
-
2013
- 2013-07-25 CN CN201310316295.9A patent/CN103408626B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102079767A (zh) * | 2009-11-26 | 2011-06-01 | 天津金耀集团有限公司 | 卤甲松单水合物的制备方法 |
CN102827229A (zh) * | 2011-06-17 | 2012-12-19 | 重庆华邦胜凯制药有限公司 | 一种纯化卤米松羧酸酯的方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104370987A (zh) * | 2014-10-22 | 2015-02-25 | 湖南明瑞制药有限公司 | 一种卤米松的精制方法 |
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CN103408626B (zh) | 2015-06-03 |
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Address after: 211198 No. 639 Longmian Avenue, Nanjing City, Jiangsu Province Co-patentee after: NANJING MEDICAL INDUSTRY MEDICAL TECHNOLOGY Co.,Ltd. Patentee after: CHINA PHARMACEUTICAL University Co-patentee after: HEFEI INDUSTRIAL PHARMACEUTICAL INSTITUTE Co.,Ltd. Address before: 211198 No. 639 Longmian Avenue, Nanjing City, Jiangsu Province Co-patentee before: NANJING MEDICAL INDUSTRY MEDICAL TECHNOLOGY Co.,Ltd. Patentee before: China Pharmaceutical University Co-patentee before: HEFEI YIGONG MEDICINE Co.,Ltd. |
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Effective date of registration: 20240105 Address after: Nanjing City, Jiangsu Province, Tong Lane 210000 No. 24 Patentee after: CHINA PHARMACEUTICAL University Patentee after: HEFEI INDUSTRIAL PHARMACEUTICAL INSTITUTE Co.,Ltd. Address before: No. 639 road in Nanjing city in Jiangsu province 211198. Patentee before: CHINA PHARMACEUTICAL University Patentee before: NANJING MEDICAL INDUSTRY MEDICAL TECHNOLOGY Co.,Ltd. Patentee before: HEFEI INDUSTRIAL PHARMACEUTICAL INSTITUTE Co.,Ltd. |