CN103385990A - Rhizoma alismatis essence and preparation method thereof - Google Patents
Rhizoma alismatis essence and preparation method thereof Download PDFInfo
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- CN103385990A CN103385990A CN2013103486924A CN201310348692A CN103385990A CN 103385990 A CN103385990 A CN 103385990A CN 2013103486924 A CN2013103486924 A CN 2013103486924A CN 201310348692 A CN201310348692 A CN 201310348692A CN 103385990 A CN103385990 A CN 103385990A
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Abstract
The invention discloses a rhizoma alismatis essence and a preparation method thereof. The rhizoma alismatis essence is a dry powder medicament extracted from rhizoma alismatis and aims at blood fat reduction. The extraction process of the essence comprises the following steps of: weighting, cleaning and drying a rhizoma alismatis raw material for later use, crushing the rhizoma alismatis raw material, adding water to form slurry, decocting the slurry for 40min, filtering to obtain a filtrate, cooling the filtrate, mixing with protease, cellulase and diastase and stirring for a period of time, adjusting the pH value to 5.0 by edible acetic acid, standing for over half a day, and drying a standing liquid to obtain a tradtional Chinese medicine essence in a dry powder state and capable of reducing blood fat. The rhizoma alismatis essence disclosed by the invention can effectively reduce serum cholesterol, triglyceride and low-density lipoprotein, improve high-density lipoprotein, inhibit fat accumulation and viscous atherosclerosis, slow down generation of intimal plaque, relieve lesion degree and diminish lesion range. The extraction process disclosed by the invention is simple in step, convenient to implement, high in extraction rate, and suitable for large-scale production in batches.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine and method for making thereof, relate in particular to a kind of Rhizoma Alismatis essence and method for making thereof, belong to Chinese medicine polish field.
Background technology
Along with people's living standard improves constantly, the variation of dietary structure and life style, crowd's blood lipid level is totally raising year by year, thereby cardiovascular and cerebrovascular disease also is ascendant trend year by year.In some cardiovascular hotspots, the hyperlipemia prevalence surpasses 20%.
Blood fat is a kind of important substance in human body, and many very Chinese medicine functions are arranged, but can not surpass certain scope.If the generation hyperlipemia, easily cause " blood is thick ", deposit on blood vessel wall, form gradually little speckle, " atherosclerosis " that namely it has often been said.These " specklees " increase, increase, and artery-clogging, make blood flow slack-off gradually.When serious, blood flow interrupts, and, if this situation occurs in heart, will cause coronary heart disease; Brain again occurs, and just there will be the brain sudden death; As be jammed in optical fundus blood vessel, will cause visual deterioration, blind; As occur in kidney, will cause renal arteriosclerosis, renal failure.This shows, hyperlipemia disease is the immediate cause that causes that coronary heart disease, hypertension, arteriosclerosis etc. are sick, and is very large to harm.
Summary of the invention
Demand in view of above-mentioned prior art exists, the objective of the invention is to propose a kind of Rhizoma Alismatis essence and pharmaceutical applications thereof, and propose the higher Chinese medicine essence extraction process of a kind of effective ingredient extraction.
One of above-mentioned purpose of the present invention Rhizoma Alismatis essence, its technical scheme that is achieved is: described Rhizoma Alismatis essence is for extracting from the dry powder state medicine of Rhizoma Alismatis and for reducing blood fat.
The method for making of two Rhizoma Alismatis essences of above-mentioned purpose of the present invention, its technical scheme that is achieved comprises operating procedure: I, weighing Rhizoma Alismatis, to carry out routine and clean in stainless steel tank, taking-up is dried standby; II, standby Rhizoma Alismatis is pulverized, smashing fineness reaches 150 orders, then adds the water of 10 times of raw material of Chinese medicine gross masses to mix, and makes the powder slurry; III, powder slurry is put into stainless-steel pan decoct after 40 minutes to filter and obtain filtrate; IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirred, be cooled to below 20 ℃, the protease, 0.15%～0.4% cellulase and 0.15%～0.2% diastase that add again Rhizoma Alismatis weight 0.15%～0.3%, stir more than 2 hours under the condition of 30 beats/mins of rotating speeds, and with tablet vinegar acid for adjusting pH value 5.0, more than standing half a day; V, standing liquid is put into centrifuge dehydration in aseptic temperature control workshop after, the precipitate that produces is put into 45 ℃ of electric heating aerator setting constant temperature carry out dry 6-8 hour, obtain the Rhizoma Alismatis essence of dry powder state, the weight of this Rhizoma Alismatis essence is the 5-7% of Rhizoma Alismatis raw material gross weight.
The technical scheme of Rhizoma Alismatis essence of the present invention and extraction process thereof, its outstanding effect is: this Rhizoma Alismatis essence can effectively reduce serum cholesterol, triglyceride, low density lipoprotein, LDL, high density lipoprotein increasing, that suppresses fat accumulates and is stained with the stickiness atherosclerosis, slows down the generation of tunica intima speckle and alleviates lesion degree, dwindles extent of disease.Extraction process step of the present invention is simple in addition, and it is convenient to implement, and extraction is higher, is suitable for scale in batches and produces.
The specific embodiment
Because at present to limited, the present situation of recurrence often of hyperlipidemia treatment means, this case creator concentrate one's attention on the Study of Traditional Chinese Medicine medical knowledge, can effectively prevent and treat Chinese herbal medicine material, the test of herpes zoster through exploration, finally finds technical solution preferably.
After deliberation, the present invention proposes a kind of Rhizoma Alismatis essence, and it is the dry powder state medicine of extraction from Rhizoma Alismatis, and can effectively reduce blood fat.
Based on rabbit experiment from pharmacology: Rhizoma Alismatis is oral to Hyperlipidemia Rabbits, has obvious reduction serum cholesterol, triglyceride, low density lipoprotein, LDL, and the effect of high density lipoprotein increasing, illustrate the rabbit hyperlipemia is had preventive and therapeutic action.The effect for reducing fat of Rhizoma Alismatis is the most remarkable with the effect of Rhizoma Alismatis terpene alcohol A-24 acetate, and Rhizoma Alismatis terpene alcohol C-23 acetate, Rhizoma Alismatis terpene alcohol A also have remarkable effect.Rhizoma Alismatis can make the absorbance of rat small intestine cholesterol obviously reduce, and can suppress the esterification of small intestinal cholesterol.The fatty liver rabbit is after the Rhizoma Alismatis treatment, and hepatic fat content obviously reduces, and can suppress accumulating of rat liver fat.Therefore the present invention is devoted to development and the extraction of essence.
From the method for making embodiments of the invention, it comprises following operating procedure.
I, weighing Rhizoma Alismatis 10kg, carry out routine and clean in stainless steel tank, taking-up is dried standby; II, standby Rhizoma Alismatis is pulverized, smashing fineness reaches 150 orders, then adds the water of 100kg to mix, and produces the powder slurry; III, powder slurry is put into stainless-steel pan, be heated to 100 ℃, decocted 40 minutes, then at the blowing valve port, add the filtration cloth bag, then open baiting valve and filter, obtain filtrate; IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirred, be cooled to 18 ℃, add again the protease of 0.03kg, the cellulase of 0.04kg and the diastase of 0.02kg, stirred 3 hours under the condition of 30 beats/mins of rotating speeds, and with tablet vinegar acid for adjusting pH value 5.0, standing 20 hours; V, standing liquid is put into centrifuge dehydration in aseptic temperature control workshop after, the precipitate that produces is put into the electric heating aerator sets 45 ℃ of constant temperature and carried out drying 8 hours, obtain the Rhizoma Alismatis essence of 0.6kg dry powder state.
The embodiment of the present invention is intended to be convenient to understand innovation essence of the present invention; but do not limit the scope of the invention; all simple modification or equivalence are replaced, or utilize this finished product powder processing and fabricating capsule, pill, injection etc., all should be contained among the scope of the present invention.
Medical record is introduced: Rhizoma Alismatis of the present invention is extracted element through development for many years, and its pharmaceutical applications can be treated hyperlipidemia, and the input clinical trial is evident in efficacy.Certain city Mr. Lu, 60 years old, health check-up in 2011 learnt that its triacylglycerol does large 3.9mmol/L.Took this Rhizoma Alismatis and extract element (a day three times, each 1g) among 1 year, again learnt that triacylglycerol was down to 1.5mmol/L in 2012 after health check-up, the patient is extremely delighted.Patient's low density lipoprotein, LDL (LDL) descends simultaneously, and high density lipoprotein (HDL) raises, and this Rhizoma Alismatis essence can't harm, has no side effect liver, nephrocyte.
This shows, the technical scheme of Rhizoma Alismatis essence of the present invention and extraction process thereof, its outstanding effect is: this Chinese medicine essence can effectively reduce serum cholesterol, triglyceride, low density lipoprotein, LDL, high density lipoprotein increasing, that suppresses fat accumulates and is stained with the stickiness atherosclerosis, slows down the generation of tunica intima speckle and alleviates lesion degree, dwindles extent of disease.Extraction process step of the present invention is simple in addition, and it is convenient to implement, and extraction is higher, is suitable for scale in batches and produces.
Claims (2)
1. Rhizoma Alismatis essence is characterized in that: described Rhizoma Alismatis essence is for extracting from the dry powder state medicine of Rhizoma Alismatis and for reducing blood fat.
2. the extraction process of a Rhizoma Alismatis essence, its feature comprises operating procedure:
I, weighing Rhizoma Alismatis, carry out routine and clean in stainless steel tank, taking-up is dried standby;
II, standby Rhizoma Alismatis is pulverized, smashing fineness reaches 150 orders, then adds the water of 10 times of raw material of Chinese medicine gross masses to mix, and makes the powder slurry;
III, powder slurry is put into stainless-steel pan decoct after 40 minutes to filter and obtain filtrate;
IV, indoor at bacteria-and dust-free, filtrate is poured in the stainless-steel pan with agitating device and stirred, be cooled to below 20 ℃, the protease, 0.15%～0.4% cellulase and 0.15%～0.2% diastase that add again Rhizoma Alismatis weight 0.15%～0.3%, stir more than 2 hours under the condition of 30 beats/mins of rotating speeds, and with tablet vinegar acid for adjusting pH value 5.0, more than standing half a day;
V, standing liquid is put into centrifuge dehydration in aseptic temperature control workshop after, the precipitate that produces is put into 45 ℃ of electric heating aerator setting constant temperature carry out dry 6-8 hour, obtain the Rhizoma Alismatis essence of dry powder state, the weight of this Rhizoma Alismatis essence is the 5-7% of Rhizoma Alismatis raw material gross weight.
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| CN201310348692.4A CN103385990B (en) | 2013-08-13 | 2013-08-13 | Rhizoma alismatis essence and preparation method thereof |
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Citations (7)
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| CN101537086A (en) * | 2009-04-29 | 2009-09-23 | 香港科技大学 | Pharmaceutical composition for resisting hepatitis B virus, lowering lipid and alleviating fatty live lesions and preparation method thereof |
| CN102793891A (en) * | 2012-08-23 | 2012-11-28 | 浙江省中医药研究院 | Traditional Chinese medicine composition having functions of reducing blood fat and resisting hyperuricemia |
| CN103182009A (en) * | 2011-12-30 | 2013-07-03 | 天津药物研究院 | Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof |
| CN103372114A (en) * | 2012-04-20 | 2013-10-30 | 北京北大维信生物科技有限公司 | Red rice and rhizoma alismatis medicinal composition for regulating blood fat and preparation method of composition |
| CN103520401A (en) * | 2013-10-21 | 2014-01-22 | 华夏先葆(北京)中药研究院有限公司 | Chinese medicinal health preservation preparation with auxiliary blood lipid reduction effect |
| CN103638223A (en) * | 2013-12-16 | 2014-03-19 | 湖北麦克森生物技术有限公司 | Compound preparation capsule for reducing blood fat |
| CN103735754A (en) * | 2013-12-23 | 2014-04-23 | 王世俊 | Preparation method of lipid-lowering medicine |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537086A (en) * | 2009-04-29 | 2009-09-23 | 香港科技大学 | Pharmaceutical composition for resisting hepatitis B virus, lowering lipid and alleviating fatty live lesions and preparation method thereof |
| CN103182009A (en) * | 2011-12-30 | 2013-07-03 | 天津药物研究院 | Hypolipidemic traditional Chinese medicine composition and preparation method and application thereof |
| CN103372114A (en) * | 2012-04-20 | 2013-10-30 | 北京北大维信生物科技有限公司 | Red rice and rhizoma alismatis medicinal composition for regulating blood fat and preparation method of composition |
| CN102793891A (en) * | 2012-08-23 | 2012-11-28 | 浙江省中医药研究院 | Traditional Chinese medicine composition having functions of reducing blood fat and resisting hyperuricemia |
| CN103520401A (en) * | 2013-10-21 | 2014-01-22 | 华夏先葆(北京)中药研究院有限公司 | Chinese medicinal health preservation preparation with auxiliary blood lipid reduction effect |
| CN103638223A (en) * | 2013-12-16 | 2014-03-19 | 湖北麦克森生物技术有限公司 | Compound preparation capsule for reducing blood fat |
| CN103735754A (en) * | 2013-12-23 | 2014-04-23 | 王世俊 | Preparation method of lipid-lowering medicine |
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| 山东省药品监督管理局: "《山东省中药炮制规范2002年版》", 31 December 2002, article "泽泻", pages: 97 * |
| 禹建春,叶红梅,林西西: "泽泻的药理研究概况", 《海峡药学》, vol. 23, no. 2, 30 April 2011 (2011-04-30), pages 92 - 93 * |
| 邓迎娜: "泽泻降脂活性组分的制备及其制剂研究", 《中国优秀硕士学位论文全文数据库》, 2 April 2008 (2008-04-02) * |
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| 黄珍，刘咏松: "泽泻降血脂药理作用及物质基础研究进展", 《山西中医学院学报》, vol. 9, no. 5, 31 May 2008 (2008-05-31), pages 55 - 56 * |
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