CN103391764A - 有机化合物 - Google Patents
有机化合物 Download PDFInfo
- Publication number
- CN103391764A CN103391764A CN2012800101196A CN201280010119A CN103391764A CN 103391764 A CN103391764 A CN 103391764A CN 2012800101196 A CN2012800101196 A CN 2012800101196A CN 201280010119 A CN201280010119 A CN 201280010119A CN 103391764 A CN103391764 A CN 103391764A
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- Prior art keywords
- compositions
- menthol
- amount
- flavor compositions
- weight
- Prior art date
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- 150000002894 organic compounds Chemical class 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 123
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 54
- 229940041616 menthol Drugs 0.000 claims abstract description 53
- 239000000796 flavoring agent Substances 0.000 claims abstract description 51
- 235000019634 flavors Nutrition 0.000 claims abstract description 47
- 150000001875 compounds Chemical class 0.000 claims abstract description 17
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract 10
- CFJYNSNXFXLKNS-UHFFFAOYSA-N p-menthane Chemical compound CC(C)C1CCC(C)CC1 CFJYNSNXFXLKNS-UHFFFAOYSA-N 0.000 claims description 66
- 235000013599 spices Nutrition 0.000 claims description 30
- 229930004008 p-menthane Natural products 0.000 claims description 19
- PNZXMIKHJXIPEK-UHFFFAOYSA-N cyclohexanecarboxamide Chemical compound NC(=O)C1CCCCC1 PNZXMIKHJXIPEK-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 230000006835 compression Effects 0.000 claims description 5
- 238000007906 compression Methods 0.000 claims description 5
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 3
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 2
- FINKDHKJINNQQW-UHFFFAOYSA-N 5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(N)=O FINKDHKJINNQQW-UHFFFAOYSA-N 0.000 abstract 2
- FPJRGEOLQICYQZ-UHFFFAOYSA-N n-[4-(cyanomethyl)phenyl]-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(=O)NC1=CC=C(CC#N)C=C1 FPJRGEOLQICYQZ-UHFFFAOYSA-N 0.000 abstract 2
- RJXZNFMRBXSXAS-UHFFFAOYSA-N 5-methyl-2-propan-2-yl-n-(2-pyridin-4-ylethyl)cyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(=O)NCCC1=CC=NC=C1 RJXZNFMRBXSXAS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002826 coolant Substances 0.000 abstract 1
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical group CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 44
- 239000000047 product Substances 0.000 description 43
- -1 Oleum Anisi Stellati Substances 0.000 description 24
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 5
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- 239000004606 Fillers/Extenders Substances 0.000 description 4
- 235000006679 Mentha X verticillata Nutrition 0.000 description 4
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- 244000299461 Theobroma cacao Species 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 4
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- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
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- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
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- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
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Abstract
本发明涉及香料组合物,其包含清凉剂化合物的混合物,所述清凉剂化合物包括薄荷醇和选自N-(4-氰基甲基苯基)对-薄荷烷甲酰胺、2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺或N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物的薄荷烷甲酰胺,其中薄荷烷甲酰胺的总量为约0.1-10%。
Description
本发明涉及包含薄荷醇和薄荷烷甲酰胺类的香料组合物,特别地,本发明涉及包含低水平薄荷醇的这种组合物。本发明还涉及消费品,特别是口腔护理产品,其包含所述的香料组合物。
本领域中已经描述了大量天然或合成来源的清凉剂化合物。然而,最为众所周知的化合物是薄荷醇,特别是l-薄荷醇,发现它天然存在于薄荷油中,特别是薄荷(Mentha arvensis L)和绿薄荷(Menthaviridis L)中。在薄荷醇的异构体中,l-异构体实际上最广泛地出现且典型地称作具有清凉特性的薄荷醇。L-薄荷醇具有特征性薄荷气味、具有清新的味道并且在施用于皮肤和粘膜表面上时发挥出清凉感觉。
为了给消费者递送强烈的新鲜和清凉感觉,香精、特别是薄荷香精可以是超过50%重量的薄荷醇且60%或以上并非不常见。
然而,尽管具有极为广泛的可接受性和应用,但是薄荷醇在单独使用时具有初始的高香味影响,但在使用后几分钟内香味影响就急剧地下降且趋向于香味香型扭曲且赋予包含它的产品苦味。此外,除苦味问题外,极为高水平的薄荷醇可能限制香味生成并且导致另外的加工限制。
为了解决一些薄荷醇应用的缺陷,越来越常用的是使用它与其他清凉剂化合物、最特别的是N-取代的-对-薄荷烷甲酰胺类的混合物。此外,GB233873公开了这样的混合物以提供不同的清凉特性和甚至更为长效的清凉效果。将仅有薄荷醇的制品与其中减少薄荷醇用量的混合物比较并且用类似用量的薄荷烷甲酰胺清凉剂替代。
当今香料工业面临的挑战在于来自消费品公司的减少包含在其组合物中的非活性物质水平的驱动。这显然与成本相关,而且是持久性的需求和将绿色产品递送给市场的需求。
因此,期望降低薄荷醇的水平而不损失感觉属性和喜好其附带应用的消费者。如果可以减少或压缩用于香料组合物中主要成分的量,则由此可以压缩用于消费品中香料组合物的量,或者可以利用较低水平的薄荷醇以允许使用更多的香料成分,由此增加香料学家生成新的和令人感兴趣的香味特性的范围并且驱动消费者的偏好。当然,如果只是通过减少薄荷醇就可以用类似用量的其他清凉剂物质替代它,则上述这种结果无一是可能的。
申请人目前已经发现,通过在香料组合物中使用一些薄荷烷甲酰胺类,能够显著地减少常用于这种组合物中的薄荷醇的量,而同时提供具有可接受的清凉和清新作用并且在偏好试验中有利地被消费者所接受。
本发明在第一个方面中提供了包含清凉剂化合物的混合物的香料组合物,所述清凉剂化合物由薄荷醇和选自N-(4-氰基甲基苯基)对-薄荷烷甲酰胺、2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺或N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物的薄荷烷甲酰胺组成,并且其中薄荷烷甲酰胺的总量为约0.1-10%。
在本发明的一个具体的实施方案中,提供了香料组合物,其包含清凉剂化合物的混合物,所述清凉剂化合物由薄荷醇和选自N-(4-氰基甲基苯基)对-薄荷烷甲酰胺、2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺或N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物的薄荷烷甲酰胺组成,其中薄荷醇的量为小于总香料组合物重量的70%,更具体地为小于50%重量,且薄荷烷甲酰胺的总量为约0.1-10%。
在本发明的一个优选的实施方案中,使用薄荷醇与单独的或与N-(4-氰基甲基苯基)对-薄荷烷甲酰胺组合的2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物。
用于本发明香料组合物中的薄荷醇的总量是有效量,此时它与薄荷烷甲酰胺类组合提供良好的清凉和呼吸清新感觉,没有苦味。用于清凉组合物中的薄荷醇的实际量是受试者对例如期望的蒸气作用度这样的因素的大致偏好。因此,薄荷醇的量可以在本文所述的宽限范围内改变,以得到终产品中期望的结果,且这种变化属于在无需过度实验情况下本领域技术人员的能力范围内。
在本发明的一个具体的实施方案中,总香料中薄荷醇的量为约1%-50%重量,仍然更具体地是5-30%重量。
在本发明的一个具体的实施方案中,总香料中薄荷烷甲酰胺的总量为约0.1-10%重量,仍然更具体地是0.5-8%重量。
在一个具体的实施方案中,薄荷烷甲酰胺由N-(4-氰基甲基苯基)对-薄荷烷甲酰胺组成,其用量为总香料的0.1-3%重量,更具体地为0.5-2%重量。
在另一个具体的实施方案中,薄荷烷甲酰胺由2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺组成,其用量为0.1-10%重量,更具体地为0.5-7%重量。
在另一个具体的实施方案中,薄荷烷甲酰胺由N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物组成,该混合物的提供量为总香料组合物的0.1-13%重量,更具体地为1-9%重量。
在本发明的另一个具体的方面中,N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物的提供比例为1:100-30:1,更具体地为1:15-4:1。
本发明的香料组合物令人意外地提供了清凉和清新效果,尽管降低或压缩了薄荷醇的量且没有用相似用量的薄荷烷甲酰胺类替代,但是其在消费者偏好测试中得到了高分级。换句话说,薄荷醇和总清凉剂化合物得到压缩。这种结果实际上是令人意外的,因为不能简单地从理论上解释基于薄荷烷甲酰胺类单纯地发挥远超薄荷醇的清凉效果这一发现。消费者偏好试验不仅是反映出清凉的强度,实际上,如果清凉组合物过于强烈,则它可能是令人厌恶和令人不愉快的且难以在消费者偏好试验中得到等级认定。而这些试验反映出喜好和愉悦度的总体印象。
此外,特别是在基础性的消费品组合物中,例如口腔护理组合物,组合物的清凉特性可以作为感觉线索起作用,从而提供给使用者组合物效力的信息,且这也可以驱动对这些类型产品的偏好或喜好。本发明中使用的薄荷烷甲酰胺类在施用于粘膜表面、特别是口腔粘膜上时都可以显示相当显著的麻刺感,这在传递这种感觉线索中特别有意义。
本发明在其另一个方面中提供了压缩用于香料组合物中薄荷醇的量的方法,所述方法包括向所述香料组合物中添加如上所述的薄荷醇和薄荷烷甲酰胺的混合物的步骤。
本发明在其另一个方面中提供了压缩用于香料组合物中的清凉剂化合物的量的方法,所述方法包括向所述香料组合物中添加如上所述的薄荷醇和薄荷烷甲酰胺的混合物的步骤。
在本发明的一个具体的实施方案中,提供了压缩包含在组合物中薄荷醇的量的方法,所述方法包括下列步骤:
I)针对一组消费者,筛选包含薄荷醇的组合物,以确定对该组合物的第一偏好评分;
II)从所述组合物中除去一定量的薄荷醇并且添加一定量的N-(4-氰基甲基苯基)对-薄荷烷甲酰胺、2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺或N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物,所添加的甲酰胺的量低于基于重量除去的薄荷醇的量,并且针对一组消费者对该组合物进行筛选,以得到高于所述第一偏好评分的第二偏好评分。
所用的消费者试验可以是任意那些由市场研究专家用于确定消费品味道偏好或喜好已知和使用的试验设计。例如,试验可以是预定义的均衡拉丁方块设计(pre-defined balanced Latin Square design)的Sequential Monadic评估,其中全部产品由有响应者测试。在下文的实施例中提供了另外的特别适合的试验。
上文涉及的薄荷烷甲酰胺类描述在国际公开号WO2005/049553和WO2007/019719中。
用于本发明的薄荷烷甲酰胺类包含不对称碳原子。可以基于其物理化学差异、通过本身公知的方法例如色谱法和/或分级结晶将这种非对映异构体混合物分离成其各个非对映异构体。可以通过经与适合的旋光化合物反应将对映异构体混合物转化成非对映异构体混合物、分离非对映异构体和将各个非对映异构体转化成相应的纯对映异构体来分离对映异构体。所有这种异构体包括非对映异构体混合物和纯对映异构体都被视为本发明的组成部分。
薄荷烷甲酰胺类的具体实例是如下所示的光学异构体:
(1R,2S,5R)-N-(4-氰基甲基)-苯 (1R,2S,5R)-2-异丙基-5-甲基基)-2-异丙基-5-甲基-环己烷甲 -N-(2-(吡啶-2-基)乙基)-环己酰胺 烷甲酰胺
本发明的香料组合物还可以包含增香剂、甜味剂和其他常用于配制这种组合物的助剂。
增香剂包括、但不限于:
天然香料、人造香料、香料调味品、作料等。典型的增香剂包括合成香料油和调味香料和/或油、油性树脂、香精、蒸馏物和来源于植物、叶、花、果实的提取物等和包含上述至少一种的组合。
典型的香料油包括留兰香油、肉桂油、冬青油(水杨酸甲酯)、胡椒薄荷油、日本薄荷油、丁香油、桂花油、八角茴香油、桉叶油、百里香油、香柏叶油、肉豆蔻油、多香果、鼠尾草油、肉豆蔻、苦杏仁油和桂皮油;有用的增香剂包括人造、天然和合成水果香料,例如香草和柠檬油,包括柠檬、橙、酸橙、葡萄柚、yazu、史达橘(sudachi)和水果香精包括苹果、梨、桃、葡萄、蓝莓、草莓、覆盆子、樱桃、李子、洋李、葡萄干、可乐、瓜拉那、橙花油、菠萝、杏子、香蕉、甜瓜、杏子、梅(ume)、樱桃、覆盆子、黑莓、热带水果、芒果、山竹果、石榴、番木瓜等。增香剂递送的另外的典型香精包括牛奶香精、黄油香精、干酪香精、奶油香精和酸奶香精;香草香精;茶或咖啡香精例如绿茶香精、乌龙茶香精、茶香精、可可香精、巧克力香精和咖啡香精;薄荷香精例如薄荷香精、留兰香香精和日本薄荷香精;香辣香精例如阿魏香精、香旱芹香精、大茴香香精、当归属香精、小茴香香精、多香果香精、肉桂香精、黄春菊香精、芥茉香精、小豆蔻香精、葛缕子香精、小茴香子香精、丁香香精、胡椒香精、芫荽子香精、黄樟香精、香旱芹菜香精、川花椒香精、紫苏香精、杜松子香精、姜香精、八角茴芹香精、辣根香精、百里香香精、龙艾香精、莳萝子香精、辣椒香精、肉豆蔻香精、罗勒香精、马郁兰香精、迷迭香香精、月桂叶香精和绿芥末(日本辣根)香精;坚果香精例如杏仁香精、榛子香精、坚果香精、花生香精、美洲山核桃香精、阿月浑子香精和胡桃香精;酒精香精例如葡萄酒香精、威士忌酒香精、白兰地酒香精、甜酒香精、杜松子酒香精和利口酒香精;花香精;和蔬菜材料例如洋葱香精、大蒜香精、甘蓝香精、胡萝卜香精、芹菜香精、香茹香精和蕃茄香精。
在一些实施方案中,另外的增香剂包括醛类和酯类,例如可以使用乙酸肉桂酯、肉桂醛、柠檬醛二乙缩醛、乙酸二氢葛缕酯、丁子香酚49甲酸酯、对-甲基茴香醇等。醛香料的另外的实例包括乙醛(苹果)、苯甲醛(樱桃,杏仁)、茴香醛(甘草,大茴香)、肉桂醛(肉桂)、柠檬醛即α-柠檬醛(柠檬,白柠檬)、橙花醛即β-柠檬醛(柠檬,白柠檬)、癸醛(橙,柠檬)、乙基香草醛(香子兰,奶油)、天芥菜即胡椒醛(香子兰,奶油)、香草醛(香子兰,奶油)、α-戊基肉桂醛(辛香水果香精)、丁醛(黄油,干酪)、戊醛(黄油,干酪)、香茅醛(修饰物,许多类型)、癸醛(柑橘类水果)、醛C-8(柑橘类水果)、醛C-9(柑橘类水果)、醛C-12(柑橘类水果)、2-乙基丁醛(浆果类)、己烯醛即反式-2(浆果类)、甲苯基醛(樱桃,杏仁)、藜芦醛(香子兰)、2,6-二甲基-5-庚烯醛即甜瓜醛(甜瓜)、2,6-二甲基辛醛(绿色果实)和2-十二碳烯醛(柑橘,橘子)等。一般而言,可以使用任意的调味剂或食品添加剂,例如描述在ChemicalsUsed in Food Processing,出版物1274,63-258页,National Academyof Sciences中的那些。将该出版物引入本文参考。
用于本发明的一些香料成分可以包含薄荷醇,例如薄荷油。就本发明的目的而言,本文涉及的薄荷醇的量与添加到香料组合物中的游离薄荷醇的量相关且与可能包含在香料成分例如香料油中的任意薄荷醇无关。
用于香料制品的香料的量可以典型地在约1%-约99%且具体量可以根据所生成的香料制品的性质的不同而改变。
甜味剂包括、但不限于:
高强度甜味剂。高强度甜味剂具有基本上大于蔗糖的甜味强度。适合的高强度甜味剂包括水溶性天然甜味剂,例如二氢查耳酮、莫尼糖蛋白、甜菊(卡哈苡苷)、甘草酸苷及其混合物。适合的水溶性人造甜味剂包括糖精及其可溶性盐,即糖精钠和钙盐、环氨酸及其盐、3,4-二氢-6-甲基-1,2,3-噁嗪噻-4-酮-2,2-二氧化物(乙酰舒泛)及其钠盐和钙盐,且尤其是3,4-二氢-6-甲基-1,2,3-噁嗪噻4-酮-2,2-二氧化物的钾盐(乙酰舒泛-K)。
适合的基于二肽的甜味剂包括L-天冬氨酸衍生的甜味剂,例如L-天冬氨酰-L-苯丙氨酸甲酯(阿司帕坦)、美国专利号US3,492,131中描述的化合物、L-α天冬氨酰-N-(2,2,4,4-四甲基-3-硫杂环丙烷基)-D-丙氨酰胺水合物(阿力甜)、L-天冬氨酰-L-苯基甘油和L-天冬氨酰-L-2,5-二氢苯基甘油的甲酯类、L天冬氨酰-2,5-二氢-L-苯丙氨酸和L-天冬氨酰-L-(l-环己烯)丙氨酸。
其他适合的水溶性甜味剂包括衍生自天然存在的水溶性甜味剂的那些,例如蔗糖的氯化衍生物,例如氯脱氧糖衍生物,例如氯脱氧蔗糖和氯脱氧半乳蔗糖衍生物。氯脱氧蔗糖和氯唾液半乳蔗糖衍生物的实例包括、但不限于1-氯-1'-脱氧蔗糖;4-氯-4-脱氧-α-D-吡喃半乳糖基-α-D-呋喃果糖苷或4-氯-4-脱氧半乳蔗糖;4-氯-4-脱氧-α-D-吡喃半乳糖基-1-氯-1脱氧-β-D-呋喃果糖苷或4,1'-二氯-4,1'二脱氧半乳蔗糖;1',6'-二氯-1',6'-二脱氧蔗糖;4-氯-4-脱氧-α-D-吡喃半乳糖基-1,6-二氯-1,6-二脱氧-β-D-呋喃果糖苷或4,1',6'-三氯-4,1',6'-三脱氧半乳蔗糖;4,6二氯-4,6-二脱氧-α-D-吡喃半乳糖基-6-氯-6-脱氧-β-D-呋喃果糖苷或4,6,6'-三氯-4,6,6'-三脱氧半乳蔗糖;6,1',6'-三氯-6,1',6'-三脱氧蔗糖;4,6-二氯4,6-二脱氧-α-D-吡喃半乳糖基-1,6-二氯-1,6-二-脱氧-β-D-呋喃果糖苷或4,6,1',6'-四氯-4,6,1',6'-四脱氧半乳蔗糖;和4,6,1',6'-四氯4,6,1',6'-四脱氧-蔗糖。在一个优选的实施方案中,氯脱氧糖衍生物是4,1',6'三氯-4,1',6'-三脱氧半乳蔗糖或4-氯4-脱氧-α-D-吡喃半乳糖基-1,6二氯1,6二脱氧-β-D-呋喃果糖苷,其在Sucralose商品名下购自McNeilSpecialty Products Company,Skillman,New Jersey。
其他适合的高强度甜味剂包括基于甜味剂的蛋白质,例如踝蛋白(thaumaoccous danielli、索马汀I和II)。
用于香料制品的甜味剂的量典型地在约0.001%-约1%,但根据所生成的香料制品的性质的不同可以使用较大或较少的量。
助剂是香料制品中的物质,其属性和特性与传递香味或甜味效果不同。助剂包括添加剂、表面活性剂、乳化剂、富脂剂、稠化剂、增稠剂、聚合物、硅氧烷化合物、脂肪、蜡、稳定剂、抗氧化剂、染料、抗微生物剂、溶剂和共溶剂;粘度和流变调节剂;胶凝剂;防腐剂材料,例如杀真菌剂和杀菌剂;色素、染料和着色物质;增充剂、填充剂和补益剂;针对热和光的有害作用的稳定剂;填充剂,可以包括矿物佐剂,其可以用作填充剂和整理剂。适合的矿物佐剂包括碳酸钙、碳酸镁、氧化铝、氢氧化铝、硅酸铝、滑石粉、磷酸三钙、磷酸三钙等,它们可以用作填充剂和整理剂。
适用的另外的填充剂(载体、增充剂)包括甜味剂,例如单糖类、二糖类、多糖类、糖醇类、聚葡萄糖和麦芽糖糊精;矿物,例如碳酸钙、滑石粉、二氧化钛、磷酸二钙;及其组合。
填充剂改变构造并且辅助加工。这种填充剂的实例为硅酸镁和硅酸铝、粘土、氧化铝、滑石粉、二氧化钛、纤维素聚合物等。
其他适合的和期望的添加剂描述在标准教科书中,例如“Handbookof Industrial Chemical Additives”,ed.M.和I.Ash,第2版,(Synapse2000)。
香料组合物或其具体成分可以以许多不同的物理形式提供,例如固体、液体或包囊形式。可以根据易于操作或贮存或为了得到特定的效果例如缓释或控释选择特定的形式。所谓“包囊形式”是指材料或成分包含在包囊材料中,从而保护和/或保留它并且允许其逐步或完全释放。可以使用所有公知的包囊方法,例如凝聚、喷雾干燥、吸附在多孔底物上等。还可以使用所有可能的包囊材料,例如天然纤维、大表面积的矿物和聚合物材料。
用于消费品中的香料组合物的量可以根据期望的具体效果的不同而改变。然而,典型地,香料组合物的使用量为消费品重量的约0.01-2%重量,更具体地为0.1-1.5%重量。
本发明的香料组合物可以用于任意方式的消费品。所谓“消费品”是指指定施用于身体或置于口腔中然后清除(例如通过冲洗)或摄入、目的在于疗法、治疗、营养或愉悦的任意产品。消费品可以是任意物理形式,例如霜剂、凝胶、洗剂、醇和水/醇溶液、乳剂、分散液、棒状制品等。
香料组合物可以用于口腔护理用消费品。
与消费品相关的“口腔护理”是指施用于口腔中的任意产品,目的在于清洁、清新、愈合、除臭该口腔或其任意的部分。这种组合物包括、但不限于牙膏、牙凝胶、牙粉、牙齿变白产品、漱口液、锭剂、牙线、牙签、抗菌斑和抗牙龈炎组合物、润喉片、润喉滴剂、炎症用组合物、用于治疗鼻症状、感冒症状和上胃肠道不适的组合物、用于缓解感冒、缓解热潮红不适感的组合物、含漱组合物。
可以通过以标准用量掺合香料组合物与一种或多种通常与这种产品相关的常用成分制备使用这些化合物的口腔护理产品。这种标准成分的实例包括、但不限于薄荷、洋薄荷、留兰香、苏格兰薄荷、合成薄荷、茴香脑、水杨酸甲酯、桉叶醇、肉桂醛、丁香酚、碳酸钙、二氧化硅(Precipitates&Xerogels)、磷酸二钙、氧化铝、十二烷基硫酸钠、甜菜碱、甘油、山梨醇、水、糖精、环拉酸钠、阿司帕坦、木糖醇、羧甲基纤维素钠、甲基纤维素、角叉菜胶酸钠(SodiumCarageenate)、黄原胶、聚乙烯吡咯烷酮、三聚磷酸钠、乙醇、氟化钠、氟磷酸钠、氟化亚锡、柠檬酸钾、氯化钾、硝酸钾、醋酸锶、氯化锶、三聚磷酸钠、十六烷基吡啶鎓、海克替啶、血根碱、三氯生、氯己定、柠檬酸锌、硫酸锌、氯化锌、甘油磷酸钙、碳酸氢钠、焦磷酸四钠、焦磷酸四钾。
这些材料的一些可以以包囊形式存在,作为该术语如上所述。
本发明的香料组合物可以用于个人护理产品,例如药物、化妆品和盥洗用品。
当用于化妆品和盥洗用品时,制品可以用于Cosmetic,Toiletriesand Fragrance Association的‘International Cosmetic IngredientDictionary and Handbook’中举出的任意“报道的产品类别”且可以与用于所报道的产品类别的任意一种或多种成分一起使用。
所报道的产品类别是:剃须后洗剂、婴儿洗剂、油、粉末和霜、各种婴儿产品、婴儿香波、底涂料和底涂层、沐浴胶囊、沐浴油、片剂和盐、各种沐浴制品、浴室肥皂和洗涤剂、胡须软化剂、腮红、身体和手部用制品、泡沫浴、清洁产品、科隆香水和化妆香水、表皮柔软剂、洁齿剂、除臭剂、脱毛剂、灌水器、洗眼液、各种眼部化妆制品、眼部卸妆水、眼影膏、画眉笔、眼线膏、面部和颈部制品、扑面粉、女性卫生除臭剂、足粉和喷雾剂、粉底霜、各种芳香制品、发漂白剂、发色喷雾剂、各种染发制品、护发素、染发剂和染色剂、带颜色的美发剂、美发用品、洗发剂、洗发香波、喷发剂、直发剂、染发剂、卷发组合、室内晒黑制品、腿和身体涂剂、唇膏、粉底、化妆固定剂、化妆制品、各种修指甲制品、睫毛膏、男用滑石粉、湿润制品、漱口液和呼吸清新剂、指甲膏和洗剂、指甲增充剂、指甲油去除剂、指甲油和光泽剂、夜用护肤制品、各种口腔卫生产品、糊状面膜、香料、永久性卷发剂、各种个人清洁产品、粉末、预剃毛洗剂、胭脂、香囊、香波、剃毛霜、各种剃毛制品、修须皂、各种皮肤护理制品、皮肤清凉剂、防晒凝胶、霜和液体、各种防晒制品、强壮药、敷料和其他毛发修正助剂。
在制备上述举出的产品的过程中,可以使用这种产品中发现的和上述的所有或任意的标准助剂,以公认的用量使用。
其他适合和期望的添加剂或助剂描述在标准教科书中,例如“Handbook of Industrial Chemical Additives”,ed.M.和I.Ash,第2版,(Synapse2000)。
与这些成分相关的有用的其他制品的详细描述可以在标准教科书中找到,例如“Handbook of Cosmetic Science and Technology”,ed.Pays,Barel&Maibach,第2版(Dekker,2005)。
本发明的香料组合物可以用于所有种类的食品、糖食、烘烤制品、糖果点心、乳制品和饮料。
术语“糖食”包括、但不限于:
口香糖(包括糖化口香糖、无糖口香糖、功能性口香糖和泡泡糖)、夹心糖食、巧克力和其他巧克力糖食、含药糖食、脆性硬糖、片剂、软果糕、薄荷糖、标准薄荷糖、强力薄荷糖、软糖、硬糖、硬糖果、呼吸和其他口腔护理膜或条、拐杖糖、棒糖、粘糖、果冻、乳脂软糖、焦糖、硬和脆松糖、乳脂糖、太妃糖、甘草、胶糖、橡皮糖、豆形胶质软糖、奶油杏仁糖、微晶糖膏或一种或多种上述糖食的组合或掺入一种或多种上述糖食的可食用组合物。
可以使用本领域技术人员公知的标准技术和设备将糖食组合物掺入另外的常规硬或软糖食形式。还可以用硬、软或颗粒包衣层给糖食组合物进行中心填充和/或包衣。
术语“烘烤制品”包括、但不限于:
夹心饼干(alfajores)、面包、包装/工业化面包、散装的/手工面包、面粉糕饼、蛋糕、包装/工业化蛋糕、散装的/手工蛋糕、饼干、巧克力糖皮饼干、三明治饼干、有馅饼干、加调味料的饼干和薄脆饼干、面包替代品。
术语“糖果点心”包括、但不限于:
早点用谷物片、可即食(“rte”)谷物、家庭早点用谷物片、薄片、早餐食品、其他rte谷物、儿童早点用谷物片和热谷物。
术语“乳制品”包括、但不限于:
冰淇淋、即兴消费的冰淇淋、单份牛奶冰淇淋、单份水冰淇淋、一包多件包装的牛奶冰淇淋、一包多件包装的水冰淇淋、带回家的冰淇淋、带回家的牛奶冰淇淋、冰淇淋甜点、散装冰淇淋、带回家的水冰淇淋、冷冻酸奶、手工冰淇淋、乳制品、乳品、新鲜/巴氏灭菌牛奶、全脂新鲜/巴氏灭菌牛奶、半脱脂新鲜/巴氏灭菌牛奶、保存期较长的/超高温奶、全脂保存期较长的/超高温奶、半脱脂保存期较长的/超高温奶、无脂保存期较长的/超高温奶、羊奶、炼乳/脱水奶、纯炼乳/脱水奶、加味的、功能性和其他炼乳、香味奶饮料、只有调味乳饮料乳制品、含果汁的香味奶饮料、豆浆、酸乳饮料、发酵奶饮料、咖啡白化剂、奶粉、香味奶粉饮料、奶油、酸奶、纯/天然酸奶、加味酸奶、加水果的酸奶、益生菌酸奶、饮用酸奶、定期饮用酸奶、益生菌饮用酸奶、冷冻点心和耐储存点心、基于乳品的点心、基于大豆的点心。
其他食品包括、但不限于:
速冻小吃、甜和风味极佳的小吃、水果小吃、油煎土豆片/炸土豆片、膨化休闲食品、玉蜀黍饼/玉米片、玉米花、椒盐卷饼、坚果、其他甜和风味极佳的点心、小吃、低脂肪小饼干、早餐棒、能量棒、水果棒、其他小吃、膳食替代品、减肥产品、恢复性饮料、即食餐、罐头即食餐、冷冻即食食品、干燥好的饭、冷冻即食餐、混合方便饭、速冻比萨、冷冻比萨、汤、汤品罐头、汤粉、速溶汤粉、冷汤、超高温汤、冷冻汤、意面、罐装意面、干意面、冷冻/新鲜意面、面条、阳春面、方便面、杯装/碗装方便面、袋装方便面、油醋汁凉面、方便面、干燥食品、什锦点心、酱油、调料和调味品、草药和香料调味品、糊状食品、果酱和蜜饯、蜂蜜、巧克力酱、基于坚果的酱和基于发酵的粉酱。
本文所用的术语“饮料”意指可饮用的液体或半液体,包括,例如调味的水、软饮料、基于咖啡的饮料、基于茶的饮料、基于果汁的饮料(包括水果和蔬菜)、基于奶的饮料、胶冻饮料、碳酸或非碳酸饮料、粉末饮料、酒精或非酒精饮料。
在制备上述举出的产品中,可以使用所有或任意标准的在这类产品中发现的成分,以本领域公认的用量使用。这种成分的实例包括(但绝不限于)溶剂和共溶剂、表面活性剂和乳化剂;粘度和流变调节剂;增稠剂和胶凝剂;防腐剂材料;色素、染料和着色物质;增量剂、填充剂和补剂;抵抗热和光的有害效应的稳定剂;填充剂、增香剂和香味增强剂;加温剂;呼吸清新剂;口腔湿润剂;着色剂;酸化剂;缓冲剂和抗氧化剂。
特别地,在口香糖组合物方面,适合的成分除水不溶性香糖胶基部分外,还包括水溶性填充部分和各种添加剂。水溶性部分可以包括甜味剂、填充剂、软化剂和/或增塑剂、蜡、增稠剂、增香剂、加温剂、呼吸清新剂、口腔湿润剂、酸化剂、着色剂、缓冲剂、抗氧化剂、营养制品、药物和其他常用的提供期望的属性的口香糖添加剂。本领域技术人员公知的其他常用口香糖添加剂也可以用于水溶性填充部分中。
软化剂和增塑剂可以用于提供不同的期望的结构和稠度特性。适合的增塑剂和软化剂可以包括羊毛脂、棕榈酸、油酸、硬脂酸、硬脂酸钠、硬脂酸钾、三乙酸甘油酯、甘油基卵磷脂、单硬脂酸甘油酯、单硬脂酸丙二醇酯、乙酰单酸甘油乙酯、甘氨酸和包含上述至少一种的组合。因为这些软化剂和增塑剂的分子量低,所以它们能够透入香糖胶基的基础结构,由此使得它具有可塑性且粘性低。
蜡可以用于香糖胶基以软化弹性体,改善香糖胶基的弹性和得到不同的期望的结构和稠度特性。适合的蜡可以包括天然和合成蜡、氢化植物油、石油蜡例如聚氨基甲酸乙酯蜡、聚乙烯蜡、石蜡、微晶蜡、硬脂山梨坦、牛油和丙二醇。低熔点蜡可以用于树胶组合物。这些蜡典型地具有低于约60℃的熔点且特别是约45-约55℃的熔点。高熔点蜡也可以用于香糖胶基。这种高熔点蜡包括蜂蜡、植物蜡、小烛树蜡、巴西棕榈蜡、大部分的石油蜡等及其组合。
适合的乳化剂包括蒸馏的单酸甘油酯类、单酸甘油酯和二脂酰甘油酯的乙酸酯类、单酸甘油酯和二脂酰甘油酯的柠檬酸酯类、单酸甘油酯和二脂酰甘油酯的乳酸酯类、单酸甘油酯类和二脂酰甘油酯类、脂肪酸的聚甘油酯类、鲸蜡硬脂醇聚醚-20、聚蓖麻油酸聚甘油酯类、脂肪酸的丙二醇酯类、月桂酸聚甘油酯、椰油酸甘油酯、阿拉伯树胶、硬脂山梨坦、三硬脂山梨坦、月桂山梨坦、油酸山梨坦、硬脂酰乳酰酸钠、硬脂酰乳酰酸钙、单酸甘油酯和二脂酰甘油酯的二乙酰基酒石酸酯类、甘油三辛酸-癸酸/中链甘油三酯类、二油酸甘油酯、油酸甘油酯、脂肪酸的甘油基乳酸酯类、甘油基乳酸棕榈酸酯、硬脂酸甘油酯、月桂酸甘油酯、二月桂酸甘油酯、单蓖麻油酸甘油酯、单硬脂酸三甘油酯、二硬脂酸六甘油酯、单硬脂酸十甘油酯、二棕榈酸十甘油酯、单油酸十甘油酯、聚甘油基10六油酸酯、中链甘油三酯类、辛酸/癸酸甘油三酯、单硬脂酸丙二醇酯、聚山梨醇酯20、聚山梨醇酯40、聚山梨醇酯60、聚山梨醇酯80、聚山梨醇酯65、二硬脂酸己基甘油酯、单硬脂酸三甘油酯、吐温类、司盘类、乳酰酸硬脂酰酯、硬脂酰-2-乳酰酸钙、硬脂酰-2-乳酰酸卵磷脂钠、磷脂铵、脂肪酸的蔗糖酯类、蔗糖甘油酯(sucroglycerid)、脂肪酸的丙-1,2-二醇酯类和包含上述的至少一种的组合。
适合的增稠剂包括纤维素醚类(例如羟乙基纤维素、羟丙基甲基纤维素或羟丙基纤维素)、甲基纤维素、羧甲基纤维素及其组合。用作增稠剂的另外的聚合物包括卡波姆、聚乙烯吡咯烷酮、聚乙烯醇、藻酸钠、聚乙二醇、天然树胶如黄原胶、西黄蓍胶、瓜尔胶、阿拉伯胶、阿拉伯树胶、水可分散的聚丙烯酸酯类如聚丙烯酸、甲基丙烯酸甲酯共聚物和羧乙烯基共聚物。
口香糖组合物还可以包含如上所述的填充剂和填料、营养制品、药物和增香剂。
可以将口香糖组合物包衣或压制并且它们是片、棒、颗粒、立方体、菱形、长方形或球的形式。不同形式的树胶组成的组合物是类似的,但在成分比例方面可变。中心填充的树胶是另一种常用的树胶形式,中心填充物典型地是水性液体或凝胶,其可在加工过程中注入树胶中心。还可以任选地给中心填充的树胶包衣并且可以将它们制备成各种形式,例如棒棒糖形式。
下面是一系列用于示例本发明的实施例。
实施例1
用丙二醇作为稀释剂以使香料达到100%制备如下三种香料:
将香料各自以1%掺入标准二氧化硅牙膏基质:
Evercool190=2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺
Evercool180=N-(4-氰基甲基苯基)对-薄荷烷甲酰胺
给全部3种牙膏进行编码,给予37位首次参与试验的志愿者。要求志愿者刷牙30秒,在如下6个时间点各自对每种牙膏的清凉感、麻刺感和新鲜度进行评分(0-10级):0分钟、5分钟、10分钟、20分钟、30分钟和60分钟。在60分钟结束时,还要求他们给出其总体偏好评分(0-10级)。结果如图1-4中所示。
包含10%添加的薄荷醇和5%Evercool190的香料B对清凉感、麻刺感和新鲜度而言表现最佳并且是最优选的。
包含10%添加的薄荷醇和2%Evercool180的香料C在10分钟后表现的效果优于香料A并且在60分钟时具有最强的表现效果。这一结果具有的总体偏好与香料A类似。
低水平的Evercool190或Evercool180可以在牙膏香料中替代高水平的薄荷醇并且仍然提供优良的感觉有益性且相对于具有高水平的薄荷醇的香料而言是优选的。
实施例2
分别包含74%和63%添加的薄荷醇的2种消费者可接受的香料中所添加的薄荷醇已经被除去且被Evercool190或Evercool190和Evercool180取代。
香料1 | 香料2 | 改进的香料1 | 改进的香料2 | |
薄荷心(香料1) | 26% | 26% | ||
薄荷心(香料2) | 37% | 37% | ||
薄荷醇 | 74% | 63% | ||
Evercool190 | 4% | 4% | ||
Evercool180 | 1.2% |
根据如下要求将香料配入典型二氧化硅牙膏,使得以较低的压缩水平调配改进的香料:
给两组样品编码,给予16位首次参与试验的志愿者,要求他们刷牙30秒并且在0分钟、5分钟、10分钟、20分钟、30分钟和60分钟对清凉度、新鲜度和麻刺感评分(0-10级)。还对每种香料的总体偏好进行评分(0-10级)。结果如图5-8中所示。
我们从本研究中可以得出结论:改进的与Evercool190/180组合的香料2是全部香料中优选的香料且在5分钟后得到了最佳清凉感和最佳的持续长久的新鲜度和麻刺感。
Claims (12)
1.香料组合物,包含清凉剂化合物的混合物,所述清凉剂化合物包括薄荷醇和选自N-(4-氰基甲基苯基)对-薄荷烷甲酰胺、2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺或N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物的薄荷烷甲酰胺,其中薄荷醇的量小于总香料组合物重量的50%,且薄荷烷甲酰胺的总量为约0.1-10%。
2.权利要求1的香料组合物,其中该香料中薄荷醇的量为约1%-50%重量,更具体地为5-30%重量。
3.权利要求1或权利要求2的香料组合物,其中该香料组合物中薄荷烷甲酰胺的总量为约0.1-10%重量,更具体地为0.5-8%重量。
4.前述权利要求任一项的香料组合物,其中薄荷烷甲酰胺由N-(4-氰基甲基苯基)对-薄荷烷甲酰胺组成,其量为香料组合物重量的0.1-3%,更具体地为0.5-2%重量。
5.权利要求1-3任一项的香料组合物,其中薄荷烷甲酰胺由2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺组成,其量为香料组合物重量的0.1-10%,更具体地为0.5-7%重量。
6.权利要求1-3任一项的香料组合物,其中薄荷烷甲酰胺由N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物组成,该混合物的提供量为香料组合物重量的0.1-13%,更具体地为1-9%重量。
7.权利要求1-3和6的香料组合物,其中N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物的提供比例为1:100-30:1,更具体地为1:15-4:1。
8.消费品组合物,包含如权利要求1-7任一项中所定义的香料组合物。
9.权利要求8的消费品组合物,其为口腔护理产品。
10.压缩香料组合物中所使用的薄荷醇的量的方法,所述方法包括将如权利要求1-7任一项中所定义的薄荷醇和薄荷烷甲酰胺的混合物添加到所述香料组合物中的步骤。
11.压缩香料组合物中所使用的清凉剂的量的方法,所述方法包括将如权利要求1-7任一项中所定义的薄荷醇和薄荷烷甲酰胺的混合物添加到所述香料组合物中的步骤。
12.压缩组合物中清凉剂的量的方法,所述方法包括下列步骤:
I)针对一组消费者,筛选包含薄荷醇的组合物,以确定对该组合物的第一偏好评分;
II)从所述组合物中除去一定量的薄荷醇并且添加一定量的N-(4-氰基甲基苯基)对-薄荷烷甲酰胺、2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺或N-(4-氰基甲基苯基)对-薄荷烷甲酰胺和2-异丙基-5-甲基-N-(2-(吡啶-4-基)乙基)环己烷甲酰胺的混合物,所添加的甲酰胺的量低于基于重量除去的薄荷醇的量,并且针对一组消费者对该组合物进行筛选,以得到高于所述第一偏好评分的第二偏好评分。
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CN113244131A (zh) * | 2021-05-19 | 2021-08-13 | 广州冰泉化妆品科技有限公司 | 一种清凉清新的口香组合物和口香牙膏及其制备方法 |
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---|---|---|---|---|
US10182573B2 (en) * | 2011-02-15 | 2019-01-22 | Freshguard Defense Llc | Antimicrobial solution for use with dental appliances |
EP2872109B1 (en) * | 2012-05-22 | 2017-06-14 | Unilever N.V. | Personal care composition comprising a cooling active and a copolymer comprising acrylamidopropyltrimonium chloride |
MX2016013618A (es) * | 2014-04-23 | 2017-02-28 | Procter & Gamble | Ciclohexanocarboxamida con propiedades de enfriamiento. |
US10392371B2 (en) | 2015-10-01 | 2019-08-27 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
JP7264049B2 (ja) * | 2017-05-31 | 2023-04-25 | ライオン株式会社 | 口腔用組成物 |
JP2018203645A (ja) * | 2017-05-31 | 2018-12-27 | ライオン株式会社 | 口腔用組成物 |
CN110621292B (zh) * | 2017-05-31 | 2022-10-28 | 狮王株式会社 | 洁齿剂组合物 |
JP6939096B2 (ja) | 2017-05-31 | 2021-09-22 | ライオン株式会社 | 液体口腔用組成物 |
DE102017125846A1 (de) | 2017-11-06 | 2019-05-09 | Fidlock Gmbh | Verbindungsvorrichtung zum lösbaren Verbinden zweier Baugruppen |
JP7431800B2 (ja) | 2018-08-10 | 2024-02-15 | フィルメニッヒ インコーポレイテッド | T2r54の拮抗薬ならびにその組成物および使用 |
DE102019123714A1 (de) | 2019-09-04 | 2021-03-04 | Fidlock Gmbh | Verbindungsvorrichtung zum lösbaren Verbinden zweier Baugruppen |
DE102020207983A1 (de) | 2020-06-26 | 2021-12-30 | Fidlock Gmbh | Verbindungsvorrichtung zum lösbaren Verbinden zweier Baugruppen |
DE202021103028U1 (de) | 2021-06-03 | 2021-08-16 | Fidlock Gmbh | Verbindungsvorrichtung mit einem Unterdruckelement |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1084387A (zh) * | 1992-05-18 | 1994-03-30 | 普罗格特-甘布尔公司 | 清凉剂组合物 |
WO2005049553A1 (en) * | 2003-11-21 | 2005-06-02 | Givaudan Sa | N-substituted p-menthane carbosamided |
WO2007019719A1 (en) * | 2005-08-15 | 2007-02-22 | Givaudan Sa | Cooling compounds |
WO2009140783A1 (en) * | 2008-05-22 | 2009-11-26 | Givaudan Sa | Cooling composition |
WO2010059289A1 (en) * | 2008-11-20 | 2010-05-27 | The Procter & Gamble Company | Personal care compositions providing enhanced cooling sensation |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB233873A (en) | 1924-05-05 | 1925-05-21 | Ronald Leighton Sandeman | Improvements in connection with looms for weaving pile fabrics |
US3492131A (en) | 1966-04-18 | 1970-01-27 | Searle & Co | Peptide sweetening agents |
US4150052A (en) | 1971-02-04 | 1979-04-17 | Wilkinson Sword Limited | N-substituted paramenthane carboxamides |
GB1353381A (en) | 1971-02-04 | 1974-05-15 | Wilkinson Sword Ltd | Substituted p-menthanes and compositions containing them |
US4136163A (en) | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
GB1351761A (en) | 1971-02-04 | 1974-05-01 | Wilkinson Sword Ltd | Substituted p-menthane carboxamides and compositions containing them |
PH10359A (en) | 1971-02-04 | 1977-01-05 | Wilkinson Sword Ltd | N-substituted-p-methane-3-carboxamides having physiological cooling activity and compositions containing them |
GB1351762A (en) | 1971-02-14 | 1974-05-01 | Wilkinson Sword Ltd | Tobacco and tobacco-containing manufactures |
GB1421744A (en) | 1972-04-18 | 1976-01-21 | Wilkinson Sword Ltd | Aliphatic n-substituted tertiary amides possessing physiological cooling activity |
US4296093A (en) | 1973-04-16 | 1981-10-20 | Wilkinson Sword Limited | Cyclic carboxamides having a physiological cooling effect |
GB1471894A (en) | 1973-12-12 | 1977-04-27 | Wilkinson Sword Ltd | Compositions for application to or consumption by the body and containing a compound having a physiological cooling effect |
GB1457671A (en) | 1974-01-31 | 1976-12-08 | Wilkinson Sword Ltd | Flavour |
US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
US6348625B1 (en) | 2000-11-10 | 2002-02-19 | Gloria Long Anderson | Method for preparing some 1-adamantancecarboxamides |
BR0315686B1 (pt) | 2002-10-28 | 2014-04-29 | Givaudan Sa | Soluções consistindo em lactato de mentila e mentol carboxamida,seu método de preparação, composição alimentícia, de cuidado bucal ou cosmética, bem como método para melhorar a solubilidade de lactato de mentila |
JP2006522750A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、11β−ヒドロキシステロイドデヒドロゲナーゼ1型阻害剤および抗高血圧剤を使用する併用療法 |
EP1656144B2 (en) | 2003-07-02 | 2017-12-20 | Genentech, Inc. | Trp-p8 active compounds and therapeutic treatment methods |
NZ597500A (en) | 2003-08-06 | 2014-08-29 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
US8362264B2 (en) | 2003-08-22 | 2013-01-29 | Dendreon Corporation | Compositions and methods for the treatment of disease associated with Trp-p8 expression |
US7169377B2 (en) | 2003-10-15 | 2007-01-30 | Wei Edward T | Radioligands for the TRP-M8 receptor and methods therewith |
WO2005048965A2 (en) | 2003-11-13 | 2005-06-02 | Wm. Wrigley Jr. Company | Method and composition for breath freshening |
US7417048B2 (en) | 2003-12-31 | 2008-08-26 | Wei Edward T | Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets |
US20050187211A1 (en) | 2004-02-23 | 2005-08-25 | Wei Edward T. | N-arylsalkyl-carboxamide compositions and methods |
GB0425661D0 (en) | 2004-11-23 | 2004-12-22 | Givaudan Sa | Organic compounds |
WO2006056096A1 (en) | 2004-11-29 | 2006-06-01 | Givaudan Sa | Substrate care product |
AU2005322104A1 (en) | 2004-12-29 | 2006-07-06 | Wm. Wrigley Jr. Company | Combinations of cooling agents for use in confections |
EP1853565B1 (en) | 2005-03-01 | 2010-09-22 | Givaudan SA | Menthane carboxamide derivatives having cooling properties |
GB0504194D0 (en) | 2005-03-02 | 2005-04-06 | Givaudan Sa | Organic compounds |
US20080319055A1 (en) | 2005-03-24 | 2008-12-25 | Givaudan Sa | Cooling Compounds |
KR20080020609A (ko) | 2005-05-27 | 2008-03-05 | 지보당 에스아 | 냉각 화합물 |
EP2033688B1 (de) | 2007-08-20 | 2012-10-17 | Symrise AG | Oxalsäurederivate und deren Verwendung als physiologische Kühlwirkstoffe |
US8377422B2 (en) | 2007-12-07 | 2013-02-19 | Givaudan S.A. | Carboxamide derivatives having cooling properties |
EP2168957B1 (de) * | 2009-03-06 | 2012-02-15 | Symrise AG | Alkylsubstituierte Tetrahydropyrane als Aromastoffe |
US20120196018A1 (en) | 2009-07-29 | 2012-08-02 | Francisco Valentino Villagran | Organic Compounds |
-
2011
- 2011-02-23 GB GBGB1103103.6A patent/GB201103103D0/en not_active Ceased
-
2012
- 2012-02-23 ES ES12705673T patent/ES2732940T3/es active Active
- 2012-02-23 EP EP12705673.7A patent/EP2677988B1/en active Active
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- 2012-02-23 US US13/980,760 patent/US20130323388A1/en not_active Abandoned
- 2012-02-23 BR BR112013021413-9A patent/BR112013021413B1/pt active IP Right Grant
- 2012-02-23 WO PCT/EP2012/053082 patent/WO2012113873A2/en active Application Filing
- 2012-02-23 MX MX2013008696A patent/MX363019B/es unknown
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- 2012-02-23 CN CN201710189762.4A patent/CN106860034B/zh active Active
- 2012-02-23 KR KR1020137024493A patent/KR101924664B1/ko active IP Right Grant
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- 2013-08-12 ZA ZA2013/06056A patent/ZA201306056B/en unknown
-
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- 2016-07-11 US US15/206,866 patent/US10299999B2/en active Active
-
2017
- 2017-11-28 JP JP2017227585A patent/JP6556811B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1084387A (zh) * | 1992-05-18 | 1994-03-30 | 普罗格特-甘布尔公司 | 清凉剂组合物 |
WO2005049553A1 (en) * | 2003-11-21 | 2005-06-02 | Givaudan Sa | N-substituted p-menthane carbosamided |
WO2007019719A1 (en) * | 2005-08-15 | 2007-02-22 | Givaudan Sa | Cooling compounds |
WO2009140783A1 (en) * | 2008-05-22 | 2009-11-26 | Givaudan Sa | Cooling composition |
WO2010059289A1 (en) * | 2008-11-20 | 2010-05-27 | The Procter & Gamble Company | Personal care compositions providing enhanced cooling sensation |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109638286A (zh) * | 2018-11-29 | 2019-04-16 | 瑞红锂电池材料(苏州)有限公司 | 一种羧甲基纤维素基粘结剂及其在锂电池中的应用 |
CN109638286B (zh) * | 2018-11-29 | 2021-03-30 | 瑞红锂电池材料(苏州)有限公司 | 一种羧甲基纤维素基粘结剂及其在锂电池中的应用 |
CN113244131A (zh) * | 2021-05-19 | 2021-08-13 | 广州冰泉化妆品科技有限公司 | 一种清凉清新的口香组合物和口香牙膏及其制备方法 |
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EP2677988B1 (en) | 2019-04-03 |
ES2732940T3 (es) | 2019-11-26 |
BR112013021413B1 (pt) | 2024-04-30 |
KR20140007912A (ko) | 2014-01-20 |
WO2012113873A3 (en) | 2013-06-06 |
JP2014507440A (ja) | 2014-03-27 |
MX363019B (es) | 2019-03-05 |
CN106860034A (zh) | 2017-06-20 |
KR101924664B1 (ko) | 2018-12-03 |
US10299999B2 (en) | 2019-05-28 |
CN106860034B (zh) | 2020-05-19 |
US20160317407A1 (en) | 2016-11-03 |
JP6556811B2 (ja) | 2019-08-07 |
EP2677988A2 (en) | 2014-01-01 |
MX2013008696A (es) | 2013-08-21 |
ZA201306056B (en) | 2014-04-30 |
JP2018070628A (ja) | 2018-05-10 |
BR112013021413A2 (pt) | 2016-08-09 |
JP6262532B2 (ja) | 2018-01-17 |
WO2012113873A2 (en) | 2012-08-30 |
GB201103103D0 (en) | 2011-04-06 |
US20130323388A1 (en) | 2013-12-05 |
CN103391764B (zh) | 2017-04-12 |
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