TWI594761B - A composition of chinese medicine for treating genital wart, its preparation method and formulation - Google Patents

Description

Traditional Chinese medicine composition for treating condyloma acuminatum, preparation method thereof and preparation thereof

The present invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating diseases such as condyloma acuminata caused by condyloma acuminata infection, and to a preparation method of the traditional Chinese medicine composition and a preparation thereof.

Genital wart (genital wart), also known as genital warts, sexually transmitted diseases, etc., is a sexually transmitted disease caused by human papillomavirus (HPV) infection. The pathogen is human papillomavirus (hereinafter referred to as HPV), belonging to the papovavirus family. (Papovaviridae) of the genus Papillomavirus. More than 90 subtypes have been discovered so far, of which more than 30 are related to condyloma acuminata, mainly HPV-6, HPV-11, HPV-16, HPV-18.

HPV is easy to survive and thrive in humid and warm environment. Condyloma acuminata usually occurs at the junction of skin and mucous membranes in the genital area. Men are more common in coronary sulcus, foreskin ligament, glans, urethral opening and stem, anus and rectum, etc. Found in the size of the labia, vaginal opening and other parts. Non-genital parts are found in the armpits, umbilical fossa, breasts, fingers, etc. From the beginning, it is a small, soft, reddish papule that gradually increases and merges to form a bumpy, moist papillary or cauliflower-like protrusion that can be eroded, exuded, and easily bleed. symptom Most people do not have any self-conscious symptoms, a small part of itching, burning pain, increased vaginal discharge, etc., anus, rectal condyloma acuminata can have pain and urgency. Pathological tissue, epidermal keratosis, significant acanthosis and papillary hyperplasia. The vesicle layer and the upper part of the spinous layer can be characterized by vacuolated cells and cytoplasm, and there are large and deeply stained nuclei in the center. Dermal edema, enlarged capillaries, and chronic inflammatory cell infiltration around.

At present, Western medicine treatment of condyloma acuminata mainly includes the following.

(1) Physical therapy: laser treatment, cryotherapy, electrocoagulation or electrocautery treatment, although the effect of the therapy is good, the operation is simple, but the patient has a strong pain during treatment, and the recurrence rate is quite high, because the condyloma acuminata is caused by HPV. It is difficult to break the roots by physical therapy.

(2) topical medication:

10.5% loofago toxin, 0.5% podophyllotoxin, topical.

250% trichloroacetic acid solution for external use.

35-fluorouracil (5-fu) ointment for topical use.

45% imiquimod cream for external use, these drugs can make the carcass disappear, but there is a possibility of recurrence.

In order to solve the problem that the drug for treating HPV disease in the prior art cannot be cured and the recurrence rate is high, the present invention provides a traditional Chinese medicine composition for treating HPV diseases, especially condyloma acuminata, which has a small pain and good effect and is difficult to be used. Recurrence, no scarring, and small side effects.

The present invention further provides a preparation of the above-mentioned traditional Chinese medicine composition for treating HPV and a preparation method thereof.

The technical solution adopted by the present invention is as follows.

A traditional Chinese medicine composition for treating condyloma acuminatum, the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 1-30 parts by weight of psyllium, 1-30 parts by weight of Fritillaria 1-30 parts by weight of gold, 1-20 parts by weight of comfrey, 1-20 parts by weight of Xanthium, 1-18 parts by weight of psoralen, 1-15 parts by weight of scutellaria and 1-15 Weight of sea bream.

Preferably, the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 5-18 parts by weight of psyllium, 5-15 parts by weight of Fritillaria, 5-15 parts by weight Thousands of gold, 3-15 parts by weight of comfrey, 5-15 parts by weight of Xanthium, 8-13 parts by weight of psoralen, 3-10 parts by weight of cantharidin and 3-10 parts by weight of sea bream.

Further preferably, the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 8-15 parts by weight of psyllium, 7-15 parts by weight of Fritillaria, 9-13 parts by weight Thousands of gold, 5-10 parts by weight of comfrey, 6-12 parts by weight of Xanthium, 8-12 parts by weight of psoralen, 4-9 parts by weight of variegated and 5-8 parts by weight of sea bream .

A preparation for treating condyloma acuminata, comprising the traditional Chinese medicine composition for treating condyloma acuminata and a pharmaceutically acceptable excipient comprising a mixture of carbonate, strong alkali hydroxide and quicklime, the carbonic acid The mass ratio of the salt, the strong alkali hydroxide and the quicklime is (1-5): (0.01-0.1): (1-5). The pharmaceutically acceptable excipient also includes salicylic acid and/or white petrolatum.

Method for preparing a preparation for treating condyloma acuminatum, the preparation method The method comprises the following steps: Step S1: crushing the wood scorpion, the golden scorpion, the jellyfish, the soil fritillary, and the scutellaria, and then sieving through a 1000 mesh sieve to form a fine powder; step S2: comfrey, scorpion and supplement The bone fat is added to the solvent for 8-12 days, and the filtrate is concentrated to a paste liquid for use; and step S3: the paste prepared in step S2 is added to the fine powder prepared in step S1, and concentrated to a thick paste liquid, and added. The pretreated pharmaceutically acceptable excipients are used in the treatment of condyloma acuminata.

The pretreatment of the pharmaceutically acceptable excipient is to put the carbonate, the strong alkaline hydroxide and the quicklime into the container, and stir evenly by adding water to the container, and the medicine can be used for 48-90 hours. The carbonate is sodium carbonate and/or potassium carbonate, and the strong alkaline hydroxide is sodium hydroxide and/or potassium hydroxide.

Preferably, in step S2, the comfrey, Xanthium and psoralen are immersed in ethanol having a concentration of 75% (v/v), and immersed for 8-12 days in a sealed state, and the filtrate after removing the residue is concentrated under reduced pressure. Thick paste. There is no special requirement for the amount of ethanol, as long as it can be soaked in the comfrey and the ear bones. It is often used to soak in a ratio of 40-60 ml of ethanol per 10 g of comfrey, 10 g of Xanthium and 10 g of psoralen.

The preparation for treating condyloma acuminata is an applicator, a cream, an ointment or a patch.

The beneficial effects brought by the technical solution provided by the present invention are as follows.

(1) The traditional Chinese medicine composition for treating condyloma acuminatum of the present invention is selected from the group consisting of hibiscus, Fritillaria and Thousand Gold, and the drug is a medicinal herb of comfrey, Xanthium and psoralen, adjuvant It is a two-flavored medicine for cantharidin and sea bream. The efficacy of these 8 herbs is as follows.

Jun medicine: wooden scorpion, bitter taste, slightly sweet, warm, toxic and toxic, scattered It has a swelling, chasing the wind and setting the pain, and the role of attacking and killing insects. Earth fritillary, bitter taste, cool, anti-viral effect, loosening the effect of detoxification. Thousands of gold, spicy, warm, blood-breaking, detoxification and insecticidal effects.

Chen medicine: comfrey, bitter taste, cold, bloody diarrhea, heat and dampness, detoxification, anti-inflammatory, anti-tumor effect. Xanthium, bitter taste, sweet, spicy, warm, dehumidification and pain relief, hurricane and itching effect, anti-pathogenic microorganisms. Buguzhi, pungent, bitter, warm, fragrant and dry, has anti-tumor effect, and has a role in skin cytochrome.

Adjuvant: spotted, spicy, warm, anti-pathogenic microorganisms, anti-virus, sore, blood stasis. Sea otter, tastes salty, glutinous, warm, and has the effect of collecting moisture and sore.

(2) The drug of the present invention was also sought by the inventors through extensive experimentation and creative labor. The medicine is sodium carbonate, sodium hydroxide and quicklime, and after being mixed for 48-90 hours, it is used as a medicine, which can effectively reconcile the Junchensuo 8 medicine, and synergistically promote the transdermal absorption of the drug on the corpus callosum tissue. The combination of various drugs has the effects of decomposing the corpus callosum and removing the saprophytic muscle, and is clinically used for treating diseases such as condyloma acuminata caused by HPV infection.

(3) The preparation for treating condyloma acuminatum according to the invention is prepared according to the traditional Chinese medicine theory, using a natural Chinese medicinal material as a raw material to prepare a smear, a cream, an ointment or a patch, which is applied to the affected part to treat the condyloma acuminata caused by HPV infection. One of the effective ways of disease. Clinical trials have shown that 1-2 courses of diseased tissue can be separated from normal tissues, the virus is killed, and the carcass naturally falls off and heals. During the treatment, the pain is small and the effect is good, no recurrence, no scar, no toxic side effects, and overcome the shortage of existing Chinese and Western medicine treatment methods. point.

In order to make the objects, technical solutions and advantages of the present invention more clear, the embodiments of the present invention will be further described in detail below.

Example 1

Ointments for the treatment of condyloma acuminata are prepared from the following components.

15g of hibiscus, 12g of Fritillaria, 5g of ginseng, 20g of comfrey, 10g of Xanthium, 10g of psoralen, 3g of scutellaria, 5g of sea bream.

Pharmaceutically acceptable adjuvant: 20 g of excipients prepared in step S0, 8 g of salicylic acid, and 5 g of white petrolatum.

The above preparation method of an ointment for treating HPV includes the following steps.

In step S0, the pharmaceutical auxiliary preparation method can also be used: 100 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of sodium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Sodium carbonate, quicklime, and sodium hydroxide were placed in a container, and while adding distilled water, the mixture was stirred with a wooden utensil, and sodium carbonate, quicklime, and sodium hydroxide were chemically reacted to form a thin paste, which was allowed to stand for 72 hours. Can be used as an excipient.

Step S1: Take the wooden scorpion (shelling), the thousand gold, the sea otter, the soil fritillary, the spotted scorpion (to the head, and the wing), crush the sift through the 1000 mesh mesh, and sieve into a fine powder.

Step S2: Take the amount of comfrey, Xanthium, and psoralen soaked in 75% (v/v) ethanol, according to every 10g comfrey, 10g Xanthium, 10g psoralen, need Soak in a ratio of 60 ml of ethanol, soak for 8 days in a sealed state, take the residue from the filter residue, and concentrate to a thick paste under reduced pressure for use.

Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate to a thick paste solution, adding 20 g of pharmaceutically acceptable excipients, 8 g of salicylic acid and 5 g of white petrolatum in step S1, and preparing the same. An ointment for the treatment of HPV.

Example 2

The spreader for treating condyloma acuminatum is prepared from the following components.

8g of scorpion, 10g of Fritillaria, 9g of ginseng, 3g of comfrey, 9g of Xanthium, 8g of psoralen, 3g of scutellaria, 4g of sea bream.

Pharmaceutically acceptable adjuvant: 10 g of excipients prepared in step S0 and 7 g of salicylic acid.

The above preparation method of the smear for treating HPV includes the following steps.

Step S0 can also be used as a pharmaceutical auxiliary preparation method: 100 g of sodium carbonate, 500 g of quicklime (breaking into a powder by a pulverizer), 10 g of sodium hydroxide, and 2500 g of distilled water are weighed. The ratio is 1:5:0.1:5. Put sodium carbonate, quicklime, and sodium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and sodium hydroxide to form a thin paste, and let it dry for three nights. The medicine is an auxiliary material.

Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

Step S2: Soak the comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soak it in 50 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soak for 8 days, remove the filter residue, concentrate to a thick pressure under reduced pressure. Paste spare.

Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate into a thick paste, adding 10 g of the pharmaceutically acceptable adjuvant in step S0 and 7 g of salicylic acid to prepare an applicator for treating HPV. .

Example 3

Creams for treating condyloma acuminata are prepared from the following components.

28g of scorpion, 15g of Fritillaria, 13g of ginseng, 20g of comfrey, 20g of Xanthium, 18g of psoralen, 5g of scutellaria, 8g of sea bream.

Pharmaceutically acceptable adjuvant: 30 g of excipients prepared in step S0, 10 g of salicylic acid, and 10 g of white petrolatum.

The above preparation method for a cream for treating HPV includes the following steps.

Step S0 can also be used as a pharmaceutical auxiliary preparation method: weigh 500 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 5 g of sodium hydroxide, and 2500 g of distilled water. The ratio is 5:1:0.05:5. Put sodium carbonate, quicklime, and sodium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and sodium hydroxide to form a thin paste, and let it cool for three nights. The medicine is an auxiliary material.

Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

Step S2: taking the amount of comfrey, Xanthium and psoralen soaked in 75% (v/v) ethanol, soaking in a ratio of 40 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soaked in air for 12 days, the filter residue is taken, and the pressure is reduced. Shrink to a thick paste for use.

Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate into a thick paste, adding 30 g of pharmaceutically acceptable adjuvant, 10 g of salicylic acid, and 10 g of white petrolatum in step S1, and preparing for treatment. HPV cream.

Example 4

Ointments for the treatment of condyloma acuminata are prepared from the following components.

Wood scorpion 18g, soil fritillary 15g, thousand gold 15g, comfrey 8g, Xanthium 12g, psoralen 10g, spotted 5g, jellyfish 6g.

Pharmaceutically acceptable excipients: 15 g of excipients prepared in step S0, 10 g of salicylic acid, and 6 g of white petrolatum.

The above preparation method of an ointment for treating HPV includes the following steps.

In step S0, the pharmaceutical auxiliary preparation method can also be used: 100 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of sodium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Put sodium carbonate, quicklime, and sodium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and sodium hydroxide to form a thin paste, and let it cool for three nights. The medicine is an auxiliary material.

Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

Step S2: immersing the amount of comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soaking in a ratio of 50 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soaked in air for 10 days, the filter residue is taken, and the pressure is reduced. Shrink to a thick paste for use.

Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate into a thick paste, adding 15 g of pharmaceutically acceptable excipients of step S0, 10 g of salicylic acid, and 6 g of white petrolatum to prepare for treatment. HPV ointment.

Example 5

The patch for treating condyloma acuminatum is prepared from the following components.

10 grams of hibiscus, 5g of Fritillaria, 7g of ginseng, 15g of comfrey, 15g of Xanthium, 13g of psoralen, 4g of scutellaria, 5g of sea bream.

Pharmaceutically acceptable adjuvant: 10 g of the excipient prepared in step S0.

The above preparation method for a patch for treating HPV includes the following steps.

In step S0, the pharmaceutical auxiliary preparation method can also be used: 100 g of potassium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of potassium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Put potassium carbonate, quicklime, and potassium hydroxide in a container, add distilled water, and stir with a wooden utensil to chemically react potassium carbonate, quicklime, and potassium hydroxide. The medicine is an auxiliary material.

Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

Step S2: immersing the amount of comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soaking in a ratio of 60 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soak for 8 days in a closed state, take the residue from the filter residue, concentrate it under reduced pressure until thick paste.

Step S3: adding the step S2 to the fine powder prepared in step S1 The paste was concentrated to a thick paste, and 10 g of the S0 pharmaceutically acceptable adjuvant was added to prepare a patch for treating HPV.

Example 6

Creams for treating condyloma acuminata are prepared from the following components.

25g of scorpion, 20g of Fritillaria, 15g of ginseng, 15g of comfrey, 12g of Xanthium, 12g of psoralen, 9g of scutellaria, 10g of sea bream.

Pharmaceutically acceptable adjuvant: 30 g of excipients prepared in step S0, 20 g of salicylic acid, and 15 g of white petrolatum.

The above preparation method for a cream for treating HPV includes the following steps.

Step S0 is also a method for preparing a medicinal auxiliary material: 100 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of potassium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Put sodium carbonate, quicklime, and potassium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and potassium hydroxide to form a thin paste, and let it cool for three nights. The medicine is an auxiliary material.

Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

Step S2: immersing the amount of comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soaking in a ratio of 60 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soak for 8 days in a closed state, take the residue from the filter residue, concentrate it under reduced pressure until thick paste.

Step S3: adding the step S2 to the fine powder prepared in step S1 The paste was concentrated to a thick paste, and 30 g of a pharmaceutically acceptable adjuvant, 20 g of salicylic acid, and 15 g of white petrolatum were added to prepare a cream for treating HPV.

Example 7

Creams for treating condyloma acuminata are prepared from the following components.

1g of hibiscus, 30g of Fritillaria, 10g of ginseng, 10g of comfrey, 6g of psyllium, 15g of psyllium, 15g of psoralen, 15g of scutellaria, 10g of sea bream.

Pharmaceutically acceptable adjuvant: 20 g of excipients prepared in step S0, 10 g of salicylic acid, and 20 g of white petrolatum.

The preparation method is the same as in Example 6.

Example 8

The HPV papillomavirus cream for treatment is prepared from the following components.

30g of hibiscus, 1g of Fritillaria, 30g of ginseng, 5g of comfrey, 1g of Xanthium, 15g of psoralen, 10g of scutellaria, 15g of sea bream.

Pharmaceutically acceptable adjuvant: 25 g of excipients prepared in step S0, 15 g of salicylic acid, and 15 g of white petrolatum.

The preparation method is the same as in Example 6.

Example 9

The spreader for treating condyloma acuminatum is prepared from the following components.

5g of hibiscus, 7g of Fritillaria, 1g of ginseng, 1g of comfrey, 5g of Xanthium, 1g of psoralen, 7g of scutellaria, 3g of sea bream.

Pharmaceutically acceptable adjuvant: 15 g of excipients prepared in step S0, 15 g of salicylic acid, and 20 g of white petrolatum.

The preparation method is the same as in Example 2.

Example 10

The spreader for treating condyloma acuminatum is prepared from the following components.

Wood scorpion 7g, soil fritillary 25g, thousand gold 20g, comfrey 6g, Xanthium 5g, psoralen 6g, spotted scorpion 1g, jellyfish 7g.

Pharmaceutically acceptable adjuvant: 15 g of excipients prepared in step S0, 15 g of salicylic acid, and 20 g of white petrolatum.

The preparation method is the same as in Example 2.

The serial numbers of the embodiments of the present invention are merely for the description, and do not represent the advantages and disadvantages of the embodiments.

Condyloma acuminata clinical trial

The applicant of the present application selected 50 patients with mild condyloma and mild patients, and conducted clinical trial using the ointment for treating HPV of Example 4 of the present invention.

Among them, patients with mild condyloma acuminata refer to a patient with a history of 1-8 months. The skin lesions are small and soft, reddish papules, and they fuse with each other to form uneven surface, moist papilla or cauliflower-like protrusions, which can be eroded. Exudation, easy bleeding.

Patients with severe condyloma acuminata refer to a patient with a history of more than 1 year, and the reddish papules are obviously enlarged and increased, forming a papillary or cauliflower-like shape, smashing, obvious exudate, and easy bleeding. The time is too long to form a giant condyloma acuminata.

The treatment of mild condyloma patients is as follows.

Take a piece of medical tape, use a curved cut to cut the circular hole equal to the diseased tissue, and attach it to the affected part to expose the corpus callosum and protect the surrounding healthy tissue, then apply the ointment for treating HPV on the corpus callosum, apply Thickness is 1.5mm, then Cut the medical tape and fix it with a cover. Change the dressing once every 2 days. After seeing the separation of the corpus callosum and the normal tissue, stop changing the dressing, and then scrape the corpus callosum with a scalpel. Apply fish stone grease to protect the wound and heal in three to five days. If you do not use a scalpel to scrape the carcass residue, let it fall off and disappear. In general, the corpus callosum virus kills, and the corpus callosum disappears naturally in a week or so. No scars left.

Patients with sharp wet weight have the same treatment as mild patients.

The above are only the preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalents, improvements, etc., which are within the spirit and scope of the present invention, should be included in the protection of the present invention. Within the scope.

Claims (10)

A traditional Chinese medicine composition for treating condyloma acuminatum, characterized in that the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 1-30 parts by weight of psyllium, 1-30 parts by weight Fritillaria, 1-30 parts by weight of gold, 1-20 parts by weight of comfrey, 1-20 parts by weight of Xanthium, 1-18 parts by weight of psoralen, 1-15 parts by weight of scutellaria And 1-15 parts by weight of sea bream. The traditional Chinese medicine composition for treating condyloma acuminata according to claim 1, wherein the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 5-18 parts by weight of psyllium, 5- 15 parts by weight of Fritillaria, 5-15 parts by weight of gold, 3-15 parts by weight of comfrey, 5-15 parts by weight of Xanthium, 8-13 parts by weight of psoralen, 3-10 weight Serve and 3-10 parts by weight of jellyfish. The traditional Chinese medicine composition for treating condyloma acuminata according to claim 2, wherein the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 8-15 parts by weight of psyllium, 7- 15 parts by weight of Fritillaria, 9-13 parts by weight of gold, 5-10 parts by weight of comfrey, 6-12 parts by weight of Xanthium, 8-12 parts by weight of psoralen, 4-9 weight Serve and 5-8 parts by weight of sea bream. A preparation for treating condyloma acuminata, the preparation for treating condyloma acuminata, comprising the traditional Chinese medicine composition for treating condyloma acuminata according to any one of claims 1 to 3, and a pharmaceutically acceptable excipient, the medicinal preparation Excipients include a mixture of carbonates, strong alkaline hydroxides, and quicklime. The mass ratio of the carbonate, the strong alkali hydroxide and the quicklime is (1-5): (0.01 - 0.1): (1-5). The preparation for treating condyloma acuminata according to claim 4, wherein the pharmaceutically acceptable excipient further comprises salicylic acid and/or white petrolatum. A preparation method for preparing a preparation for treating condyloma acuminatum, the preparation method comprising the following steps: Step S1: pulverizing wood scorpion, sapling, sea bream, earth fritillary, and scutellaria, and then sieving through 1000 mesh mesh. Fine powder; Step S2: immersing comfrey, Xanthium and psoralen in a solvent for 8-12 days, taking the filtrate to concentrate to a paste solution; and Step S3: adding step S2 to the fine powder obtained in step S1 The prepared cream liquid is concentrated to a thick paste liquid, and a pretreated pharmaceutically acceptable adjuvant is added to obtain a preparation for treating condyloma acuminatum. The preparation method for preparing a preparation for treating condyloma acuminata according to claim 6, wherein the medicinal auxiliary material is pretreated by placing a carbonate, a strong alkaline hydroxide and quicklime into the container and into the container. Stir well with water and administer for 48-90 hours. The preparation method for preparing a preparation for treating condyloma acuminata according to claim 7, wherein the carbonate is sodium carbonate and/or potassium carbonate, and the strong alkaline hydroxide is sodium hydroxide and/or potassium hydroxide. The preparation method for preparing a preparation for treating condyloma acuminata according to claim 6, wherein the step S2 is: immersing comfrey, Xanthium and psoralen in ethanol having a concentration of 75% (v/v), The mixture was immersed for 8-12 days, and the filtrate after removing the residue was concentrated under reduced pressure to a thick paste. A preparation method for preparing a preparation for treating condyloma acuminata according to claim 8, wherein the preparation for treating condyloma acuminata is an applicator, a cream, an ointment or a patch.