CN101999652B - Blood fat-reducing health-care food and preparation method thereof - Google Patents
Blood fat-reducing health-care food and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a blood fat-reducing health-care food and a preparation method thereof. The method comprises: weighing 3 to 25 parts of red yeast rice extract, 3 to 30 parts of Pu-Er ripe tea extract, 40 to 93 parts of plukenetia volubilis linneo oil and 1 to 8 parts of beewax; and the raw materials processed by a conventional process into soft capsules. In the invention, the health-care food prepared by using the plukenetia volubilis linneo oil as the main ingredient and combining the red yeast rice extract, the Pu-Er ripe tea extract and the beewax have obvious blood fat reducing and antithrombotic effects, is obvious in effect, safe, highly controllable and stable in quality and is a new choice for daily health care of people. In addition, the use of the plukenetia volubilis linneo oil as a dispersant is favorable for the forming of the soft capsules. The soft capsules are favorable for the uniform dispersion of the active ingredients such as Lovastatin in the red yeast rice extract in the oil and absorption by human body. Meanwhile, the Pu-Er ripe tea extract is susceptible to moisture absorption, and the soft capsules enable the product to be stored for a long time.
Description
Technical field
The invention belongs to the health products preparing technical field, be specifically related to a kind ofly be primary raw material, have a health food of hypolipemic function with plukenetia volubilis linneo oil.The present invention also relates to the preparation method of this health food simultaneously.
Background technology
Lipoid material in the blood is referred to as blood fat.Lipid in the blood plasma comprises cholesterol, triglycerides, phosphatide and non-free fatty etc., they in blood be with different protein bound together, exist with the form of " lipoprotein ".Blood fat is a kind of important material in the human body, and many very important functions are arranged.If but hyperlipemia then causes " blood viscousness " easily, blood fat deposits on vascular wall, forms little patch (being exactly " atherosclerotic " that we often say) gradually.These " patches " increase, increase, and artery-clogging makes blood flow slack-off gradually, and blood flow is interrupted when serious.If this situation occurs in heart, just cause coronary heart disease; Occur in brain, headstroke will occur; If the obstruction optical fundus blood vessel will cause eyesight to descend, lose one's sight; If occur in kidney, will cause renal arteriosclerosis, renal failure; Occur in lower limb, limb necrosis can occur, fester etc.In addition, high fat of blood can cause hypertension, gall stone, pancreatitis, increases the weight of hepatitis, causes male sexual disfunction, disease such as senile dementia.Current research prompting high fat of blood also maybe be relevant with the morbidity of cancer.Along with growth in the living standard, people's dietary fat intake increases.Some crowds, fatty energy supply has surpassed 30% of gross energy, and high lipid diet has been the definite risk factors of hyperlipemia.Big quantity research shows; Hyperlipemia is a key factor that threatens human health, regulates the incidence that human body serum lipids level can reduce cardiovascular and cerebrovascular diseases such as coronary heart disease death rate and ischemic heart incident (myocardial infarction, sudden death, unstable angina), hypertension, cerebral hemorrhage.Therefore, regulate blood fat with the caused disease of prevention hyperlipemia, become the focus of current health care research through natural food.
Summary of the invention
The objective of the invention is to the deficiency to prior art, a kind of novel healthy food is provided, this product is a primary raw material with plukenetia volubilis linneo oil, through the reasonable assembly to natural food material, realizes convenient, significant blood fat reducing function.
The present invention also aims to provide a kind of method for preparing said health food.
A kind of health food with hypolipemic function is formed by the feedstock production of following weight parts: 3～25 parts of Red Yeast Rice P.Es, 3～30 parts of Pu'er cooked tea extracts, 40～93 parts of plukenetia volubilis linneo oil and 1～8 part in beeswax; Each raw material is processed into soft capsule by common process.
Further, described raw material is formed preferred following proportioning: 8～15 parts of Red Yeast Rice P.Es, 5～20 parts of Pu'er cooked tea extracts, 2～6 parts in 61～85 parts of plukenetia volubilis linneo oil and beeswax.
Described optimum material proportion with health food of hypolipemic function is: 12 parts of Red Yeast Rice P.Es, 8 parts of Pu'er cooked tea extracts, 3 parts in 77 parts of plukenetia volubilis linneo oil and beeswax.
Wherein, plukenetia volubilis linneo oil is the edible oil that the kind benevolence of the perennial bejuco plukenetia volubilis linneo of Euphorbiaceae obtains after squeezing.Former area, mountain range, South America Andean (Andes) tropical rain forest that grows in height above sea level 80～1700m of plukenetia volubilis linneo.Become wild by the Inca at first and plant into family, seal adds language and claims Sacha Inchi or Inca Inchi, and seal adds more than one thousand years has been used in area (Peru) by local original inhabitant history in South America.Modern medicine proves; The plukenetia volubilis linneo oil that is rich in polyunsaturated fatty acid is in control cardiovascula arteriosclerosis property disease; Regulate cholesterol, lipids contents, reduce platelet aggregation rate, suppress tumor growth and thrombus and atherosclerotic plaque formation, there is remarkable efficacy aspects such as adjusting function of human body.Plukenetia volubilis linneo oil can reduce rat blood serum T-CHOL and the content that significantly reduces serum triglyceride, and the body weight of rat is not had obvious influence.
Red Yeast Rice P.E derives from the red colouring agent for food, also used as a Chinese medicine of rice fermentation; A large amount of research confirms, take red colouring agent for food, also used as a Chinese medicine after 23 days serum cholesterols obviously reduce, HDL-C obviously raises; Human body is taken red colouring agent for food, also used as a Chinese medicine 1-2g every day; Cut down its spit of fland 5-10mg comprising the effective component Lip river, red colouring agent for food, also used as a Chinese medicine has the comprehensive adjustment blood fat, effectively reduces serum total cholesterol (TC), triglycerides (TG), LDL-C (LDL-C), the effect of increasing high density lipoprotein cholesterol (HDL-C).Simultaneously red colouring agent for food, also used as a Chinese medicine can also activate blood circulation and disperse blood clots, and reduces blood viscosity, reduces AI, the fatty liver that high fat of blood is caused, diabetes, hypertension, uncomfortable in chest, breathe hard, dizziness, headache, weakness of limbs and extremity numbness etc. have mitigation.
The Pu'er cooked tea extract is to shine the polyphenolic substance complex that blue or green tea extracts the tealeaves processed from the natural plants large leaf after fermentation; Account for 25% of dry weight of tea leaves greatly, mainly comprise four big types of materials such as catechin, flavones and flavonols, anthocyan, phenolic acid and depside by its chemical constitution.The main component of Pu'er cooked tea extract is a catechin, accounts for about 80% of its total amount.Catechin in the tealeaves is mainly catechin, L-Epicatechin gallate, epigallocatechin and Epigallo-catechin gallate (EGCG) etc.Research confirms; The Pu'er cooked tea extract has plurality of health care functions and pharmacodynamics effect, as antibiotic, antiviral, antitoxin, anti-cancer, anticancer, anti-sudden change, reducing blood lipid, hypotensive, hypoglycemic, prevent artery sclerosis and thrombosis, protection liver, anti-ageing, anti-carious tooth, antiallergy etc.
The wax of preferred apis cerana of beeswax or apis mellifera secretion.
Prepare described method, specifically may further comprise the steps with health food of hypolipemic function:
1, take by weighing 3～25 parts of Red Yeast Rice P.Es, 3～30 parts of Pu'er cooked tea extracts, and both are dropped in the powder mixer, mix obtaining mixed powder in 20 minutes;
2, take by weighing 40～93 parts of plukenetia volubilis linneo oil and beeswax and place material-compound tank for 1～8 part, stir also heating, treat that beeswax all dissolves the back cooling, oily wax liquid;
3, in said oily wax liquid, add the mixed powder that step (1) obtains, stir 30min, feed liquid is mixed rearmounted colloid mill and milled three times, vacuumizes after having ground and takes off most bubble, processes the content feed liquid, and is for use;
4, the content feed liquid is placed the soft capsule pellet press, be pressed into soft capsule.
The present invention is a main component with plukenetia volubilis linneo oil, and is aided with Red Yeast Rice P.E, Pu'er tea and beeswax, and made health food has tangible reducing blood lipid, anti thrombotic action; And drug effect is obvious, safety; Controllability is strong, and steady quality is for people's daily health caring provides new selection.And, helping the soft capsule moulding with plukenetia volubilis linneo oil as dispersant, the active ingredients such as Lovastatin that soft capsule dosage form also helps in the Red Yeast Rice P.E are dispersed in the fluid, are convenient to absorption of human body.Simultaneously, because the easy moisture absorption of Pu'er tea, soft capsule dosage form also is convenient to the product long preservation.
The specific embodiment
Through embodiment the present invention is done further detailed description below, but they are not the qualification to technical scheme of the present invention.
Embodiment 1
Red colouring agent for food, also used as a Chinese medicine extracts 2～4 times with 3～8 times of amount 60～80% alcohol heating reflux respectively; The each extraction 1～4 hour; 120～200 order filter clothes filter the back merging filtrate; Filtrate decompression is condensed into medicinal extract, medicinal extract through vacuum drying (65～90 ℃ of temperature, vacuum≤-0.08Mpa) become to pulverize 100～140 mesh sieves behind the dry extract and get Red Yeast Rice P.E; Pu'er cooked tea extracts 1～3 time for 70～95 ℃ with 5～10 times of water gagings respectively; The each extraction 1～3 hour; 120～180 order filter clothes filter the back merging filtrate; It is 10～20% backs spray-dried (160～220 ℃ of EATs, 70～95 ℃ of leaving air temps) that filtrate decompression is concentrated in the concentrate solid content, crosses 100～140 mesh sieves and gets the Pu'er cooked tea extract.
Take by weighing Red Yeast Rice P.E 120g, Pu'er cooked tea extract 80g, and both are dropped in the powder mixer, mix obtaining mixed powder in 20 minutes, subsequent use.Take by weighing oily 760g of plukenetia volubilis linneo and beeswax 40g and place material-compound tank, stir also heating, treat that beeswax all dissolves the back cooling, gets oily wax liquid.In said oily wax liquid, add subsequent use mixed powder, stir 30min, feed liquid is mixed rearmounted colloid mill and is milled three times, vacuumizes after having ground and takes off most bubble, processes the content feed liquid.The content feed liquid is placed the soft capsule pellet press, be pressed into soft capsule (500mg/ grain).The soft capsule that suppresses is put in the typing rotating cage and is finalized the design, and uses 95% ethanol with the eccysis of soft capsule surface and oil contaminant then.The capsule and pill of cleaning is put into drying room went out ball in dry 24 hours, choose useless balls such as underproof big piller, special-shaped ball, thin-walled ball, flat ball, after pack warehouse-in after the assay was approved
Embodiment 2
Repeat embodiment 1, following difference is arranged: take by weighing Red Yeast Rice P.E 120g, Pu'er cooked tea extract 80g, plukenetia volubilis linneo oil 770g and beeswax 30g.The capsule and pill of cleaning was put into drying room dry 48 hours.
Embodiment 3
Repeat embodiment 1, following difference is arranged: take by weighing Red Yeast Rice P.E 80g, Pu'er cooked tea extract 50g, plukenetia volubilis linneo oil 610g and beeswax 20g.
Embodiment 4
Repeat embodiment 1, following difference is arranged: take by weighing Red Yeast Rice P.E 150g, Pu'er cooked tea extract 200g, plukenetia volubilis linneo oil 850g and beeswax 60g.
Embodiment 5
Repeat embodiment 1, following difference is arranged: take by weighing Red Yeast Rice P.E 30g, Pu'er cooked tea extract 30g, plukenetia volubilis linneo oil 400g and beeswax 10g.
Embodiment 6
Repeat embodiment 1, following difference is arranged: take by weighing Red Yeast Rice P.E 250g, Pu'er cooked tea extract 300g, plukenetia volubilis linneo oil 930g and beeswax 80g.
Application implementation example 1
Embodiment 1 products obtained therefrom is estimated according to the health food check and the auxiliary lipid-lowering function zoopery evaluation method of assessment technique standard, shown that this product has the function of reducing blood lipid.
Respectively with 83,167, the sample of 333mg/kg BW (be equivalent to human body respectively and recommend 5,10,20 times of consumption) dosage gives hyperlipidemia model rat continuous irrigation stomach 35 days; Can reduce serum total cholesterol (TC) and triglycerides (TG) content of hyperlipidemia model rat; Its serum high-density LP cholesterol (HDL-C) content that raises does not have obvious influence to the body weight gain of rat.This shows that this sample has the hypolipemic function effect.
Application implementation example 2
Embodiment 2 products obtained therefroms are carried out the human clinical trial.Meet people with hyperlipidemia 106 examples (control group 53 examples: male 23 examples, women 30 examples that this test is tried inclusion criteria; Test-meal group 53 examples: male 18 examples, women 35 examples), wherein test-meal group 53 examples were taken this product 30 days (2 times for each person every day continuously; Each 1; Specification is the 0.5g/ grain) after, test-meal sample person serum TC and TG content obviously reduce as a result, and test-meal sample person self relatively reaches with control group more all has conspicuousness (P＜0.01 or P＜0.05); Total effective rate is 78.64%, has significant difference (P＜0.01) with 26.35% of control group; And experimenter's routine blood test, stool and urine routine, blood parameters and other clinical examinations are all no abnormal.This shows that this sample has the hypolipemic function effect, and to the healthy harmless effect of experimenter crowd.
Claims (3)
1. health food with hypolipemic function is formed by the feedstock production of following weight parts: 3～25 parts of Red Yeast Rice P.Es, 3～30 parts of Pu'er cooked tea extracts, 40～93 parts of plukenetia volubilis linneo oil and 1～8 part in beeswax; Its preparation method may further comprise the steps:
(1) red colouring agent for food, also used as a Chinese medicine extracts 2～4 times with 3～8 times of amount 60～80% alcohol heating reflux respectively, extracts 1～4 hour at every turn, filters the back merging filtrate, and filtrating concentrates, gets Red Yeast Rice P.E after vacuum drying and the pulverizing through decompression again; Pu'er cooked tea with 70～95 ℃ of extractions of 5～10 times of water gagings 1～3 time, extracted 1～3 hour respectively at every turn, merging filtrate after the filtration, and filtrating gets the Pu'er cooked tea extract again after reduce pressure concentrated and spray-drying;
(2) take by weighing 3～25 parts of Red Yeast Rice P.Es, 3～30 parts of Pu'er cooked tea extracts, and both are dropped in the powder mixer, mix obtaining mixed powder in 20 minutes;
(3) take by weighing 40～93 parts of plukenetia volubilis linneo oil and beeswax and place material-compound tank for 1～8 part, stir also heating, treat that beeswax all dissolves the back cooling, gets oily wax liquid;
(4) in said oily wax liquid, add the mixed powder that step (2) obtains, stir 30min, feed liquid is mixed rearmounted colloid mill and milled three times, vacuumizes after having ground and takes off most bubble, processes the content feed liquid, and is for use;
(5) the content feed liquid is placed the soft capsule pellet press, be pressed into soft capsule.
2. the health food with hypolipemic function according to claim 1 is characterized in that: the weight portion proportioning that raw material is formed is: 8～15 parts of Red Yeast Rice P.Es, 5～20 parts of Pu'er cooked tea extracts, 2～6 parts in 61～85 parts of plukenetia volubilis linneo oil and beeswax.
3. the health food with hypolipemic function according to claim 1 is characterized in that: the weight portion proportioning that raw material is formed is: 12 parts of Red Yeast Rice P.Es, 8 parts of Pu'er cooked tea extracts, 3 parts in 77 parts of plukenetia volubilis linneo oil and beeswax.
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| CN105050611A (en) * | 2013-03-08 | 2015-11-11 | 深圳华大基因科技有限公司 | Composition and preparation method thereof |
| JP6420587B2 (en) * | 2014-08-05 | 2018-11-07 | 学校法人東京農業大学 | Body fat reduction promoter and food containing the same |
| WO2016078088A1 (en) * | 2014-11-21 | 2016-05-26 | 深圳华大基因科技有限公司 | Use of sacha inchi oil in regulating animal intestinal tract flora |
| CN105901466B (en) * | 2016-07-12 | 2019-01-22 | 西双版纳印奇生物资源开发有限公司 | A kind of oil and fat of sacha inchi companion and preparation method thereof |
| CN107495035A (en) * | 2017-08-17 | 2017-12-22 | 张桂英 | A kind of hyperglycemic patients beverage |
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| CN101317660B (en) * | 2008-06-23 | 2012-10-24 | 谢键泓 | Method for improving soly solubility of monascus lovastatin in water and application thereof |
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