CN103393896B - Traditional Chinese medicine formulation paris polyphylla direct-oral decoction piece for preventing and treating tumors - Google Patents
Traditional Chinese medicine formulation paris polyphylla direct-oral decoction piece for preventing and treating tumors Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines and relates to a processing method of a traditional Chinese medicine formulation paris polyphylla direct-oral decoction piece, namely a paris polyphylla freeze-dried powder wall-breaking oral decoction piece, with the effects of clearing away heat and toxic materials and preventing and treating tumors. A finished product is obtained through the following steps of: pretreating; freeze-drying; drying for the second time; crushing; granulating, and the like. The prepared product ensures that the paris polyphylla freeze-dried powder wall-breaking oral decoction piece disclosed by the invention has the advantages of light weight, portability, flexibility in preparation and fast usage, can be used for farthest preserving the drug effect components of an original drug and reducing the property of a crude drug, enhances the quality and drug effect of the paris polyphylla decoction piece, reduces the waste and consumption of paris polyphylla wild resources and improves the utilization ratio of the effective components of paris polyphylla.
Description
Technical field
The invention belongs to technical field of Chinese medicines, for having the direct oral medicinal slice of Chinese medicine preparation Rhizoma Paridis of heat-clearing and toxic substances removing, prevention and therapy tumor, namely the concocting method of Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice, belongs to preparing new-type medical herbs drink tablets.
Background technology
Rhizoma Paridis is the dry rhizome of liliaceous plant Rhizoma Paridis or Rhizoma Paridis, nature and flavor, bitter, is slightly cold, returns Liver Channel.State clearly according to version " Chinese Pharmacopoeia " in 2010 and there is heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.For furuncle carbuncle, laryngopharynx swelling and pain, snake bite and insect sting, falls and flutters the pain of injury, the effect of convulsion with spasms.It is the main composition medicine of the secret formula YUNNAN BAIYAO of famous Chinese patent medicine country.Take 3g ~ 6g Rhizoma Paridis day through modern Chinese medicine clinical research and confirmation, there is effect of prevention and therapy tumor, be specially, to the tumor for the treatment of human body, there is certain curative effect; Simultaneously to being just diagnosed as tumor, but not yet determining the patient of therapeutic scheme, first can take Rhizoma Paridis powder 3g ~ 6g day, effectively control tumor diffusion, catch valuable therapy apparatus meeting.Simultaneously to the also extremely important effect for the treatment of snakebite, also can coordinate with other medicines and carry out anaphase and rehabilitation.
Rhizoma Paridis another name Rhizoma Paridis, as rare plant, current wild resource is in the majority, and comparatively strict to environmental requirement, except indivedual place was once carried out except experimental cultivation, be all wild, such plant propagation rate is low, from germination to medicinal, generally needs more than 5 years.And because of growing environment difference, Rhizoma Paridis can be divided into colloid Rhizoma Paridis and opaque Rhizoma Paridis by its quality difference, colloid Rhizoma Paridis quality is comparatively hard, and it extracts relative difficulty, and when being used as medicine, effective ingredient is separated out less, causes the serious waste of resource.The traditional diamond-making technique of Rhizoma Paridis decoction pieces: usual employing runs through shave baking drying and loads woven bag again after sulfur fumigation.The elite Rhizoma Paridis saponin running through and toast Rhizoma Paridis in dry run runs off or is destroyed, significantly reduce drug effect and active component, sulfur fumigation in the course of processing of the more seriously traditional Rhizoma Paridis decoction pieces Rhizoma Paridis inferior that makes to go mouldy cannot be differentiated, and sulfur dioxide residue is harmful, safe mass all can not be ensured.Tradition Rhizoma Paridis decoction pieces needs the instructions of taking of decocting, can only fried for the drug effect of 10% ~ 20%, most active ingredient waste; The Rhizoma Paridis of its preciousness can not be use up, and it is used, and utilization rate is low.
Summary of the invention
The object of this invention is to provide a kind of preparing new-type medical herbs drink tablets and Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice, effectively can solve colloid Rhizoma Paridis quality stiff, the Rhizoma Paridis decoction pieces that effective ingredient separates out difficulty and the traditional method process of preparing Chinese medicine easily goes mouldy, damages by worms, not easily store and utilization rate low, the defect that quality not easily ensures.
In order to solve the problems of the technologies described above, the present invention is solved by following technical proposals:
For a concocting method for the direct oral medicinal slice of Chinese medicine preparation Rhizoma Paridis of prevention and therapy tumor, comprise the following steps:
Step a: select fresh Rhizoma Paridis medical material, removes impurity;
Step b: carry out ultrasonic cleaning 20-30min with sodium hydroxide solution;
Step c: by the Rhizoma Paridis medical material section cleaned, slice thickness is 0.2-2cm;
Steps d: first carry out microwave drying treatment after the Rhizoma Paridis sabot of section, microwave power is 400-600w, and microwave drying total time is 1-2.5h, lyophilizing, after freeze drying box temperature is down to-20 ~-60 DEG C, keeps 1.5 ~ 2.5h;
Step e: after freeze drying box temperature is down to-40 ~-60 DEG C, keeps 1.5 ~ 2.5h, evacuation, and after continuing 3 ~ 5h, first time drying is warming up to-20 DEG C and keeps 2 ~ 3h; Again be warming up to-5 DEG C and keep 3 ~ 5h; Continue to be warming up to 20 DEG C and keep 1 ~ 2h; Start redrying, be warming up to 35 DEG C, keep 4 ~ 6h, when vacuum change is little, terminate the drying of product;
Step f: Rhizoma Paridis sheet drying completed carries out wall breaking pulverization under the cryogenic conditions of-20 ~ 10 DEG C, sieves, obtains 50-100 order coarse powder;
Step g: the coarse powder of gained is continued to be crushed to more than 200 orders under the cryogenic conditions of-20 ~ 10 DEG C, obtains Rhizoma Paridis micropowder;
Step h: step g gained Rhizoma Paridis micropowder water is made soft material, the soft material obtained is transferred in rotary granulator, obtains 80 ~ 100 order granules;
Step I: get the granule that step h is obtained, after microwave sterilizating, aseptic subpackaged, obtained finished product.
Finished product of the present invention (Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice) adopts rp-hplc determination Rhizoma Paridis saponin I (C44H70O16) by Chinese Pharmacopoeia version one ministerial standard in 2010, chonglou saponin Ⅱ (C51H82O20), polyphyllin Ⅵ (C39H62013) and Rhizoma Paridis saponin VII (C51H82O21), record Rhizoma Paridis saponin I (C44H70O16), chonglou saponin Ⅱ (C51H82O20), total amount >=1.3% of polyphyllin Ⅵ (C39H62013) and Rhizoma Paridis saponin VII (C51H82O21), moisture≤8.0%.And explained hereafter traditional at present Rhizoma Paridis out, content can only reach 0.6%, and moisture Control is 12%.Therefore, the present invention effectively can improve the drug activity of Rhizoma Paridis.
The present invention adopts the cleaning of the sodium bicarbonate solution specialty degree of depth to Rhizoma Paridis, microwave+vacuum freeze-drying technique, and the time to vacuum freezing, the parameters such as temperature reasonably design, and pulverize at low temperature wall breaking technology, solve colloid Rhizoma Paridis quality harder, it extracts relative difficulty, and the Rhizoma Paridis decoction pieces that traditional method is concocted easily goes mouldy, damage by worms, not easily store and utilization rate low, the defect that quality not easily ensures, ensure that Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice is lightweight, easy to carry, make up a prescription flexibly, use quick, the active ingredient of former medicine can be preserved to greatest extent and go back the performance of crude drug in whole, improve quality and the drug effect of Rhizoma Paridis decoction pieces, decrease waste and the consumption of Rhizoma Paridis wild resource, improve the utilization rate of Rhizoma Paridis effective ingredient.
The processing of Chinese medicine medically occupies very consequence in motherland, and the quality of the medicine that can be right processing, directly affects the effect of disease therapy.Adopt the Rhizoma Paridis of PROCESS FOR TREATMENT of the present invention, to retentive activity composition, improve Rhizoma Paridis drug effect, improve Rhizoma Paridis quality, reduce the Rhizoma Paridis wasting of resources and consumption, increase operation rate, reduce drying time, reduce energy consumption, promote the modernization of Chinese medicine, the development for Chinese Traditional Medicine opens new road.Simultaneously, preparation technology both met Chinese traditional medicine principle, the preparing new-type medical herbs drink tablets meeting again modern production requirement substitutes, meet the requirement of the preventing and treating diseases that the people improves constantly, this is the requirement of social progress, also be the step that prepared slices of Chinese crude drugs industry must be stepped out, the research and development of Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice to raising enterprise and economic results in society significant.
The present invention, owing to have employed above technical scheme, has significant technique effect:
1, Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice complexion is stronger than traditional decoction pieces;
2, lightweight, easy to carry, make up a prescription flexibly, use quick, effectively for snakebite strove for for the first treatment time, alleviate the misery of victim, reduce and avoid disability, kept limbs, avoided death;
3, tumor patient taking convenience, determined curative effect.
4, do not limit by the seasonality of medical material, also colloid Rhizoma Paridis quality is solved harder, it extracts relative difficulty, the low feature of utilization rate, the active ingredient of former medicine can be preserved to greatest extent and go back the performance of crude drug in whole, improve quality and the drug effect of Rhizoma Paridis decoction pieces, decrease waste and the consumption of Rhizoma Paridis wild resource, improve the utilization rate of Rhizoma Paridis effective ingredient.
Accompanying drawing explanation
Fig. 1 is the freeze-drying curve figure of embodiment 1.
Fig. 2 is the freeze-drying curve figure of embodiment 2.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail:
In the present invention, if not refer in particular to, the raw material adopted and equipment etc. all can be buied from market or this area is conventional.
Method in following embodiment, if no special instructions, is the conventional method of this area.
embodiment 1
(1) pretreatment:
Select fresh Rhizoma Paridis medical material 50kg, remove impurity;
Carry out ultrasonic cleaning about 30min with sodium hydroxide solution to clean;
By the Rhizoma Paridis medical material section cleaned, slice thickness is about 0.5cm;
(2) lyophilization:
After the Rhizoma Paridis sabot of section, first carry out microwave drying treatment, microwave power is 480w, and microwave drying total time is 2 hours, after then putting into freeze drying box, starts freeze dryer, after freeze drying box temperature is down to-60 DEG C, keeps 1.5 hours;
Dry: freeze drying box starts evacuation, below vacuum 30Pa continued after 3 hours, and first time, dry intensification-20 DEG C kept 2 hours, and vacuum is less than 30Pa; Be warming up to-5 DEG C again to keep 3 hours; Continue to be warming up to 20 DEG C to keep 1 hour; Start redrying, be warming up to 35 DEG C, keep 4 hours, when making vacuum change little, terminate the drying of product;
Pulverize: Rhizoma Paridis sheet drying completed carries out wall breaking pulverization under the cryogenic conditions of-10 DEG C, sieves, and obtains 50-100 order coarse powder.
The coarse powder of gained is continued to be crushed to more than 200 orders under the cryogenic conditions of-10 DEG C, obtains Rhizoma Paridis micropowder.
Through above process, under high power microscope, record its sporoderm-broken rate more than 98%.
Granulate: gained Rhizoma Paridis micropowder water is made soft material, the soft material obtained is transferred in rotary granulator, obtain 80 ~ 100 order granules.
Subpackage and packaging: get obtained granule, after microwave sterilizating, the aseptic subpackaged room subpackage more than 10 grades, carries out subpackage and outer package according to every bag of 3g specification, obtained finished product.
Finished product Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice is detected, after the requirement inspection of Chinese Pharmacopoeia version in 2010, record Rhizoma Paridis saponin I (C44H70O16), chonglou saponin Ⅱ (C51H82O20), the total amount 1.68% of polyphyllin Ⅵ (C39H62013) and Rhizoma Paridis saponin VII (C51H82O21), moisture 6.0%.
embodiment 2
Pretreatment:
Select fresh Rhizoma Paridis medical material 20kg, remove impurity;
Carry out ultrasonic cleaning about 30min with sodium hydroxide solution to clean;
By the Rhizoma Paridis medical material section cleaned, slice thickness is about 1cm;
Lyophilization: first carry out microwave drying treatment after the Rhizoma Paridis sabot of section, microwave power is 400w, and microwave drying total time is 1 hour, after then putting into freeze drying box, starts freeze dryer, after freeze drying box temperature is down to-40 DEG C, keeps 2.5 hours;
Dry: freeze drying box starts evacuation, below vacuum 30Pa continued after 5 hours, and first time, dry intensification-20 DEG C kept 3 hours, and vacuum is less than 30Pa; Be warming up to-5 DEG C again to keep 5 hours; Continue to be warming up to 20 DEG C to keep 2 hours; Start redrying, be warming up to 35 DEG C, keep 6 hours, when making vacuum change little, terminate the drying of product;
Pulverize: Rhizoma Paridis sheet drying completed carries out wall breaking pulverization under the cryogenic conditions of 0 DEG C, sieves, and obtains 50-100 order coarse powder.
The coarse powder of gained is continued under the cryogenic conditions of 0 DEG C, be crushed to more than 200 orders, obtains Rhizoma Paridis micropowder.
Treated, under high power microscope, record its sporoderm-broken rate more than 98%.
Granulate: gained Rhizoma Paridis micropowder water is made soft material, the soft material obtained is transferred in rotary granulator, obtain 80 ~ 100 order granules.
Subpackage and packaging: get the granule that step (4) is obtained, after microwave sterilizating, the aseptic subpackaged room subpackage more than 10 grades, carries out subpackage and outer package according to every bag of 2g specification, obtained finished product, can preserve for a long time.
Finished product Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice is detected, after the requirement inspection of Chinese Pharmacopoeia version in 2010, record Rhizoma Paridis saponin I (C44H70O16), chonglou saponin Ⅱ (C51H82O20), the total amount 1.82% of polyphyllin Ⅵ (C39H62013) and Rhizoma Paridis saponin VII (C51H82O21), moisture 5.0%.
comparative example 1
This comparative example adopts method of the present invention to carry out, and difference is wherein drying mode, Rhizoma Paridis sheet precooling 1.5 ~ 2.5 hours at-40 DEG C ~-60 DEG C that this comparative example adopts the mode of single drying to be about to obtain, and directly carries out secondary distillation lyophilization.
comparative example 2
This comparative example adopts method of the present invention to carry out, and difference is wherein drying mode, and the Rhizoma Paridis sheet that this comparative example adopts the mode of single drying to be about to obtain directly carries out microwave drying under 400-600 W power.
Rhizoma Paridis sheet is after microwave of the present invention-vacuum freezing combination drying, in Rhizoma Paridis sheet, reconstitution rate have dropped 0.5-1.2 doubly, adopt rp-hplc determination Rhizoma Paridis saponin I (C44H70O16), chonglou saponin Ⅱ (C51H82O20), the total amount of polyphyllin Ⅵ (C39H62013) and Rhizoma Paridis saponin VII (C51H82O21) is 1.5-4 times of comparative example 1, comparative example 2 and traditional processing mode.
As can be seen here, the present invention is compared with traditional processing mode, the efficacy component of former medicine can be preserved to greatest extent and go back the performance of crude drug in whole, the performance of drug effect is more fully absorbed, improve Rhizoma Paridis decoction pieces drug effect, improve Rhizoma Paridis prepared slice quality, reduce the Rhizoma Paridis wasting of resources and consumption, improve the utilization rate of Rhizoma Paridis effective ingredient.The Rhizoma Paridis lyophilized powder breaking cellular wall oral medicinal slice shelf-life that the present invention obtains is 36 months, and the Rhizoma Paridis decoction pieces general shelf-life that traditional processing mode obtains, the present invention stored conveniently, long shelf-life, steady quality at about 24 months.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.
Claims (1)
1., for a concocting method for the direct oral medicinal slice of Chinese medicine preparation Rhizoma Paridis of prevention and therapy tumor, it is characterized in that, comprise the following steps:
Step a: select fresh Rhizoma Paridis medical material, removes impurity;
Step b: carry out ultrasonic cleaning 30min with sodium hydroxide solution;
Step c: by the Rhizoma Paridis medical material section cleaned, slice thickness is 1cm;
Steps d: first carry out microwave drying treatment after the Rhizoma Paridis sabot of section, microwave power is 400w, and microwave drying total time is 1h, lyophilizing, after freeze drying box temperature is down to-40 DEG C, keeps 2.5h;
After step e: evacuation, below vacuum 30Pa continue 5h, first time drying is warming up to-20 DEG C and keeps 3h; Again be warming up to-5 DEG C and keep 5h; Continue to be warming up to 20 DEG C and keep 2h; Start redrying, be warming up to 35 DEG C, keep 6h, when vacuum change is little, terminate the drying of product;
Step f: Rhizoma Paridis sheet drying completed carries out wall breaking pulverization under the cryogenic conditions of 0 DEG C, sieves, obtains 50-100 order coarse powder;
Step g: the coarse powder of gained is continued to be crushed to more than 200 orders under the cryogenic conditions of 0 DEG C, obtains Rhizoma Paridis micropowder;
Step h: step g gained Rhizoma Paridis micropowder water is made soft material, the soft material obtained is transferred in rotary granulator, obtains 80 ~ 100 order granules;
Step I: get the granule that step h is obtained, after microwave sterilizating, aseptic subpackaged, obtained finished product.
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| CN103989637B (en) * | 2014-04-25 | 2016-03-30 | 江苏华冠生物技术股份有限公司 | A kind of granulating molding method for preparing of botanical herbs material |
| CN106771010A (en) * | 2016-05-21 | 2017-05-31 | 广州今典精方医药科技有限公司 | The quality standard and manufacturing process of honeysuckle breaking-wall cell powder |
| CN106620156A (en) * | 2016-09-30 | 2017-05-10 | 道真仡佬族苗族自治县华毅中药材专业合作社 | Processing technology of rhizoma paridis ultrafine powder |
| CN106511463A (en) * | 2016-12-20 | 2017-03-22 | 广东美泰制药有限公司 | Production process of compound radix salviae miltiorrhizae decoction pieces |
| CN108158813A (en) * | 2017-11-29 | 2018-06-15 | 宁夏百草王药业有限公司 | Tcm and herbal slice processing spraying demulcen softening process |
| CN109999129A (en) * | 2019-05-30 | 2019-07-12 | 胡爱娣 | A kind of activity Paris polyphylla pure powder tablet preparation method |
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| CN102067958B (en) * | 2010-12-09 | 2012-09-26 | 江南大学 | Quality assurance method by high-quality composite degradation of pesticide residues in orange peels |
| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
| CN103190578A (en) * | 2013-04-16 | 2013-07-10 | 江苏大学 | Preparation technology for ultra-fine powder of radish sprouts |
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| CN102067958B (en) * | 2010-12-09 | 2012-09-26 | 江南大学 | Quality assurance method by high-quality composite degradation of pesticide residues in orange peels |
| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
| CN103190578A (en) * | 2013-04-16 | 2013-07-10 | 江苏大学 | Preparation technology for ultra-fine powder of radish sprouts |
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