New! View global litigation for patent families

GB1457671A - Flavour - Google Patents

Flavour

Info

Publication number
GB1457671A
GB1457671A GB458774A GB458774A GB1457671A GB 1457671 A GB1457671 A GB 1457671A GB 458774 A GB458774 A GB 458774A GB 458774 A GB458774 A GB 458774A GB 1457671 A GB1457671 A GB 1457671A
Authority
GB
Grant status
Application
Patent type
Prior art keywords
carbon
alkyl
group
atom
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB458774A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wilkinson Sword Ltd
Original Assignee
Wilkinson Sword Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00Chewing gum
    • A23G4/06Chewing gum characterised by the composition containing organic or inorganic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/40Tea flavour; Tea oil; Flavouring of tea or tea extract
    • A23F3/405Flavouring with flavours other than natural tea flavour or tea oil
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F5/00Coffee; Coffee substitutes; Preparations thereof
    • A23F5/46Coffee flavour; Coffee oil; Flavouring of coffee or coffee extract
    • A23F5/465Flavouring with flavours other than natural coffee flavour or coffee oil
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20Synthetic spices, flavouring agents or condiments
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SMOKERS' REQUISITES
    • A24BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00Chemical features or treatment of tobacco; Tobacco substitutes
    • A24B15/18Treatment of tobacco products or tobacco substitutes
    • A24B15/28Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances

Abstract

1457671 Flavour modifiers WILKINSON SWORD Ltd 29 Jan 1975 [31 Jan 1974 18 April 1974] 04587/74 and 17088/74 Headings A2B and A2C The flavour of ingestible preparations including tobacco is modified by incorporation therein of a compound capable of stimulating the cold receptors of the nervous system of the body when brought into contact therewith but being incorporated into the preparation in an amount below the threshold of practical physiological cooling activity (as hereinbefore defined), said compound being a compound of the formula where, in formula I, R 1 is H or C 1 -C 6 alkyl, R 2 and R 3 , when taken separately, are each alkyl or cycloalkyl of up to 6 carbon atoms, or up to 7 when X is OH or CH 2 OH, R 2 and R 3 , when taken together, represent a C 4 -C 11 straight or branched chain alkylene group, it being provided that: i) when R 1 is H then the alkylene group is branched at a carbon atom in a beta or gamma position relative to the group X; ii) that when X is OH or CH 2 OH, then said alkylene group may contain an OH substituent; and iii) that when R, is H and X is OH, then the cyclic group represented by is other than a p-menth-3-yl group; R 1 , R 2 and R 3 together provide a total of from 6-18 carbon atoms; X is COOR 7 , CONR 8 R 9 , SO x NR 8 R 9 or SO x R 10 ; R 7 is H, an alkali or alkaline earth metal, ammonium, alkyl- or hydroxyalkyl-substituted ammonium, or a hydroxyalkyl, hydroxyalkoxyalkyl, carboxyalkyl or alkoxycarbonylalkyl group of up to 12 carbon atoms; R 8 and R 9 , when taken separately, are each H or alkyl, hydroxyalkyl, carboxyalkyl or alkoxycarbonylalkyl of up to 12 carbon atoms, with the proviso that when R 8 is H, R 9 may also be cycloalkyl of up to 8 carbon atoms, phenyl or benzyl, or substituted phenyl or benzyl containing hydroxy, C 1 -C 4 alkyl or C 1 -C 4 alkoxy substituents; R 8 and R 9 , when taken together represent an alkylene group of up to 12 carbon atoms, the carbon atom chain of which may optionally be interrupted by oxygen or an -NH- group; R 10 is alkyl, hydroxyalkyl, carboxyalkyl or alkoxycarbonylalkyl of up to 12 carbon atoms; and x is 1 or 2; and where in formula II, R 4 is C 3 -C 20 alkyl; R 5 is C 3 -C 8 alkyl or cycloalkyl; R 6 is C 1 -C 8 alkyl or C 3 -C 8 cycloalkyl or alkylcycloalkyl; it being provided that at least one of R 4 , R 5 and R 6 is branched at a carbon atom in an α, # or γ position relative to the phosphorus atom, and that R 4 , R 5 and R 6 together provide a total of from 10-24 carbon atoms; and where, in formula III, R 11 when taken separately, is H, C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl; R 12 , when taken separately, is C 3 -C 10 alkyl or C 3 -C 10 alkylcycloalkyl, cycloalkyl, or cycloalkylalkyl, with the proviso that R 12 is branched at an α- or #-carbon atom relative to the N atom, this condition to be satisfied, in the case of cyclic groups, when the carbon atom α- or #- to the N atom is part of the cycle; R 11 and R 12 , when taken together, represent a branched chain alkylene group having 3-7 carbon atoms and branching at an α- or #-carbon atom relative to the N atom, and the chain optionally containing an ether (-O-) oxygen atom; R 11 and R 12 when separate groups and when taken together provide a total of at least 5 carbon atoms; Y represents R 13 CO-, R 14 SO 2 - or R 15 R 16 NOC-; R 13 is H, C 1 -C 6 alkyl or alkenyl, C 3 -C 6 cycloalkyl C 1 -C 10 hydroxyalkyl, C 2 -C 10 carboxyalkyl, C 3 -C 10 alkoxycarbonylalkyl, phenyl or phenyl containing C 1 -C 4 alkyl, alkoxy, OH, COOH or NO 2 substituents, with the proviso that when R 13 is C 6 alkyl it is primary in structure; R 14 is C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl, with the proviso that when R 14 is C 5 or C 6 alkyl it is primary in structure; R 15 and R 16 , when taken separately, are each H, C 1 -C 6 alkyl, C 3 -C 6 alkylcycloalkyl, cycloalkyl, or cycloalkylalkyl, C 1 -C 10 hydroxyalkyl, C 2 -C 10 carboxyalkyl or C 3 -C 10 alkoxycarbonylalkyl; or together represent a straight or branched chain C 3 -C 10 alkylene group optionally substituted with oxygen or an oxygen-containing group or containing an ether oxygen atom; and R 11 , R 12 and Y provide a total of from 7-16 carbon atoms. The following classes of compounds fall within the given formulae: cyclic amides, acyclic secondary and tertiary amides, cyclic carboxylic acids, salts and esters, cyclic sulphonamides and sulphinamides, acyclic sulphonamides and sulphinamides, cyclic and acyclic sulphoxides and sulphones, phosphine oxides, acyclic secondary and tertiary alcohols, cyclic alcohols, methylol compounds substituted ureas, amides, sulphonamides, p-methane diols, and acyclic carboxylic acids, salts and esters. Exhaustive lists are included in the specification.
GB458774A 1974-01-31 1974-01-31 Flavour Expired GB1457671A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB458774A GB1457671A (en) 1974-01-31 1974-01-31 Flavour
GB1708874 1974-04-18

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB458774A GB1457671A (en) 1974-01-31 1974-01-31 Flavour
CA 218377 CA1055772A (en) 1974-01-31 1975-01-21 Flavour modifiers
LU71748A LU71748A1 (en) 1974-01-31 1975-01-29
JP1228975A JPS50111264A (en) 1974-01-31 1975-01-29
DE19752503555 DE2503555A1 (en) 1974-01-31 1975-01-29 A process for the modification of the taste of ingestible materials
NL7501135A NL7501135A (en) 1974-01-31 1975-01-30 A method for modeficeren the taste of orally fragrance materials to be used, the method fragrance compositions for the preparation of flavor.
DK31575A DK31575A (en) 1974-01-31 1975-01-30
FR7502883A FR2272610B3 (en) 1974-01-31 1975-01-30
BE2054121A BE825025A (en) 1974-01-31 1975-01-31 Modifiers aroma

Publications (1)

Publication Number Publication Date
GB1457671A true true GB1457671A (en) 1976-12-08

Family

ID=26239244

Family Applications (1)

Application Number Title Priority Date Filing Date
GB458774A Expired GB1457671A (en) 1974-01-31 1974-01-31 Flavour

Country Status (7)

Country Link
JP (1) JPS50111264A (en)
CA (1) CA1055772A (en)
DE (1) DE2503555A1 (en)
DK (1) DK31575A (en)
FR (1) FR2272610B3 (en)
GB (1) GB1457671A (en)
NL (1) NL7501135A (en)

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214788B1 (en) 1999-03-31 2001-04-10 Firmenich Sa Use of cubebol as a flavoring ingredient
WO2005049553A1 (en) * 2003-11-21 2005-06-02 Givaudan Sa N-substituted p-menthane carbosamided
WO2005097735A1 (en) * 2004-04-02 2005-10-20 Millennium Specialty Chemicals Physiological cooling compositions containing highly purified ethyl ester of n-[[5-methyl-2-(1-methylethyl)cyclohexyl)carbonyl]glycine
WO2006056087A1 (en) * 2004-11-23 2006-06-01 Givaudan Sa Carboxamides and their use
WO2006084184A2 (en) * 2005-02-04 2006-08-10 Senomyx, Inc. Molecules comprising linked organic moieties as flavor modifiers for comestible compositions
US7417048B2 (en) 2003-12-31 2008-08-26 Wei Edward T Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets
WO2008141469A2 (en) * 2007-05-23 2008-11-27 Givaudan Sa Butone derivatives useful as cooling agents
US7476399B2 (en) 2003-08-06 2009-01-13 Senomyx Inc. Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
EP2186506A1 (en) * 2009-10-06 2010-05-19 Symrise GmbH & Co. KG Teeth cleaning compound containing menthol with reduced bitter sensation
US7842324B2 (en) 2005-06-15 2010-11-30 Senomyx, Inc. Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
US7893072B2 (en) 2003-07-02 2011-02-22 Genentech, Inc. Trp-p8 active compounds and therapeutic treatment methods
US8343945B2 (en) 2007-12-07 2013-01-01 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8362091B2 (en) 2003-08-04 2013-01-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8377422B2 (en) 2007-12-07 2013-02-19 Givaudan S.A. Carboxamide derivatives having cooling properties
US8435498B2 (en) 2002-10-25 2013-05-07 Foamix Ltd. Penetrating pharmaceutical foam
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8486375B2 (en) 2003-04-28 2013-07-16 Foamix Ltd. Foamable compositions
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
US8618081B2 (en) 2009-10-02 2013-12-31 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US8664261B2 (en) 2009-05-05 2014-03-04 Givaudan S.A. Organic compounds having cooling properties
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US8722021B2 (en) 2002-10-25 2014-05-13 Foamix Ltd. Foamable carriers
US8784782B2 (en) 2005-02-04 2014-07-22 Senomyx, Inc. Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
US8795635B2 (en) 2006-11-14 2014-08-05 Foamix Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9072313B2 (en) 2006-04-21 2015-07-07 Senomyx, Inc. Comestible compositions comprising high potency savory flavorants, and processes for producing them
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US9446267B2 (en) 2009-10-06 2016-09-20 Symrise Ag Products comprising a flavoring agent composition
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9622947B2 (en) 2002-10-25 2017-04-18 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US9884017B2 (en) 2009-04-28 2018-02-06 Foamix Pharmaceuticals Ltd. Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3724900C2 (en) * 1986-08-08 2000-04-06 Colgate Palmolive Co N-alkyl neoalkanamides and their use
JP2016535742A (en) * 2013-10-22 2016-11-17 エドワード タク ウェイWEI, Edward Tak Di as a therapeutic for local drug sensory discomfort - isopropyl - alkane (dapa) Compound

Cited By (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214788B1 (en) 1999-03-31 2001-04-10 Firmenich Sa Use of cubebol as a flavoring ingredient
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US8741265B2 (en) 2002-10-25 2014-06-03 Foamix Ltd. Penetrating pharmaceutical foam
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US9622947B2 (en) 2002-10-25 2017-04-18 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9492412B2 (en) 2002-10-25 2016-11-15 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9713643B2 (en) 2002-10-25 2017-07-25 Foamix Pharmaceuticals Ltd. Foamable carriers
US8435498B2 (en) 2002-10-25 2013-05-07 Foamix Ltd. Penetrating pharmaceutical foam
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US8840869B2 (en) 2002-10-25 2014-09-23 Foamix Ltd. Body cavity foams
US8722021B2 (en) 2002-10-25 2014-05-13 Foamix Ltd. Foamable carriers
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8486375B2 (en) 2003-04-28 2013-07-16 Foamix Ltd. Foamable compositions
US7893072B2 (en) 2003-07-02 2011-02-22 Genentech, Inc. Trp-p8 active compounds and therapeutic treatment methods
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8703105B2 (en) 2003-08-04 2014-04-22 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9050253B2 (en) 2003-08-04 2015-06-09 Foamix Pharmaceuticals Ltd. Oleaginous pharmaceutical and cosmetic foam
US9101662B2 (en) 2003-08-04 2015-08-11 Foamix Pharmaceuticals Ltd. Compositions with modulating agents
US9636405B2 (en) 2003-08-04 2017-05-02 Foamix Pharmaceuticals Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8362091B2 (en) 2003-08-04 2013-01-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
US7476399B2 (en) 2003-08-06 2009-01-13 Senomyx Inc. Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US8404455B2 (en) 2003-08-06 2013-03-26 Senomyx, Inc. Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides
US9091686B2 (en) 2003-08-06 2015-07-28 Senomyx, Inc. Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides
US7888470B2 (en) 2003-08-06 2011-02-15 Senomyx, Inc. Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides
US9459250B2 (en) 2003-08-06 2016-10-04 Senomyx, Inc. Use of T1R3 venus flytrap region polypeptide to screen for taste modulators
US8735081B2 (en) 2003-08-06 2014-05-27 Senomyx, Inc. T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
US8124121B2 (en) 2003-08-06 2012-02-28 Senomyx, Inc. Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US8895050B2 (en) 2003-08-06 2014-11-25 Senomyx, Inc. Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
WO2005049553A1 (en) * 2003-11-21 2005-06-02 Givaudan Sa N-substituted p-menthane carbosamided
US7414152B2 (en) 2003-11-21 2008-08-19 Givaudan, Sa N-substituted p-menthane carboxamides
USRE44339E1 (en) 2003-11-21 2013-07-02 Givaudan S.A. N-substituted P-menthane carboxamides
US7417048B2 (en) 2003-12-31 2008-08-26 Wei Edward T Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets
WO2005097735A1 (en) * 2004-04-02 2005-10-20 Millennium Specialty Chemicals Physiological cooling compositions containing highly purified ethyl ester of n-[[5-methyl-2-(1-methylethyl)cyclohexyl)carbonyl]glycine
WO2006056087A1 (en) * 2004-11-23 2006-06-01 Givaudan Sa Carboxamides and their use
WO2006084184A2 (en) * 2005-02-04 2006-08-10 Senomyx, Inc. Molecules comprising linked organic moieties as flavor modifiers for comestible compositions
US8784782B2 (en) 2005-02-04 2014-07-22 Senomyx, Inc. Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
US8968708B2 (en) 2005-02-04 2015-03-03 Senomyx, Inc. Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
WO2006084184A3 (en) * 2005-02-04 2006-11-30 Vincent Darmohusodo Molecules comprising linked organic moieties as flavor modifiers for comestible compositions
US7842324B2 (en) 2005-06-15 2010-11-30 Senomyx, Inc. Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
US9072313B2 (en) 2006-04-21 2015-07-07 Senomyx, Inc. Comestible compositions comprising high potency savory flavorants, and processes for producing them
US9682021B2 (en) 2006-11-14 2017-06-20 Foamix Pharmaceuticals Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8795635B2 (en) 2006-11-14 2014-08-05 Foamix Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2008141469A3 (en) * 2007-05-23 2009-05-07 David Max Dastrup Butone derivatives useful as cooling agents
WO2008141469A2 (en) * 2007-05-23 2008-11-27 Givaudan Sa Butone derivatives useful as cooling agents
US7935848B2 (en) 2007-05-23 2011-05-03 Givaudan S.A. Butone derivatives useful as cooling agents
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9662298B2 (en) 2007-08-07 2017-05-30 Foamix Pharmaceuticals Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US8377422B2 (en) 2007-12-07 2013-02-19 Givaudan S.A. Carboxamide derivatives having cooling properties
US9795564B2 (en) 2007-12-07 2017-10-24 Foamix Pharmaceuticals Ltd. Oil-based foamable carriers and formulations
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
US9549898B2 (en) 2007-12-07 2017-01-24 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US8343945B2 (en) 2007-12-07 2013-01-01 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US9161916B2 (en) 2007-12-07 2015-10-20 Foamix Pharmaceuticals Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8900553B2 (en) 2007-12-07 2014-12-02 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US9884017B2 (en) 2009-04-28 2018-02-06 Foamix Pharmaceuticals Ltd. Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
US8664261B2 (en) 2009-05-05 2014-03-04 Givaudan S.A. Organic compounds having cooling properties
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9572775B2 (en) 2009-07-29 2017-02-21 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US8871184B2 (en) 2009-10-02 2014-10-28 Foamix Ltd. Topical tetracycline compositions
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US8992896B2 (en) 2009-10-02 2015-03-31 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US8618081B2 (en) 2009-10-02 2013-12-31 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
US9675700B2 (en) 2009-10-02 2017-06-13 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US8945516B2 (en) 2009-10-02 2015-02-03 Foamix Pharmaceuticals Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
US8865139B1 (en) 2009-10-02 2014-10-21 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
EP2364689A3 (en) * 2009-10-06 2015-12-09 Symrise AG Teeth cleaning compound containing menthol with reduced bitter sensation
US9446267B2 (en) 2009-10-06 2016-09-20 Symrise Ag Products comprising a flavoring agent composition
EP2186506A1 (en) * 2009-10-06 2010-05-19 Symrise GmbH & Co. KG Teeth cleaning compound containing menthol with reduced bitter sensation

Also Published As

Publication number Publication date Type
CA1055772A1 (en) grant
FR2272610B3 (en) 1977-10-21 grant
JPS50111264A (en) 1975-09-01 application
DE2503555A1 (en) 1975-08-14 application
CA1055772A (en) 1979-06-05 grant
NL7501135A (en) 1975-08-04 application
DK31575A (en) 1975-09-22 application
FR2272610A1 (en) 1975-12-26 application

Similar Documents

Publication Publication Date Title
US5962516A (en) Immunosuppressive compounds and methods
JPS6185319A (en) Antineoplastic agent
DE2909754A1 (en) Benzofuranyl:oxy or benzothienyl:oxy substd. alkanoic acid derivs. - with hypolipidaemic activity, useful as anti-atherosclerosis agents
GB1169945A (en) Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives
JPS6354321A (en) Blood sugar lowering agent
GB1489359A (en) Alicyclic carboxamides having physiological cooling activity
Berger et al. Central depressant and anticonvulsant activity of compounds isomeric with 2-methyl-2-n-propyl-1, 3-propanediol dicarbamate (miltown)
JPH02149577A (en) Tocopherol aminoalkylcarboxylic acid ester and salt thereof
GB1435573A (en) Indoloquinolizines
GB1345880A (en) Pyridazine derivatives
GB1253830A (en) Method of preparing injections
GB2010270A (en) Novel "soft" anticholinergic agents exhibiting anti-secretory activity
GB1404596A (en) Ingestible topical and other compositions containing physiolog cal cooling agents
JPS60184005A (en) Cosmetic for preventing aging of skin
US3303193A (en) Derivatives of cephalosporanic acid
GB1086192A (en) Phenylcyclopropane derivatives
JPS58218038A (en) Magnetic recording body
GB1178322A (en) Improvements in or relating to Pharmacologically-Active Substituted Benzotriazines.
TAKENOUCHI et al. ABSORPTION AND EXCRETION OF THIAMINE PROPYL DISULFIDE-S35
Gibson et al. Pharmacology of a Short-Acting Non-Sulphur Barbituric Acid Derivative
GB797237A (en) Composition for reducing period of anesthesia
GB1206487A (en) Derivatives of n-acylaminoacid amides
Powloski The effects of combining hunger and thirst motives in a discrimination habit.
JPS5860957A (en) Additive for animal feed or feed containing the same
WO1992014705A1 (en) Benzamide derivative

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee