CN104490991A - Traditional Chinese medicine composition for treating HPV papilloma virus as well as preparation method and preparation thereof - Google Patents
Traditional Chinese medicine composition for treating HPV papilloma virus as well as preparation method and preparation thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a traditional Chinese medicine composition for treating HPV papilloma virus as well as a preparation method and a preparation thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-30 parts of semen momordicae, 1-30 parts of rhizoma bolbostemmae, 1-30 parts of moleplant seed, 1-20 parts of radix arnebiae seu lithospermi, 1-20 parts of cocklebur fruit, 1-18 parts of fructus psoraleae, 1-15 parts of Chinese blister beetle and 1-15 parts of ossa sepiae. The traditional Chinese medicine composition disclosed by the invention has the advantages of causing small pain feeling to a patient, being good in effect, causing no recurrence, causing no scars and being small in toxic and side effects when being used for treating a HPV papilloma virus disease, especially for treating condyloma acuminate.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be particularly used for the treatment of the pharmaceutical composition of the diseases such as the condyloma acuminatum caused by HPV parillomarvirus infections, the invention still further relates to preparation method and the preparation thereof of this Chinese medicine composition.
Background technology
Condyloma acuminatum is also known as genital wart, and genital wart etc., be infect by people HPV human papillomavirus HPV a kind of sexually transmitted disease (STD) caused, pathogen is HPV, belongs to the HPV Papillomavirus of papovaviridae.Found that more than 90 plant hypotype so far, wherein relevant to condyloma acuminatum have more than 30 to plant, mainly HPV-6,11,16,18 types.
HPV is survival and reproduction under moist thermal environment easily, and condyloma acuminatum is generally apt to occur in the mucocutaneous intersection of genital area, and male is more common in coronary sulcus, frenulum of prepuce, glans penis, urethral orifice and stem, the position such as anus and rectum, women is more common in large nympha, the positions such as vaginal orifice.The places such as non-genital area sees axillary fossa, omphalos, breast, finger.From the beginning of for little and soft, pale red pimple, increases gradually, and merge mutually and form surface irregularity, moistening mamillary or cauliflower form projection, erosion can occur, sepage, easily hemorrhage.Symptom is general most without any subjective symptoms, and small part has pruritus, causalgia, leucorrhoea grow in quantity etc., and anus, condyloma acuminatum of rectum can have pain and tenesmus.Pathological tissue, keratinization of epidermis is incomplete, remarkable acanthosis and papillomatous hyperplasia; The physaliphore of granular layer and spinous layer top visible features, the light dye of endochylema, there are the core of engrain greatly in central authorities.Corium edema, blood capillary expands, and has chronic inflammatory cell to infiltrate around.
Current western medical treatment condyloma acuminatum disease mainly comprises:
(1), physiotherapy: laser therapy, cold therapy, coagulation or treatment of fulgerizing, though such therapy effect is good, simple to operate; But during treatment, patient pain feels strong, and relapse rate is quite high, because condyloma acuminatum is caused by HPV virus, is difficult to be completely cured by physiotherapy.
(2) topical medications:
1. 0.5% podophyllinic acid lactone tincture, 0.5% podophyllotoxin tincture, external.
2. 50% trichloroacetic acid solution, external.
3. 5-fluorouracil (5-fu) ointment, external.
4. 5% imiquimod frost external, these medicines can make wart body disappear, but have recurrence possibility.
Summary of the invention
Exist cannot effect a radical cure and the high problem of relapse rate to solve in prior art the medicine for the treatment of HPV human papillomavirus disease, the invention provides one and treat HPV human papillomavirus disease, especially the Chinese medicine composition of condyloma acuminatum, it has, and to allow patient keenly feel little and effective, not easily recur, do not stay cicatrix, the advantage that toxic and side effects is little.
The present invention and then provide above-mentioned and be used for the treatment of preparation of HPV human papillomavirus Chinese medicine composition and preparation method thereof.
The technical solution used in the present invention is as follows:
Be used for the treatment of a Chinese medicine composition for HPV human papillomavirus, described in be used for the treatment of HPV human papillomavirus Chinese medicine composition be prepared from by following component:
Semen Momordicae 1-30 weight portion, Rhizoma Bolbostematis 1-30 weight portion, Semen Euphorbiae 1-30 weight portion,
Radix Arnebiae (Radix Lithospermi) 1-20 weight portion, Fructus Xanthii 1-20 weight portion, Fructus Psoraleae 1-18 weight portion,
Mylabris 1-15 weight portion, Endoconcha Sepiae 1-15 weight portion.
Preferably, the Chinese medicine composition being used for the treatment of HPV human papillomavirus described in is prepared from by following component:
Semen Momordicae 5-18 weight portion, Rhizoma Bolbostematis 5-15 weight portion, Semen Euphorbiae 5-15 weight portion,
Radix Arnebiae (Radix Lithospermi) 3-15 weight portion, Fructus Xanthii 5-15 weight portion, Fructus Psoraleae 8-13 weight portion,
Mylabris 3-10 weight portion, Endoconcha Sepiae 3-10 weight portion.
Further preferably, the Chinese medicine composition being used for the treatment of HPV human papillomavirus described in is prepared from by following component:
Semen Momordicae 8-15 weight portion, Rhizoma Bolbostematis 7-15 weight portion, Semen Euphorbiae 9-13 weight portion,
Radix Arnebiae (Radix Lithospermi) 5-10 weight portion, Fructus Xanthii 6-12 weight portion, Fructus Psoraleae 8-12 weight portion,
Mylabris 4-9 weight portion, Endoconcha Sepiae 5-8 weight portion.
One is used for the treatment of HPV papillomatosis toxin preparation, comprise the described Chinese medicine composition being used for the treatment of HPV human papillomavirus and pharmaceutically acceptable auxiliaries, described pharmaceutically acceptable auxiliaries comprises the mixture of carbonate, strong alkali hydroxides and quicklime, and described carbonate, strong alkali hydroxides and Lime Quality are than being (1-5): (1-5): (0.01-0.1).Described pharmaceutically acceptable auxiliaries also comprises salicylic acid and/or white vaseline.
Described in be used for the treatment of the preparation method of HPV papillomatosis toxin preparation, described method comprises the steps:
S1, by Semen Momordicae, Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, Radix Arnebiae (Radix Lithospermi), Fructus Xanthii and Fructus Psoraleae add solvent soaking 8-12 days, and getting soak, to be concentrated into paste for subsequent use;
The paste liquid adding step S3 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds pretreated pharmaceutic adjuvant, must be used for the treatment of HPV papillomatosis toxin preparation.
The pretreatment of described pharmaceutic adjuvant is: carbonate, strong alkali hydroxides and quicklime are put into container, stirs while add waterside in container, within static 48-90 hour, can be used as medicine.Described carbonate is sodium carbonate and/or potassium carbonate, and described strong alkali hydroxides is sodium hydroxide and/or potassium hydroxide.
Preferably, described step S2 is by Radix Arnebiae (Radix Lithospermi), and it is in the ethanol of 75% (v/v) that Fructus Xanthii and Fructus Psoraleae are soaked in concentration, airtight immersion 8-12 days, removes the filtrate reduced in volume after filtering residue to paste liquid.The consumption of ethanol does not specially require, as long as can not have Radix Arnebiae (Radix Lithospermi), Fructus Xanthii volume Fructus Psoraleae.Frequent employing be according to every 10g Radix Arnebiae (Radix Lithospermi), 10g Fructus Xanthii and 10g Fructus Psoraleae use 40-60ml proportion of ethanol are soaked.
The described HPV of being used for the treatment of papillomatosis toxin preparation is liniment, ointment, ointment or posts agent.
The beneficial effect that technical scheme provided by the invention is brought is:
(1) monarch drug selected of the Chinese medicine composition of the HPV of being used for the treatment of human papillomavirus of the present invention is Semen Momordicae, Rhizoma Bolbostematis and Semen Euphorbiae, and ministerial drug is Radix Arnebiae (Radix Lithospermi), Fructus Xanthii and Fructus Psoraleae three taste medicine, and adjuvant drug is Mylabris and Endoconcha Sepiae two taste medicine.Effect of this 8 taste medicine is as follows:
Monarch drug: Semen Momordicae, bitter in the mouth, micro-sweet, warm in nature, matter poison is attacked loose, has mass dissipating and swelling eliminating, chases after wind analgesic therapy, the effect of detoxicating and killing parasites; Rhizoma Bolbostematis, bitter in the mouth, cool in nature, there is antivirus action, effect that eliminating stagnation is drawn out pus by applying a plaster to the affected part; Semen Euphorbiae, acrid in the mouth, warm in nature, there is removing blood stasis Xiao Disorder, effect of removing toxic substances parasite killing.
Ministerial drug: Radix Arnebiae (Radix Lithospermi), bitter in the mouth, cold in nature, have removing heat from blood rash, clearing away heat-damp and promoting diuresis, effect of removing toxic substances, has antiinflammatory, antitumor action; Fructus Xanthii, bitter in the mouth, sweet, pungent, warm in nature, there is removing damp and stopping pain, effect of dispelling wind for relieving itching, have resisting pathogenic microbes effect; Fructus Psoraleae, acrid in the mouth, bitter, warm in nature, fragrant dry falling is held back, and has antitumor action, has the effect to Skin Cell pigment.
Adjuvant drug: Mylabris, acrid in the mouth, warm in nature, there is resisting pathogenic microbes effect, have effect of counteracting toxic substances phagedenoma, removing blood stasis eliminating stagnation; Endoconcha Sepiae, salty in the mouth, puckery, warm in nature, external has effect of removing dampness sore.
(2) medicine that makes of the present invention is also that inventor seeks through a large amount of experiments and creative work, medicine is made to be sodium carbonate, sodium hydroxide and quicklime, be used as medicine after static 48-90 hour after its mixing, the monarch and his subjects that can effectively be in harmonious proportion help 8 taste medicines, produce synergism and promote medicine Transdermal absorption on wart body pathological tissues.All medicines share, and have and decompose wart body horny layer.Effect of removing the necrotic tissue and promoting granulation, is clinically used for the treatment of the diseases such as condyloma acuminatum caused by HPV viral infection.
(3) HPV of being used for the treatment of human papillomavirus compositions of the present invention selects natural Chinese medicine to be that raw material is made into liniment, ointment, ointment or posts agent according to Traditional Chinese medical theory, applying at affected part, is one of effective ways of the condyloma acuminatum disease caused by treatment HPV viral infection.Clinical trial proves, use 1-2 the course for the treatment of pathological tissues can be separated with normal structure, virus is killed, and wart body comes off disappearance naturally, recovery from illness this.Keenly feel in therapeutic process little and effective, do not recur, do not stay cicatrix, toxic and side effects is little, overcomes the shortcomings such as the deficiency of existing therapeutic method of traditional Chinese and western medicine.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below embodiment of the present invention is described further in detail.
Embodiment 1
Be used for the treatment of HPV human papillomavirus ointment to be prepared from by following component.
Semen Momordicae 15g, Rhizoma Bolbostematis 12g, Semen Euphorbiae 5g, Radix Arnebiae (Radix Lithospermi) 20g, Fructus Xanthii 10g, Fructus Psoraleae 10g, Mylabris 3g, Endoconcha Sepiae 5g.
Adjuvant 20g prepared by pharmaceutic adjuvant: step S0, salicylic acid 8g, white vaseline 5g.
The preparation method of the above-mentioned HPV of being used for the treatment of human papillomavirus ointment comprises the steps:
S0, pharmaceutic adjuvant method for making: take sodium carbonate 100g, quicklime (enter pulverizer and be broken into powder) 100g, sodium hydroxide 1g, aquae destillata 500g.Ratio is 1: 1: 0.01: 5.Make sodium carbonate, quicklime, sodium hydroxide puts into container, adds aquae destillata, while mix with wooden implements, makes sodium carbonate, quicklime, sodium hydroxide generation chemical reaction, becomes scattered paste shape, coolly to dry in the air, leaves standstill 72 and can be used as medicine for adjuvant.
S1, get Semen Momordicae (shelling), Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris (decaptitate, remove wing) pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, get deal Radix Arnebiae (Radix Lithospermi), Fructus Xanthii, Fructus Psoraleae are soaked in 75% (v/v) ethanol, and according to every 10g Radix Arnebiae (Radix Lithospermi), 10g Fructus Xanthii, 10g Fructus Psoraleae, need soak by 60ml proportion of ethanol, airtight immersion 8 days, residue obtained liquid, is evaporated to paste for subsequent use.
The paste liquid adding step S2 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds S1 pharmaceutic adjuvant 20g, salicylic acid 8g, white vaseline 5g, is obtainedly used for the treatment of HPV human papillomavirus ointment.
Embodiment 2
Be used for the treatment of HPV human papillomavirus liniment to be prepared from by following component.
Semen Momordicae 8g, Rhizoma Bolbostematis 10g, Semen Euphorbiae 9g, Radix Arnebiae (Radix Lithospermi) 3g, Fructus Xanthii 9g, Fructus Psoraleae 8g, Mylabris 3g, Endoconcha Sepiae 4g.
Adjuvant 10g prepared by pharmaceutic adjuvant: step S0, salicylic acid 7g.
The preparation method of the above-mentioned HPV of being used for the treatment of human papillomavirus liniment comprises the steps:
S0, pharmaceutic adjuvant method for making: take sodium carbonate 100g, quicklime (enter pulverizer and be broken into powder) 500g, sodium hydroxide 10g, aquae destillata 2500g.Ratio is 1: 5: 0.1: 5.Make sodium carbonate, quicklime, sodium hydroxide puts into container, adds aquae destillata, while mix with wooden implements, makes sodium carbonate, quicklime, sodium hydroxide generation chemical reaction, becomes scattered paste shape, coolly to dry in the air, spent for three nights and can be used as medicine for adjuvant.
S1, get deal Semen Momordicae (shelling), Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris (decaptitate, remove wing) pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, get deal Radix Arnebiae (Radix Lithospermi), Fructus Xanthii, Fructus Psoraleae are soaked in 75% (v/v) ethanol, and according to every 10g Radix Arnebiae (Radix Lithospermi), 10g Fructus Xanthii, 10g Fructus Psoraleae, need use 50ml soak with ethanol, and airtight immersion 8 days, residue obtained liquid, is evaporated to paste for subsequent use.
The paste liquid adding step S2 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds S0 pharmaceutic adjuvant 10g, salicylic acid 7g, is obtainedly used for the treatment of HPV human papillomavirus liniment.
Embodiment 3
Be used for the treatment of HPV human papillomavirus ointment to be prepared from by following component.
Semen Momordicae 28g, Rhizoma Bolbostematis 15g, Semen Euphorbiae 13g, Radix Arnebiae (Radix Lithospermi) 20g, Fructus Xanthii 20g, Fructus Psoraleae 18g, Mylabris 5g, Endoconcha Sepiae 8g.
Adjuvant 30g prepared by pharmaceutic adjuvant: step S0, salicylic acid 10g, white vaseline 10g.
The preparation method of the above-mentioned HPV of being used for the treatment of human papillomavirus ointment comprises the steps:
S0, pharmaceutic adjuvant method for making: take sodium carbonate 500g, quicklime (enter pulverizer and be broken into powder) 100g, sodium hydroxide 5g, aquae destillata 2500g.Ratio is 5: 1: 0.05: 5.Make sodium carbonate, quicklime, sodium hydroxide puts into container, adds aquae destillata, while mix with wooden implements, makes sodium carbonate, quicklime, sodium hydroxide generation chemical reaction, becomes scattered paste shape, coolly to dry in the air, spent for three nights and can be used as medicine for adjuvant.
S1, get deal Semen Momordicae (shelling), Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris (decaptitate, remove wing) pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, get deal Radix Arnebiae (Radix Lithospermi), Fructus Xanthii, Fructus Psoraleae are soaked in 75% (v/v) ethanol, according to every 10g Radix Arnebiae (Radix Lithospermi), 10g Fructus Xanthii, 10g Fructus Psoraleae, need soak by 40ml proportion of ethanol, airtight immersion 12 days, residue obtained liquid, is evaporated to paste for subsequent use.
The paste liquid adding step S2 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds S1 pharmaceutic adjuvant 30g, salicylic acid 10g, white vaseline 10g, is obtainedly used for the treatment of HPV human papillomavirus ointment.
Embodiment 4
Be used for the treatment of HPV human papillomavirus ointment to be prepared from by following component.
Semen Momordicae 18g, Rhizoma Bolbostematis 15g, Semen Euphorbiae 15g, Radix Arnebiae (Radix Lithospermi) 8g, Fructus Xanthii 12g, Fructus Psoraleae 10g, Mylabris 5g, Endoconcha Sepiae 6g.
Adjuvant 15g prepared by pharmaceutic adjuvant: step S0, salicylic acid 10g, white vaseline 6g.
The preparation method of the above-mentioned HPV of being used for the treatment of human papillomavirus ointment comprises the steps:
S0, pharmaceutic adjuvant method for making: take sodium carbonate 100g, quicklime (enter pulverizer and be broken into powder) 100g, sodium hydroxide 1g, aquae destillata 500g.Ratio is 1: 1: 0.01: 5.Make sodium carbonate, quicklime, sodium hydroxide puts into container, adds aquae destillata, while mix with wooden implements, makes sodium carbonate, quicklime, sodium hydroxide generation chemical reaction, becomes scattered paste shape, coolly to dry in the air, spent for three nights and can be used as medicine for adjuvant.
S1, get deal Semen Momordicae (shelling), Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris (decaptitate, remove wing) pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, get deal Radix Arnebiae (Radix Lithospermi), Fructus Xanthii, Fructus Psoraleae are soaked in 75% (v/v) ethanol, and according to every 10g Radix Arnebiae (Radix Lithospermi), 10g Fructus Xanthii, 10g Fructus Psoraleae, need soak by 50ml proportion of ethanol, airtight immersion 10 days, residue obtained liquid, is evaporated to paste for subsequent use.
The paste liquid adding step S2 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds S0 pharmaceutic adjuvant 15g, salicylic acid 10g, white vaseline 6g, is obtainedly used for the treatment of HPV human papillomavirus ointment.
Embodiment 5
Be used for the treatment of HPV human papillomavirus patch to be prepared from by following component.
Semen Momordicae 10g, Rhizoma Bolbostematis 5g, Semen Euphorbiae 7g, Radix Arnebiae (Radix Lithospermi) 15g, Fructus Xanthii 15g, Fructus Psoraleae 13g, Mylabris 4g, Endoconcha Sepiae 5g.
Adjuvant 10g prepared by pharmaceutic adjuvant: step S0.
The preparation method of the above-mentioned HPV of being used for the treatment of human papillomavirus ointment comprises the steps:
S0, pharmaceutic adjuvant method for making: take potassium carbonate 100g, quicklime (enter pulverizer and be broken into powder) 100g, potassium hydroxide 1g, aquae destillata 500g.Ratio is 1: 1: 0.01: 5.Make potassium carbonate, quicklime, potassium hydroxide puts into container, adds aquae destillata, while mix with wooden implements, makes sodium carbonate, quicklime, sodium hydroxide generation chemical reaction, becomes scattered paste shape, coolly to dry in the air, spent for three nights and can be used as medicine for adjuvant.
S1, get deal Semen Momordicae (shelling), Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris (decaptitate, remove wing) pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, get deal Radix Arnebiae (Radix Lithospermi), Fructus Xanthii, Fructus Psoraleae are soaked in 75% (v/v) ethanol, and according to every 10g Radix Arnebiae (Radix Lithospermi), 10g Fructus Xanthii, 10g Fructus Psoraleae, need soak by 60ml proportion of ethanol, airtight immersion 8 days, residue obtained liquid, is evaporated to paste for subsequent use.
The paste liquid adding step S2 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds S0 pharmaceutic adjuvant 10g, is obtainedly used for the treatment of HPV human papillomavirus patch.
Embodiment 6
Be used for the treatment of HPV human papillomavirus ointment to be prepared from by following component.
Semen Momordicae 25g, Rhizoma Bolbostematis 20g, Semen Euphorbiae 15g, Radix Arnebiae (Radix Lithospermi) 15g, Fructus Xanthii 12g, Fructus Psoraleae 12g, Mylabris 9g, Endoconcha Sepiae 10g.
Adjuvant 30g prepared by pharmaceutic adjuvant: step S0, salicylic acid 20g, white vaseline 15g.
The preparation method of the above-mentioned HPV of being used for the treatment of human papillomavirus ointment comprises the steps:
S0, pharmaceutic adjuvant method for making: take sodium carbonate 100g, quicklime (enter pulverizer and be broken into powder) 100g, potassium hydroxide 1g, aquae destillata 500g.Ratio is 1: 1: 0.01: 5.Make sodium carbonate, quicklime, potassium hydroxide puts into container, adds aquae destillata, while mix with wooden implements, makes sodium carbonate, quicklime, sodium hydroxide generation chemical reaction, becomes scattered paste shape, coolly to dry in the air, spent for three nights and can be used as medicine for adjuvant.
S1, get deal Semen Momordicae (shelling), Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris (decaptitate, remove wing) pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, get deal Radix Arnebiae (Radix Lithospermi), Fructus Xanthii, Fructus Psoraleae are soaked in 75% (v/v) ethanol, and according to every 10g Radix Arnebiae (Radix Lithospermi), 10g Fructus Xanthii, 10g Fructus Psoraleae, need soak by 60ml proportion of ethanol, airtight immersion 8 days, residue obtained liquid, is evaporated to paste for subsequent use.
The paste liquid adding step S2 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds S0 pharmaceutic adjuvant 30g, salicylic acid 20g, white vaseline 15g, is obtainedly used for the treatment of HPV human papillomavirus ointment.
Embodiment 7
Be used for the treatment of HPV human papillomavirus ointment to be prepared from by following component.
Semen Momordicae 1g, Rhizoma Bolbostematis 30g, Semen Euphorbiae 10g, Radix Arnebiae (Radix Lithospermi) 10g, Fructus Xanthii 6g, Fructus Psoraleae 15g, Mylabris 15g, Endoconcha Sepiae 10g.
Adjuvant 20g prepared by pharmaceutic adjuvant: step S0, salicylic acid 10g, white vaseline 20g.
Its preparation method is with embodiment 6.
Embodiment 8
Be used for the treatment of HPV human papillomavirus ointment to be prepared from by following component.
Semen Momordicae 30g, Rhizoma Bolbostematis 1g, Semen Euphorbiae 30g, Radix Arnebiae (Radix Lithospermi) 5g, Fructus Xanthii 1g, Fructus Psoraleae 15g, Mylabris 10g, Endoconcha Sepiae 15g.
Adjuvant 25g prepared by pharmaceutic adjuvant: step S0, salicylic acid 15g, white vaseline 15g.
Its preparation method is with embodiment 6.
Embodiment 9
Be used for the treatment of HPV human papillomavirus liniment to be prepared from by following component.
Semen Momordicae 5g, Rhizoma Bolbostematis 7g, Semen Euphorbiae 1g, Radix Arnebiae (Radix Lithospermi) 1g, Fructus Xanthii 5g, Fructus Psoraleae 1g, Mylabris 7g, Endoconcha Sepiae 3g.
Adjuvant 15g prepared by pharmaceutic adjuvant: step S0, salicylic acid 15g, white vaseline 20g.
Its preparation method is with embodiment 2.
Embodiment 10
Be used for the treatment of HPV human papillomavirus liniment to be prepared from by following component.
Semen Momordicae 7g, Rhizoma Bolbostematis 25g, Semen Euphorbiae 20g, Radix Arnebiae (Radix Lithospermi) 6g, Fructus Xanthii 5g, Fructus Psoraleae 6g, Mylabris 1g, Endoconcha Sepiae 7g.
Adjuvant 15g prepared by pharmaceutic adjuvant: step S0, salicylic acid 15g, white vaseline 20g.
Its preparation method is with embodiment 2.
The invention described above embodiment sequence number, just to describing, does not represent the quality of embodiment.
Condyloma acuminatum clinical trial
The applicant of the application have chosen condyloma acuminatum patients with mild, each 50 examples of severe patient, adopts the HPV human papillomavirus ointment that is used for the treatment of of the embodiment of the present invention 4 to carry out clinical trial.
Wherein condyloma acuminatum patients with mild refers to: patient medical history 1-8 month, and skin lesion is from the beginning of for little and soft, and pale red pimple, merge mutually and form surface irregularity, moistening mamillary or cauliflower form projection, erosion can occur, sepage, easily hemorrhage.
Severe patients with condyloma acuminatum refers to: patient's medical history more than 1 year, and pale red pimple obviously increases and increases, and merges mutually and forms mamillary or cauliflower form, and rotten to the corn, sepage is obvious, and easily hemorrhage, overlong time forms huge condyloma acuminatum.
The therapeutic modality that condyloma acuminatum patients with mild adopts is as follows:
Get medical proof fabric one piece; the circular hole equal with pathological tissues is cut with curved scissors; and be affixed on affected part and expose wart body and protect surrounding health tissue; then apply and be used for the treatment of HPV human papillomavirus ointment on wart body; drug of topical application thickness is 1.5mm; cut medical proof fabric one piece subsides lid again fix and secure, within 2 days, change dressings once.After seeing that the residual body of wart body is separated with normal structure and comes off, stop changing dressings, then scrape off the residual body of wart body with scalpel.Apply YUSHIZHI RUANGAO and protect wound, recovery from illness in three to five days.As scraped off the residual body of wart body without scalpel, allow its self falling disappear also can, general this lecture wart precursor virus kills, the Lock-out in about a week of the residual body of wart body.Do not stay cicatrix.
The therapeutic modality that sharp-pointed moist unit weight patient adopts is identical with patients with mild.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. be used for the treatment of a Chinese medicine composition for HPV human papillomavirus, it is characterized in that, described in be used for the treatment of HPV human papillomavirus Chinese medicine composition be prepared from by following component:
Semen Momordicae 1-30 weight portion, Rhizoma Bolbostematis 1-30 weight portion, Semen Euphorbiae 1-30 weight portion,
Radix Arnebiae (Radix Lithospermi) 1-20 weight portion, Fructus Xanthii 1-20 weight portion, Fructus Psoraleae 1-18 weight portion,
Mylabris 1-15 weight portion, Endoconcha Sepiae 1-15 weight portion.
2. the Chinese medicine composition being used for the treatment of HPV human papillomavirus according to claim 1, is characterized in that, described in be used for the treatment of HPV human papillomavirus Chinese medicine composition be prepared from by following component:
Semen Momordicae 5-18 weight portion, Rhizoma Bolbostematis 5-15 weight portion, Semen Euphorbiae 5-15 weight portion,
Radix Arnebiae (Radix Lithospermi) 3-15 weight portion, Fructus Xanthii 5-15 weight portion, Fructus Psoraleae 8-13 weight portion,
Mylabris 3-10 weight portion, Endoconcha Sepiae 3-10 weight portion.
3. the Chinese medicine composition being used for the treatment of HPV human papillomavirus according to claim 2, is characterized in that, described in be used for the treatment of HPV human papillomavirus Chinese medicine composition be prepared from by following component:
Semen Momordicae 8-15 weight portion, Rhizoma Bolbostematis 7-15 weight portion, Semen Euphorbiae 9-13 weight portion,
Radix Arnebiae (Radix Lithospermi) 5-10 weight portion, Fructus Xanthii 6-12 weight portion, Fructus Psoraleae 8-12 weight portion,
Mylabris 4-9 weight portion, Endoconcha Sepiae 5-8 weight portion.
4. one kind is used for the treatment of HPV papillomatosis toxin preparation, it is characterized in that, the described HPV papillomatosis toxin preparation that is used for the treatment of comprises the arbitrary described Chinese medicine composition being used for the treatment of HPV human papillomavirus of claim 1-3 and pharmaceutically acceptable auxiliaries, described pharmaceutically acceptable auxiliaries comprises the mixture of carbonate, strong alkali hydroxides and quicklime, and described carbonate, strong alkali hydroxides and Lime Quality are than being (1-5): (1-5): (0.01-0.1).
5. be used for the treatment of a HPV papillomatosis toxin preparation described in claim 4, it is characterized in that, described pharmaceutically acceptable auxiliaries also comprises salicylic acid and/or white vaseline.
6. be used for the treatment of a preparation method for HPV papillomatosis toxin preparation described in claim 4 or 5, it is characterized in that, described method comprises the steps:
S1, by Semen Momordicae, Semen Euphorbiae, Endoconcha Sepiae, Rhizoma Bolbostematis, Mylabris pulverize after cross 1000 order dusting covers, sieve into fine powder;
S2, Radix Arnebiae (Radix Lithospermi), Fructus Xanthii and Fructus Psoraleae add solvent soaking 8-12 days, and getting soak, to be concentrated into paste for subsequent use;
The paste liquid adding step S3 obtained in S3, the fine powder prepared to step S1 is concentrated into paste, adds pretreated pharmaceutic adjuvant, must be used for the treatment of HPV papillomatosis toxin preparation.
7. want according to right the preparation method being used for the treatment of HPV papillomatosis toxin preparation described in 6, it is characterized in that:
The pretreatment of described pharmaceutic adjuvant is: carbonate, strong alkali hydroxides and quicklime are put into container, stirs while add waterside in container, within static 48-90 hour, can be used as medicine.
8. want according to right the preparation method being used for the treatment of HPV papillomatosis toxin preparation described in 7, it is characterized in that:
Described carbonate is sodium carbonate and/or potassium carbonate, and described strong alkali hydroxides is sodium hydroxide and/or potassium hydroxide.
9. be used for the treatment of the preparation method of HPV papillomatosis toxin preparation according to claim 6, it is characterized in that,
Described step S2 is by Radix Arnebiae (Radix Lithospermi), and it is in the ethanol of 75% (v/v) that Fructus Xanthii and Fructus Psoraleae are soaked in concentration, airtight immersion 8-12 days, removes the filtrate reduced in volume after filtering residue to paste liquid.
10. be used for the treatment of the preparation method of HPV papillomatosis toxin preparation according to claim 8, it is characterized in that,
The described HPV of being used for the treatment of papillomatosis toxin preparation is liniment, ointment, ointment or posts agent.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410781645.3A CN104490991B (en) | 2014-12-16 | 2014-12-16 | For treating HPV papillomavirus Chinese medicine composition, preparation method and preparation |
| HK15108372.4A HK1207590A1 (en) | 2014-12-16 | 2015-08-28 | A composition of chinese medicine for treating hpv papillomavirus, as well as its preparation method and formulation hpv |
| PCT/CN2015/097249 WO2016095772A1 (en) | 2014-12-16 | 2015-12-14 | Traditional chinese medicine composition for treating human papillomavirus, preparation method and formulation thereof |
| TW104142316A TWI594761B (en) | 2014-12-16 | 2015-12-16 | A composition of chinese medicine for treating genital wart, its preparation method and formulation |
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| CN201410781645.3A CN104490991B (en) | 2014-12-16 | 2014-12-16 | For treating HPV papillomavirus Chinese medicine composition, preparation method and preparation |
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| CN104490991B CN104490991B (en) | 2018-11-06 |
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| HK (1) | HK1207590A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016095772A1 (en) * | 2014-12-16 | 2016-06-23 | 邓圣平 | Traditional chinese medicine composition for treating human papillomavirus, preparation method and formulation thereof |
| CN105920455A (en) * | 2016-06-28 | 2016-09-07 | 解恒珍 | Chinese medicinal preparation for treating verrucosis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695659A (en) * | 2004-05-13 | 2005-11-16 | 余炜 | Method of preparing medicine for treating condyloma acuminatum |
| CN101204435A (en) * | 2007-12-13 | 2008-06-25 | 凌志贤 | Tincture medicine for infectious molluscum |
| CN103919838A (en) * | 2014-05-04 | 2014-07-16 | 邓圣平 | Six-ingredient composition for removing wart, preparation method and preparation thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490991B (en) * | 2014-12-16 | 2018-11-06 | 邓圣平 | For treating HPV papillomavirus Chinese medicine composition, preparation method and preparation |
-
2014
- 2014-12-16 CN CN201410781645.3A patent/CN104490991B/en not_active Expired - Fee Related
-
2015
- 2015-08-28 HK HK15108372.4A patent/HK1207590A1/en unknown
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695659A (en) * | 2004-05-13 | 2005-11-16 | 余炜 | Method of preparing medicine for treating condyloma acuminatum |
| CN101204435A (en) * | 2007-12-13 | 2008-06-25 | 凌志贤 | Tincture medicine for infectious molluscum |
| CN103919838A (en) * | 2014-05-04 | 2014-07-16 | 邓圣平 | Six-ingredient composition for removing wart, preparation method and preparation thereof |
Non-Patent Citations (4)
| Title |
|---|
| 司富春等: ""中医治疗尖锐湿疣用药规律分析"", 《中医学报》 * |
| 徐宜厚: "《徐宜厚皮肤病用药心得十讲》", 31 January 2013 * |
| 朱德生: "《皮肤病学》", 31 October 1959 * |
| 贾金涛: ""中医药治疗扁平疣的临床体会"", 《内蒙古中医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016095772A1 (en) * | 2014-12-16 | 2016-06-23 | 邓圣平 | Traditional chinese medicine composition for treating human papillomavirus, preparation method and formulation thereof |
| CN105920455A (en) * | 2016-06-28 | 2016-09-07 | 解恒珍 | Chinese medicinal preparation for treating verrucosis |
| CN105920455B (en) * | 2016-06-28 | 2019-10-18 | 解恒珍 | A kind of Chinese materia medica preparation for treating verrucosis |
Also Published As
| Publication number | Publication date |
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| CN104490991B (en) | 2018-11-06 |
| HK1207590A1 (en) | 2016-02-05 |
| TW201622737A (en) | 2016-07-01 |
| WO2016095772A1 (en) | 2016-06-23 |
| TWI594761B (en) | 2017-08-11 |
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