CN107648287A - A kind of young phoenix cream ointment and its application in puerpera's cracked nipple is treated - Google Patents
A kind of young phoenix cream ointment and its application in puerpera's cracked nipple is treated Download PDFInfo
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Abstract
A kind of application the invention provides young phoenix cream ointment and its in puerpera's cracked nipple is treated.The young phoenix cream ointment includes the component of following parts by weight：1 part of yolk oil extract, 0.5~1.5 part of sesame oil, 1.5~2.5 parts of pure natural lanolin, wherein, the preparation method of described yolk oil extract is as follows：Egg is cooked, strips yolk, is crushed, with food level ethyl acetate cold soaking or ultrasonic extraction, ethyl acetate is recovered under reduced pressure in obtained extract solution, obtains described yolk oil extract.The young phoenix cream ointment that this method is prepared, available for the treatment of puerpera's cracked nipple, party's genealogy of law will in traditional Chinese medicine ancient books and records have long medication history local method, presented with modern way.The young phoenix ointment preparation, technique is simple, is adapted to this specific group of mother and baby, is adapted to this moment of nursing period, has no side effect to mother and baby, do not influence to breast-feed, safely and effectively.
Description
Technical field
The invention belongs to medicine, health products, cosmetics, daily necessities field, and in particular to a kind of young phoenix cream ointment and its
Treat the application in puerpera's cracked nipple.
Background technology
Cracked nipple is the problem of newborn puerpera is usually perplexed, and chap is mainly shown as that breast epithelium comes off, nipple root
Portion's breach or surrounding ulcer, mostly occur in breast-feeding early stage, cracked nipple, often " the thorough heart of pain ", domestic puerpera's nipple pain
Pain accounts for 78%, mostly occurs 24~72 hours postpartum.Research display：Pain caused by cracked nipple, be puerpera early stage abandon it is pure
One of the main reason for breast-feeding.
It is clinical have at present the ointment prepared for some chemicalses or Chinese herbal medicine of cracked nipple treatment, cream,
Gel etc., such as：Myogenic rubine sliver, cornu cerve degelatinatum, lanolin emulsifiable paste, clostridiopetidase A etc..It is but young due to the particularity of nursing period
Mother is afraid of coating drug influence infantile health on nipple, often abandons the use of medicine；Some puerperas give even with medicine
The medicine remained on wiped clean nipple is needed before baby nursing again, also or the degree of cracked nipple can be aggravated or trigger nipple sense
Dye.
Egg oil is the oil taken from the yolk of egg.Because egg oil contains abundant vitamin A, D and lecithin
Deng regeneration and metabolism important role of these materials to human body skin.Egg oil is cured the disease, long history.The Ming Dynasty《Herbal guiding principle
Mesh》Say " ovum gallinaceum, which is fried, takes oil, and powder applies head sore ".Cloud " chicken with yolk, which is wasted lamp oil by not sleeping at night, puts it on the skin, controls cane sore and has broken, very wonderful " again.
Proved recipe of traditional Chinese medicine egg oil, be referred to as " young phoenix cream " in ancient books, it is mild-natured, it is sweet, there is removing toxicity for detumescence, expelling pus and promoting granulation it
Effect." young phoenix cream " has long medication history for treating cracked nipple, safely and effectively, among the people wide-spread.
It is family workshop property that ancient method, which prepares " young phoenix cream ", and technological operation is uncontrollable, over-emitting black exhaust, and gained egg oil brown is extremely
It is burned black, destructible yolk oil quality, and it is troublesome in poeration, it is not suitable for the allegro life of modern, although therefore " young phoenix cream " safety
Effectively, but do not received by modern society still.
Extraction egg oil is industrialized with modernism, establishes preparation among simple, safety egg oil, it is ensured that egg
The quality of butter；By Modern preparations technique, suitable ointment matrix is added, takes into full account that nursing period uses the safety of ointment
Property, it is very urgent to establish modern " young phoenix cream " ointment preparation technology.
At present, in terms of the extraction process of egg oil, Chinese patent " a kind of preparation method of refined egg oil " discloses
A kind of preparation method of high-purity egg yolk oil, including yolk powder supercritical fluid extraction, obtain thick egg oil, thick egg oil is through having
Solvent extracts, and oxidized aluminium column chromatography, organic solvent elute extract again, obtain refined egg oil.This method can be prepared into
The egg oil higher to purity, but vitamin, the lecithin isopolarity in egg oil are larger, need to use during supercritical fluid extraction
The larger entrainer of methanol, ethanol isopolarity, in addition, organic solvent has been used for multiple times in the technique, has used aluminum oxide, so,
The egg oil that this method is prepared, it is understood that there may be organic solvent etc. remains, this colony of unsuitable mother and baby and lactation this
Specific period.
In terms of the extraction process of egg oil,《Chinese livestock products and food》The 5th phase " extraction of egg oil of volume 7 in 2000
And constituent analysis " a kind of method that egg oil is prepared using ethanol percolation extraction is disclosed, this method technique is also relatively simple, and
Using food-grade ethanol diacolation, but egg oil physicochemical property is oily, is extracted with the larger ethanol percolation of polarity, easily extracted
The larger impurity of some polarity, influence the quality of egg oil.
The quality of ancient method " young phoenix cream " mesolecithal oil is sufficiently reserved, using egg oil as intermediate, adds appropriate substrate, prepares soft
Cream, applied to puerpera's cracked nipple, this particular time of lactation is taken into full account, take into full account this specific group of mother and baby, it is modern
The document and patent of " young phoenix cream " related preparations preparation method have not been reported.
The content of the invention
The purpose of the present invention is that " young phoenix cream " prepared by ancient method can not be promoted for safe and effective in traditional Chinese medicine ancient books and records,
Can not be by industrialized production, in-convenience in use this problem, there is provided a kind of scientific and reasonable, technological operation is simple, close to ancient method, again
The method of modern times " young phoenix cream " ointment for the preparation of industrialization that can be approved by newborn puerpera.With ancient method " young phoenix cream ", i.e.,：Egg oil
For intermediate, the conventional sesame oil of Chinese medicine ointment is added, pure natural lanolin is matrix, and explores regulation egg oil and matrix
Ratio, prepare modern " young phoenix cream " ointment.
A kind of young phoenix cream ointment, include the component of following parts by weight：
1 part of yolk oil extract
0.5~1.5 part of sesame oil
Pure natural 1.5~2.5 parts of lanolin
Wherein, the preparation method of described yolk oil extract is as follows：
Egg is cooked, strips yolk, is crushed, with food level ethyl acetate cold soaking or ultrasonic extraction, obtained extract solution
Ethyl acetate is recovered under reduced pressure, obtains described yolk oil extract.
Sesame oil：It is sweet, cool in nature, there is the effect of solution taking poison and growing muscle due.According to《Compendium of Materia Medica》Record：Sesame oil, which has, " to be moisturized, solves
Poison, analgesic, the work(of detumescence ".Pure sesame oil has containing abundant vitamin E and promotes the functions such as cell division.
Pure natural lanolin is odorless, tasteless, has good water imbibition, can promote Medicated Permeation, absorb, lanoline grease cream is also
It is recommended as preventing, treat cracked nipple medication by countries in the world, pure natural lanolin has no side effect, also edible, this " young phoenix
Lanolin is added in cream " ointment, can also adjust the denseness and hardness of ointment.
Using food level ethyl acetate as Extraction solvent, be very suitable for extracting lecithin in yolk, vitamins into
Point, the effective substance in ancient method young phoenix cream can more efficiently, be fully obtained, and be avoided that the larger impurity quilt of a large amount of polarity
Extract.Ethyl acetate safety, is adapted to industrial production；Fragrant esters solvent is safe as egg oil Extraction solvent, also easily
Receive in by young mother.
Extracting method used in the present invention is cold-maceration or ultrasonic extraction, and it is low that two kinds of extracting methods are respectively provided with energy consumption, safety,
The advantages that green, environmentally friendly, and egg oil intermediate extraction efficiency is high.
Preferably, food level ethyl acetate extraction time is 2 times, each 20min, constantly stirs, shake in extraction process
Shake.
Preferably, each dosage of the food level ethyl acetate is 5~10 times of yolk quality.
Preferably, described young phoenix cream ointment preparation method is as follows：
Pure natural lanolin is heated in 45 DEG C of water-baths, makes its fusing, then adds egg oil and sesame oil, room temperature
Under, stirring, until ointment is molded.
For the moulding process using egg oil as intermediate, selected matrix is that Chinese medicine ointment often uses matrix：Sesame oil and pure day
Right lanolin.Egg oil-sesame oil-pure natural lanolin is with mass fraction 2:1:4 ratio fusion.In order to obtain it is more stable,
Uniform ointment, first melts lanoline grease, adds liquid-type yolk oil, sesame oil, is stirred continuously, until it is solid to be cooled to half
Body shape yellow, transparent ointment.
The preparation method specifically includes following steps：
(1) Fresh Egg is taken, is cooked, yolk is stripped, yolk crushing, is soaked with food level ethyl acetate, cold soaking or ultrasound
Extraction 2 times, 20min/ times, is constantly stirred, and is shaken, and filtering, collects extract solution；The food level ethyl acetate dosage is yolk matter
Measure 5~10 times/time (i.e. ethyl acetate dosage is 5~10mL/g yolk)；Cold-maceration normal temperature extraction energy consumption is low, safe and simple easy
OK, the destruction or degraded of thermal sensitivity active ingredient will not also be caused.
(2) step (1) extract solution, which is concentrated under reduced pressure, reclaims ethyl acetate, produces egg oil intermediate.Ethyl acetate polarity is big
In petroleum ether, ether, chloroform, dichloromethane etc., can be extracted compared with limits vitamin A in yolk, D and lecithin isoreactivity into
Point, it is often more important that ethyl acetate used is food-grade, there is peat-reek, is also easily new life even if there is very small amount dissolvent residual
Puerpera receives；Ethyl acetate industrial production also complies with the theories such as green, environmental protection.
(3) 4 parts of lanoline grease is taken, is placed in container, 45 DEG C is heated to about, lanolin is melted, adds 2 parts of egg oils
Intermediate, 1 part of sesame oil matrix, fusion, it is stirred continuously, is cooled to room temperature, produce.It is liquid under egg oil and sesame oil normal temperature
State, inconvenient for use as ointment, lanoline grease is that Chinese medicine ointment often uses matrix, the addition of lanoline grease, can improve young phoenix
The hardness of cream ointment, and lanoline grease cream also has the prevention of certain cracked nipple, therapeutic action.
Present invention also offers a kind of application of described young phoenix cream ointment in pharmaceutical formulating art, described medicine is used
In treatment puerpera's cracked nipple.
The young phoenix cream ointment, available for treating newborn puerpera's cracked nipple.Egg oil, it is to be used to control in traditional Chinese medicine ancient books and records
The clinical proved recipe of newborn puerpera's cracked nipple is treated, is presented with modern, simple method.The extracting method is simple, safety, and quality can
Control；The ointment base added：Sesame oil, edible is ointment often with one of matrix；Pure natural lanolin, it can adjust
Ointment hardness, safety, does not influence lactation.Indicate that the young phoenix cream ointment can be used for the treatment of newborn puerpera's cracked nipple, and pacify
Entirely, suitable for this special group of mother and baby, and this specific period of nursing period.
More specifically, the ointment by ancient method young phoenix cream (i.e.：Egg oil prepared by local method) with modern extraction process, system
Agent technique is presented, and is advantageous to industrialized production, and be advantageous to the excellent tradition medicine in Chinese Traditional Medicine ancient books and records, treatment side
Method is developed；The preparation method has taken into full account that local method prepares the physicochemical property of gained egg oil, molten with food-grade perfume (or spice) ester type
Matchmaker extracts the effective substance in ancient method young phoenix cream, and ethyl acetate extraction egg oil meets rule of similarity, and industry
Production green, environmental protection, safety, on the premise of having to use organic solvent, food level ethyl acetate as Extraction solvent,
It is easy to be received by newborn puerpera.Extraction gained egg oil intermediate is yellow, transparent, oily liquids, inconvenient for use, therefore is added
Chinese medicine ointment often uses matrix：Sesame oil and pure natural lanolin, the two it is documented that, also have certain prevention, treatment
The effect of newborn puerpera's cracked nipple, or patient symptom can be improved, it is often more important that the addition of matrix, modern young phoenix cream can be promoted
The shaping of ointment, regulation ointment hardness, it is more beneficial for the convenient use of ointment.
The modern young phoenix cream ointment being prepared according to the inventive method, technique is simple, safety, green, environmental protection, is adapted to mother
This specific group of baby, it is adapted to this moment of nursing period, active constituent content is high, and it is new to fill up or supplement in the market treatment
Produce the shortage of woman's cracked nipple medicine or mother and baby's product, can also promote to a certain extent " breast-feeding " this by medical field
The infant feeding mode generally accepted.
Brief description of the drawings
Influence results of the Fig. 1 for different pharmaceutical in embodiment 7 to people's normal breast cell MCF 10A versus cell vigor
Figure.
Embodiment
With reference to specific embodiment, the present invention is described further, but protection scope of the present invention is not limited in
This：
Embodiment 1
The modern young phoenix ointment preparation of the present embodiment, comprises the steps：
A, yolk oil extract：Fresh Egg is taken, is cooked, strips yolk.200g yolk is taken, is crushed, with 8 times of amount food-grade second
Acetoacetic ester soaks, and cold soaking extracts 2 times, 20min/ times, constantly stirs, and shakes, and filtering, collects extract solution.Extract total solvent volume
16 times equivalent to yolk quality are measured (total spends food level ethyl acetate 3.2L).
B, extract solution concentrates：Combining step (1) twice gained extract solution, be concentrated under reduced pressure recovery ethyl acetate, produce yolk
Oily intermediate, obtain egg oil intermediate 48.54g.Ethyl acetate can extract vitamin A in yolk, D and lecithin compared with limits
Fat isoreactivity composition.
C, prepared by young phoenix cream ointment：Lanoline grease 20g is weighed, is put in container, in 45 DEG C of heating in water-bath, makes its fusing,
It is another to weigh egg oil 10g, sesame oil 5g, both are fused with lanoline grease, quick stirring, room temperature is cooled to ointment immediately
Shaping, that is, obtain yellow, transparence ointment.
Embodiment 2
A, yolk oil extract：Fresh Egg is taken, is cooked, strips yolk.200g yolk is taken, is crushed, with 8 times of amount food-grade second
Acetoacetic ester soaks, ultrasonic extraction 2 times, 20min/ times, filtering, collects extract solution.Total solvent volume is extracted equivalent to yolk quality
16 times amount (total spends food level ethyl acetate 3.2L).
B, extract solution concentrates：Combining step (1) twice gained extract solution, be concentrated under reduced pressure recovery ethyl acetate, produce yolk
Oily intermediate, obtain egg oil intermediate 47.54g.
C, prepared by ointment：Lanoline grease 20g is weighed, is put in container, in 45 DEG C of heating in water-bath, makes its fusing, it is another to claim
Take egg oil 10g, sesame oil 5g, both fused with lanoline grease, immediately quick stirring, to ointment be cooled to room temperature into
Type, that is, obtain yellow, transparence ointment.
Embodiment 2 uses ultrasonic extraction, and ultrasonic extraction also has the advantages that energy consumption is low, and extracts active ingredients yield is high.
Compared with embodiment 1, yolk oil extract yield and cold-maceration almost indifference.Gained egg oil is prepared according to ultrasonic extraction,
When preparing ointment, physicochemical property also can also use ultrasonic extraction with embodiment indifference, therefore yolk oil extract.
Embodiment 3
A, yolk oil extract：Fresh Egg is taken, is cooked, strips yolk.200g yolk is taken, is crushed, with appropriate food-grade second
Acetoacetic ester soaks, and fills post seepage pressure effects, because ethyl acetate permeability is weaker, ethyl acetate is as Extraction solvent, it is difficult to flow out
Diacolation post, therefore percolation is not suitable for the extraction of egg oil.
Embodiment 4
A, yolk oil extract：Fresh Egg is taken, is cooked, strips yolk.200g yolk is taken, is crushed, with 8 times of amount food-grade second
Acetoacetic ester soaks, refluxing extraction 2 times, 20min/ times, filtering, collects extract solution.Total solvent volume is extracted equivalent to yolk quality
16 times amount (total spends food level ethyl acetate 3.2L).
B, extract solution concentrates：Combining step (1) twice gained extract solution, be concentrated under reduced pressure recovery ethyl acetate, produce yolk
Oily intermediate, obtain egg oil intermediate 52.39g.
C, prepared by ointment：Lanoline grease 20g is weighed, is put in container, in 45 DEG C of heating in water-bath, makes its fusing, it is another to claim
Take egg oil 10g, sesame oil 5g, both fused with lanoline grease, immediately quick stirring, to ointment be cooled to room temperature into
Type, that is, obtain ointment.
Embodiment 4 uses reflux extraction, and reflux extraction energy consumption is higher, technical grade multi-function extractor extraction yolk
Oil, security, the feature of environmental protection, which need to have, necessarily to be considered.Compared with embodiment 1, yolk oil extract yield is compared with cold-maceration, ultrasonic extraction
It is slightly higher, but gained intermediate egg oil color is slightly deep, in yellowish-brown.Gained egg oil is prepared according to reflux extraction, is being prepared
During ointment, physicochemical property is also with embodiment 1 without larger difference, but gained ointment color is also slightly deep, and vision perception is relatively implemented
Example 1 is slightly poor.
Embodiment 5
Young phoenix cream ointment is prepared with the gained egg oil intermediate of embodiment 1.Weigh egg oil 10g, sesame oil 10g is pure
Lanolin 20g, puts in container, and in 40 DEG C of heating in water-bath, quick stirring makes its fusion, room temperature forming is cooled to ointment,
Produce ointment.Ointment obtained by the method is opaque, and egg oil intermediate can not be fused fully with matrix, and gained ointment is in
Semifluid shape.
Embodiment 6
Young phoenix cream ointment is prepared with the gained egg oil intermediate of embodiment 1.Lanoline grease 40g is weighed, is put in container, Yu Shui
45 DEG C of heating are bathed, make its fusing, separately weigh egg oil 10g, sesame oil 10g, both are fused with lanoline grease, immediately quickly
Stirring, is cooled to room temperature forming to ointment, that is, obtains ointment.Ointment obtained by the method is also yellow transparent shape, but gained
Ointment is in semifluid shape.
Comparative example 1
After egg is cooked, strip that yolk is standby, and perfuming oil is appropriate in pot, after heating, is put into the yolk smashed to pieces, slow fire decocts
To yolk slagging, brown transparence fluid is separated out.
Embodiment 7
The local method young phoenix cream that the young phoenix cream ointment and comparative example 1 obtained to embodiment 1 obtains, carry out external promotion people's mammary gland
Epithelial cell proliferation experimental study.
It is research object to select normal human mammary epithelial cell MCF 10A (being purchased from Chinese Academy of Sciences's Shanghai cell bank).Take
The MCF 10A cells of exponential phase, are washed 2 times with PBS, add the digestion of 0.05% pancreatin, after digestion completely, add 0.1%
Soybean trypsin inhibitor terminates digestion, centrifugation, removes supernatant.Add human mammary epithelial cell MCF 10A complete culture solutions
(MEGM culture mediums), after adjusting cell concentration, 96 porocyte culture plates are inoculated in, 2 × 10 are added per hole3Individual cell, cumulative volume
It is (wherein, young with 0,5,10,20,40,80,160 μ g/mL young phoenix cream ointment or local method young phoenix cream processing cell respectively for 100 μ L
The amount of phoenix cream ointment is measured with whole ointment, including matrix).After 96 hours, 20 μ L 5mg/mL MTT solution is added per hole, is mixed
It is even, put 37 DEG C, 5%CO2Cultivated 4 hours in saturated humidity incubator.Add the liquid of 100 μ L tri- (10% lauryl sodium sulfate-
5% isobutanol -0.012M hydrochloric acid), it is completely dissolved bluish violet formazan precipitation.It is placed in ELIASA, absorbance is detected in 570nm
Value, experiment is in triplicate.As a result as shown in Figure 1.
Experimental result shows that the made young phoenix cream ointment of embodiment 1 and the made local method young phoenix cream of comparative example 1 have promotion MCF
10A proliferation activities.After administration 96 hours, cell viability, drug dose and the cell viability amount of having-effect dependence are detected.Give
After medicine 96 hours, when dosage is 160 μ g/mL, the young phoenix cream ointment and local method young phoenix cream, galactophore epithelial cell is increased
Grow and respectively facilitated about 1.5 times and 0.6 times.
The validity of local method young phoenix cream, further confirm the young phoenix cream of classic of TCM record in treatment puerpera's cracked nipple
The validity of aspect.Puerpera's cracked nipple is treated with promoting normal mammary epithelial propagation closely bound up, the present invention passes through existing
For experimental method, illustrate the scientific meaning of ancient method young phoenix cream application, also prompt the present invention be in centering medicine ancient books and records it is outstanding into
The inheritance and innovation of fruit.
The local method of comparative example 1 prepares young phoenix cream, belongs to family workshop property, it is difficult to standardized operation, and quality is uncontrollable, it is difficult to
Promote.The made young phoenix cream of local method is brown, and perception is slightly poor.With the fried egg oil of edible oil, because heated time is grown, may cause
The active ingredients such as vitamin are destroyed, although therefore embodiment 1 has added 2.5 times of matrix measured in egg oil, the young phoenix cream ointment of embodiment 1
Mammary epithelial cell proliferation activity is promoted still to be much better than local method young phoenix cream described in comparative example 1.
Specific embodiment described in the present invention is only to spirit explanation for example of the invention.Technology belonging to the present invention
The technical staff in field can make various modifications or supplement to described specific embodiment or using similar mode
Substitute, but without departing from the spiritual of the present invention or surmount scope defined in appended claims.
Claims (7)
1. a kind of young phoenix cream ointment, it is characterised in that include the component of following parts by weight：
1 part of yolk oil extract
0.5~1.5 part of sesame oil
Pure natural 1.5~2.5 parts of lanolin
Wherein, the preparation method of described yolk oil extract is as follows：
Egg is cooked, strips yolk, is crushed, with food level ethyl acetate cold soaking or ultrasonic extraction, obtained extract solution decompression
Ethyl acetate is reclaimed, obtains described yolk oil extract.
2. young phoenix cream ointment according to claim 1, it is characterised in that food level ethyl acetate extraction time is 2 times, often
Secondary 20min, constantly stir in extraction process, shake.
3. young phoenix cream ointment according to claim 2, it is characterised in that each dosage of the food level ethyl acetate is
5~10 times of yolk quality.
4. young phoenix cream ointment according to claim 1, it is characterised in that the preparation method of described young phoenix cream ointment is such as
Under：
Pure natural lanolin is heated in 40~50 DEG C of water-baths, makes its fusing, then adds egg oil and sesame oil, room temperature
Under, stirring, until ointment is molded.
5. young phoenix cream ointment according to claim 4, it is characterised in that the yolk oil extract, sesame oil and pure day
The mass ratio of right lanolin is 2：1：4.
6. a kind of application of the young phoenix cream ointment in pharmaceutical formulating art as described in any one of Claims 1 to 5, its feature exists
In described medicine is used to treat puerpera's cracked nipple.
7. application of the young phoenix cream ointment according to claim 6 in pharmaceutical formulating art, it is characterised in that described medicine
Thing is used to promote human mammary epithelial cell to breed.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110538244A (en) * | 2019-08-29 | 2019-12-06 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for promoting skin wound healing |
| CN111686131A (en) * | 2020-07-20 | 2020-09-22 | 武汉自然萃创新科技有限公司 | Anal fissure egg yolk cream and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376488A (en) * | 2001-12-31 | 2002-10-30 | 杨荣 | Ointment for treating cracked nipple |
-
2017
- 2017-10-16 CN CN201710957598.7A patent/CN107648287B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376488A (en) * | 2001-12-31 | 2002-10-30 | 杨荣 | Ointment for treating cracked nipple |
Non-Patent Citations (2)
| Title |
|---|
| 严建业等: "蛋黄油的现代研究进展", 《中国中医药信息杂志》 * |
| 聂向红等: "蛋黄油在乳头皲裂治疗中的应用", 《内蒙古医学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110538244A (en) * | 2019-08-29 | 2019-12-06 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for promoting skin wound healing |
| CN111686131A (en) * | 2020-07-20 | 2020-09-22 | 武汉自然萃创新科技有限公司 | Anal fissure egg yolk cream and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN107648287B (en) | 2020-08-11 |
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