ATE396708T1 - Zusammensetzungen für die chemoembolotherapie solider tumoren - Google Patents

Zusammensetzungen für die chemoembolotherapie solider tumoren

Info

Publication number
ATE396708T1
ATE396708T1 AT04710431T AT04710431T ATE396708T1 AT E396708 T1 ATE396708 T1 AT E396708T1 AT 04710431 T AT04710431 T AT 04710431T AT 04710431 T AT04710431 T AT 04710431T AT E396708 T1 ATE396708 T1 AT E396708T1
Authority
AT
Austria
Prior art keywords
chemoembolotherapy
compositions
solid tumors
polymer
water
Prior art date
Application number
AT04710431T
Other languages
German (de)
English (en)
Inventor
Andrew Lewis
Peter Straford
Simon Leppard
Brenda Hall
Fajardo Maria Gonzalez
Pedro Garcia
Original Assignee
Biocompatibles Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0305322A external-priority patent/GB0305322D0/en
Application filed by Biocompatibles Uk Ltd filed Critical Biocompatibles Uk Ltd
Application granted granted Critical
Publication of ATE396708T1 publication Critical patent/ATE396708T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/14—Organic medium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/48—Isomerisation; Cyclisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/30—Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AT04710431T 2003-02-12 2004-02-12 Zusammensetzungen für die chemoembolotherapie solider tumoren ATE396708T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03250868 2003-02-12
GB0305322A GB0305322D0 (en) 2003-03-07 2003-03-07 Chemoembolisation

Publications (1)

Publication Number Publication Date
ATE396708T1 true ATE396708T1 (de) 2008-06-15

Family

ID=32870779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04710431T ATE396708T1 (de) 2003-02-12 2004-02-12 Zusammensetzungen für die chemoembolotherapie solider tumoren

Country Status (9)

Country Link
EP (1) EP1592405B1 (enExample)
JP (2) JP4895802B2 (enExample)
KR (1) KR101157260B1 (enExample)
CN (4) CN103393605B (enExample)
AT (1) ATE396708T1 (enExample)
DE (1) DE602004014101D1 (enExample)
ES (1) ES2308149T3 (enExample)
HK (1) HK1079980B (enExample)
WO (1) WO2004071495A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072281A2 (en) 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
ES2361919T3 (es) * 2004-09-07 2011-06-24 Biocompatibles Uk Limited Suministro de fármaco a partir de agentes embólicos.
CN101237857A (zh) 2005-05-09 2008-08-06 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
JP5075130B2 (ja) * 2006-01-24 2012-11-14 バイオコンパティブルズ ユーケー リミテッド ポリマー粒子を薬物で負荷する方法
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP2034951B2 (en) * 2006-06-22 2020-03-25 Biocompatibles UK Limited Rehydratable pharmaceutical product
EP1985286A1 (en) * 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
US8940334B2 (en) 2007-05-11 2015-01-27 Nerviano Medical Sciences S.R.L. Pharmaceutical composition of an anthracycline
ES2706023T3 (es) * 2007-08-16 2019-03-27 Biocompatibles Uk Ltd Administración de combinaciones de fármacos
US20110293672A1 (en) * 2008-12-02 2011-12-01 Biocompatibles Uk Limited Pancreatic tumour treatment
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
JP5957610B2 (ja) 2012-08-31 2016-07-27 チュンアン ユニバーシティー インダストリー アカデミック コアポレイション ファウンデイション 塞栓用のミクロスフェアの製造方法及び薬物含有ナノ輸送体が結合されたミクロスフェアの製造方法
WO2014152488A2 (en) 2013-03-15 2014-09-25 Dreher Matthew R Imageable embolic microsphere
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
WO2016139606A1 (en) 2015-03-02 2016-09-09 Accurate Medical Therapeutics Ltd. Preventing non-target embolization
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
WO2017158482A1 (en) 2016-03-14 2017-09-21 Biocompatibles Uk Limited Emulsion comprising particles
ES2865433T3 (es) 2016-05-04 2021-10-15 Accurate Medical Therapeutics Ltd Cabezal de microcatéter de embolización que tiene un patrón ranurado
EP3541368B1 (en) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Imageable particles, methods of making and methods of use thereof
CN110891550B (zh) 2017-07-13 2023-03-07 瓦里安医疗系统公司 栓塞微球
JP7364193B2 (ja) 2017-11-02 2023-10-18 アキュレイト メディカル セラピューティクス リミテッド 内蔵フィルタを有する塞栓術用カテーテル
US11702498B2 (en) 2018-06-29 2023-07-18 Biocompatibles Uk Limited Radiopaque polymers
EP3941437A1 (en) 2019-03-22 2022-01-26 Biocompatibles UK Limited Embolic microspheres and methods
US12433600B2 (en) 2019-05-23 2025-10-07 Argon Medical Devices, Inc. Embolization catheter for reflux free delivery of microspheres
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
CN115484961A (zh) * 2020-02-25 2022-12-16 海必恩制药公司 环孢菌素类似物用于治疗癌症的用途
CN114099442B (zh) * 2020-08-25 2024-01-30 复旦大学 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
JP2025501572A (ja) 2021-12-23 2025-01-22 ボストン サイエンティフィック メディカル デバイス リミテッド 化学塞栓用組成物とそれを使用する治療方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978713A (en) * 1987-12-16 1990-12-18 Ciba-Geigy Corporation Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom
JP3041627B2 (ja) * 1989-04-13 2000-05-15 武田薬品工業株式会社 アントラサイクリン系抗生物質の安定組成物
JPH06329542A (ja) * 1993-05-21 1994-11-29 Kibun Food Chemifa Co Ltd 不溶性アルギン酸塩粒子を含む局所血管止血用組成物および動脈化学塞栓用組成物
JP4619457B2 (ja) * 1993-11-18 2011-01-26 シルテックス、メディカル、リミテッド 徐放性製剤
AU8877098A (en) * 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
WO2001068720A1 (en) * 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
EP1325046B1 (en) * 2000-10-06 2007-06-27 Biocompatibles UK Limited Zwitterionic polymers
US20060165804A1 (en) * 2002-09-25 2006-07-27 Lewis Andrew L Polymer compositions for administration to animals

Also Published As

Publication number Publication date
HK1079980B (en) 2008-11-14
CN106267325A (zh) 2017-01-04
HK1079980A1 (en) 2006-04-21
JP5616251B2 (ja) 2014-10-29
EP1592405A1 (en) 2005-11-09
JP2011178784A (ja) 2011-09-15
CN102895662B (zh) 2017-09-12
CN103908704B (zh) 2017-09-01
KR20050103224A (ko) 2005-10-27
CN103908704A (zh) 2014-07-09
CN102895662A (zh) 2013-01-30
CN103393605B (zh) 2018-05-29
CN106267325B (zh) 2019-09-24
EP1592405B1 (en) 2008-05-28
ES2308149T3 (es) 2008-12-01
WO2004071495A1 (en) 2004-08-26
JP4895802B2 (ja) 2012-03-14
CN103393605A (zh) 2013-11-20
KR101157260B1 (ko) 2012-06-15
DE602004014101D1 (de) 2008-07-10
JP2006515358A (ja) 2006-05-25

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