CN104524215B - Treat capsule of stomach trouble and preparation method thereof - Google Patents
Treat capsule of stomach trouble and preparation method thereof Download PDFInfo
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- CN104524215B CN104524215B CN201410831232.1A CN201410831232A CN104524215B CN 104524215 B CN104524215 B CN 104524215B CN 201410831232 A CN201410831232 A CN 201410831232A CN 104524215 B CN104524215 B CN 104524215B
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Engineering & Computer Science (AREA)
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- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
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- Biotechnology (AREA)
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Abstract
The invention discloses a kind of capsule for treating stomach trouble and preparation method thereof, the capsule of the treatment stomach trouble, count in parts by weight, including：2~30 parts of 10~60 parts of bletilla, 2~30 parts of fritillaria thunbergii, 1~10 part of agalloch eaglewood, 1~10 part of pseudo-ginseng and the coptis.The capsule of the treatment stomach trouble has the routed intestines of significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach, gastritis effect, for treating chronic gastritis, stomach energy phlegm ruffian, stagnation of QI and blood, epigastric distending pain, the routed intestines of stomach and duodenal ulcer, have the characteristics that curative effect is fast, cure rate is high and has no side effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of capsule for treating stomach trouble and preparation method thereof.
Background technology
Stomach trouble includes chronic gastritis, stomach energy phlegm ruffian, stagnation of QI and blood, epigastric distending pain, stomach routed intestines and duodenal ulcer etc., its
Middle chronic gastritis is divided into chronic superficial gastritis and atrophic gastritis, and chronic superficial gastritis develops into severe stage, i.e.,
For atrophic gastritis.Atrophic gastritis is more obstinate refractory digestive system common disease, frequently-occurring disease, is easily converted
For stomach cancer.The cause of disease of chronic gastritis not yet illustrates at present, therefore modern medicine only takes local targetedly symptomatic treatment or hand
Art is treated.Therefore, the middle medicine of exploitation treatment stomach trouble has very important significance.
The content of the invention
Based on this, it is necessary to provide capsule for the treatment of stomach trouble that a kind of curative effect is fast, cure rate is high and preparation method thereof.
A kind of capsule for treating stomach trouble, is counted in parts by weight, including：10~60 parts of bletilla, 2~30 parts of fritillaria thunbergii, agalloch eaglewood 1
2~30 parts of~10 parts, 1~10 part of pseudo-ginseng and the coptis.
In one of the embodiments, count in parts by weight, including：10~45 parts of bletilla, 2~20 parts of fritillaria thunbergii, agalloch eaglewood 4
2~20 parts of~10 parts, 4~10 parts of pseudo-ginseng and the coptis.
In one of the embodiments, count in parts by weight, including：25~45 parts of bletilla, 8~20 parts of fritillaria thunbergii, agalloch eaglewood 4
8~20 parts of~8 parts, 4~8 parts of pseudo-ginseng and the coptis.
A kind of preparation method for the capsule for treating stomach trouble, comprises the following steps：
By 10~60 parts of bletilla, 2~30 parts of fritillaria thunbergii, 1~10 part of agalloch eaglewood, 1~10 part of pseudo-ginseng and 2~30 parts
The coptis crush and/or with solvent extraction, capsule is made.
In one of the embodiments, comprise the following steps：
The bletilla of above-mentioned mass parts is crushed/solvent extraction is used, obtain bletilla powder and/or bletilla cream；
The agalloch eaglewood of above-mentioned mass parts is crushed, obtains agalloch eaglewood powder；
The pseudo-ginseng of above-mentioned mass parts is crushed, obtains Radix Notoginseng powder；
By the fritillaria thunbergii of above-mentioned mass parts and coptis solvent extraction, clear cream is obtained；And
The bletilla powder and/or bletilla cream, agalloch eaglewood powder, Radix Notoginseng powder and clear cream are mixed, capsule is made.
In one of the embodiments, following steps：The bletilla of above-mentioned parts by weight is divided into first part and second part totally two
Part, first part of bletilla is crushed to obtain bletilla powder, by second part of bletilla solvent extraction, is concentrated to give bletilla cream, by institute
State bletilla powder, the fritillaria thunbergii of the bletilla cream and above-mentioned parts by weight, agalloch eaglewood, pseudo-ginseng and the coptis to mix, capsule is made.
In one of the embodiments, described first part of bletilla and described second part of bletilla weight ratio are 1~2:1.
In one of the embodiments, the solvent is at least one of water and ethanol.
In one of the embodiments, comprise the following steps：By 10~60 parts of bletilla, 2~30 parts of fritillaria thunbergii, 1~
10 parts of agalloch eaglewood, 1~10 part of pseudo-ginseng and 2~30 parts of coptis solvent extraction, obtain concentrate, obtain the treatment stomach trouble
Capsule.
In one of the embodiments, it is described by 10~60 parts of bletilla, 2~30 parts of fritillaria thunbergii, 1~10 part heavy
Fragrant, 1~10 part of pseudo-ginseng and 2~30 parts of the coptis crush and/or with after solvent extractions, including step：It dry, pulverize granulation dress
Capsule, obtain the capsule of the treatment stomach trouble.
The capsule of present invention treatment stomach trouble is based on theory of traditional Chinese medical science, with reference to clinical practice, from traditional Chinese medicine material treasure-house
What is filtered out a series of has promoting blood circulation and stopping pain, the Chinese medicine of astringing to arrest bleeding effect.Wherein, bletilla, property is bitter, it is sweet be slightly cold, have and receive
Hold back hemostasis, the effect of detumescence and promoting granulation, spitted blood for hemoptysis, traumatism and bleeding, sore swollen toxin, chapped skin, pulmonary tuberculosis hemoptysis, ulcer
The external application such as the diseases such as sick bleeding and sore, burn and scald；Fritillaria thunbergii bitter sweet, is slightly cold, and has the effect of hemostasisization disease, for lung heat cough
Cough, heat-clearing dissipating bind, the disease such as scrofula and carbuncle swells；Agalloch eaglewood, there is strong antibacterial efficacy and clear refreshing qi-regulating, tonifying five zang organs, cough-relieving
The effect of phlegm, warm stomach temperature spleen, ventilation analgesic therapy；Pseudo-ginseng, property sugariness slight bitter is warm-natured, can hemostasia and dissipation blood stasis, swelling and pain relieving, have good
Hemostasia effect, significant hematopoiesis function；The coptis, sweet cold nature, there is the effect of relieving heat toxin, irritated for pyreticosis, mouth is told
Raw sore, spits blood, bleeding from five sense organs or subcutaneous tissue, the disease such as red eye, swell pain, dysentery hemorrhoid, gastropyretic vomiting.The drug component of the capsule of present invention treatment stomach trouble
Through dialectical compatibility, complemented each other using, there is synergy, play promoting blood circulation and stopping pain, astringing to arrest bleeding and other effects altogether.Above-mentioned treatment
The capsule of stomach trouble has the routed intestines of significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach, gastritis effect, for treating chronic gastritis, stomach energy
Phlegm ruffian, stagnation of QI and blood, epigastric distending pain, the routed intestines of stomach and duodenal ulcer, have the spies such as curative effect is fast, cure rate is high and has no side effect
Point.
Embodiment
For the ease of understanding the present invention, the present invention is described more fully below, and gives the preferable of the present invention
Embodiment.But the present invention can realize in many different forms, however it is not limited to embodiment described herein.Phase
Instead, there is provided the purpose of these embodiments is to make the understanding more thorough and comprehensive to the disclosure.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The implication that technical staff is generally understood that is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein " and/or " include one or more phases
The arbitrary and all combination of the Listed Items of pass.
A kind of capsule for treating stomach trouble, is counted in parts by weight, including：10~60 parts of bletilla, 2~30 parts of fritillaria thunbergii, agalloch eaglewood 1
2~30 parts of~10 parts, 1~10 part of pseudo-ginseng and the coptis.
Especially, the coptis connects for evodia rutaecarpa manufacture-yellow.Coptis bitter cold injures one's stomach, and evodia rutaecarpa property is hot, so evodia rutaecarpa is fried
The cold of the coptis can be mitigated after the coptis, such coptis is not cold then will not the impairment of the spleen.
Preferably, count in parts by weight, including：10~45 parts of bletilla, 2~20 parts of fritillaria thunbergii, 4~10 parts of agalloch eaglewood, pseudo-ginseng 4
~10 parts and 2~20 parts of the coptis.
It is furthermore preferred that count in parts by weight, including：25~45 parts of bletilla, 8~20 parts of fritillaria thunbergii, 4~8 parts of agalloch eaglewood, pseudo-ginseng
4~8 parts and 8~20 parts of the coptis.
The capsule of present invention treatment stomach trouble is based on theory of traditional Chinese medical science, with reference to clinical practice, from traditional Chinese medicine material treasure-house
What is filtered out a series of has promoting blood circulation and stopping pain, the Chinese medicine of astringing to arrest bleeding effect.
Wherein, bletilla, property is bitter, it is sweet be slightly cold, there is the effect of astringing to arrest bleeding, detumescence and promoting granulation, spitted blood for hemoptysis, wound goes out
The external application such as disease and sore, burn and scald such as blood, sore swollen toxin, chapped skin, pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Fritillaria thunbergii bitter sweet, is slightly cold, and has the effect of hemostasisization disease, for cough with lung heat, heat-clearing dissipating bind, scrofula and carbuncle swells etc.
Disease.
Agalloch eaglewood, there is strong antibacterial efficacy and clear refreshing qi-regulating, tonifying five zang organs, relieving cough and reducing sputum, warm stomach temperature spleen, ventilation analgesic therapy
The effect of.
Pseudo-ginseng, property sugariness slight bitter is warm-natured, can hemostasia and dissipation blood stasis, swelling and pain relieving, have good hemostasia effect, significantly make
Blood function.
The coptis, sweet cold nature, there is the effect of relieving heat toxin, irritated for pyreticosis, mouth tells raw sore, spits blood, bleeding from five sense organs or subcutaneous tissue, hot eyes
The disease such as swelling and pain, dysentery hemorrhoid, gastropyretic vomiting.
The drug component of the capsule of present invention treatment stomach trouble complements each other using through dialectical compatibility, there is collaboration to make
With playing promoting blood circulation and stopping pain, astringing to arrest bleeding and other effects altogether.The capsule of above-mentioned treatment stomach trouble have significant promoting blood circulation and stopping pain, astringing to arrest bleeding and
Anti- stomach is burst intestines, gastritis effect, and for treating chronic gastritis, stomach energy phlegm ruffian, stagnation of QI and blood, epigastric distending pain, stomach, which is burst, intestines and 12 to be referred to
Enterelcosis, have the characteristics that curative effect is fast, cure rate is high and has no side effect.
The preparation method of the capsule of above-mentioned treatment stomach trouble, comprises the following steps：
S1：The bletilla of above-mentioned parts by weight is divided into two parts, a copy of it bletilla is crushed to obtain bletilla powder, another is white
And with solvent extraction, it is concentrated to give bletilla cream.
Especially, bletilla was crushed to 100 mesh sieves.Especially, for the bletilla crushed and the bletilla for extracting
Weight ratio is 1~2:1, preferably 1:1.
Especially, solvent is selected from least one of water and ethanol.It is with the method for solvent extraction by second part of bletilla
Water boiling and extraction method, alcohol dipping extraction method or ethanol percolation extraction method.
Preferably, it is water boiling and extraction method with the method for solvent extraction by second part of bletilla, and takes and carry step by step twice
Take.Extract for the first time, obtain the first filtrate and the first filter residue, the first filter residue is carried out into second extracts, and is filtrated to get the second filter
Liquid and the second filter residue, merge the first filtrate and the second filtrate.
Extract for the first time：4~10 times of the bletilla quality that the amount for adding water is second part, the time of extraction opens from boiling water
Beginning clocks, and is 0.5~2 hour.Preferably, 7 times of the bletilla quality that the amount for adding water is second part, the time of extraction boil from water
Rise and start to clock, be 1 hour.
Second of extraction：4~10 times of the bletilla quality that the amount for adding water is second part, the time of extraction opens from boiling water
Beginning clocks, and is 0.5~2 hour.Preferably, 6 times of the bletilla quality that the amount for adding water is second part, the time of extraction boil from water
Rise and start to clock, be 1 hour.
S2：The agalloch eaglewood of above-mentioned mass parts is crushed, obtains agalloch eaglewood powder.
Especially, agalloch eaglewood was crushed to 100 mesh sieves.
S3：The pseudo-ginseng of above-mentioned mass parts is crushed, obtains Radix Notoginseng powder.
Especially, pseudo-ginseng was crushed to 100 mesh sieves.
S4：By the fritillaria thunbergii of above-mentioned mass parts and coptis solvent extraction, clear cream is obtained.
Especially, solvent is selected from least one of water and ethanol.The method of extraction is water boiling and extraction method, alcohol dipping
Extraction method or ethanol percolation extraction method.
Preferably, it is ethanol percolation extraction method with the method for solvent extraction by the fritillaria thunbergii of above-mentioned mass parts and the coptis.It is special
Not, fritillaria thunbergii and the coptis are added into ethanol and carries out diacolation, collect percolate, when percolate is without color, stopped diacolation, will ooze
Liquid of filtering concentrates, that is, the capsule for the stomach trouble that obtains medical treatment.Especially, fritillaria thunbergii and the coptis are added into ethanol progress diacolation step also to obtain
Filter residue, filter residue is squeezed, obtain pressed liquor, pressed liquor is merged with percolate, concentrated.It is appreciated that can be by fritillaria thunbergii
Individually extracted with the coptis.
Especially, the ethanol of addition and the liquid-solid ratio of fritillaria thunbergii and coptis total amount are 5~8:2~5, and ethanol is soaked all the time
Do not have medicinal powder surface.It is furthermore preferred that the ethanol added is 7 with the liquid-solid ratio of fritillaria thunbergii and coptis total amount:3.Wherein, the ethanol is
Absolute ethyl alcohol.
S5：Bletilla powder, agalloch eaglewood powder, Radix Notoginseng powder and clear cream are mixed.
S6：After bletilla powder, agalloch eaglewood powder, Radix Notoginseng powder and clear cream are mixed, it is encapsulated to dry, pulverize granulation, obtains described control
Treat the capsule of stomach trouble.
It is appreciated that step S1 can be omitted, bletilla is all crushed or all with solvent extraction, obtains extract solution
Or concentrate, carry out step S5.Step S2 can be omitted, and by agalloch eaglewood solvent extraction, obtained extract solution or concentrate, walked
Rapid S5.Step S3 can be omitted, and by pseudo-ginseng solvent extraction, obtained extract solution or concentrate, carried out step S5.Can be by step S4
With solvent extraction, extract solution is obtained, directly carries out step S5.Step S4 can be omitted, and fritillaria thunbergii and the coptis are crushed, walked
Rapid S5.Step S6 can be omitted, and directly mix bletilla powder, agalloch eaglewood powder, Radix Notoginseng powder and clear cream.
It is appreciated that above-mentioned preparation method can not be used, bletilla, fritillaria thunbergii, agalloch eaglewood, pseudo-ginseng and the coptis are crushed, obtained
Treat the capsule of stomach trouble；Or bletilla, fritillaria thunbergii, agalloch eaglewood, pseudo-ginseng and the coptis are extracted, the capsule for the stomach trouble that obtains medical treatment.
The preparation method of the capsule of above-mentioned treatment stomach trouble, method is simple to operation, takes full advantage of the active ingredient of raw material,
Raw material is maximally utilised, the capsule for the treatment stomach trouble being prepared has significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach
Routed intestines, gastritis effect, for treating chronic gastritis, stomach energy phlegm ruffian, stagnation of QI and blood, epigastric distending pain, the routed intestines of stomach and duodenum are burst
Ulcer, have the characteristics that curative effect is fast, cure rate is high and has no side effect.
It is specific embodiment below.
Embodiment 1
A kind of capsule for treating stomach trouble of the present embodiment, is counted in parts by weight, including：35 parts of bletilla, 20 parts of fritillaria thunbergii, agalloch eaglewood
12 parts of 6 parts, 4 parts of pseudo-ginseng and the coptis.
The preparation method of the capsule of above-mentioned treatment stomach trouble, comprises the following steps：
By bletilla according to 2:1 ratio is divided into two parts, and by 2/3rds bletillas, the agalloch eaglewood and pseudo-ginseng of above-mentioned parts by weight crush
To fine powder, fritillaria thunbergii and the coptis are subjected to diacolation and obtain clear cream, the ethanol and the liquid-solid ratio of fritillaria thunbergii and coptis total amount of addition are
7:3, and ethanol is submerged medicinal powder surface all the time.By 1/3rd bletilla water boiling and extractions, the amount for adding water is bletilla quality
7 times, the time of the extraction clocks since boiling water, be 1 hour, filtration, filter residue is continued use water boiling and extraction, addition
The amount of water is 6 times of bletilla quality, and the time of the extraction clocks since boiling water, is 1 hour, filtration, and merging filtrate will
Filtrate is concentrated to give thick paste.Fine powder, clear cream and thick paste are mixed again, dry, pulverize encapsulated, the glue for the stomach trouble that obtains medical treatment of pelletizing
Capsule.
Embodiment 2
A kind of capsule for treating stomach trouble of the present embodiment, is counted in parts by weight, including：45 parts of bletilla, 12 parts of fritillaria thunbergii, agalloch eaglewood
8 parts of 4 parts, 8 parts of pseudo-ginseng and the coptis.
The preparation method of the capsule of above-mentioned treatment stomach trouble, comprises the following steps：
Bletilla, fritillaria thunbergii, agalloch eaglewood, pseudo-ginseng and the coptis are merged, addition ethanol progress diacolation, the ethanol and bletilla of addition,
Fritillaria thunbergii, agalloch eaglewood, the liquid-solid ratio of pseudo-ginseng and coptis total amount are 5:5, and ethanol is submerged medicinal powder surface all the time.Collect percolate,
When percolate is without color, stops diacolation, percolate is concentrated, dry, pulverize encapsulated, that is, the glue for the stomach trouble that obtains medical treatment of pelletizing
Capsule.
Embodiment 3
A kind of capsule for treating stomach trouble of the present embodiment, is counted in parts by weight, including：25 parts of bletilla, 8 parts of fritillaria thunbergii, agalloch eaglewood 8
20 parts of part, 6 parts of pseudo-ginseng and the coptis.
The preparation method of the capsule of above-mentioned treatment stomach trouble, comprises the following steps：
The bletilla of above-mentioned parts by weight, fritillaria thunbergii, agalloch eaglewood, pseudo-ginseng and the coptis are crushed, add water 100mL and honey 40g, is mixed
It is even, dry, pulverize granulation it is encapsulated, obtain it is described treatment stomach trouble capsule.
Embodiment 4
A kind of capsule for treating stomach trouble of the present embodiment, is counted in parts by weight, including：10 parts of bletilla, 30 parts of fritillaria thunbergii, agalloch eaglewood
2 parts of 1 part, 10 parts of pseudo-ginseng and the coptis.
The preparation method of the capsule of above-mentioned treatment stomach trouble, comprises the following steps：
Bletilla is divided into two parts, by a bletilla, the agalloch eaglewood and pseudo-ginseng of above-mentioned parts by weight crush to obtain fine powder, by bulb of thunberg fritillary
The female and coptis carries out diacolation and obtains clear cream, and ethanol and the liquid-solid ratio of fritillaria thunbergii and coptis total amount of addition are 8:2, and ethanol is begun
Submergence medicinal powder surface eventually.By another bletilla water boiling and extraction, the amount for adding water is 7 times of bletilla quality, the extraction
Time clocks since boiling water, is 1 hour, filtration, is concentrated to give thick paste.Fine powder, clear cream and thick paste are mixed again, controlled
Treat the capsule of stomach trouble.
Embodiment 5
A kind of capsule for treating stomach trouble of the present embodiment, is counted in parts by weight, including：60 parts of bletilla, 2 parts of fritillaria thunbergii, sink
30 parts of fragrant 10 parts, 1 part of pseudo-ginseng and the coptis.
The preparation method of the capsule of above-mentioned treatment stomach trouble, comprises the following steps：
Bletilla, fritillaria thunbergii, agalloch eaglewood, pseudo-ginseng and the coptis are merged, addition ethanol progress diacolation, the ethanol and bletilla of addition,
Fritillaria thunbergii, agalloch eaglewood, the liquid-solid ratio of pseudo-ginseng and coptis total amount are 7:3, and ethanol is submerged medicinal powder surface all the time.Collect percolate,
When percolate is without color, stops diacolation, percolate is concentrated, that is, the capsule for the stomach trouble that obtains medical treatment.
First, effect learns experiment
According to the effect of the capsule of present invention treatment stomach trouble with curing mainly, according to《Study of tcm new drug guide》Principle and side
Method, it is carried out to control effect, influence gastric emptying and function of promoting blood circulation to disperse blood clots etc. and function to the pre- of atrophic gastritis
Cure mainly relevant Pharmacodynamic test of active extract research.
Atrophic gastritis is tested：0.02% ammoniacal liquor is freely drunk to rat after 60 days, rat gastric juice and gastric acid secretion
Reduce, pepsin activity reduces, and histopathological examination is shown as chronic inflammation change.By 0.2,0.4,0.8g/kg, to big
The preventative gavage of mouse gives the capsule of the invention for treating stomach trouble 30 days, and atrophic gastritis experiment shows that the present invention treats stomach trouble
Capsule can promote the secretion of gastric juice and hydrochloric acid in gastric juice, increase pepsin activity, improve the pathological change degree of gastric tissue.
0.02% ammoniacal liquor is freely drunk to rat after 90 days, rat gastric juice and gastric acid secretion are reduced, pepsin activity drop
Low, histopathological examination is shown as chronic inflammation change.After ammoniacal liquor is drunk 60 days, while continuing to drink ammoniacal liquor, press
0.2nd, 0.4,0.8g/kg, to capsule 30 days of the therapeutic gavage of rat to present invention treatment stomach trouble, atrophic gastritis experiment
Show, the capsule of present invention treatment stomach trouble can promote the secretion of gastric juice and hydrochloric acid in gastric juice, increase pepsin activity, improve gastric tissue
Pathological change degree.
Emptying test：Kunming mouse 40, male and female half and half, 20~25g of body weight, fasting 12h, freely drinks before experiment
Water.It is randomly divided into 4 groups, every group 10.This experiment is divided into experimental group and control group, wherein, experimental group is divided into low dose group 0.2g/
Kg, middle dose group 0.4g/kg, tri- groups of high dose group 0.8g/kg.Control group is normally fed.Experimental group successive administration 10 days, daily
1 time, fasting 16h (can't help water) after last dose, every mouse stomach is located to take off after giving 0.1% methyl orange solution 0.2mL, 30min
Mortar puts to death mouse, opens abdomen rapidly, wins stomach and be placed in beaker, adds 10ml water, cuts off coat of the stomach, stomach is fully washed into Yu Shui
In, with sodium bicarbonate solution regulation pH value to 6~6.5, centrifuge tube is poured into, 4min is centrifuged with 5000r/min, pours out supernatant,
The absorbance of solution is determined under wavelength 420nm with spectrophotometer, as remaining methyl orange amount in stomach, is averaged.Methyl
(0.1% methyl orange 0.2mL is added orange Stomach residue rate (%)=stomach methyl orange absorbance/radix methyl orange absorbance × 100%
10mL distilled water measures its absorbance as radix methyl orange absorbance after shaking up).Experimental result is shown in Table 1：
Table 1
The result of table 1 shows：The capsule of the treatment stomach trouble of the present invention substantially reduces methyl orange in experimental mice stomach and remained
Rate, illustrate that the capsule of the treatment stomach trouble of the present invention effectively promotes gastric emptying.
Experiment promoting blood circulation and removing blood stasis：By 0.2,0.4,0.8g/kg, to capsule of the therapeutic gavage of rat to present invention treatment stomach trouble
30 days, experiment promoting blood circulation and removing blood stasis showed, the capsule of present invention treatment stomach trouble can increase rat mesentery capillary vessel number, and bore increases
Greatly, VPV is accelerated, and prompting can improve Rat Mesenteric Microcirculation, have function of promoting blood circulation to disperse blood clots.
Result of the test illustrates that the Chronic Atrophic Gastritis in Rat that the capsule of present invention treatment stomach trouble is induced ammoniacal liquor has preventing and treating
Effect, while also have and promote gastric emptying and function of promoting blood circulation to disperse blood clots.
2nd, anxious poison experiment, long term toxication
Anxious poison experiment：After the capsule mouse stomach administration of present invention treatment stomach trouble, obvious acute toxicity, mouse one are not found
Day maximum dosage-feeding is 50g/kg.
Long term toxication：According to new Chinese medicine toxicologic study technical requirements, the capsule pair of present invention treatment stomach trouble have studied
Six months (3~6 times of clinical course for the treatment of) long term toxicities of rat.As a result show, with the present invention treat the capsule of stomach trouble according to 3,10,
15g/kg, to rat continuous gavage six months, in addition to increasing to rat body weight and having certain facilitation, to the general shape of rat
Condition, hematology, blood biochemical analysis, routine urinalysis, electrocardiogram, Systematic anatomy, organ coefficient and histopathology have no significant effect,
Toxic reaction is not found, and convalescence is also without retardance toxic reaction.
Through anxious poison, long term toxication observation, have no toxic side effect.
3rd, clinical test
30 sufferers that atrophic gastritis is diagnosed as from hospital outpatient and inpatient department.Wherein male 15, female
Property 15.Age was at 18~60 years old.Atrophic gastritis is clinically divided into liver-stomach disharmony, deficiency-cold in spleen and stomach, weakness of the spleen and the stomach etc.
Card type, it is mainly shown as upper abdomen dull pain, anorexia, the glutted after meal and disease such as become thin, be tired.Symptom to sufferer and
Parameters for observation on effect takes symptom integral value, and symptom integral value takes level Four point system, it is point light, in, again, seriously, remember 1 respectively,
2nd, 3,4 points.30 sufferers are observation case, do not set contrast groups, the capsule of oral present invention treatment stomach trouble during observation, every time
0.35g, 2 times a day.Continuously take 30 days, strictly control other variable factors.Statistical result.
Curative effect judging standard and experimental result
Cure：Symptom integral value declines more than 91%；It is effective：Symptom integral value declines 71%~90%；Effectively：Symptom is accumulated
Score value declines 35%~70%；It is invalid：Symptom integral value declines less than 35%.Total effective rate for (cure number of cases+effective number of cases+
Effective number of cases)/total number of cases.
Experimental result is shown in Table 2：
Table 2
As can be known from the results of Table 2, the sufferer for being diagnosed as atrophic gastritis takes present invention treatment stomach trouble continuous
Capsule after 30 days, total effective rate has reached 93.3%.The capsule of present invention treatment stomach trouble has significant promoting blood circulation and stopping pain, convergence
Hemostasis and the routed intestines of anti-stomach, gastritis effect, have the characteristics that curative effect is fast, cure rate is high and has no side effect for treating chronic gastritis.
During medication is observed, sufferer blood, urine, stool routine and liver function no abnormality seen change, and find no the secondary work of any poison
With with adverse reaction.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (2)
1. a kind of preparation method for the capsule for treating stomach trouble, it is characterised in that comprise the following steps：
10 ~ 60 parts of bletilla, 2 ~ 30 parts of fritillaria thunbergii, 1 ~ 10 part of agalloch eaglewood, 1 ~ 10 part of pseudo-ginseng and 2 ~ 30 parts of the coptis is provided；
The bletilla of above-mentioned parts by weight is divided into first part and second part totally two parts, first part of bletilla is crushed to obtain bletilla powder, by
Two parts of bletilla is extracted with water boiling and extraction method, and takes step by step arithmetic twice, and extraction for the first time obtains the first filtrate and first
Filter residue, the first filter residue is carried out second and extracted, is filtrated to get the second filtrate and the second filter residue, merges the first filtrate and the second filter
Liquid, it is concentrated to give bletilla cream；Wherein, extract for the first time：The amount for adding water is 4 ~ 10 times of bletilla quality, and time of extraction is from water
Boiling starts to clock, and is 0.5 ~ 2 hour；Second of extraction：The amount for adding water is 4 ~ 10 times of bletilla quality, time of extraction from
Boiling water starts to clock, and is 0.5 ~ 2 hour；
The agalloch eaglewood of above-mentioned mass parts is crushed, obtains agalloch eaglewood powder；
The pseudo-ginseng of above-mentioned mass parts is crushed, obtains Radix Notoginseng powder；
By the fritillaria thunbergii of above-mentioned mass parts and coptis solvent extraction, clear cream is obtained；And
The bletilla powder, bletilla cream, agalloch eaglewood powder, Radix Notoginseng powder and clear cream are mixed, it is encapsulated to dry, pulverize granulation, is made described
Treat the capsule of stomach trouble.
2. the preparation method of the capsule for the treatment of stomach trouble according to claim 1, it is characterised in that described first part of bletilla
Bletilla weight ratio with described second part is 1 ~ 2:1.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54135210A (en) * | 1978-04-07 | 1979-10-20 | Shigeru Yuuchi | Tumor treating agent |
| JPH037235A (en) * | 1989-03-24 | 1991-01-14 | Nitto Denko Corp | Medicine for stomach and bowel |
| CN1291505A (en) * | 1999-08-31 | 2001-04-18 | 周智勇 | Medicine for treating gastroenteropathy and its preparing process |
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2014
- 2014-12-26 CN CN201410831232.1A patent/CN104524215B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54135210A (en) * | 1978-04-07 | 1979-10-20 | Shigeru Yuuchi | Tumor treating agent |
| JPH037235A (en) * | 1989-03-24 | 1991-01-14 | Nitto Denko Corp | Medicine for stomach and bowel |
| CN1291505A (en) * | 1999-08-31 | 2001-04-18 | 周智勇 | Medicine for treating gastroenteropathy and its preparing process |
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