CN103393605B - 用于实体瘤的化学栓塞治疗的组合物 - Google Patents

用于实体瘤的化学栓塞治疗的组合物 Download PDF

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Publication number
CN103393605B
CN103393605B CN201310320841.6A CN201310320841A CN103393605B CN 103393605 B CN103393605 B CN 103393605B CN 201310320841 A CN201310320841 A CN 201310320841A CN 103393605 B CN103393605 B CN 103393605B
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China
Prior art keywords
water
polymer
composition according
microballoon
particle
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Expired - Lifetime
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CN201310320841.6A
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English (en)
Chinese (zh)
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CN103393605A (zh
Inventor
A·L·刘易斯
P·W·斯特拉福德
S·W·莱帕德
B·霍尔
M·V·冈萨雷斯福哈多
P·加西亚
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Boston Scientific Medical Device Ltd
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Biocompatibles UK Ltd
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Priority claimed from GB0305322A external-priority patent/GB0305322D0/en
Application filed by Biocompatibles UK Ltd filed Critical Biocompatibles UK Ltd
Priority claimed from CNA2004800040624A external-priority patent/CN1747721A/zh
Publication of CN103393605A publication Critical patent/CN103393605A/zh
Application granted granted Critical
Publication of CN103393605B publication Critical patent/CN103393605B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00Processes of polymerisation
    • C08F2/12Polymerisation in non-solvents
    • C08F2/14Organic medium
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12Polymers provided for in subclasses C08C or C08F
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/30Introducing nitrogen atoms or nitrogen-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/48Isomerisation; Cyclisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23Carbohydrates
    • A61L2300/232Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00Chemical modification of a polymer
    • C08F2810/30Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
CN201310320841.6A 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物 Expired - Lifetime CN103393605B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03250868 2003-02-12
EP03250868.1 2003-02-12
GB0305322.0 2003-03-07
GB0305322A GB0305322D0 (en) 2003-03-07 2003-03-07 Chemoembolisation
CNA2004800040624A CN1747721A (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800040624A Division CN1747721A (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物

Publications (2)

Publication Number Publication Date
CN103393605A CN103393605A (zh) 2013-11-20
CN103393605B true CN103393605B (zh) 2018-05-29

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Application Number Title Priority Date Filing Date
CN201310320841.6A Expired - Lifetime CN103393605B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201410044028.5A Expired - Lifetime CN103908704B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201210299592.2A Expired - Lifetime CN102895662B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201610844279.0A Expired - Lifetime CN106267325B (zh) 2003-02-12 2004-02-12 一种组合物的生产方法

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CN201410044028.5A Expired - Lifetime CN103908704B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201210299592.2A Expired - Lifetime CN102895662B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201610844279.0A Expired - Lifetime CN106267325B (zh) 2003-02-12 2004-02-12 一种组合物的生产方法

Country Status (9)

Country Link
EP (1) EP1592405B1 (enExample)
JP (2) JP4895802B2 (enExample)
KR (1) KR101157260B1 (enExample)
CN (4) CN103393605B (enExample)
AT (1) ATE396708T1 (enExample)
DE (1) DE602004014101D1 (enExample)
ES (1) ES2308149T3 (enExample)
HK (1) HK1079980B (enExample)
WO (1) WO2004071495A1 (enExample)

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WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
EP2269580A3 (en) * 2004-09-07 2011-11-09 Biocompatibles UK Limited Compositions comprising camptothecins in microspheres
MX2007013914A (es) 2005-05-09 2008-02-22 Biosphere Medical S A Composiciones y metodos que usan microesferas y agentes de contraste no ionicos.
JP5075130B2 (ja) * 2006-01-24 2012-11-14 バイオコンパティブルズ ユーケー リミテッド ポリマー粒子を薬物で負荷する方法
EP1986707A2 (en) 2006-01-30 2008-11-05 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US9107833B2 (en) 2006-06-22 2015-08-18 Biocompatibles Uk Limited Rehydratable pharmaceutical product
EP1985286A1 (en) * 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
JP5302300B2 (ja) * 2007-05-11 2013-10-02 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ アンスラサイクリンの医薬組成物
US20110229572A1 (en) * 2007-08-16 2011-09-22 Biocompatibles Uk Limited Delivery of drug combinations
CN104382862A (zh) 2008-12-02 2015-03-04 生物相容英国有限公司 胰腺肿瘤治疗
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
WO2014035206A2 (ko) 2012-08-31 2014-03-06 중앙대학교 산학협력단 색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법
WO2014152488A2 (en) * 2013-03-15 2014-09-25 Dreher Matthew R Imageable embolic microsphere
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
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WO2016139590A1 (en) * 2015-03-02 2016-09-09 Accurate Medical Therapeutics Ltd. Embolization particulates for occluding a blood vessel
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US20190070332A1 (en) 2016-03-14 2019-03-07 Biocompatibles Uk Limited Oily compositions
CA3021780C (en) 2016-05-04 2020-09-08 Accurate Medical Therapeutics Ltd. Embolization microcatheter head having slitted pattern
EP3541368B1 (en) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Imageable particles, methods of making and methods of use thereof
US11235084B2 (en) 2017-07-13 2022-02-01 Varian Medical Systems, Inc. Embolic microspheres
KR102870709B1 (ko) 2017-11-02 2025-10-16 애커러트 메디컬 테라퓨틱스 엘티디. 필터가 내장된 색전술용 마이크로카테터
WO2020003147A2 (en) 2018-06-29 2020-01-02 Biocompatibles Uk Limited Radiopaque polymers
WO2020198108A1 (en) 2019-03-22 2020-10-01 Biocompatibles Uk Limited Embolic microspheres and methods
CN114173687A (zh) 2019-05-23 2022-03-11 阿克瑞特医学治疗有限公司 用于微球的无回流递送的栓塞导管
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
MX2022010454A (es) * 2020-02-25 2022-09-19 Hepion Pharmaceuticals Inc Uso de analogos de ciclosporina para el tratamiento contra el cancer.
CN114099442B (zh) * 2020-08-25 2024-01-30 复旦大学 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
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Publication number Publication date
ES2308149T3 (es) 2008-12-01
EP1592405A1 (en) 2005-11-09
EP1592405B1 (en) 2008-05-28
CN102895662A (zh) 2013-01-30
KR20050103224A (ko) 2005-10-27
CN106267325B (zh) 2019-09-24
DE602004014101D1 (de) 2008-07-10
HK1079980A1 (en) 2006-04-21
CN106267325A (zh) 2017-01-04
HK1079980B (en) 2008-11-14
ATE396708T1 (de) 2008-06-15
JP5616251B2 (ja) 2014-10-29
JP2006515358A (ja) 2006-05-25
KR101157260B1 (ko) 2012-06-15
JP4895802B2 (ja) 2012-03-14
WO2004071495A1 (en) 2004-08-26
CN103908704A (zh) 2014-07-09
CN103393605A (zh) 2013-11-20
JP2011178784A (ja) 2011-09-15
CN103908704B (zh) 2017-09-01
CN102895662B (zh) 2017-09-12

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