CN109730174A - A kind of tea for reducing hypertension and fat - Google Patents
A kind of tea for reducing hypertension and fat Download PDFInfo
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Abstract
The invention discloses a kind of tea for reducing hypertension and fat, the tea for reducing hypertension and fat includes the raw material of following parts by weight: 1~2 part of gynostemma pentaphylla, 0.5~1 part of Folium Apocyni Veneti, 2.9~4.2 parts of dark green tea, 0.5~1.5 part of vine tea, 0.5~1.5 part of Litsea coreana.The existing similar ingredient of five kinds of ingredients of the prescription, all there are also the different Flavonoid substances of content, and contain other compositions respectively: containing Total saponin in gynostemma pentaphylla；Contain tannin, tea polyphenols and vitamin C in bluish dogbane, contains tannic acid, Quercetin in bluish dogbane；Vine tea contains dihydromyricetin；There are tea polyphenols, Lovastatin in dark green tea；There are γ-aminobutyric acid GABA, selenium element in Litsea coreana, the Flavonoid substances that these other compositions and 5 kinds of components all contain complement each other together, reach more excellent blood pressure lowering and blood fat reducing function；And this five kinds of components can overcome mutually side effect, while can improve mutual pharmacological action, it is curative for effect and have no toxic side effect.
Description
Technical field
The present invention relates to tea technology field more particularly to a kind of tea for reducing hypertension and fat.
Background technique
Hypertension, hyperlipemia disease incidence is high, is the common disease of the middle-aged and the old.Hyperlipidemia is that the heart, brain blood occur for hypertensive patient
Manage unexpected important risk factor.Blood lipid level is inspected periodically, hyperlipidemia is reduced, for reducing the hair of coronary heart disease, cerebral apoplexy
Raw rate and the death rate are of crucial importance.But some drugs for hypertension have detrimental effect, such as diuretics (thiophene to the metabolism of blood lipid
Piperazine class and loop diuretic class) it can make blood lipid level raising print receptor blocker that blood serum triglyceride level can be made to increase and high density rouge
Protein level reduces.Therefore it is needed with caution when clinical use drug.Patient often drinks some conducive to drop in addition to drug therapy to be adhered to
The tea of pressure drop rouge can play good auxiliary therapeutic action.
Hypertension and hyperlipemia medicinal herb tea currently on the market is many kinds of, but its effect and unsatisfactory for various reasons.It is right
Than file 1: application No. is " CN201510369961.4 ", a kind of entitled " guarantor with antihypertensive, hyperglycemia and hyperlipidemia
Strong tea " can effectively solve the problems, such as antihypertensive, hyperglycemia and hyperlipidemia, and method is, by the component of following weight percent meter
It is made: coreopsis tinctoria 4-6%, corn stigma 13-17%, gynostemma pentaphylla 13-17%, cape jasmine 15-19%, STEVIA REBAUDIANA 1.5-2.5%, sieve
Chinese fruit 2.5-3.5%, bluish dogbane 15-20%, leaves of Hawthorn 8-12% and dark green tea 13-17%, said components are dried, and are crushed, mistake
50 meshes are distributed into bag, and every bag of 3-4g is at tea bag, the preparation easy to produce of invention abundant raw material, at low cost, effect convenient to take
It is good, there is the effect of antihypertensive, hyperglycemia and hyperlipidemia, but also there is anticancer, promote digestion, lose weight, delays senescence, drop
The effect of cholesterol can prevent and cure diseases and have the advantages that quench one's thirst, there is significant economic and social benefit.However bluish dogbane,
Three kinds of gynostemma pentaphylla, dark green tea raw materials have side effect: nervous system toxicity and renal toxicity may be generated by such as taking bluish dogbane；Clothes
It might have renal toxicity and digestive system toxicity with gynostemma pentaphylla；Dark green tea is in process of production it is possible that some such as Aspergillus flavus
Equal harmful bacterias.
Summary of the invention
It is an object of the invention to overcome the defect of the prior art, a kind of tea for reducing hypertension and fat, 5 kinds of groups of the invention are provided
Divide and complement each other, reaches more excellent blood pressure lowering and blood fat reducing function；And this five kinds of components can overcome mutually side effect, simultaneously
It can improve mutual pharmacological action, it is curative for effect and have no toxic side effect.
The present invention is implemented as follows:
It is an object of that present invention to provide a kind of tea for reducing hypertension and fat, the tea for reducing hypertension and fat includes the raw material of following parts by weight:
1~2 part of gynostemma pentaphylla, 0.5~1 part of Folium Apocyni Veneti, 2.9~4.2 parts of dark green tea, 0.5~1.5 part of vine tea, Litsea coreana 0.5~1.5
Part.
Preferably, the tea for reducing hypertension and fat includes the raw material of following parts by weight: 1.5~2 parts of gynostemma pentaphylla, Folium Apocyni Veneti 0.5
~0.7 part, 3~3.5 parts of dark green tea, 0.8~1.2 part of vine tea, 0.8~1.2 part of Litsea coreana.
Preferably, the tea for reducing hypertension and fat includes the raw material of following parts by weight: 2 parts of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, black
3 parts of tea, 1 part of vine tea, 1 part of Litsea coreana.
Preferably, total number meter by weight, the ratio of (gynostemma pentaphylla+Folium Apocyni Veneti+dark green tea) and (vine tea+Litsea coreana)=
5~6.2:1.6~2.4；Litsea coreana is mainly used for the prevention of disease of digestive system, and Litsea coreana can be with dark green tea combination gram
Take gynostemma pentaphylla and bluish dogbane bring digestive tract side effects；Dark green tea is in process of production it is possible that some harmful bacterias, and rattan
The deactivation of tea having to harmful bacteria；γ-aminobutyric acid in Litsea coreana is a kind of ammonia for having neurotransmitter function
The effect of base is sour, can generate blood pressure lowering can combine collaboration together with the diuresis of bluish dogbane and play antihypertensive effect；In short,
Vine tea+Litsea coreana of ratio in this way can overcome gynostemma pentaphylla+Folium Apocyni Veneti+dark green tea side effect, while can improve mutual
Pharmacological action；It complements each other together, reaches more excellent blood pressure lowering and blood fat reducing function.
Activity is as follows the effect of each primary raw material in the present invention:
1, gynostemma pentaphylla
Pharmacological property: bitter, micro-sweet, cool in nature, nontoxic, return lung, spleen, kidney channel.Effect: replenishing qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing solution
Poison.Chemical component: this product ingredient includes gypenoside class, mainly contains dammarane saponins；It additionally include polysaccharide, flavones
Class, 18 kinds of amino acid and various trace elements etc..
Pharmacological action:
(1) antitumor action: gynostemma pentaphylla has significant inside and outside antitumor action, can significantly inhibit mouse leukemia
The growth of L1210 cell, glycosides under this generation with active oxygen, mitochondria potential.Gypenosides can induce people Huh-7 cell and wither
It dies, there is apoptosis induction and inhibited proliferation to HeLa cell.
(2) regulating blood lipid action: experimental atherosclerosis rats blood lipid, maintenance liver can be significantly reduced in gypenoside
Damage, can obviously improve the disorders of lipid metabolism as caused by experimental hyperlipidemia.Its effect for reducing blood fat mechanism is in liver
With lipid metabolism related gene apolipoprotein AI, cholesterol 7α-hydroxylase (Cyp7 α 1), 3- hydroxyl -3- methylglutaric acid list acyl coenzyme A
Reductase and the expression regulation of sterol regulatory element combination transcription factor 2 are related.
(3) hypoglycemic effect: Herb Gynostemmae Pentaphylli extract and gynostemma pentaphylla polysaccharide have good improvement to diabetes and complication
Effect.Gynostemma pentaphyllum total extract can reduce the blood glucose (GLU) of diabetic mice, free fatty acid (NEFA), total cholesterol (TC), sweet
Oily three esters (TG) and malonaldehyde (MDA) value, increases serum superoxide dismutases (SOD) value of diabetic mice, alleviates glycosuria
The symptom of sick mouse " three-many-one-little ".Gynostemma pentaphylla polysaccharide can reduce the fasting blood-glucose and sugar tolerance of alloxan hyperglycemic rat,
Its hypoglycemic mechanism, which may stimulate the release of insulin with it or promote inflammation of pancreatic islet, to be restored, and inhibits alpha amylase, carbohydrate is delayed to exist
The absorption of small intestine is related.
(4) protect liver: gypenosides, which have big white mouse acute liver damage caused by carbon tetrachloride, significantly to be changed
Kind effect, can promote liver cell regeneration.Gypenosides have significant antibody Monoclonal and effect of anti hepatic fibrosis, significantly reduce big
Mouse serum glutamic pyruvic transminase, hepatic tissue hydroxyproline (Hyp) content.
(5) cardiovascular protective effect: gynostemma pentaphyllum total flavones can significantly improve ischemia-reperfusion rat blood serum and cardiac muscular tissue
Oxidative stress reduces myocardial infarction area.
(6) anti-aging effects: gynostemma pentaphylla and gypenoside all have antifatigue, anti anoxia, resistant to high temperatures, low-temperature resistance, prolong
The service life of growth cell and drosophila, mouse can significantly improve SOD activity, reduce the content of the heart, brain, liver cell lipofuscin.
(7) immunoregulation effect: gypenosides and polysaccharide also have immunoregulation effect.Gypenoside can be shown
The index and spleen index and thymus index for improving mouse are write, while the content of Ig G and IgA in mice serum can also be significantly improved, to small
The generation of IL-2 also has certain facilitation in mouse serum.It is immune to mouse spleen that gynostemma pentaphylla polysaccharide can alleviate cyclophosphamide
The depression effect of function.
Related gynostemma pentaphylla research overview both at home and abroad
(1) " national Chinese herbal medicine compilation " is recorded: being drunk gynostemma pentaphylla, is treated tracheitis, sphagitis, migraine, blood pressure lowering, drop
Blood lipid, help sleep etc..Drug effects that it is recorded in Compendium of Material Medica has " controlling boil, insect bite, removing pattogenic heat from the blood and toxic material from the body, diuresis " etc.." legendary god of farming's sheet
Grass warp " for Bai Pingli gynostemma pentaphylla energy, " main all public attention are dizzy, distending pain, mesh are intended to take off, the dead flesh of skin, foul wind arthritis with fixed pain caused by dampness, long term usage benefit gas, gently
The diligent macrobiosis of body."
(2) it is recorded in " the small book series of Ming and Qing TCM Clinical " page 380: gynostemma pentaphylla boosting qi and nourishing yin, clearing lung and eliminating phlegm, nourishing heart peace
Mind, production of sperm controlling nocturnal emission with astringent drugs.
(3) " Chinese herbal medicine coloured picture handbook " first record: gynostemma pentaphylla is clearing heat and detoxicating, cough-relieving apophlegmatic, and has similar ginseng
Strong benefiting action.Clinical application is in treatment chronic bronchitis, various tumours, canker and insomnia, headache etc..
(4) in the research and clinical application of Japan, " pharmaceutical journal ", " foreign medical science " are middle to be recorded gynostemma pentaphylla: nourishing and fit keeping function,
Energy amphicheirality adjusts function of human body, builds up health, and improves immunity.Adjust blood pressure, reducing blood lipid, hypoglycemic, weight-reducing.Calmness peace
Mind improves sleep, controls nervous breakdown.It is clearing heat and detoxicating, vivotoxin can be cleared up, inhibits cell carcinogenesis and kills cancer cell.Increase
Add human body cell generation to pass number, delays senescence.
2, Folium Apocyni Veneti: pharmacological property: sweet, bitter, cool, return liver warp.Effect: suppressing liver-YANG, reducing fever and causing diuresis.Chemical component: main
Contain flavonoid glycoside, phenolic substance, organic acid, amino acid, polysaccharide glycosides, tannin, sterol, steroid sapogenin and triterpene substance.
Pharmacological action: (1) hypotensive activity；(2) effect for reducing blood fat；(3) function of resisting myocardial fibrillation；(4) anti anoxia function
The protective effect of energy and anoxia-induced apoptosis；(5) anti-diabetic vascular lesion acts on.In addition, there are also antianxiety, depressions to make for Folium Apocyni Veneti
With, diuresis, anti-aging effects, calmness, anticonvulsant action adjusts immune and the effects of inhibit influenza virus.
Adverse reaction: bradycardia and proiosystole can also occur in nausea,vomiting,diarrhea, epigastric discomfort.Suction is spreaded out
Numb cigarette is to may occur in which dizziness, cough of choking, nausea, insomnia etc..
Think that bluish dogbane is the main ingredient of " leaf sumac blueness viscous dissipate " in " Huatuo's biographies ", there is long term usage to go three worms, relieving the five internal organs, gently
Body, the effect of keeping the number of people not white.Recorded in Ming Dynasty's herbal for Relief of Famines: " it is steamed to adopt tender leaf, dries, do tea eat also can "；The Qing Dynasty's " this
Careless detailed outline is picked up any lost article from the road " it records: " Zhejiang Changshan, there is a face cigarette, sharp dissolving phlegm such as mind, and all the elderlys cough the person of spitting just before dawn, and cough stops, and phlegm is also
Disappear "." planting medicine will in Jiangsu ": milk can healing of wound." middle traditional Chinese medicines plant illustrated handbook ": tender leaf steams and fries kneading offspring's tea, there is refrigerant go
Fire prevents dizzy and heart tonifying function." Shaanxi Chinese herbal medicine ": refrigerant purging intense heat, heart tonifying diuresis, blood pressure lowering.Control heart disease, high blood
Pressure, neurasthenia, ephritis edema.Modern clinic discovery, bluish dogbane have clearing away heat and promoting diuresis, and calming the liver sedative action can be used for treating
Hypertension, dizzy, palpitaition, insomnia etc..In addition, bluish dogbane to prevent and treat senile hypertension, flu, tracheitis, to enhancing
Certain effect such as immunity of organisms.
3, vine tea: pharmacological property: bitter, micro-puckery, it is cool in nature.Effect: clearing heat and promoting diuresis, calming the liver decompression are promoting blood circulation and removing obstruction in channels.Main dysentery；Diarrhea；
Urine leaching pain；Hypertension；Dizzy mesh is swollen；Traumatic injury.Chemical component: contain flavonoids, ampelopsin, dihydromyricetin in vine tea
Element, soluble sugar, tea polyphenols etc., and rich in 14 kinds of microelements such as 17 kinds of amino acid and potassium, calcium, iron, zinc, selenium.
Pharmacological action: the main active in vine tea is flavone compound, and substance of this kind, which has, to be removed free radical, resists
A variety of peculiar effects such as oxidation, antithrombotic, antitumor, anti-inflammatory；And dihydromyricetin is a kind of flavones more special in vine tea
Class compound is releasing alcoholism, prevention alcoholic liver, fatty liver, liver cell is being inhibited to deteriorate, disease incidence, the anti-height of reduction liver cancer
Blood pressure, reduces blood lipid and blood glucose level at the formation for inhibiting extracorporeal platelet aggregation and internal thrombus, improves SOD activity and protects
Protecting liver etc. has special efficacy.
Vine tea is run after fame first recorded in " tea warp " with " vine tea ", " drink the positive medicine of meals " later, " vegetation just side ", " canopy folk rhyme ",
The ancient books such as " big bamboo county annals ", " commenting king's certificate an official document or note book to pass for note " continue to use this name." vegetation is just square " is recorded: " vine tea Ye Ganwen quenches one's thirst,
All tympanites swollen moons are living, and pellet is stopped the supple of gas or steam, and swollen lower cup is malicious, and convenient logical intestines are drunk for tea ".It is recorded in " the newly organized Chinese medicine formulas or directions put into verse " of Zhou Dengcheng: " sweet tea
Tea rattan is clearing heat and detoxicating, is used for icterohepatitis sore-throat, and mesh swells carbuncle furuncle "." Chinese medicine resource will will " be recorded: " vine tea heat-clearing solution
Poison is used for jaundice, anemopyretic cold, abscess of throat, carbuncle furuncle "." national Chinese herbal medicine name mirror " carries: " vine tea can be used for acute conjunctiva
It is scorching ".There is clearing heat and detoxicating, inducing diuresis and reducing edema record vine tea in " national Chinese herbal medicine compilation ", " China's book on Chinese herbal medicine ", calming the liver decompression, promoting blood circulation are logical
The effect of network, is suitable for the diseases such as high blood pressure, dizzy mesh is swollen, red eye, swell pain, carbuncle swells boil, dysentery, diarrhea, urine leaching pain.
4, dark green tea
Dark green tea, which has, to quench the thirst, is anti-radiation, anticancer, giving protection against cancer, helping and sober up, promote digestion, weight-reducing, anti-aging, norcholesterol etc.
Effect can enhance the movable acuteness of brain centres nerve, improve elaborative faculty, blood pressure lowering, inhibit artery sclerosis etc..
Contain flavone compound (Kaempferol, Quercetin and its glucosides), pigment (theabrownin), flavanol compound in dark green tea
Closing object (catechin), phenolic acid (gallic acid), mineral element (lead, copper, barium), alkaloid and its derivative, (caffeine, thymus gland are phonetic
Pyridine, uracil), phenol methoxy compound (1,2- dimethoxy benzene, 1,2,3- trimethoxy-benzenes), carbohydrate it is (tea polysaccharide, water-soluble
Property sugar), statin compound etc..
The main component of dark green tea soup look is theabrownin, including theaflavin and thearubigin, and result of study shows theaflavin not only
It is a kind of effective free radical scavenger and antioxidant, and there is anticancer, antimutation, inhibitory anti-virus, improvement and treatment
The different physiological roles such as cardiovascular and cerebrovascular disease, treatment diabetes.
The main function ingredient of dark green tea is tea complex polysaccharide class compound, and this kind of compound is thought to adjust by medical field
Internal glycometabolism is saved, blood fat and blood pressure is reduced, anticoagulant, thrombus, improves body immunity.Dark green tea can inhibit underbelly fat heap
Product.Tea polyphenols and its oxidation product energy dissolved fat in dark green tea, and lipid material is promoted to be discharged, thus can reduce total in blood
Cholesterol, free cholesterol, the content of low density lipoprotein cholesterol and triglyceride, to reduce in arterial blood tube wall
Cholesterol deposition reduces the disease incidence of arterial revascularization.It can accelerate lipolysis with activation of protein kinases, it is intracorporal to reduce machine
Fat content plays functions of lowering blood-fat and reducing weight.
Dark green tea effective component inhibit human body stomach in harmful microorganism growth while, and can promote beneficial bacterium (as cream
Sour bacterium) growth and breeding, have the function of that good adjustment functions of intestines and stomach, alkaloids can promote the secretion of gastric juice, flavane
Alcohols can significantly increase enterogastric peristalsis.Catechin compounds and theafolisaponin in dark green tea are to oral bacteria, pylori, large intestine
The growth of a variety of pathogens such as bacillus, Typhoid and paratyphoid bacillus, staphylococcus has killing and inhibiting effect, thus has significant
The stagflation that disappears, stopping leak, eliminate constipation effect.Theanine etc. in dark green tea has the function of good enhance human immunity.
Catechin and complicated flavonoid substances in dark green tea, have very active hydroxyl hydrogen, can provide a large amount of Hydrogen Proton
With radical reaction, extra free radical is removed, to protect human health long-lived.
Theanine in dark green tea can play the role of inhibiting blood pressure raised, and alkaloid and flavonoid substances have makes vascular wall
It is loose, increase the effective diameter of blood vessel, declines blood pressure and making vasodilation.Tea polysaccharide in tealeaves to it is hypoglycemic have it is bright
Effective fruit acts on similar insulin.And contain more tea polysaccharide in dark green tea, it is the ideal drink for preventing and treating diabetes
Product.There are also anti-cancer, reducing blood lipid, radiation protection, the health-care effects of the tealeaves general character such as anti-inflammatory for dark green tea.
5, Litsea coreana: the century-old above history has been passed on from one to another as a kind of ancient tea kind.Litsea coreana contains Multiple components, such as amino
The substances such as acid, mineral element, vitamin C, vitamin B1, vitamin B2, flavonoids, Polyphenols, caffeine, it has recently been found that have point
It Wei not cupreol (1), oleanolic acid (2), hesperetin (3), dihydroquercetin (4), Kaempferol (5), apiolin (6).Simultaneously
Containing high-speed rail, high selenium, Gao Xin, high chromium feature, therefore its function of being conducive to improvement hemopoietic system and endocrine system；It is other micro
Element such as rubidium, phosphorus, zinc etc. is with health role to cranial nerve and cardiovascular and cerebrovascular.With quench one's thirst drive away summer heat, help digestion solve it is swollen, removing toxic substances disappear
It swells, intelligence development of refreshing oneself, improving eyesight stomach invigorating, removing blood stasis and acesodyne, antidiarrheal, the only multiple efficacies such as belch.Litsea coreana sweet and cool-natured, tool inducing resuscitation, heart tonifying,
The function have one's ideas straightened out, promote the production of body fluid, relieved summer heat.Litsea coreana does not influence to sleep without excitation, and is rich in mineral matter element, participates in human body egg
The metabolism of white matter, amino acid and carbohydrate, especially γ-aminobutyric acid have protective effect to angiocarpy.Especially disappear
The effect of oil removal, is significant, long-term drinking can reducing blood lipid, blood pressure lowering, wherein the selenium of high-content more has the effect of conditioning skin and losing.Always
General flavone in hawk black tea has very strong hypoglycemic effect, and Litsea coreana can also promote serum insulin secretion, adjusts rouge
Matter metabolic disorder.
Claim in " tea warp ": " Litsea coreana is many containing aromatic oil, also contains polyphenol compound, and compared with faint scent when steeping drink, flavour is thick
It is real." Compendium of Material Medica record Litsea coreana " have cough-relieving, eliminating the phlegm, relieving asthma, sober up, detoxifying, relieve summer heat quench one's thirst, regulating qi-flowing for strengthening spleen, stomach function regulating
The effect of soothing the spirit ".
Compared with prior art, the invention has the advantages that and effect:
1, a kind of tea for reducing hypertension and fat provided by the invention, the gynostemma pentaphylla of the tea for reducing hypertension and fat, Folium Apocyni Veneti, vine tea, dark green tea
And Litsea coreana, the effect of 5 kinds of components equal blood pressure lowering and reducing blood lipid, but the area mechanism Jun You of the main hypertension and hyperlipemia of 5 kinds of raw materials
Not, it complements each other simultaneously, reaches more excellent blood pressure lowering and blood fat reducing function；Hypertension and hyperlipemia mechanism is specific as follows:
(1) main component of gynostemma pentaphylla has a gynosaponin, gynostemma pentaphylla glucoside (polysaccharide), water-soluble amino acids, flavonoids,
Multivitamin, microelement, the gynostemma pentaphyllum total saponins such as minerals (Gypenoside GPs) system mention from gynostemma plant
The saponin mixture taken, content highest.Its chemistry point complexity, basic chemical structure have panaxoside similar to skeleton tetracyclic triterpene
Dammarane type structure, part of ingredient is identical with panaxoside.GPs can reduce the creatine phosphokinase of serum, cream
The activity of acidohydrogenase reduces the content of serum free fatty acid and lipid peroxide, improves superoxide dismutase and paddy Guang
The activity of sweet peptide peroxidase reduces the blood vessel endothelium injury because of caused by blood supply insufficiency, so having stronger anti-artery
The effect of hardening, GPs can reduce left ventricular systolic pressure, can play the role of reducing blood pressure, and GPs energy anti-lipid peroxidation entangles
Just high lipid diets when the metabolic disorder that occurs, so have reduction total cholesterol, triglyceride, the drop such as low-density lipoprotein
The effect of blood lipid, while high-density lipoprotein can be improved.Gynostemma pentaphylla also Flavonoid substances rich in simultaneously, can also play
The effect of blood pressure lowering and reducing blood lipid.
(2) dogbane tea contains tannin, is similar to vitamin P activity, is able to maintain or restores the normal resistance of capillary
Power enhances the flexibility and elasticity of blood vessel, can reduce serum cholesterol, prevents fat from depositing in vascular wall.In Folium Apocyni Veneti
Tannic acid blood pressure can be inhibited to increase, and to the effect that the blood pressure of hypertensive patient is reduced.Especially dogbane tea is to egg
White matter and fat have good decomposition.Tea polyphenols and vitamin C can reduce cholesterol and blood lipid；Quercetin is to spread out simultaneously
One of the principle active component of fiber crops, on the one hand, quercitrin is known as apparent diuresis, to have the function that reduce blood pressure；Separately
One side quercitrin is known as the release action for inhibiting platelet aggregation and serotonin (5-HT).Quercetin is to ADP, fibrin ferment and blood
The platelet aggregation of platelet activation factor (PAF) induction has obvious inhibiting effect, wherein the inhibiting effect to PAF is most strong, from
And declining blood viscosity, resistance of blood flow reduces, and reaches antihypertensive effect.These ingredients make bluish dogbane have blood pressure lowering and drop blood
The function of rouge.
(3) main component of vine tea is dihydromyricetin, the adrenaline secretion that dihydromyricetin can obviously inhibit increase and
Caused blood pressure increases, while the inflammatory reaction of blood vessel endothelium can be made substantially reduced, and resistance of blood flow is reduced, and inhibits blood pressure liter indirectly
It is high.Dihydromyricetin can in serum serum total cholesterol (TC) and triacylglycerol (TG) have reduction effect, to high density rouge
Protein cholesterol (HDL2C) content has no significant effect.
(4) substance for having vasoactive in dark green tea is mainly tea polyphenols, especially the catechins ECG in tea polyphenols and
EGC and its oxidation product theaflavin etc. can inhibit vascular endothelial cell hyperplasia because of caused by oxidative damage, to inhibit artery
Atherosis, while blood viscosity can be reduced, fibrinogen activity is reduced, blood flow resistance is reduced；Another party
Face, tea polyphenols have the active effect of stronger inhibition converting Enzyme, so tea polyphenols can play reduction or keep blood pressure stabilization
Effect；Dark green tea can generate Lovastatin in process of production, and Lovastatin (Lovastatin) can be such that the synthesis of cholesterol subtracts
It is few, also increase LDL receptor synthesis, as a result main function position makes cholesterolemia and low-density lipoprotein in liver
White cholesterol levels reduce, and thus act on the prevention and treatment generation of atherosclerosis and coronary heart disease.This product also reduces serum glycerol
Three ester levels and increase blood hdl level.Oral absorption is good, but on an empty stomach absorb reduce 30%, both at
It point is the main component that dark green tea generates blood pressure lowering and reducing blood lipid.
(5) main component of Litsea coreana is Flavonoid substances and phenols goods and materials, since its growing environment is mostly selenium-rich
Area, so the selenium element containing needed by human body, Flavonoid substances are mainly flavonols and flavanone, at the same dark green tea contain it is abundant
Amino acid, especially γ-aminobutyric acid GABA, γ-aminobutyric acid is not only a kind of amino acid, and is a kind of very heavy
The neurotransmitter wanted, GABA are almost existed only in nerve fiber, and the content in mesencephalic tissue is about 0.1-0.6mg/ grams
Tissue, immunological investigation show that the highest region of its concentration is black substance in brain.GABA is the more deep one kind of current research
Important inhibitory neurotransmitter, it participates in a variety of metabolic activities, has very high physiological activity.It is a kind of naturally occurring
Non-protein forms amino acid, and GABA can act on the vasomotor center of spinal cord, effectively facilitate blood vessel dilatation, reach and reduce blood pressure
Purpose.Another effective component is selenium element, is the ingredient for constituting Selenonic protein and selenoenzyme.Into the intracorporal selenium overwhelming majority
In conjunction with protein, referred to as " Selenonic protein ".Wherein, by codeword triplet UGA coding selenocystein (Sec) ginseng on mRNA
The protein entered is otherwise known as " selenoprotein ".It it is now recognized that only selenoprotein has biological function, and is body Selenium Nutrition State institute
It adjusts.They play anti-oxidant, adjusting thyroid hormone metabolism and maintain vitamin C and the effect of other molecule reduction-states etc..It is main
The Selenonic protein wanted has with selenoenzyme: glutathione peroxidase (GSH-Px, GPX), have protection cell and cell membrane from
The effect of oxidative damage can shield to vascular endothelial cell, be resistance of blood flow decline, reach the mesh of blood pressure lowering indirectly
's.
In short, this existing similar ingredient of five kinds of ingredients of gynostemma pentaphylla, Folium Apocyni Veneti, vine tea, dark green tea and Litsea coreana, all also
(this substance has extremely strong protective effect to cardiovascular disease to the Flavonoid substances for having content different, can protect blood vessel endothelium
Cell reduces lipid and is attached to vascular wall, reduces various free radicals to the detrimental effect of vascular endothelial cell and cardiac muscle cell),
It is again (as described above: the function of blood pressure lowering and reducing blood lipid can be played in gynostemma pentaphylla containing gynostemma pentaphyllum total saponin containing other compositions respectively
Effect；Have the function of lipid-loweringing, the tannic acid contained in bluish dogbane, Quercetin containing tannin, tea polyphenols and vitamin C in bluish dogbane
All have the effect of decompression；The dihydromyricetin that vine tea contains has decompression lipid-lowering effect；The tea polyphenols that have in dark green tea, Lip river are cut down
Statin has decompression lipid-lowering effect；γ-aminobutyric acid GABA, selenium element in Litsea coreana have decompression lipid-lowering effect), these
The mechanism of action of other compositions hypertension and hyperlipemia is different, and the Flavonoid substances all contained with 5 kinds of components complement each other together, reach
More excellent blood pressure lowering and blood fat reducing function.Above five kinds of traditional Chinese medicine ingredients have similar pharmacological action, such as reduce blood pressure and
Reduce blood lipid.But emphasis is different: (1) bluish dogbane mainly has the effect of reducing blood pressure；(2) gynostemma pentaphylla is then mainly improved
The effect of the immunity of body and pre- preventing tumor；(3) vine tea is mainly calming the liver decompression；(4) dark green tea is mainly calming the liver lipid-loweringing；(5)
Litsea coreana is mainly blood fat-reducing blood pressure-decreasing.
2, there are side effects for gynostemma pentaphylla and bluish dogbane: gynostemma pentaphylla and bluish dogbane Chinese herbal medicine will appear liver more in use
Kidney function damage, gynostemma pentaphylla is more to Influence on kidney, and bluish dogbane is more to liver function influence, and two kinds of Chinese herbal medicines have simultaneously
Digestive system side effect；And dark green tea generates a large amount of dietary fiber and other beneficiating ingredients during the fermentation, has to alimentary canal
Significant protective effect, and Litsea coreana is mainly used for the prevention of disease of digestive system, so dark green tea and Litsea coreana is organic
In conjunction with gynostemma pentaphylla and bluish dogbane bring digestive tract side effects can be overcome；
There is also side effects for dark green tea: since dark green tea is in process of production it is possible that some harmful bacteria (such as Aspergillus flavus
Deng), and vine tea have to harmful bacteria deactivation (experiment show vine tea to staphylococcus aureus, staphylococcus epidermis,
Beta hemolytic streptococcus, escherichia coli, shigella dysenteriae, Aspergillus flavus etc. have apparent inhibiting effect, to common in food
The inhibiting effect of bacterium is better than common preservative benzoic acid), the two has complementary functions；
Make simultaneously because dark green tea can generate Lovastatin class blood lipid-lowering medicine, tea polyphenols and its oxidation product with lipid-loweringing
With there are also higher Flavonoid substances, the Selenonic proteins of Litsea coreana to have hypotensive activity, gynostemma pentaphyllum total saponin GPs for vine tea
It can obviously improve the disorders of lipid metabolism as caused by experimental hyperlipidemia；Dark green tea, vine tea, Litsea coreana, gynostemma pentaphylla, bluish dogbane
Extremely strong blood fat reducing function is played together.
We have found that amino acid content is higher to Litsea coreana in the detection, especially γ-aminobutyric acid, are that one kind has mind
Amino acid through mediator function, the effect of blood pressure lowering can be generated, can and the diuresis of bluish dogbane (quercitrin in bluish dogbane is known as
Apparent diuresis is to have the function that reduce blood pressure) it combines, specifically: γ-aminobutyric acid has vasodilative effect
(GABA can act on the vasomotor center of spinal cord, effectively facilitate blood vessel dilatation), bluish dogbane have bidirectional pressure regulating effect, for
Dysarteriotony person spreads out the expansible blood vessel of sinks and γ-aminobutyric acid and cooperates with performance antihypertensive effect together；Meanwhile spreading out Matong
Overfill hyperemia potassium, balance blood sodium so that have extremely strong hypotensive activity (be rich in bluish dogbane, calcium, manganese, magnesium, zinc, selenium, strontium
Etc. various trace elements, wherein potassium can improve the acid-base balance of into the cell suitable osmotic pressure and body fluid, participate in endocellular sugar
With the metabolism of protein, when the high sodium of intake incurs hypertension, potassium has hypotensive activity).Simultaneously with dark green tea, vine tea, old
The tea polyphenols and its metabolite contained in three kinds of tealeaves of hawk black tea together, generate stronger blood pressure reduction effect.
In conclusion this five kinds of components can overcome mutually side effect, while mutual pharmacological action can be improved.
3, from the point of view of Chinese medicine attribute, vine tea, Litsea coreana are cool in nature, and gynostemma pentaphylla, bluish dogbane are cold in nature, and dark green tea is warm-natured, make together
It is cold with that can neutralize, to reduce side effect；From the point of view of Chinese medicine channel tropism, Chinese medicine thinks gynostemma pentaphylla return lung, spleen, kidney channel, bluish dogbane
Return liver warp, the two action compensating are conducive to the various functions for adjusting human body, body function are made to be in optimum state, meanwhile, vine tea
Has effects that liver protecting；Dark green tea has the function of promoting digestion；Litsea coreana has cough-relieving, eliminating the phlegm, regulating qi-flowing for strengthening spleen, stomach function regulating happy
The effect of refreshing；5 kinds of components adjust liver, spleen, stomach, kidney together, and body function is made to be in optimum state.
Detailed description of the invention
Fig. 1 is vine tea standard substance high-efficient liquid phase chromatogram.
Specific embodiment
Embodiment 1
1, a kind of tea for reducing hypertension and fat
The tea for reducing hypertension and fat includes the raw material of following parts by weight: 2 parts of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, and 3 parts of dark green tea, rattan
1 part of tea, 1 part of Litsea coreana.
2, the preparation method of the tea for reducing hypertension and fat
By weight ratio by 2 parts of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, 3 parts of dark green tea, 1 part of vine tea, 1 part of Litsea coreana, wash
It is net dry, it is uniformly mixed, is distributed into outer packaging bag, is got product after vacuum sealing.
Embodiment 2
1, a kind of tea for reducing hypertension and fat
The tea for reducing hypertension and fat includes the raw material of following parts by weight: 1 part of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, and 2.9 parts of dark green tea,
0.5 part of vine tea, 0.5 part of Litsea coreana.
2, the preparation method of the tea for reducing hypertension and fat
By weight ratio by 1 part of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, 2.9 parts of dark green tea, 0.5 part of vine tea, Litsea coreana 0.5
Part, clean dry is uniformly mixed, is distributed into outer packaging bag, gets product after vacuum sealing.
Embodiment 3
1, a kind of tea for reducing hypertension and fat
The tea for reducing hypertension and fat includes the raw material of following parts by weight: 2 parts of gynostemma pentaphylla, 1 part of Folium Apocyni Veneti, and 4.2 parts of dark green tea, rattan
1.5 parts of tea, 1.5 parts of Litsea coreana.
2, the preparation method of the tea for reducing hypertension and fat
It incites somebody to action by weight ratio: 2 parts of gynostemma pentaphylla, 1 part of Folium Apocyni Veneti, 4.2 parts of dark green tea, 1.5 parts of vine tea, Litsea coreana 1.5
Part, clean dry is uniformly mixed, is distributed into outer packaging bag, gets product after vacuum sealing.Instructions of taking: daily 100ml,
Point sooner or later one after each meal twice, 7 days as one therapeutic course.
Embodiment 4
1, a kind of tea for reducing hypertension and fat
The tea for reducing hypertension and fat includes the raw material of following parts by weight: 1.5 parts of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, and 3 parts of dark green tea,
0.8 part of vine tea, 0.8 part of Litsea coreana.
2, the preparation method of the tea for reducing hypertension and fat
It incites somebody to action by weight ratio: 1.5 parts of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, 3 parts of dark green tea, 0.8 part of vine tea, Litsea coreana
0.8 part, clean dry is uniformly mixed, is distributed into outer packaging bag, gets product after vacuum sealing.
Embodiment 5
1, a kind of tea for reducing hypertension and fat
The tea for reducing hypertension and fat includes the raw material of following parts by weight: 2 parts of gynostemma pentaphylla, 0.7 part of Folium Apocyni Veneti, and 3.5 parts of dark green tea,
1.2 parts of vine tea, 1.2 parts of Litsea coreana.
2, the preparation method of the tea for reducing hypertension and fat
It incites somebody to action by weight ratio: 2 parts of gynostemma pentaphylla, 0.7 part of Folium Apocyni Veneti, 3.5 parts of dark green tea, 1.2 parts of vine tea, Litsea coreana
1.2 parts, clean dry is uniformly mixed, is distributed into outer packaging bag, gets product after vacuum sealing.Every tea bag in embodiment 1-5
9g, heating bubble are made 100 milliliters of references, have drunk in one day.
Comparative example 1
The tea for reducing hypertension and fat of the comparative example includes 2 parts of gynostemma pentaphylla, and 0.5 part of Folium Apocyni Veneti, 3 parts of dark green tea, clean dry mixes
Uniformly, it is distributed into outer packaging bag, is got product after vacuum sealing.
Comparative example 2
The tea for reducing hypertension and fat of the comparative example by weight ratio will be ripe using gynostemma pentaphylla, bluish dogbane, ripe Pu'er tea as raw material
13 parts of Pu'er tea, 4 parts of gynostemma pentaphylla, 3 parts of clean dries of bluish dogbane are uniformly mixed, are distributed into outer packaging bag, after vacuum sealing i.e.
Obtain finished product.
The test of 1 pharmacological toxicity of experimental example
1, animal acute toxicity test
Drug: the tea for reducing hypertension and fat that 1- of embodiment of the present invention embodiment 5 provides.
Experimental animal: regular grade NIH mouse, weight 18g ± 2g, half male and half female.
Method and result:
Experimental group 1-5: by tea for reducing hypertension and fat 100ml made from 1- of embodiment of the present invention embodiment 5, rice flour is added.Control
Group: the rice flour of feeding equivalent；Experiment mice is randomly divided into five groups of half male and half females, respectively experimental group 1-5 and control group, volume
1ml/10g weight, close observation 8 hours are simultaneously noted down, and observation 7 days is continued；In 7 days, for mouse without death, behavior is active, ingests
Amount is as usual, and hair color light is without loose dirt, no convulsions addicted to saliva, eye, mouth, nose, ear and crissum secretion without exception, no rotten toe of docking.
5 execution are selected from five groups respectively, finding of naked eye: the heart, liver, lung, in stomach and important organs, the no abnormality seen such as thymus gland change,
Show the tea for reducing hypertension and fat of the offer of 1- of embodiment of the present invention embodiment 5 without acute toxicity.
2, long-term toxicity test for animals
Drug: by tea for reducing hypertension and fat 100ml made from 1- of embodiment of the present invention embodiment 5, rice flour experimental group 1-5: is added.
Control group: the rice flour of feeding equivalent；
Animal: regular grade SD rat, weight 200g ± 10g, half male and half female.
Method and result:
Experimental group 1-5 and control group continue feeding 40 days repeatedly respectively, observe animal general toxic reaction and severity,
Each position is checked by operating instruction after execution, and carries out the main organs such as hematology, ALT, BUN and the heart, liver, spleen, lung, kidney, stomach
Pathological examination；
By long-term feeding, two groups of rats do not occur toxic reaction.Growth and development is good.Macroscopic appearance and main organs
No abnormality seen.Peripheral hemogram and Serum ALT, BUN change without pathologic compared with the control group.The pathological replacement heart, liver, spleen, lung,
The not significant change such as kidney, stomach, it is understood that through proved by pathology, the drop of the offer of 1- of embodiment of the present invention embodiment 5
Fat decreasing tea is pressed to show animal without chronic toxicity.
Pass through two above toxicity test, it was demonstrated that the tea for reducing hypertension and fat safety that 1- of embodiment of the present invention embodiment 5 provides,
It has no toxic side effect, can be used to carry out clinical test to clinical patients.
2 pharmacological experiment of experimental example
1, material
(1) drug: 1- of embodiment of the present invention embodiment 5 is prepared into the tea for reducing hypertension and fat containing 9g/10ml；Hydrochloride is double
Guanidine；The tea for reducing hypertension and fat of comparative example 1-2.
(2) animal: regular grade NIH mouse 60, half male and half female, weight (18g ± 2g) are attached by the Central China University of Science and Technology
Concord Hospital's animal experimental center provides.
(3) reagent and instrument streptozotocin (STZ) are purchased from magnificent company.
2, method
(1) modeling and grouping
Hyperlipidemia: animal is bought back, after adaptable fed 1 week, is randomly divided into normal non-hyperlipidemia group (negative control
Group) 6, experiment modeling group 54, test modeling group fasting 12 hours before modeling, modeling, which is given, to be contained 1% gallbladder for 1 week or more and consolidate
Alcohol, 20% lard, 2% sodium taurocholate, 1% propylthio pyrimidine high lipoprotein emulsion, 1 time a day, continuous 7 days.By modeling success mouse
(experiment modeling group 54) is randomly divided into 9 groups, model control group, melbine group, comparative example 1-2 1-5 group of the embodiment of the present invention
Each 6.
(2) administration and measuring method Normal group and model control group (isometric physiological saline)；Hydrochloride is double
Guanidine group (0.20g/kg)；Tea for reducing hypertension and fat group (the tea for reducing hypertension and fat 3.0g/ of daily 1-5 of the embodiment of the present invention respectively of the present invention
kg)；Comparative example 1-2 group (3.0g/kg)；Each group difference gastric infusion, 1 time/d, continuous 30 days.12h fasting before last dose, gives
2h after medicine plucks eye and takes blood, measures blood lipid with automatic clinical chemistry analyzer.
(3) all data of statistical procedures indicate that data are handled using the analysis of SPSS11.5 statistical software with "-χ ± S ".
3, result
The influence (- χ ± S) of hypertension and hyperlipemia difference table 1- of the invention to lipid of mice
Note: compared with Normal group, Δ Δ P < 0.01；Compared with model control group, * P < 0.05, * * P < 0.01；
NS, physiological saline.
As shown in Table 1, the tea for reducing hypertension and fat of 1-5 of the embodiment of the present invention can be substantially reduced the TC of hyperlipemia mice model
(serum total cholesterol), TG (triglycerides) content, compared with model control group, statistically significant (P < 0.05, the P < of difference
0.01).In summary, the tea for reducing hypertension and fat of 1-5 of the embodiment of the present invention has the effect of apparent reducing blood lipid.Wherein embodiment 1
For most preferred embodiment；Implement 4, embodiment 5 as more preferably embodiment.Compared with comparative example 1-2, it is known that 1-5 of the embodiment of the present invention
Tea for reducing hypertension and fat have stronger fat-reducing effect.
Experimental example 3
The tea for reducing hypertension and fat of embodiment 1 is drunk by 15 hypertension volunteers, line trace of going forward side by side measures blood pressure.
1, volunteer's basic condition is as follows:
1 st volunteer, the age 49 years old, gender male, blood pressure 149/92mmHg
2 st volunteers, the age 54 years old, gender male, blood pressure 148/97mmHg
3 st volunteers, the age 46 years old, gender male, blood pressure 158/93mmHg
4 st volunteers, the age 58 years old, gender male, blood pressure 150/95mmHg
5 st volunteers, the age 51 years old, gender female, blood pressure 149/94mmHg
6 st volunteers, the age 56 years old, gender male, blood pressure 148/92mmHg
7 st volunteers, the age 55 years old, gender male, blood pressure 146/95mmHg
8 st volunteers, the age 47 years old, gender male, blood pressure 158/90mmHg
9 st volunteers, the age 59 years old, gender male, blood pressure 150/94mmHg
10 st volunteers, the age 51 years old, gender female, blood pressure 148/94mmHg
11 st volunteers, the age 69 years old, gender male, blood pressure 149/91mmHg
12 st volunteers, the age 55 years old, gender male, blood pressure 148/96mmHg
13 st volunteers, the age 47 years old, gender male, blood pressure 159/91mmHg
14 st volunteers, the age 58 years old, gender male, blood pressure 151/94mmHg
15 st volunteers, the age 50 years old, gender female, blood pressure 149/91mmHg
2, the requirement during testing to volunteer
(1) refuse to obey during testing and use depressor；
(2) food that black fungus, celery, kelp, mung bean and onion these types may reduce blood pressure is not eaten during testing
Object；
(3) it during testing, follows the doctor's advice, not Excess free enthalpy fat, protein and carbohydrate.
3, blood pressure detecting surveys record.
1-5 st volunteer it is daily nine when, 16 when, 20 a period of time drink the embodiment of the present invention 1 tea for reducing hypertension and fat it is brewed
100 milliliters of hypertension and hyperlipemia tea,
6-10 st volunteer it is daily nine when, 16 when, 20 a period of time drink the brewed decompression of tea for reducing hypertension and fat of comparative example 1
100 milliliters of lipid-loweringing tea,
11-15 st volunteer it is daily nine when, 16 when, 20 a period of time drink the brewed drop of tea for reducing hypertension and fat of comparative example 2
100 milliliters of pressure drop rouge tea,
100 milliliters of hypertension and hyperlipemia tea is injected 100 milliliters of boiling water and is brewed by 9 grams of tea for reducing hypertension and fat.20th
It, the blood pressure of each volunteer was detected in 30 days, 40 days, 50 days, 60 days.Testing result is as follows:
Table 2
As shown in Table 2, the 20th day for continuously drinking the tea for reducing hypertension and fat of the offer of the embodiment of the present invention 1, blood pressure, which declines to a great extent, returns
Blood pressure gradually tends towards stability in the normal range after normal value ,-the 60 day the 30th day.In summary, drop provided by the invention
Pressure drop rouge tea has the effect of apparent blood pressure lowering.6-10 st volunteer drinks the lipid-lowering effect of the tea for reducing hypertension and fat of comparative example 1
It is far short of what is expected, drink 60 days also not completely by blood pressure stabilization in the normal range；11-15 st volunteer drinks the decompression of comparative example 2
The lipid-lowering effect of fat decreasing tea, it is slightly good compared with comparative example 1, but effect or far short of what is expected compared with Example 1.
Experimental example 4
One, vine tea quality safety index and primary functional components analyze test result
(1) detection project:
Moisture, total ash, pesticide residue, heavy metal, healthy trace elements with household, general flavone, dihydromyricetin, total polyphenols, phenol
Acids, total amino acid content, Water-soluble Total Sugar, protein etc..
(2) detection foundation and method
(1) the flavones ingredients detection method such as dihydromyricetin
Using reversed-phased high performace liquid chromatographic, quantified by external standard method.First standard items prepare the feed liquor facies analysis of various concentration gradient,
The despumation of re-optimization separation condition is to quantitative interference, accurate quantification.
(2) general flavone quantitative approach
Using aluminium ion combination flavones development process, flavone compound carries out complex reaction with aluminium salt, under alkaline condition
Generate red complex compound.Its absorbance is measured under 510nm wavelength with spectrophotometry, compared with rutin standard items, is carried out
The quantitative determination of general flavone in determinand.The drafting of standard curve: pipette control substance of Rutin 0,0.50,1.00,1.50,2.00,
2.50,3.00,3.50,4.00mL, are respectively placed in 25mL volumetric flask, and 5% NaNO is added2Solution 0.30mL, shakes up, and stands
6min, then plus 10% Al (NO3)3Solution 0.30mL, shakes up, and stands 6min, adds 4% NaOH solution 4.00mL, add water
It is settled to scale, is shaken up, 12min is stood.Make reference solution with blank solution, measures absorbance, at 510nm wavelength with extinction
Spending (A) is ordinate, and concentration (C) is abscissa (0-0.54mg/mL), draws standard curve.
The measurement of sample: weighing tea sample 0.2g (being accurate to 0.0001g), with 1:500 (m/v) extracting in boiling water 45min, therebetween
It is primary every 15min shaking flask, filter while hot, filtrate is cooled to after room temperature be settled to 100mL with deionized water after, for use.2mL is taken to mention
It takes liquid to be placed in the volumetric flask of 25mL, 5% NaNO is added2Solution 0.30mL, shakes up, stand 6min, then plus 10% Al
(NO3)3Solution 0.30mL, shakes up, and stands 6min, adds 4% NaOH solution 4.00mL, add water to be settled to scale, shake up,
Stand 12min.Make reference solution with blank solution, absorbance is measured at 510nm wavelength.
(3) total amino acid content ninhydrin method detects
1g sample boiling water bath 45min is settled to 100mL after cooling, for use.Again by the buffer of 2 × pH5.6 of 200 μ L,
200 μ L water or vine tea leaf aqueous extract (30min is boiled in rattan tea-water proportion 1:250, boiling) and 400 μ L ninhydrin solution color development systems,
Even mixing is simultaneously fully cooled with tap water immediately after certain time boiling is boiled and deionized water 4.8mL is added and be sufficiently mixed,
It is measured in 570nm.
(4) Water-soluble Total Sugar Anthrone-sulfuricacid method measures
It weighs and grinds 0.2 gram of tea sample, add 40 milliliters of water to extract 45 minutes in boiling water bath, after filtering is settled to 100mL, take
PVPP0.1g15min is added in 5mL, shakes up.Take 1 milliliter of test solution, add 4 milliliters of anthrone-concentrated sulfuric acid solutions (boiling water bath 10 minutes, take
It is put into cold water after out and cools down rapidly, measure light absorption value in 620 nanometers.
(4) tea polyphenols total amount Forint phenol method measures
It weighs and grinds 0.2 gram of tea sample, add 40 milliliters of water to extract 45 minutes in boiling water bath, filter dilute after being settled to 100mL
After releasing 5 times, measured by national standard method (GB/T 8313-2008).
(6) moisture content
By GB/T 8304-2002,5 grams of dry teas, 103 DEG C are dried 4 hours, measure dehydration weight.
(7) ash content
It is operated by GB5009.4-2016.
(8) protein
Using Kjeldahl's method.
(9) pesticide residue (Continental Europe detection)
582, using makings chromatography.
(10) metallic element (lead, copper, selenium refer to alternative tea standard)
It is operated by GB5009.268-2016.
Three, testing result
Each mark product separation condition (254nm/Synergi 4u Hydro-RP 80A) is optimized using HPLC, such as Fig. 1 and table
Shown in 3.
Flavonoids and liposoluble ingredient high performance liquid chromatography detection result in 3 vine tea bud-leaf of table
Total protein, flavones, polyphenol, total reducing sugar, total amino acid and total ash testing result in 4 vine tea bud-leaf of table
5 vine tea bud-leaf middle peasant of table is residual and part metals Element detection result
Table 3 and Fig. 1 are it is found that carried out efficient liquid phase detection to 12 kinds of polyphenol, flavonoid components in vine tea bud and leaf, as a result
9 kinds of ingredients are detected, result illustrates that dihydromyricetin content highest in vine tea, the content in bud are up to 27% in table, and high
In Ye Zhongyi times or more.It secondly is dihydroquercetin, content is 1% or so.Myricetin, myricetrin content is 5% or so.Do not eat
For sub- acid content 0.1% or so, myricetin -3-O- galactoside, (+) catechin content are lower than 0.1%, gallicin,
Progallin A content is down to one thousandth and a ten thousandth.
For table 4 it is found that bud is compared with leaf, the content of total protein, general flavone, total polyphenols and total amino acid in bud is higher than leaf.
And content of the total reducing sugar in bud is 2.8%, lower than about 3 times in leaf.The content of moisture and ash content in bud is lower than leaf.
For table 5 it is found that lead content is lower than national standard 5mg/kg, copper content is lower than the limit value 60mg/kg of GB9679-88 copper.
Se content in leaf has reached standard (GH/T 1090-2014) 0.2-4.0mg/kg of Se rich tea.Pesticide residue is not examined in bud
Out, only detection lambda-cyhalothrin and gamma cyhalothrin, cypermethrin, content are respectively 0.008mg/kg in leaf,
0.009mg/kg, far below the 0.01mg/kg of standard.
Two, Litsea coreana quality safety index and primary functional components analyze test result
The testing result of 6 Litsea coreana amino acids of table
The testing result of 7 Litsea coreana microelement kind of table
By table 6 and table 7 it is found that Litsea coreana swells amino acid rich in, especially γ-aminobutyric acid GABA；And contain
There is selenium element abundant.
Described is only presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on should all include within protection scope of the present invention.
Claims (3)
1. a kind of tea for reducing hypertension and fat, which is characterized in that the tea for reducing hypertension and fat includes the raw material of following parts by weight: gynostemma pentaphylla 1~2
Part, 0.5~1 part of Folium Apocyni Veneti, 2.9~4.2 parts of dark green tea, 0.5~1.5 part of vine tea, 0.5~1.5 part of Litsea coreana.
2. tea for reducing hypertension and fat as described in claim 1, which is characterized in that the tea for reducing hypertension and fat includes the original of following parts by weight
Material: 1.5~2 parts of gynostemma pentaphylla, 0.5~0.7 part of Folium Apocyni Veneti, 3~3.5 parts of dark green tea, 0.8~1.2 part of vine tea, Litsea coreana 0.8
~1.2 parts.
3. tea for reducing hypertension and fat as described in claim 1, which is characterized in that the tea for reducing hypertension and fat includes the original of following parts by weight
Material: 2 parts of gynostemma pentaphylla, 0.5 part of Folium Apocyni Veneti, 3 parts of dark green tea, 1 part of vine tea, 1 part of Litsea coreana.
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| CN111467421A (en) * | 2020-05-11 | 2020-07-31 | 恩施硒谷科技股份有限公司 | Selenium-rich compound lipid-lowering tea pigment and preparation method thereof |
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Application publication date: 20190510 |
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