TWI594761B - A composition of chinese medicine for treating genital wart, its preparation method and formulation - Google Patents

A composition of chinese medicine for treating genital wart, its preparation method and formulation Download PDF

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TWI594761B
TWI594761B TW104142316A TW104142316A TWI594761B TW I594761 B TWI594761 B TW I594761B TW 104142316 A TW104142316 A TW 104142316A TW 104142316 A TW104142316 A TW 104142316A TW I594761 B TWI594761 B TW I594761B
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鄧聖平
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程韻
趙曉軍
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Description

用於治療尖銳濕疣的中藥組合物、其製備方法及其製劑 Traditional Chinese medicine composition for treating condyloma acuminatum, preparation method thereof and preparation thereof

本發明關於一種中藥組合物,特別關於用於治療尖銳濕疣感染所致的尖銳濕疣等疾病的中藥組合物,本發明還關於該中藥組合物的製備方法及其製劑。 The present invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating diseases such as condyloma acuminata caused by condyloma acuminata infection, and to a preparation method of the traditional Chinese medicine composition and a preparation thereof.

尖銳濕疣(genital wart)又稱生殖器疣、性病疣等,是由人類乳突病毒(HPV)感染引起的一種性傳播疾病,病原體為人類乳突病毒(以下簡稱HPV),屬於乳多空病毒科(papovaviridae)的乳突病毒屬。迄今已發現90餘種亞型,其中與尖銳濕疣相關的有30餘種,主要是HPV-6、HPV-11、HPV-16、HPV-18型。 Genital wart (genital wart), also known as genital warts, sexually transmitted diseases, etc., is a sexually transmitted disease caused by human papillomavirus (HPV) infection. The pathogen is human papillomavirus (hereinafter referred to as HPV), belonging to the papovavirus family. (Papovaviridae) of the genus Papillomavirus. More than 90 subtypes have been discovered so far, of which more than 30 are related to condyloma acuminata, mainly HPV-6, HPV-11, HPV-16, HPV-18.

HPV易在潮濕溫熱環境下生存繁殖,尖銳濕疣一般好發於生殖器部位皮膚黏膜交界處,男性多見於冠狀溝、包皮系帶、龜頭、尿道口及莖部、肛門和直腸等部位,女性多見於大小陰唇、陰道口等部位。非生殖器部位見於腋窩、臍窩、乳房、手指等處。初起為小而柔軟、淡紅色丘疹,逐漸增大增多,互相融合形成表面凹凸不平、濕潤的乳頭狀或菜花狀突起,可發生糜爛、滲液、易出血。症狀 一般多數無任何自覺症狀,少部分有搔癢、灼痛、白帶增多等,肛門、直腸尖銳濕疣可有疼痛和裡急後重。病理組織、表皮角化不全,顯著棘層肥厚和乳頭瘤樣增生。顆粒層和棘層上部可見特徵性的空泡細胞、胞漿淡染,中央有大而深染的核。真皮水腫,毛細血管擴大,周圍有慢性炎性細胞浸潤。 HPV is easy to survive and thrive in humid and warm environment. Condyloma acuminata usually occurs at the junction of skin and mucous membranes in the genital area. Men are more common in coronary sulcus, foreskin ligament, glans, urethral opening and stem, anus and rectum, etc. Found in the size of the labia, vaginal opening and other parts. Non-genital parts are found in the armpits, umbilical fossa, breasts, fingers, etc. From the beginning, it is a small, soft, reddish papule that gradually increases and merges to form a bumpy, moist papillary or cauliflower-like protrusion that can be eroded, exuded, and easily bleed. symptom Most people do not have any self-conscious symptoms, a small part of itching, burning pain, increased vaginal discharge, etc., anus, rectal condyloma acuminata can have pain and urgency. Pathological tissue, epidermal keratosis, significant acanthosis and papillary hyperplasia. The vesicle layer and the upper part of the spinous layer can be characterized by vacuolated cells and cytoplasm, and there are large and deeply stained nuclei in the center. Dermal edema, enlarged capillaries, and chronic inflammatory cell infiltration around.

目前西醫治療尖銳濕疣疾病主要包括以下。 At present, Western medicine treatment of condyloma acuminata mainly includes the following.

(1)物理療法:雷射治療、冷凍治療、電凝或電灼治療,這樣療法效果雖好,操作簡單,但治療時患者疼痛感強,而復發率相當高,因尖銳濕疣是HPV所致,靠物理療法很難斷根。 (1) Physical therapy: laser treatment, cryotherapy, electrocoagulation or electrocautery treatment, although the effect of the therapy is good, the operation is simple, but the patient has a strong pain during treatment, and the recurrence rate is quite high, because the condyloma acuminata is caused by HPV. It is difficult to break the roots by physical therapy.

(2)局部藥物治療: (2) topical medication:

①0.5%足葉草毒素酊、0.5%鬼臼毒素酊,外用。 10.5% loofago toxin, 0.5% podophyllotoxin, topical.

②50%三氯醋酸溶液,外用。 250% trichloroacetic acid solution for external use.

③5-氟脲嘧啶(5-fu)軟膏,外用。 35-fluorouracil (5-fu) ointment for topical use.

④5%咪喹莫特霜外用,這些藥物都能使疣體消失,但都有復發可能。 45% imiquimod cream for external use, these drugs can make the carcass disappear, but there is a possibility of recurrence.

為了解決先前技術中治療HPV疾病的藥物存在無法根治且復發率高的問題,本發明提供了一種治療HPV疾病,尤其是尖銳濕疣的中藥組合物,其具有讓患者疼痛感小而效果好、不易復發、不留瘢痕、毒副作用小的優點。 In order to solve the problem that the drug for treating HPV disease in the prior art cannot be cured and the recurrence rate is high, the present invention provides a traditional Chinese medicine composition for treating HPV diseases, especially condyloma acuminata, which has a small pain and good effect and is difficult to be used. Recurrence, no scarring, and small side effects.

本發明進而提供上述用於治療HPV的中藥組合物的製劑及其製備方法。 The present invention further provides a preparation of the above-mentioned traditional Chinese medicine composition for treating HPV and a preparation method thereof.

本發明採用的技術方案如下。 The technical solution adopted by the present invention is as follows.

一種用於治療尖銳濕疣的中藥組合物,該用於治療尖銳濕疣的中藥組合物是由下述組分製備而成:1-30重量份之木鱉子、1-30重量份之土貝母、1-30重量份之千金子、1-20重量份之紫草、1-20重量份之蒼耳子、1-18重量份之補骨脂、1-15重量份之斑蝥及1-15重量份之海螵蛸。 A traditional Chinese medicine composition for treating condyloma acuminatum, the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 1-30 parts by weight of psyllium, 1-30 parts by weight of Fritillaria 1-30 parts by weight of gold, 1-20 parts by weight of comfrey, 1-20 parts by weight of Xanthium, 1-18 parts by weight of psoralen, 1-15 parts by weight of scutellaria and 1-15 Weight of sea bream.

較佳地,該用於治療尖銳濕疣的中藥組合物是由下述組分製備而成:5-18重量份之木鱉子、5-15重量份之土貝母、5-15重量份之千金子、3-15重量份之紫草、5-15重量份之蒼耳子、8-13重量份之補骨脂、3-10重量份之斑蝥及3-10重量份之海螵蛸。 Preferably, the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 5-18 parts by weight of psyllium, 5-15 parts by weight of Fritillaria, 5-15 parts by weight Thousands of gold, 3-15 parts by weight of comfrey, 5-15 parts by weight of Xanthium, 8-13 parts by weight of psoralen, 3-10 parts by weight of cantharidin and 3-10 parts by weight of sea bream.

進一步較佳地,該用於治療尖銳濕疣的中藥組合物是由下述組分製備而成:8-15重量份之木鱉子、7-15重量份之土貝母、9-13重量份之千金子、5-10重量份之紫草、6-12重量份之蒼耳子、8-12重量份之補骨脂、4-9重量份之斑蝥及5-8重量份之海螵蛸。 Further preferably, the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 8-15 parts by weight of psyllium, 7-15 parts by weight of Fritillaria, 9-13 parts by weight Thousands of gold, 5-10 parts by weight of comfrey, 6-12 parts by weight of Xanthium, 8-12 parts by weight of psoralen, 4-9 parts by weight of variegated and 5-8 parts by weight of sea bream .

一種用於治療尖銳濕疣的製劑,包括所述的用於治療尖銳濕疣的中藥組合物和可藥用輔料,該可藥用輔料包括碳酸鹽、強鹼性氫氧化物和生石灰的混合物,該碳酸鹽、該強鹼性氫氧化物和該生石灰的質量比為(1-5):(0.01-0.1):(1-5)。該可藥用輔料還包括水楊酸及/或白凡士林。 A preparation for treating condyloma acuminata, comprising the traditional Chinese medicine composition for treating condyloma acuminata and a pharmaceutically acceptable excipient comprising a mixture of carbonate, strong alkali hydroxide and quicklime, the carbonic acid The mass ratio of the salt, the strong alkali hydroxide and the quicklime is (1-5): (0.01-0.1): (1-5). The pharmaceutically acceptable excipient also includes salicylic acid and/or white petrolatum.

一種用於治療尖銳濕疣的製劑的製備方法,該製備方 法包括下述步驟:步驟S1:將木鱉子、千金子、海螵蛸、土貝母、斑蝥粉碎後過1000網目細篩,篩成細粉;步驟S2:紫草、蒼耳子和補骨脂加入溶劑浸泡8-12天,取濾液濃縮至膏狀液備用;以及步驟S3:向步驟S1製得的細粉中加入步驟S2製得的膏狀液,濃縮至稠膏狀液,加入預處理過的可藥用輔料,即得用於治療尖銳濕疣的製劑。 Method for preparing a preparation for treating condyloma acuminatum, the preparation method The method comprises the following steps: Step S1: crushing the wood scorpion, the golden scorpion, the jellyfish, the soil fritillary, and the scutellaria, and then sieving through a 1000 mesh sieve to form a fine powder; step S2: comfrey, scorpion and supplement The bone fat is added to the solvent for 8-12 days, and the filtrate is concentrated to a paste liquid for use; and step S3: the paste prepared in step S2 is added to the fine powder prepared in step S1, and concentrated to a thick paste liquid, and added. The pretreated pharmaceutically acceptable excipients are used in the treatment of condyloma acuminata.

該可藥用輔料的預處理為將碳酸鹽、強鹼性氫氧化物和生石灰放入容器內,邊向容器內加水邊攪拌均勻,靜止48-90小時即可入藥。所述的碳酸鹽為碳酸鈉及/或碳酸鉀,所述的強鹼性氫氧化物為氫氧化鈉及/或氫氧化鉀。 The pretreatment of the pharmaceutically acceptable excipient is to put the carbonate, the strong alkaline hydroxide and the quicklime into the container, and stir evenly by adding water to the container, and the medicine can be used for 48-90 hours. The carbonate is sodium carbonate and/or potassium carbonate, and the strong alkaline hydroxide is sodium hydroxide and/or potassium hydroxide.

較佳地,該步驟S2為將紫草、蒼耳子和補骨脂浸泡於濃度為75%(v/v)的乙醇中,密閉浸泡8-12天,去除濾渣後的濾液減壓濃縮至稠膏狀液。乙醇的用量沒有特別要求,只要能夠浸泡沒過紫草、蒼耳子額補骨脂即可。經常採用的是按照每10g紫草、10g蒼耳子和10g補骨脂使用用40-60ml乙醇比例進行浸泡。 Preferably, in step S2, the comfrey, Xanthium and psoralen are immersed in ethanol having a concentration of 75% (v/v), and immersed for 8-12 days in a sealed state, and the filtrate after removing the residue is concentrated under reduced pressure. Thick paste. There is no special requirement for the amount of ethanol, as long as it can be soaked in the comfrey and the ear bones. It is often used to soak in a ratio of 40-60 ml of ethanol per 10 g of comfrey, 10 g of Xanthium and 10 g of psoralen.

該用於治療尖銳濕疣的製劑為塗抹劑、乳膏劑、軟膏劑或帖劑。 The preparation for treating condyloma acuminata is an applicator, a cream, an ointment or a patch.

本發明提供的技術方案帶來的有益效果如下。 The beneficial effects brought by the technical solution provided by the present invention are as follows.

(1)本發明的用於治療尖銳濕疣的中藥組合物所選用的君藥為木鱉子、土貝母和千金子,臣藥為紫草、蒼耳子和補骨脂三味藥,佐藥為斑蝥和海螵蛸兩味藥。這8味藥的功效如下。 (1) The traditional Chinese medicine composition for treating condyloma acuminatum of the present invention is selected from the group consisting of hibiscus, Fritillaria and Thousand Gold, and the drug is a medicinal herb of comfrey, Xanthium and psoralen, adjuvant It is a two-flavored medicine for cantharidin and sea bream. The efficacy of these 8 herbs is as follows.

君藥:木鱉子,味苦,微甘,性溫,質毒攻散,有散 結消腫,追風定痛,攻毒殺蟲的作用。土貝母,味苦,性涼,有抗病毒作用,散結拔毒的功效。千金子、味辛,性溫,有破血消癥,解毒殺蟲的功效。 Jun medicine: wooden scorpion, bitter taste, slightly sweet, warm, toxic and toxic, scattered It has a swelling, chasing the wind and setting the pain, and the role of attacking and killing insects. Earth fritillary, bitter taste, cool, anti-viral effect, loosening the effect of detoxification. Thousands of gold, spicy, warm, blood-breaking, detoxification and insecticidal effects.

臣藥:紫草,味苦,性寒,有涼血透疹,清熱利濕,解毒的功效,有抗炎,抗腫瘤作用。蒼耳子,味苦、甘、辛,性溫,有除濕止痛,祛風止癢的功效,有抗病原微生物作用。補骨脂,味辛、苦,性溫,香燥降斂,有抗腫瘤作用,有對皮膚細胞色素的作用。 Chen medicine: comfrey, bitter taste, cold, bloody diarrhea, heat and dampness, detoxification, anti-inflammatory, anti-tumor effect. Xanthium, bitter taste, sweet, spicy, warm, dehumidification and pain relief, hurricane and itching effect, anti-pathogenic microorganisms. Buguzhi, pungent, bitter, warm, fragrant and dry, has anti-tumor effect, and has a role in skin cytochrome.

佐藥:斑蝥,味辛,性溫,有抗病原微生物作用,有攻毒蝕瘡、破血散結的功效。海螵蛸,味鹹、澀,性溫,外用有收濕斂瘡的功效。 Adjuvant: spotted, spicy, warm, anti-pathogenic microorganisms, anti-virus, sore, blood stasis. Sea otter, tastes salty, glutinous, warm, and has the effect of collecting moisture and sore.

(2)本發明的使藥也是發明人經過大量的實驗和創造性勞動尋求到的。該使藥為碳酸鈉、氫氧化鈉和生石灰,其混合後靜止48-90小時後入藥,可以有效調和君臣佐8味藥,產生協同作用促進藥物在疣體病變組織上透皮吸收。諸藥合用,具有分解疣體角質層和去腐生肌之功效,臨床用於治療HPV感染所致的尖銳濕疣等疾病。 (2) The drug of the present invention was also sought by the inventors through extensive experimentation and creative labor. The medicine is sodium carbonate, sodium hydroxide and quicklime, and after being mixed for 48-90 hours, it is used as a medicine, which can effectively reconcile the Junchensuo 8 medicine, and synergistically promote the transdermal absorption of the drug on the corpus callosum tissue. The combination of various drugs has the effects of decomposing the corpus callosum and removing the saprophytic muscle, and is clinically used for treating diseases such as condyloma acuminata caused by HPV infection.

(3)本發明的用於治療尖銳濕疣的製劑根據傳統中醫理論選用天然中藥材為原料製作成塗抹劑、乳膏劑、軟膏劑或帖劑,敷在患部,是治療HPV感染所致的尖銳濕疣疾病的有效方法之一。臨床試驗證明,使用1-2個療程病變組織即可與正常組織分離,病毒殺死,疣體自然脫落消失,痊癒。治療過程中痛感小而效果好、不復發、不留瘢痕、毒副作用小,克服了現有中西醫治療方法的不足等缺 點。 (3) The preparation for treating condyloma acuminatum according to the invention is prepared according to the traditional Chinese medicine theory, using a natural Chinese medicinal material as a raw material to prepare a smear, a cream, an ointment or a patch, which is applied to the affected part to treat the condyloma acuminata caused by HPV infection. One of the effective ways of disease. Clinical trials have shown that 1-2 courses of diseased tissue can be separated from normal tissues, the virus is killed, and the carcass naturally falls off and heals. During the treatment, the pain is small and the effect is good, no recurrence, no scar, no toxic side effects, and overcome the shortage of existing Chinese and Western medicine treatment methods. point.

為使本發明的目的、技術方案和優點更加清楚,下面將對本發明實施方式作進一步地詳細描述。 In order to make the objects, technical solutions and advantages of the present invention more clear, the embodiments of the present invention will be further described in detail below.

實施例1 Example 1

用於治療尖銳濕疣的軟膏劑由下述組分製備而成。 Ointments for the treatment of condyloma acuminata are prepared from the following components.

木鱉子15g、土貝母12g、千金子5g、紫草20g、蒼耳子10g、補骨脂10g、斑蝥3g、海螵蛸5g。 15g of hibiscus, 12g of Fritillaria, 5g of ginseng, 20g of comfrey, 10g of Xanthium, 10g of psoralen, 3g of scutellaria, 5g of sea bream.

可藥用輔料:步驟S0製備的輔料20g、水楊酸8g、白凡士林5g。 Pharmaceutically acceptable adjuvant: 20 g of excipients prepared in step S0, 8 g of salicylic acid, and 5 g of white petrolatum.

上述用於治療HPV的軟膏劑的製備方法包括下述步驟。 The above preparation method of an ointment for treating HPV includes the following steps.

步驟S0,亦即可藥用輔料製法:稱取碳酸鈉100g、生石灰(入粉碎機打碎成粉未)100g、氫氧化鈉1g、蒸餾水500g。比例為1:1:0.01:5。使碳酸鈉、生石灰、氫氧化鈉放入容器內,一邊加入蒸餾水,一邊用木製器物攪和,使碳酸鈉、生石灰、氫氧化鈉發生化學反應,成稀糊狀,涼晾、靜置72小時即可入藥為輔料。 In step S0, the pharmaceutical auxiliary preparation method can also be used: 100 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of sodium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Sodium carbonate, quicklime, and sodium hydroxide were placed in a container, and while adding distilled water, the mixture was stirred with a wooden utensil, and sodium carbonate, quicklime, and sodium hydroxide were chemically reacted to form a thin paste, which was allowed to stand for 72 hours. Can be used as an excipient.

步驟S1:取木鱉子(去殼)、千金子、海螵蛸、土貝母、斑蝥(去頭、去翅)粉碎後過1000網目細篩,篩成細粉。 Step S1: Take the wooden scorpion (shelling), the thousand gold, the sea otter, the soil fritillary, the spotted scorpion (to the head, and the wing), crush the sift through the 1000 mesh mesh, and sieve into a fine powder.

步驟S2:取份量紫草、蒼耳子、補骨脂浸泡於75%(v/v)乙醇內,按照每10g紫草、10g蒼耳子、10g補骨脂,需用 60ml乙醇比例浸泡,密閉浸泡8天,濾渣取液,減壓濃縮至稠膏狀備用。 Step S2: Take the amount of comfrey, Xanthium, and psoralen soaked in 75% (v/v) ethanol, according to every 10g comfrey, 10g Xanthium, 10g psoralen, need Soak in a ratio of 60 ml of ethanol, soak for 8 days in a sealed state, take the residue from the filter residue, and concentrate to a thick paste under reduced pressure for use.

步驟S3:向步驟S1製得的細粉中加入步驟S2製得的膏狀液濃縮至稠膏狀液,加入步驟S1的可藥用輔料20g、水楊酸8g、白凡士林5g,製得用於治療HPV的軟膏劑。 Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate to a thick paste solution, adding 20 g of pharmaceutically acceptable excipients, 8 g of salicylic acid and 5 g of white petrolatum in step S1, and preparing the same. An ointment for the treatment of HPV.

實施例2 Example 2

用於治療尖銳濕疣的塗抹劑由下述組分製備而成。 The spreader for treating condyloma acuminatum is prepared from the following components.

木鱉子8g、土貝母10g、千金子9g、紫草3g、蒼耳子9g、補骨脂8g、斑蝥3g、海螵蛸4g。 8g of scorpion, 10g of Fritillaria, 9g of ginseng, 3g of comfrey, 9g of Xanthium, 8g of psoralen, 3g of scutellaria, 4g of sea bream.

可藥用輔料:步驟S0製備的輔料10g、水楊酸7g。 Pharmaceutically acceptable adjuvant: 10 g of excipients prepared in step S0 and 7 g of salicylic acid.

上述用於治療HPV的塗抹劑的製備方法包括下述步驟。 The above preparation method of the smear for treating HPV includes the following steps.

步驟S0,亦即可藥用輔料製法:稱取碳酸鈉100g、生石灰(入粉碎機打碎成粉未)500g、氫氧化鈉10g、蒸餾水2500g。比例為1:5:0.1:5。使碳酸鈉、生石灰、氫氧化鈉放入容器內,一邊加入蒸餾水,一邊用木製器物攪和,使碳酸鈉、生石灰、氫氧化鈉發生化學反應,成稀糊狀,涼晾,過三夜即可入藥為輔料。 Step S0 can also be used as a pharmaceutical auxiliary preparation method: 100 g of sodium carbonate, 500 g of quicklime (breaking into a powder by a pulverizer), 10 g of sodium hydroxide, and 2500 g of distilled water are weighed. The ratio is 1:5:0.1:5. Put sodium carbonate, quicklime, and sodium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and sodium hydroxide to form a thin paste, and let it dry for three nights. The medicine is an auxiliary material.

步驟S1:取份量木鱉子(去殼)、千金子、海螵蛸、土貝母、斑蝥(去頭、去翅)粉碎後過1000網目細篩,篩成細粉。 Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

步驟S2:取份量紫草、蒼耳子、補骨脂浸泡於75%(v/v)乙醇內,按照每10g紫草、10g蒼耳子、10g補骨脂,需用50ml乙醇浸泡,密閉浸泡8天,濾渣取液,減壓濃縮至稠 膏狀備用。 Step S2: Soak the comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soak it in 50 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soak for 8 days, remove the filter residue, concentrate to a thick pressure under reduced pressure. Paste spare.

步驟S3:向步驟S1製備的細粉中加入步驟S2製得的膏狀液濃縮至稠膏狀,加入步驟S0的可藥用輔料10g、水楊酸7g,製得用於治療HPV的塗抹劑。 Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate into a thick paste, adding 10 g of the pharmaceutically acceptable adjuvant in step S0 and 7 g of salicylic acid to prepare an applicator for treating HPV. .

實施例3 Example 3

用於治療尖銳濕疣的乳膏劑由下述組分製備而成。 Creams for treating condyloma acuminata are prepared from the following components.

木鱉子28g、土貝母15g、千金子13g、紫草20g、蒼耳子20g、補骨脂18g、斑蝥5g、海螵蛸8g。 28g of scorpion, 15g of Fritillaria, 13g of ginseng, 20g of comfrey, 20g of Xanthium, 18g of psoralen, 5g of scutellaria, 8g of sea bream.

可藥用輔料:步驟S0製備的輔料30g、水楊酸10g、白凡士林10g。 Pharmaceutically acceptable adjuvant: 30 g of excipients prepared in step S0, 10 g of salicylic acid, and 10 g of white petrolatum.

上述用於治療HPV的乳膏劑的製備方法包括下述步驟。 The above preparation method for a cream for treating HPV includes the following steps.

步驟S0,亦即可藥用輔料製法:稱取碳酸鈉500g、生石灰(入粉碎機打碎成粉未)100g、氫氧化鈉5g、蒸餾水2500g。比例為5:1:0.05:5。使碳酸鈉、生石灰、氫氧化鈉放入容器內,一邊加入蒸餾水,一邊用木製器物攪和,使碳酸鈉、生石灰、氫氧化鈉發生化學反應,成稀糊狀,涼晾、過三夜即可入藥為輔料。 Step S0 can also be used as a pharmaceutical auxiliary preparation method: weigh 500 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 5 g of sodium hydroxide, and 2500 g of distilled water. The ratio is 5:1:0.05:5. Put sodium carbonate, quicklime, and sodium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and sodium hydroxide to form a thin paste, and let it cool for three nights. The medicine is an auxiliary material.

步驟S1:取份量木鱉子(去殼)、千金子、海螵蛸、土貝母、斑蝥(去頭、去翅)粉碎後過1000網目細篩,篩成細粉。 Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

步驟S2:取份量紫草,蒼耳子、補骨脂浸泡於75%(v/v)乙醇內,按照每10g紫草、10g蒼耳子、10g補骨脂,需用40ml乙醇比例浸泡,密閉浸泡12天,濾渣取液,減壓濃 縮至稠膏狀備用。 Step S2: taking the amount of comfrey, Xanthium and psoralen soaked in 75% (v/v) ethanol, soaking in a ratio of 40 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soaked in air for 12 days, the filter residue is taken, and the pressure is reduced. Shrink to a thick paste for use.

步驟S3:向步驟S1製備的細粉中加入步驟S2製得的膏狀液濃縮至稠膏狀,加入步驟S1的可藥用輔料30g、水楊酸10g、白凡士林10g,製得用於治療HPV的乳膏劑。 Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate into a thick paste, adding 30 g of pharmaceutically acceptable adjuvant, 10 g of salicylic acid, and 10 g of white petrolatum in step S1, and preparing for treatment. HPV cream.

實施例4 Example 4

用於治療尖銳濕疣的軟膏劑由下述組分製備而成。 Ointments for the treatment of condyloma acuminata are prepared from the following components.

木鱉子18g、土貝母15g、千金子15g、紫草8g、蒼耳子12g、補骨脂10g、斑蝥5g、海螵蛸6g。 Wood scorpion 18g, soil fritillary 15g, thousand gold 15g, comfrey 8g, Xanthium 12g, psoralen 10g, spotted 5g, jellyfish 6g.

可藥用輔料:步驟S0製備的輔料15g、水楊酸10g、白凡士林6g。 Pharmaceutically acceptable excipients: 15 g of excipients prepared in step S0, 10 g of salicylic acid, and 6 g of white petrolatum.

上述用於治療HPV的軟膏劑的製備方法包括下述步驟。 The above preparation method of an ointment for treating HPV includes the following steps.

步驟S0,亦即可藥用輔料製法:稱取碳酸鈉100g、生石灰(入粉碎機打碎成粉未)100g、氫氧化鈉1g、蒸餾水500g。比例為1:1:0.01:5。使碳酸鈉、生石灰、氫氧化鈉放入容器內,一邊加入蒸餾水,一邊用木製器物攪和,使碳酸鈉、生石灰、氫氧化鈉發生化學反應,成稀糊狀,涼晾、過三夜即可入藥為輔料。 In step S0, the pharmaceutical auxiliary preparation method can also be used: 100 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of sodium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Put sodium carbonate, quicklime, and sodium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and sodium hydroxide to form a thin paste, and let it cool for three nights. The medicine is an auxiliary material.

步驟S1:取份量木鱉子(去殼)、千金子、海螵蛸、土貝母、斑蝥(去頭、去翅)粉碎後過1000網目細篩,篩成細粉。 Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

步驟S2:取份量紫草、蒼耳子、補骨脂浸泡於75%(v/v)乙醇內,按照每10g紫草、10g蒼耳子、10g補骨脂,需用50ml乙醇比例浸泡,密閉浸泡10天,濾渣取液,減壓濃 縮至稠膏狀備用。 Step S2: immersing the amount of comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soaking in a ratio of 50 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soaked in air for 10 days, the filter residue is taken, and the pressure is reduced. Shrink to a thick paste for use.

步驟S3:向步驟S1製備的細粉中加入步驟S2製得的膏狀液濃縮至稠膏狀,加入步驟S0的可藥用輔料15g、水楊酸10g、白凡士林6g,製得用於治療HPV的軟膏劑。 Step S3: adding the paste prepared in step S2 to the fine powder prepared in step S1 to concentrate into a thick paste, adding 15 g of pharmaceutically acceptable excipients of step S0, 10 g of salicylic acid, and 6 g of white petrolatum to prepare for treatment. HPV ointment.

實施例5 Example 5

用於治療尖銳濕疣的貼劑由下述組分製備而成。 The patch for treating condyloma acuminatum is prepared from the following components.

木鱉子10g、土貝母5g、千金子7g、紫草15g、蒼耳子15g、補骨脂13g、斑蝥4g、海螵蛸5g。 10 grams of hibiscus, 5g of Fritillaria, 7g of ginseng, 15g of comfrey, 15g of Xanthium, 13g of psoralen, 4g of scutellaria, 5g of sea bream.

可藥用輔料:步驟S0製備的輔料10g。 Pharmaceutically acceptable adjuvant: 10 g of the excipient prepared in step S0.

上述用於治療HPV的貼劑的製備方法包括下述步驟。 The above preparation method for a patch for treating HPV includes the following steps.

步驟S0,亦即可藥用輔料製法:稱取碳酸鉀100g、生石灰(入粉碎機打碎成粉未)100g、氫氧化鉀1g、蒸餾水500g。比例為1:1:0.01:5。使碳酸鉀、生石灰、氫氧化鉀放入容器內,一邊加入蒸餾水,一邊用木製器物攪和,使碳酸鉀、生石灰、氫氧化鉀發生化學反應,成稀糊狀,涼晾、過三夜即可入藥為輔料。 In step S0, the pharmaceutical auxiliary preparation method can also be used: 100 g of potassium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of potassium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Put potassium carbonate, quicklime, and potassium hydroxide in a container, add distilled water, and stir with a wooden utensil to chemically react potassium carbonate, quicklime, and potassium hydroxide. The medicine is an auxiliary material.

步驟S1:取份量木鱉子(去殼)、千金子、海螵蛸、土貝母、斑蝥(去頭、去翅)粉碎後過1000網目細篩,篩成細粉。 Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

步驟S2:取份量紫草、蒼耳子、補骨脂浸泡於75%(v/v)乙醇內,按照每10g紫草、10g蒼耳子、10g補骨脂,需用60ml乙醇比例浸泡,密閉浸泡8天,濾渣取液,減壓濃縮至稠膏狀備用。 Step S2: immersing the amount of comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soaking in a ratio of 60 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soak for 8 days in a closed state, take the residue from the filter residue, concentrate it under reduced pressure until thick paste.

步驟S3:向步驟S1製備的細粉中加入步驟S2製得的 膏狀液濃縮至稠膏狀,加入步驟的S0可藥用輔料10g,製得用於治療HPV的貼劑。 Step S3: adding the step S2 to the fine powder prepared in step S1 The paste was concentrated to a thick paste, and 10 g of the S0 pharmaceutically acceptable adjuvant was added to prepare a patch for treating HPV.

實施例6 Example 6

用於治療尖銳濕疣的乳膏劑由下述組分製備而成。 Creams for treating condyloma acuminata are prepared from the following components.

木鱉子25g、土貝母20g、千金子15g、紫草15g、蒼耳子12g、補骨脂12g、斑蝥9g、海螵蛸10g。 25g of scorpion, 20g of Fritillaria, 15g of ginseng, 15g of comfrey, 12g of Xanthium, 12g of psoralen, 9g of scutellaria, 10g of sea bream.

可藥用輔料:步驟S0製備的輔料30g、水楊酸20g、白凡士林15g。 Pharmaceutically acceptable adjuvant: 30 g of excipients prepared in step S0, 20 g of salicylic acid, and 15 g of white petrolatum.

上述用於治療HPV的乳膏劑的製備方法包括下述步驟。 The above preparation method for a cream for treating HPV includes the following steps.

步驟S0,亦即可藥用輔料製法:稱取碳酸鈉100g、生石灰(入粉碎機打碎成粉未)100g、氫氧化鉀1g、蒸餾水500g。比例為1:1:0.01:5。使碳酸鈉,生石灰、氫氧化鉀放入容器內,一邊加入蒸餾水,一邊用木製器物攪和,使碳酸鈉、生石灰、氫氧化鉀發生化學反應,成稀糊狀,涼晾、過三夜即可入藥為輔料。 Step S0 is also a method for preparing a medicinal auxiliary material: 100 g of sodium carbonate, 100 g of quicklime (breaking into a powder by a pulverizer), 1 g of potassium hydroxide, and 500 g of distilled water are weighed. The ratio is 1:1:0.01:5. Put sodium carbonate, quicklime, and potassium hydroxide in a container, add distilled water, stir with a wooden utensil, and chemically react sodium carbonate, quicklime, and potassium hydroxide to form a thin paste, and let it cool for three nights. The medicine is an auxiliary material.

步驟S1:取份量木鱉子(去殼)、千金子、海螵蛸、土貝母、斑蝥(去頭、去翅)粉碎後過1000網目細篩,篩成細粉。 Step S1: Take the amount of wood scorpion (shelled), thousand gold, sea bream, soil fritillary, scutellaria (headed, winged), crushed and sieved through 1000 mesh, and sieved into fine powder.

步驟S2:取份量紫草、蒼耳子、補骨脂浸泡於75%(v/v)乙醇內,按照每10g紫草、10g蒼耳子、10g補骨脂,需用60ml乙醇比例浸泡,密閉浸泡8天,濾渣取液,減壓濃縮至稠膏狀備用。 Step S2: immersing the amount of comfrey, Xanthium, and psoralen in 75% (v/v) ethanol, soaking in a ratio of 60 ml of ethanol per 10 g of comfrey, 10 g of Xanthium sibiricum, and 10 g of psoralen. Soak for 8 days in a closed state, take the residue from the filter residue, concentrate it under reduced pressure until thick paste.

步驟S3:向步驟S1製備的細粉中加入步驟S2製得的 膏狀液濃縮至稠膏狀,加入步驟S0的可藥用輔料30g、水楊酸20g、白凡士林15g,製得用於治療HPV的乳膏劑。 Step S3: adding the step S2 to the fine powder prepared in step S1 The paste was concentrated to a thick paste, and 30 g of a pharmaceutically acceptable adjuvant, 20 g of salicylic acid, and 15 g of white petrolatum were added to prepare a cream for treating HPV.

實施例7 Example 7

用於治療尖銳濕疣的乳膏劑由下述組分製備而成。 Creams for treating condyloma acuminata are prepared from the following components.

木鱉子1g、土貝母30g、千金子10g、紫草10g、蒼耳子6g、補骨脂15g、斑蝥15g、海螵蛸10g。 1g of hibiscus, 30g of Fritillaria, 10g of ginseng, 10g of comfrey, 6g of psyllium, 15g of psyllium, 15g of psoralen, 15g of scutellaria, 10g of sea bream.

可藥用輔料:步驟S0製備的輔料20g、水楊酸10g、白凡士林20g。 Pharmaceutically acceptable adjuvant: 20 g of excipients prepared in step S0, 10 g of salicylic acid, and 20 g of white petrolatum.

其製備方法同實施例6。 The preparation method is the same as in Example 6.

實施例8 Example 8

用於治療HPV乳頭瘤病毒乳膏劑由下述組分製備而成。 The HPV papillomavirus cream for treatment is prepared from the following components.

木鱉子30g、土貝母1g、千金子30g、紫草5g、蒼耳子1g、補骨脂15g、斑蝥10g、海螵蛸15g。 30g of hibiscus, 1g of Fritillaria, 30g of ginseng, 5g of comfrey, 1g of Xanthium, 15g of psoralen, 10g of scutellaria, 15g of sea bream.

可藥用輔料:步驟S0製備的輔料25g、水楊酸15g、白凡士林15g。 Pharmaceutically acceptable adjuvant: 25 g of excipients prepared in step S0, 15 g of salicylic acid, and 15 g of white petrolatum.

其製備方法同實施例6。 The preparation method is the same as in Example 6.

實施例9 Example 9

用於治療尖銳濕疣的塗抹劑由下述組分製備而成。 The spreader for treating condyloma acuminatum is prepared from the following components.

木鱉子5g、土貝母7g、千金子1g、紫草1g、蒼耳子5g、補骨脂1g、斑蝥7g、海螵蛸3g。 5g of hibiscus, 7g of Fritillaria, 1g of ginseng, 1g of comfrey, 5g of Xanthium, 1g of psoralen, 7g of scutellaria, 3g of sea bream.

可藥用輔料:步驟S0製備的輔料15g、水楊酸15g、白凡士林20g。 Pharmaceutically acceptable adjuvant: 15 g of excipients prepared in step S0, 15 g of salicylic acid, and 20 g of white petrolatum.

其製備方法同實施例2。 The preparation method is the same as in Example 2.

實施例10 Example 10

用於治療尖銳濕疣的塗抹劑由下述組分製備而成。 The spreader for treating condyloma acuminatum is prepared from the following components.

木鱉子7g、土貝母25g、千金子20g、紫草6g、蒼耳子5g、補骨脂6g、斑蝥1g、海螵蛸7g。 Wood scorpion 7g, soil fritillary 25g, thousand gold 20g, comfrey 6g, Xanthium 5g, psoralen 6g, spotted scorpion 1g, jellyfish 7g.

可藥用輔料:步驟S0製備的輔料15g、水楊酸15g、白凡士林20g。 Pharmaceutically acceptable adjuvant: 15 g of excipients prepared in step S0, 15 g of salicylic acid, and 20 g of white petrolatum.

其製備方法同實施例2。 The preparation method is the same as in Example 2.

上述本發明實施例序號僅僅為了描述,不代表實施例的優劣。 The serial numbers of the embodiments of the present invention are merely for the description, and do not represent the advantages and disadvantages of the embodiments.

尖銳濕疣臨床試驗 Condyloma acuminata clinical trial

本申請的申請人選取了尖銳濕疣輕度患者、重度患者各50例,採用本發明實施例4的用於治療HPV的軟膏劑進行了臨床試驗。 The applicant of the present application selected 50 patients with mild condyloma and mild patients, and conducted clinical trial using the ointment for treating HPV of Example 4 of the present invention.

其中尖銳濕疣輕度患者是指,患者病史1-8個月,皮損初起為小而柔軟,淡紅色丘疹,互相融合形成表面凹凸不平,濕潤的乳頭狀或菜花狀突起,可發生糜爛、滲液、易出血。 Among them, patients with mild condyloma acuminata refer to a patient with a history of 1-8 months. The skin lesions are small and soft, reddish papules, and they fuse with each other to form uneven surface, moist papilla or cauliflower-like protrusions, which can be eroded. Exudation, easy bleeding.

重度尖銳濕疣患者是指,患者病史1年以上,淡紅色丘疹明顯增大增多,互相融合形成乳頭狀或菜花狀,糜爛,滲液明顯,易出血,時間過長形成巨型尖銳濕疣。 Patients with severe condyloma acuminata refer to a patient with a history of more than 1 year, and the reddish papules are obviously enlarged and increased, forming a papillary or cauliflower-like shape, smashing, obvious exudate, and easy bleeding. The time is too long to form a giant condyloma acuminata.

尖銳濕疣輕度患者採用的治療方式如下。 The treatment of mild condyloma patients is as follows.

取醫用膠布一塊,用彎剪剪與病變組織相等的圓孔,並貼於患部暴露出疣體並保護好周圍健康組織,然後敷上用於治療HPV的軟膏劑在疣體上,敷藥厚度為1.5mm,再 剪醫用膠布一塊貼蓋固定並封牢,2天換藥一次。看到疣體殘體和正常組織分離脫落後,停止換藥,然後用手術刀刮去疣體殘體。敷上魚石脂軟膏保護好創口,三至五天痊癒。如不用手術刀刮去疣體殘體,讓其自行脫落消失也可,一般而言,疣體病毒殺死,疣體殘體一周左右自然消失。不留瘢痕。 Take a piece of medical tape, use a curved cut to cut the circular hole equal to the diseased tissue, and attach it to the affected part to expose the corpus callosum and protect the surrounding healthy tissue, then apply the ointment for treating HPV on the corpus callosum, apply Thickness is 1.5mm, then Cut the medical tape and fix it with a cover. Change the dressing once every 2 days. After seeing the separation of the corpus callosum and the normal tissue, stop changing the dressing, and then scrape the corpus callosum with a scalpel. Apply fish stone grease to protect the wound and heal in three to five days. If you do not use a scalpel to scrape the carcass residue, let it fall off and disappear. In general, the corpus callosum virus kills, and the corpus callosum disappears naturally in a week or so. No scars left.

尖銳濕重度患者採用的治療方式和輕度患者相同。 Patients with sharp wet weight have the same treatment as mild patients.

以上所述僅為本發明的較佳實施例,並不用以限制本發明,凡在本發明的精神和原則之內,所作的任何修改、等同替換、改進等,均應包含在本發明的保護範圍之內。 The above are only the preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalents, improvements, etc., which are within the spirit and scope of the present invention, should be included in the protection of the present invention. Within the scope.

Claims (10)

一種用於治療尖銳濕疣的中藥組合物,其特徵在於,該用於治療尖銳濕疣的中藥組合物是由下述組分製備而成:1-30重量份之木鱉子、1-30重量份之土貝母、1-30重量份之千金子、1-20重量份之紫草、1-20重量份之蒼耳子、1-18重量份之補骨脂、1-15重量份之斑蝥及1-15重量份之海螵蛸。 A traditional Chinese medicine composition for treating condyloma acuminatum, characterized in that the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 1-30 parts by weight of psyllium, 1-30 parts by weight Fritillaria, 1-30 parts by weight of gold, 1-20 parts by weight of comfrey, 1-20 parts by weight of Xanthium, 1-18 parts by weight of psoralen, 1-15 parts by weight of scutellaria And 1-15 parts by weight of sea bream. 如請求項1所記載之用於治療尖銳濕疣的中藥組合物,其中該用於治療尖銳濕疣的中藥組合物是由下述組分製備而成:5-18重量份之木鱉子、5-15重量份之土貝母、5-15重量份之千金子、3-15重量份之紫草、5-15重量份之蒼耳子、8-13重量份之補骨脂、3-10重量份之斑蝥及3-10重量份之海螵蛸。 The traditional Chinese medicine composition for treating condyloma acuminata according to claim 1, wherein the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 5-18 parts by weight of psyllium, 5- 15 parts by weight of Fritillaria, 5-15 parts by weight of gold, 3-15 parts by weight of comfrey, 5-15 parts by weight of Xanthium, 8-13 parts by weight of psoralen, 3-10 weight Serve and 3-10 parts by weight of jellyfish. 如請求項2所記載之用於治療尖銳濕疣的中藥組合物,其中該用於治療尖銳濕疣的中藥組合物是由下述組分製備而成:8-15重量份之木鱉子、7-15重量份之土貝母、9-13重量份之千金子、5-10重量份之紫草、6-12重量份之蒼耳子、8-12重量份之補骨脂、4-9重量份之斑蝥及5-8重量份之海螵蛸。 The traditional Chinese medicine composition for treating condyloma acuminata according to claim 2, wherein the traditional Chinese medicine composition for treating condyloma acuminatum is prepared from the following components: 8-15 parts by weight of psyllium, 7- 15 parts by weight of Fritillaria, 9-13 parts by weight of gold, 5-10 parts by weight of comfrey, 6-12 parts by weight of Xanthium, 8-12 parts by weight of psoralen, 4-9 weight Serve and 5-8 parts by weight of sea bream. 一種用於治療尖銳濕疣的製劑,該用於治療尖銳濕疣的製劑包括如請求項1至3中任一項所記載之用於治療尖銳濕疣的中藥組合物和可藥用輔料,該可藥用輔料包括碳酸鹽、強鹼性氫氧化物和生石灰的混合物, 該碳酸鹽、該強鹼性氫氧化物和該生石灰的質量比為(1-5):(0.01-0.1):(1-5)。 A preparation for treating condyloma acuminata, the preparation for treating condyloma acuminata, comprising the traditional Chinese medicine composition for treating condyloma acuminata according to any one of claims 1 to 3, and a pharmaceutically acceptable excipient, the medicinal preparation Excipients include a mixture of carbonates, strong alkaline hydroxides, and quicklime. The mass ratio of the carbonate, the strong alkali hydroxide and the quicklime is (1-5): (0.01 - 0.1): (1-5). 如請求項4所記載之用於治療尖銳濕疣的製劑,其中該可藥用輔料還包括水楊酸及/或白凡士林。 The preparation for treating condyloma acuminata according to claim 4, wherein the pharmaceutically acceptable excipient further comprises salicylic acid and/or white petrolatum. 一種製備用於治療尖銳濕疣的製劑的製備方法,該製備方法包括以下步驟:步驟S1:將木鱉子、千金子、海螵蛸、土貝母、斑蝥粉碎後過1000網目細篩,篩成細粉;步驟S2:將紫草、蒼耳子和補骨脂加入溶劑浸泡8-12天,取濾液濃縮至膏狀液備用;以及步驟S3:向步驟S1製得的細粉中加入步驟S2製得的膏狀液,濃縮至稠膏狀液,加入預處理過的可藥用輔料,即得用於治療尖銳濕疣的製劑。 A preparation method for preparing a preparation for treating condyloma acuminatum, the preparation method comprising the following steps: Step S1: pulverizing wood scorpion, sapling, sea bream, earth fritillary, and scutellaria, and then sieving through 1000 mesh mesh. Fine powder; Step S2: immersing comfrey, Xanthium and psoralen in a solvent for 8-12 days, taking the filtrate to concentrate to a paste solution; and Step S3: adding step S2 to the fine powder obtained in step S1 The prepared cream liquid is concentrated to a thick paste liquid, and a pretreated pharmaceutically acceptable adjuvant is added to obtain a preparation for treating condyloma acuminatum. 如請求項6所記載之製備用於治療尖銳濕疣的製劑的製備方法,其中該可藥用輔料的預處理為將碳酸鹽、強鹼性氫氧化物和生石灰放入容器內,邊向容器內加水邊攪拌均勻,靜止48-90小時即可入藥。 The preparation method for preparing a preparation for treating condyloma acuminata according to claim 6, wherein the medicinal auxiliary material is pretreated by placing a carbonate, a strong alkaline hydroxide and quicklime into the container and into the container. Stir well with water and administer for 48-90 hours. 如請求項7所記載之製備用於治療尖銳濕疣的製劑的製備方法,其中該碳酸鹽為碳酸鈉及/或碳酸鉀,該強鹼性氫氧化物為氫氧化鈉及/或氫氧化鉀。 The preparation method for preparing a preparation for treating condyloma acuminata according to claim 7, wherein the carbonate is sodium carbonate and/or potassium carbonate, and the strong alkaline hydroxide is sodium hydroxide and/or potassium hydroxide. 如請求項6所記載之製備用於治療尖銳濕疣的製劑的製備方法,其中該步驟S2為將紫草、蒼耳子和補骨脂浸泡於濃度為75%(v/v)的乙醇中,密閉浸泡8-12天,去除濾渣後的濾液減壓濃縮至稠膏狀液。 The preparation method for preparing a preparation for treating condyloma acuminata according to claim 6, wherein the step S2 is: immersing comfrey, Xanthium and psoralen in ethanol having a concentration of 75% (v/v), The mixture was immersed for 8-12 days, and the filtrate after removing the residue was concentrated under reduced pressure to a thick paste. 如請求項8所記載之製備用於治療尖銳濕疣的製劑的製備方法,其中該用於治療尖銳濕疣的製劑為塗抹劑、乳膏劑、軟膏劑或貼劑。 A preparation method for preparing a preparation for treating condyloma acuminata according to claim 8, wherein the preparation for treating condyloma acuminata is an applicator, a cream, an ointment or a patch.
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