CN103403004B - 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺 - Google Patents

作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺 Download PDF

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CN103403004B
CN103403004B CN201280011207.8A CN201280011207A CN103403004B CN 103403004 B CN103403004 B CN 103403004B CN 201280011207 A CN201280011207 A CN 201280011207A CN 103403004 B CN103403004 B CN 103403004B
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pain
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alkyl
compound
cycloalkyl
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CN103403004A (zh
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S·S·哈迪达鲁阿
E·A·卡莱尔
M·T·米勒
V·阿勒穆加姆
J·麦卡特尼
C·安德森
P·D·J·格鲁坦辉斯
L·江
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201280011207.8A 2011-02-02 2012-02-02 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺 Active CN103403004B (zh)

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CN201610319591.8A CN106008504A (zh) 2011-02-02 2012-02-02 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺

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Application Number Priority Date Filing Date Title
US201161438685P 2011-02-02 2011-02-02
US61/438,685 2011-02-02
US201161440987P 2011-02-09 2011-02-09
US61/440,987 2011-02-09
US201161495538P 2011-06-10 2011-06-10
US61/495,538 2011-06-10
PCT/US2012/023593 WO2012106499A1 (en) 2011-02-02 2012-02-02 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels

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CN103403004A CN103403004A (zh) 2013-11-20
CN103403004B true CN103403004B (zh) 2016-06-01

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CN201610319591.8A Pending CN106008504A (zh) 2011-02-02 2012-02-02 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺

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CN101827593B (zh) 2007-08-24 2013-07-24 沃泰克斯药物股份有限公司 用于治疗(特别是)囊性纤维化的异噻唑并吡啶酮
EP2595989B1 (en) 2010-05-06 2016-07-13 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
PL2670752T3 (pl) * 2011-02-02 2016-09-30 Pirolopirazynowe spirocykliczne piperydynoamidy jako modulatory kanałów jonowych
MX2013009393A (es) 2011-02-18 2013-08-29 Vertex Pharma Piperidinamidas cromano-espirociclicas como moduladores de canales de iones.
ES2618929T3 (es) 2011-03-14 2017-06-22 Vertex Pharmaceuticals Incorporated Morfolina-Spiro piperidina amida cíclica como moduladores del canal iónico
EP2773637B1 (en) 2011-10-31 2016-06-08 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
CN104093716B (zh) 2011-10-31 2017-06-23 克赛农制药股份有限公司 联芳醚磺酰胺化合物及其作为治疗剂的用途
CA2874621A1 (en) 2012-05-22 2013-11-28 Genentech, Inc. N-substituted benzamides and their use in the treatment of pain
BR112015000187A2 (pt) 2012-07-06 2017-06-27 Genentech Inc benzamidas substituídas com n e métodos de uso das mesmas
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