ATE396708T1 - Zusammensetzungen für die chemoembolotherapie solider tumoren - Google Patents

Zusammensetzungen für die chemoembolotherapie solider tumoren

Info

Publication number
ATE396708T1
ATE396708T1 AT04710431T AT04710431T ATE396708T1 AT E396708 T1 ATE396708 T1 AT E396708T1 AT 04710431 T AT04710431 T AT 04710431T AT 04710431 T AT04710431 T AT 04710431T AT E396708 T1 ATE396708 T1 AT E396708T1
Authority
AT
Austria
Prior art keywords
chemoembolotherapy
compositions
solid tumors
polymer
water
Prior art date
Application number
AT04710431T
Other languages
German (de)
English (en)
Inventor
Andrew Lewis
Peter Straford
Simon Leppard
Brenda Hall
Fajardo Maria Gonzalez
Pedro Garcia
Original Assignee
Biocompatibles Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0305322A external-priority patent/GB0305322D0/en
Application filed by Biocompatibles Uk Ltd filed Critical Biocompatibles Uk Ltd
Application granted granted Critical
Publication of ATE396708T1 publication Critical patent/ATE396708T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/14—Organic medium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/48—Isomerisation; Cyclisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/30—Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AT04710431T 2003-02-12 2004-02-12 Zusammensetzungen für die chemoembolotherapie solider tumoren ATE396708T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03250868 2003-02-12
GB0305322A GB0305322D0 (en) 2003-03-07 2003-03-07 Chemoembolisation

Publications (1)

Publication Number Publication Date
ATE396708T1 true ATE396708T1 (de) 2008-06-15

Family

ID=32870779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04710431T ATE396708T1 (de) 2003-02-12 2004-02-12 Zusammensetzungen für die chemoembolotherapie solider tumoren

Country Status (9)

Country Link
EP (1) EP1592405B1 (enExample)
JP (2) JP4895802B2 (enExample)
KR (1) KR101157260B1 (enExample)
CN (4) CN102895662B (enExample)
AT (1) ATE396708T1 (enExample)
DE (1) DE602004014101D1 (enExample)
ES (1) ES2308149T3 (enExample)
HK (1) HK1079980B (enExample)
WO (1) WO2004071495A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE01918975T1 (de) 2000-03-24 2006-04-13 Biosphere Medical, Inc., Rockland Mikrokügelchen zur aktiven Embolisierung
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
EP3085361A1 (en) * 2004-09-07 2016-10-26 Biocompatibles UK Limited Compositions comprising camptothecins in microspheres
KR20140090270A (ko) * 2005-05-09 2014-07-16 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법
US20080305176A1 (en) * 2006-01-24 2008-12-11 Biocompatibles Uk Limited Process For Loading Polymer Particles With Drug
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP2034951B2 (en) 2006-06-22 2020-03-25 Biocompatibles UK Limited Rehydratable pharmaceutical product
EP1985286A1 (en) 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
JP5302300B2 (ja) * 2007-05-11 2013-10-02 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ アンスラサイクリンの医薬組成物
WO2009022190A1 (en) * 2007-08-16 2009-02-19 Biocompatibles Uk Limited Delivery of drug combinations
EP3181123A1 (en) 2008-12-02 2017-06-21 Biocompatibles Uk Ltd. Pancreatic tumour treatment
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
US20150224221A1 (en) 2012-08-31 2015-08-13 Chung-Ang University Industry-Academic Cooperation Foundation Method for preparing microspheres for emboli, and method for preparing microspheres to which drug-containing carrier is bound
JP6420817B2 (ja) * 2013-03-15 2018-11-07 バイオコンパティブルズ ユーケー リミテッド 結像可能な塞栓性微小球
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
PL3264997T3 (pl) 2015-03-02 2019-07-31 Accurate Medical Therapeutics Ltd. Cewniki z otworami bocznymi do modyfikowania i podawania zawiesin pacjentowi
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
CN115137870B (zh) 2016-03-14 2024-05-10 生物相容性英国公司 包含颗粒的乳液
JP6921116B2 (ja) 2016-05-04 2021-08-18 アキュレイト メディカル セラピューティクス リミテッド スリットパターンを有する塞栓マイクロカテーテルヘッド
US11382990B2 (en) 2016-11-16 2022-07-12 The Usa, As Represented By The Secretary, Dhhs Imageable polymers, methods of making and methods of use thereof
CN116173284B (zh) * 2017-07-13 2025-09-19 瓦里安医疗系统公司 栓塞微球
JP7364193B2 (ja) 2017-11-02 2023-10-18 アキュレイト メディカル セラピューティクス リミテッド 内蔵フィルタを有する塞栓術用カテーテル
TW202000189A (zh) 2018-06-29 2020-01-01 英商白康帝英國有限公司 不透射線聚合物
CN113727699A (zh) 2019-03-22 2021-11-30 生物相容英国有限公司 栓塞微球和方法
WO2020234889A1 (en) 2019-05-23 2020-11-26 Accurate Medical Therapeutics Ltd. Embolization catheter for reflux free delivery of microspheres
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
AU2021227230A1 (en) * 2020-02-25 2022-09-08 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating cancer
CN114099442B (zh) * 2020-08-25 2024-01-30 复旦大学 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
CN118434411A (zh) 2021-12-23 2024-08-02 波士顿科学医疗设备有限公司 化学栓塞组合物及其治疗方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978713A (en) * 1987-12-16 1990-12-18 Ciba-Geigy Corporation Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom
JP3041627B2 (ja) * 1989-04-13 2000-05-15 武田薬品工業株式会社 アントラサイクリン系抗生物質の安定組成物
JPH06329542A (ja) * 1993-05-21 1994-11-29 Kibun Food Chemifa Co Ltd 不溶性アルギン酸塩粒子を含む局所血管止血用組成物および動脈化学塞栓用組成物
DE69432867T2 (de) * 1993-11-18 2004-04-22 Sirtex Medical Ltd., Burswood Zubereitung mit gesteuerter freisetzung
WO1999012577A1 (en) * 1997-09-05 1999-03-18 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising a contrast agent for chemoembolization
EP1263803B1 (en) * 2000-03-13 2007-09-19 BioCure, Inc. Embolic compositions
AU2001292092A1 (en) * 2000-10-06 2002-04-15 Biocompatibles Uk Limited Zwitterionic polymers
US20060165804A1 (en) * 2002-09-25 2006-07-27 Lewis Andrew L Polymer compositions for administration to animals

Also Published As

Publication number Publication date
CN103908704B (zh) 2017-09-01
JP5616251B2 (ja) 2014-10-29
CN103393605B (zh) 2018-05-29
CN103908704A (zh) 2014-07-09
CN102895662B (zh) 2017-09-12
CN102895662A (zh) 2013-01-30
KR101157260B1 (ko) 2012-06-15
CN106267325A (zh) 2017-01-04
CN103393605A (zh) 2013-11-20
JP2006515358A (ja) 2006-05-25
JP4895802B2 (ja) 2012-03-14
ES2308149T3 (es) 2008-12-01
WO2004071495A1 (en) 2004-08-26
KR20050103224A (ko) 2005-10-27
DE602004014101D1 (de) 2008-07-10
JP2011178784A (ja) 2011-09-15
HK1079980A1 (en) 2006-04-21
CN106267325B (zh) 2019-09-24
EP1592405B1 (en) 2008-05-28
EP1592405A1 (en) 2005-11-09
HK1079980B (en) 2008-11-14

Similar Documents

Publication Publication Date Title
ATE396708T1 (de) Zusammensetzungen für die chemoembolotherapie solider tumoren
MXPA05007165A (es) Reactivos polimericos que comprnden una cetona o un grupo funcional relacionado.
GB2442374A (en) Crosslinkable polymer compositions
TW200510454A (en) Conjugates comprising human IL-18 and substitution mutants thereof
AU4263201A (en) Gel compositions
BR0108555A (pt) Composições de polìmero com constância de propriedades aperfeiçoada
AR035977A1 (es) Inmunoconjugados de anticuerpos cd44 citotoxicos.
ATE445386T1 (de) Polymerische parfümpartikel
NL2000281A1 (nl) Vaste farmaceutische samenstellingen die pregabaline bevatten.
DE502004003225D1 (de) (meth)acryls ureester monoalkoxilierter polyole und deren he rstellung
WO2006119365A3 (en) Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster
GEP20063917B (en) Pulmonary administration of chemically modified insulin
MY141940A (en) Oral care composition with cross-linked polymer peroxide
BRPI0409133A (pt) formulações farmacêuticas contendo metilnaltrexona
WO2004103303A3 (en) Therapeutic dental composition
HRP20050353B1 (hr) Polimerski konjugati smanjene antigeniäśnosti, postupci njihova pripravljanja i primjena
BRPI0510568A (pt) copolìmero, processo para preparação do mesmo, partìcula biodegradável, uso da mesma, processo para preparação de um sistema de liberação, composição para perfumar, e, produto perfumado
DE602005027477D1 (de) Arzneimittelabgabe aus embolischen mitteln
BR0308127B1 (pt) poliol enxertado, processos para a preparação do mesmo e de poliuretanos, e, uso de um poliol enxertado.
ATE362776T1 (de) Quellbare hydrogelbildende polymere mit geringem feinstaubanteil
PT1656410E (pt) Processo para preparação de polímeros funcionalizados a partir de álcoois poliméricos
GB2451599A (en) Nanostructures suitable for delivery of agents
MXPA05013665A (es) Composiciones cosmeticas autobronceantes que comprenden un compuesto de vitamina b3 soluble en agua y un agente alfa-hidroxicarbonilo autobronceante.
ATE546130T1 (de) Dispersion von polymerteilchen
WO2003063824A3 (en) Pharmaceutical composition

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties