CN103385990B - Rhizoma alismatis essence and preparation method thereof - Google Patents
Rhizoma alismatis essence and preparation method thereof Download PDFInfo
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- CN103385990B CN103385990B CN201310348692.4A CN201310348692A CN103385990B CN 103385990 B CN103385990 B CN 103385990B CN 201310348692 A CN201310348692 A CN 201310348692A CN 103385990 B CN103385990 B CN 103385990B
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Abstract
The invention discloses a rhizoma alismatis essence and a preparation method thereof. The rhizoma alismatis essence is a dry powder medicament extracted from rhizoma alismatis and aims at blood fat reduction. The extraction process of the essence comprises the following steps of: weighting, cleaning and drying a rhizoma alismatis raw material for later use, crushing the rhizoma alismatis raw material, adding water to form slurry, decocting the slurry for 40min, filtering to obtain a filtrate, cooling the filtrate, mixing with protease, cellulase and diastase and stirring for a period of time, adjusting the pH value to 5.0 by edible acetic acid, standing for over half a day, and drying a standing liquid to obtain a tradtional Chinese medicine essence in a dry powder state and capable of reducing blood fat. The rhizoma alismatis essence disclosed by the invention can effectively reduce serum cholesterol, triglyceride and low-density lipoprotein, improve high-density lipoprotein, inhibit fat accumulation and viscous atherosclerosis, slow down generation of intimal plaque, relieve lesion degree and diminish lesion range. The extraction process disclosed by the invention is simple in step, convenient to implement, high in extraction rate, and suitable for large-scale production in batches.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine and method for making thereof, particularly relate to a kind of Rhizoma Alismatis essence and method for making thereof, belong to Chinese medicine polish field.
Background technology
Along with people's living standard improves constantly, the change of dietary structure and life style, the blood lipid level of crowd is totally raising year by year, and thus cardiovascular and cerebrovascular disease is also in ascendant trend year by year.In some cardiovascular hotspots, hyperlipemia prevalence is more than 20%.
Blood fat is a kind of important substance in human body, has many very Chinese medicine functions, but can not exceed certain scope.If generation hyperlipemia, then easily cause " blood is thick ", blood vessel wall deposits, form little speckle gradually, " atherosclerosis " that namely it has often been said.These " specklees " increase, increase, and artery-clogging gradually makes blood flow slack-off.Blood flow ceases time serious, if this situation occurs in heart, will cause coronary heart disease; There is brain again, just there will be brain sudden death; As being jammed in optical fundus blood vessel, visual deterioration, blind will be caused; As occurred in kidney, renal arteriosclerosis, renal failure will be caused.As can be seen here, hyperlipemia disease is the immediate cause causing coronary heart disease, hypertension, arteriosclerosis etc. sick, very large to harm.
Summary of the invention
In view of the demand that above-mentioned prior art exists, the object of the invention is to propose a kind of Rhizoma Alismatis essence and pharmaceutical applications thereof, and propose the higher Traditional Chinese medicine essence extraction process of a kind of effective ingredient extraction.
One of above-mentioned purpose of the present invention Rhizoma Alismatis essence, its technical scheme be achieved is: described Rhizoma Alismatis essence is that extraction is from the dry powder state medicine of Rhizoma Alismatis and for reduction blood fat.
The method for making of two Rhizoma Alismatis essences of above-mentioned purpose of the present invention, its technical scheme be achieved comprises operating procedure: I, weigh Rhizoma Alismatis, and in stainless steel tank, carry out routine cleaning, taking-up is dried for subsequent use; II, pulverized by Rhizoma Alismatis for subsequent use, smashing fineness reaches 150 orders, then adds the water mixing of raw material of Chinese medicine gross mass 10 times, makes powder slurry; III, powder slurry is put into stainless-steel pan to decoct to filter after 40 minutes and obtain filtrate; IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirs, be cooled to less than 20 DEG C, add the protease of Rhizoma Alismatis weight 0.15% ~ 0.3%, 0.15% ~ 0.4% cellulase and 0.15% ~ 0.2% diastase again, stir more than 2 hours under the condition of rotating speed 30 beats/min, and by alimentary acetic acid adjust ph 5.0, leave standstill more than half a day; V, after standing liquid being put into centrifuge dehydration in aseptic temperature control workshop, produced precipitate is put into electric heating aerator to set constant temperature 45 DEG C and carry out dry 6-8 hour, obtain the Rhizoma Alismatis essence of dry powder state, the weight of this Rhizoma Alismatis essence is the 5-7% of Rhizoma Alismatis raw material gross weight.
The technical scheme of Rhizoma Alismatis essence of the present invention and extraction process thereof, its outstanding effect is: this Rhizoma Alismatis essence can effectively reduce serum cholesterol, triglyceride, low density lipoprotein, LDL, high density lipoprotein increasing, suppress the accumulation of fat and be stained with stickiness atherosclerosis, slow down the generation of tunica intima speckle and alleviate lesion degree, reduce extent of disease.In addition extraction process step of the present invention is simple, and it is convenient to implement, and extraction is higher, is suitable for lot-size and produces.
Detailed description of the invention
Because at present to limited, the present situation that often recurs of hyperlipidemia treatment means, this case creator concentrates one's attention on Study of Traditional Chinese Medicine medical knowledge, through exploring Chinese herbal medicine material, the test that effectively can prevent and treat herpes zoster, finally finds good technical solution.
After deliberation, the present invention proposes a kind of Rhizoma Alismatis essence, and it is extract the dry powder state medicine from Rhizoma Alismatis, and effectively can reduce blood fat.
Based on rabbit experiment from pharmacology: Rhizoma Alismatis is oral to Hyperlipidemia Rabbits, have and obviously reduce serum cholesterol, triglyceride, low density lipoprotein, LDL, the effect of high density lipoprotein increasing, illustrate there is preventive and therapeutic action to rabbit hyperlipemia.The effect for reducing fat of Rhizoma Alismatis is the most remarkable with the effect of alisol A-24 acetate, and alisol C-23 acetate, alisol A also have remarkable effect.Rhizoma Alismatis can make the absorbance of rat small intestine cholesterol obviously reduce, and can suppress the esterification of small intestinal cholesterol.Fatty liver rabbit is after Rhizoma Alismatis treatment, and hepatic fat content obviously reduces, and can suppress the accumulation of rat liver fat.Therefore the present invention is devoted to development and the extraction of essence.
From method for making embodiments of the invention, it comprises following operating procedure.
I, weigh Rhizoma Alismatis 10kg, in stainless steel tank, carry out routine cleaning, taking-up is dried for subsequent use; II, pulverized by Rhizoma Alismatis for subsequent use, smashing fineness reaches 150 orders, then adds the water mixing of 100kg, produces powder slurry; III, powder slurry is put into stainless-steel pan, be heated to 100 DEG C, decoct 40 minutes, then add filter cloth bag at blowing valve port, then open baiting valve and filter, obtain filtrate; IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirs, be cooled to 18 DEG C, add the diastase of the protease of 0.03kg, the cellulase of 0.04kg and 0.02kg again, stir 3 hours under the condition of rotating speed 30 beats/min, and by alimentary acetic acid adjust ph 5.0, leave standstill 20 hours; V, after standing liquid being put into centrifuge dehydration in aseptic temperature control workshop, produced precipitate is put into electric heating aerator and set constant temperature 45 DEG C and carry out drying 8 hours, obtain the Rhizoma Alismatis essence of 0.6kg dry powder state.
The embodiment of the present invention is intended to be convenient to understand innovation essence of the present invention; but do not limit the scope of the invention; all simple modification or equivalence are replaced, or utilize this finished product powder processing and fabricating capsule, pill, injection etc., all should be contained among the scope of the present invention.
Medical record is introduced: Rhizoma Alismatis of the present invention extracts element through developing for many years, and its pharmaceutical applications can treat hyperlipidemia, and it is evident in efficacy to drop into clinical trial.Certain city Mr. Lu, 60 years old, health check-up in 2011 learnt that its triacylglycerol does large 3.9mmol/L.Among 1 year, take this Rhizoma Alismatis extract element (a day three times, each 1g), within 2012, again learn that triacylglycerol is down to 1.5mmol/L after health check-up, patient is extremely delighted.Patient's low density lipoprotein, LDL (LDL) declines simultaneously, and high density lipoprotein (HDL) raises, and this Rhizoma Alismatis essence can't harm liver, nephrocyte, has no side effect.
As can be seen here, the technical scheme of Rhizoma Alismatis essence of the present invention and extraction process thereof, its outstanding effect is: this Traditional Chinese medicine essence can effectively reduce serum cholesterol, triglyceride, low density lipoprotein, LDL, high density lipoprotein increasing, suppress the accumulation of fat and be stained with stickiness atherosclerosis, slow down the generation of tunica intima speckle and alleviate lesion degree, reduce extent of disease.In addition extraction process step of the present invention is simple, and it is convenient to implement, and extraction is higher, is suitable for lot-size and produces.
Claims (1)
1. an extraction process for Rhizoma Alismatis essence, its feature comprises operating procedure:
I, weigh Rhizoma Alismatis, in stainless steel tank, carry out routine cleaning, taking-up is dried for subsequent use;
II, pulverized by Rhizoma Alismatis for subsequent use, smashing fineness reaches 150 orders, then adds the water mixing of raw material of Chinese medicine gross mass 10 times, makes powder slurry;
III, powder slurry is put into stainless-steel pan to decoct to filter after 40 minutes and obtain filtrate;
IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirs, be cooled to less than 20 DEG C, add the protease of Rhizoma Alismatis weight 0.15% ~ 0.3%, 0.15% ~ 0.4% cellulase and 0.15% ~ 0.2% diastase again, stir more than 2 hours under the condition of rotating speed 30 beats/min, and by alimentary acetic acid adjust ph 5.0, leave standstill more than half a day;
V, after standing liquid being put into centrifuge dehydration in aseptic temperature control workshop, produced precipitate is put into electric heating aerator to set constant temperature 45 DEG C and carry out dry 6-8 hour, obtain the Rhizoma Alismatis essence of dry powder state, the weight of this Rhizoma Alismatis essence is the 5-7% of Rhizoma Alismatis raw material gross weight.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310348692.4A CN103385990B (en) | 2013-08-13 | 2013-08-13 | Rhizoma alismatis essence and preparation method thereof |
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| CN201310348692.4A CN103385990B (en) | 2013-08-13 | 2013-08-13 | Rhizoma alismatis essence and preparation method thereof |
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| CN103385990B true CN103385990B (en) | 2015-06-17 |
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Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101537086B (en) * | 2009-04-29 | 2012-10-03 | 香港科技大学 | Pharmaceutical composition for resisting hepatitis B virus, lowering lipid and alleviating fatty live lesions and preparation method thereof |
| CN103182009B (en) * | 2011-12-30 | 2014-12-10 | 天津药物研究院 | Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof |
| CN103372114B (en) * | 2012-04-20 | 2015-01-21 | 北京北大维信生物科技有限公司 | Red rice and rhizoma alismatis medicinal composition for regulating blood fat and preparation method of composition |
| CN102793891B (en) * | 2012-08-23 | 2013-09-11 | 浙江省中医药研究院 | Traditional Chinese medicine composition having functions of reducing blood fat and resisting hyperuricemia |
| CN103520401B (en) * | 2013-10-21 | 2016-03-02 | 华夏先葆(北京)中药研究院有限公司 | A kind of Traditional Chinese medicine health-preserving preparation with auxiliary lipid-lowering function |
| CN103638223A (en) * | 2013-12-16 | 2014-03-19 | 湖北麦克森生物技术有限公司 | Compound preparation capsule for reducing blood fat |
| CN103735754A (en) * | 2013-12-23 | 2014-04-23 | 王世俊 | Preparation method of lipid-lowering medicine |
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