CN113318139A - A Chinese medicinal composition used as both medicine and food for lowering blood sugar and reducing blood lipid - Google Patents
A Chinese medicinal composition used as both medicine and food for lowering blood sugar and reducing blood lipid Download PDFInfo
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- CN113318139A CN113318139A CN202110804717.1A CN202110804717A CN113318139A CN 113318139 A CN113318139 A CN 113318139A CN 202110804717 A CN202110804717 A CN 202110804717A CN 113318139 A CN113318139 A CN 113318139A
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention relates to a traditional Chinese medicine, in particular to a medicine and food dual-purpose traditional Chinese medicine composition for reducing blood sugar and blood fat. The feed is prepared from the following raw materials in parts by weight: 10-70 parts of chicory and 30-90 parts of poria cocos. The chicory is taken as a core component, and the screened classical medicinal material tuckahoe is compounded with the chicory to play a role in soothing the liver and benefiting the gallbladder, strengthening the spleen and stomach and tonifying the kidney, strengthening the spleen and stomach, eliminating dampness and discharging turbidity, and detoxifying and promoting diuresis. The formulation of the formula is based on the theory of 'liver and spleen related' traditional Chinese medicine, and the formula is reasonable, so that various metabolic diseases of glycolipid can be adjusted. The compound preparation can generate mutual synergistic action, the synergistic action can obviously reduce blood fat, blood sugar and the like, improve various metabolic diseases and integrally treat the multiple disease conditions of the old.
Description
Technical Field
The invention relates to a traditional Chinese medicine, in particular to a medicine and food dual-purpose traditional Chinese medicine composition for reducing blood sugar and blood fat.
Technical Field
The data of the national Bureau of statistics of China shows that by the end of 2019, the population of China aged 60 and above is about 2.54 hundred million, which accounts for 18.1% of the total population. The aging trend of the population structure in China is obvious, the physiological functions of all visceral organs of the aged are reduced along with the increase of the age, the incidence of cardiovascular diseases and diabetes is obviously increased, heavy burden is brought to patients and the society, and the development of sugar and lipid metabolic diseases needs to be slowed down by gathering the common force of the whole society. The elderly are low in immunity and prone to various chronic diseases such as hypertension, diabetes, coronary heart disease, gout, tumor and the like. Elderly patients are generally "co-morbid elderly": one person often has more than two diseases. Existing data display: the elderly have about 90% of one chronic disease, about 70% of two chronic diseases, about 50% of three chronic diseases, and half of the elderly over 65 years old have more than three chronic diseases, which are common to many diseases and have several pathological changes even in one organ. The disability rate and the fatality rate of the diseases are extremely high, for the elderly population with multiple diseases and multiple senile metabolic syndromes coexisting, the elderly population is often confronted with a complicated process of multiple registration and multiple medical visits, and the drug treatment of the elderly population also has the risk of generating combined side effects due to the mixture of the multiple diseases, so that the diseases are more looked and more looked more heavily. According to survey, about 25 percent of old people over 65 years old in China take 4-6 medicines simultaneously, and the problems caused by improper medicine use are more than those of people of other ages.
Therefore, it is necessary to develop non-drug intervention, develop a safe and effective nutritional health food which can simultaneously regulate various metabolic disorders such as sugar, fat and the like and is suitable for the elderly with integrated multi-disease characteristics; the integrated treatment meets the special requirements of the health of the old.
Chicory (Cichorium intybus L.) also known as endive, French endive, chicory, coffee, etc., is a perennial plant of the family Cichorium, native to Mediterranean, Central Asia and North Africa, and has been cultivated as early as in ancient Rome and Greece. Chicory is cultivated in europe for many years and has been used for many years as a replacement for leafy vegetables, pasture, sugar-making raw materials and coffee. China also has distribution in Xinjiang, Shandong, inner Mongolia and other places. Chicory is a commonly used medicinal material in Uygur and Mongolian nationalities, and the record of the national medicinal material standard Uygur medicine records that the chicory can be used as a medicine and has slightly bitter, salty and cool properties; collected in the Xinjiang Chinese herbal handbook, the Chinese herbal medicine composition is slightly bitter, salty and cool in nature, has the effects of clearing liver and promoting bile flow, invigorating stomach and promoting digestion, and inducing diuresis to reduce edema, and is used for treating diseases such as damp-heat jaundice, stomachache and anorexia, edema and oliguria and the like. Injection of chicory flowers into animals can excite the central nervous system and enhance cardiac activity; the decoction has antibacterial and astringent effects. The root can improve appetite and promote digestion, and the high concentration infusion can improve gastric secretion without enhancing smooth muscle tone. Seeds have non-specific phytohemagglutinin ". The research and report of the chicory medicinal use are also reported abroad. Research shows that the chicory extract is not only an important source of inulin, chicoric acid, fructose and the like, but also has complex components, and polysaccharides, terpenoids (especially sesquiterpenes), flavonoids, phenolic acid compounds, various vitamins, metal elements and other chemical components are separated from the chicory at present. But also has many physiological activities such as immunity enhancement, anti-inflammatory action, uric acid reduction, cholesterol and blood sugar reduction, etc.
Poria is dry sclerotium of Wolf of Polyporaceae fungus Poria Poriacos (Schw.); the Chinese medicinal material has the characteristics that the Chinese medicinal material is one of four traditional medicinal materials which are used as both medicine and food in clinic, the Chinese medicinal material has the theory of 'one hundred square nine-poria', the annual demand of dried poria cocos in China reaches more than 3 ten thousand tons, the dried poria cocos is a main raw material medicinal material of Chinese patent medicines, and the industrial output value of the poria cocos exceeds 100 hundred million yuan. The tuckahoe is mainly produced in Hubei, Anhui, Fujian, Yunnan, Hunan, Guizhou, Sichuan provinces and the like, has sweet and light taste, is neutral in nature and non-toxic, has the effects of promoting diuresis and excreting dampness, strengthening spleen and calming heart, is mainly used for treating edema and oliguria, phlegm and fluid retention and dizziness and palpitation, spleen deficiency and poor appetite, loose stool and diarrhea, uneasiness, palpitation and insomnia and the like, is compatible with proper medicaments, and can play the unique effect regardless of cold, warm, wind and dampness. Poria cocos is grown by pine roots, is called Fu Tu ancient times, and has the application of Poria cocos in the Chinese generation as early as more than 2000 years, and is listed as the ' top grade ' for reducing weight, tonifying qi and prolonging life ' in Shen nong Ben Cao Jing. For example, the traditional Chinese medicine composition can be used for treating adverse qi in chest and hypochondrium, palpitation caused by fright anger fright, palpitation, nodal pain under the heart, cold and heat, dysphoria, cough, dry mouth and tongue, and diuresis; recorded in Ben Cao gang mu, Fu Ling has a bland flavor and a weak nature to promote the circulation of body fluid, open the striae and nourish the water. The chemical components found in tuckahoe include polysaccharides, triterpenes, sterols, amino acids, fatty acids, etc. and the compounds with biological activity reported in tuckahoe are mainly concentrated in triterpenes and polysaccharides. At present, 84 triterpene components and more than 60 polysaccharide components are identified by coseparation. The chemical components of tuckahoe mainly play roles of tuckahoe polysaccharides and tuckahoe triterpenes, and the medicine effect is rich. Pachyman has effects of resisting tumor, protecting liver, promoting urination, reducing uric acid, resisting aging, resisting inflammation, reducing blood lipid, reducing blood glucose, enhancing immunity, and hypnotizing; the Poria triterpene has effects of resisting tumor, protecting liver, resisting aging, resisting inflammation, and enhancing immunity.
Disclosure of Invention
The invention aims to provide a medicine and food dual-purpose traditional Chinese medicine composition for reducing blood sugar and blood fat;
the invention is realized by the following technical scheme:
a medicine and food dual purpose Chinese medicinal composition for reducing blood sugar and blood fat is prepared from the following raw materials in parts by weight: 10-70 parts of chicory and 30-90 parts of poria cocos.
The health-care food is further prepared from the following raw materials in parts by weight: 25-55 parts of chicory and 45-75 parts of poria cocos. The health-care food is further prepared from the following raw materials in parts by weight: 34 parts of chicory and 66 parts of poria cocos.
Further, the preparation method of the traditional Chinese medicine composition comprises the following steps:
s1: adding 4-30 times of water into herba Cichorii and Poria, decocting, extracting under reflux at 100 deg.C for 5-8 hr, filtering the extractive solution with filter cloth plate frame to obtain mixed medicinal liquid;
s2: concentration: concentrating the obtained mixed liquid medicine to relative density of 1.0-1.3;
s3: preparing medicinal powder: spray drying the concentrated mixed medicinal liquid at atomizer frequency of 15Hz-20Hz and air exhaust temperature of 100 deg.C, pulverizing, and sieving to obtain the Chinese medicinal composition.
Further, the traditional Chinese medicine composition is added with pharmaceutically or physiologically acceptable auxiliary materials, wherein the auxiliary materials are one or more of a filling agent, a flavoring agent, a lubricating agent and a disintegrating agent.
Further, the traditional Chinese medicine composition is prepared into granules, powder, capsules, tablets, pills and liquid formulations.
The invention has the advantages that:
the inventor successively observes the pharmacological action of the chicory extract on various metabolic interaction disorders and the like and carries out mechanism research. Research proves that the chicory extract can obviously reduce the serum TG, UA and Glu levels of rats with interaction disorder such as hypertriglyceridemia, hyperuricemia, hyperglycemia and the like, and the action mechanism of the chicory extract is related to the inhibition of FAS and XO activity and the increase of Ins content.
The formula has the characteristics that: the chicory is taken as a core component, and the screened classic medicinal material tuckahoe is compounded with the chicory to play a role in soothing the liver and benefiting the gallbladder, strengthening the spleen and stomach and tonifying the kidney, strengthening the spleen and stomach, eliminating dampness and discharging turbidity, and detoxifying and promoting diuresis. The formulation of the formula is based on the theory of 'liver and spleen related' traditional Chinese medicine, and the formula is reasonable, so that various metabolic diseases of glycolipid can be adjusted. The compound preparation can generate mutual synergistic action, the synergistic action can obviously reduce blood fat, blood sugar and the like, improve various metabolic diseases and integrally treat the multiple disease conditions of the old.
The formula of chicory and poria cocos with mild drug properties is screened based on the integrated treatment strategy of the traditional Chinese medicine, both the chicory and the poria cocos can invigorate the spleen and eliminate dampness, and the chicory also has the effects of soothing the liver and benefiting the gallbladder, clearing away heat and toxic materials and freeing the joints, and is a medicine composition for treating both symptoms and root causes under the integrated treatment strategy of Zhang Ice professor. The two medicines integrally regulate metabolic disorder through the functions of soothing liver, benefiting gallbladder, strengthening spleen and stomach, promote the elimination of metabolic wastes in vivo by promoting diuresis and discharging turbidity, can detoxify, promote diuresis and enhance immunity, and have ingenious medicine selection and unique originality.
Chicory is slightly bitter, salty and cool. It enters liver, gallbladder and stomach meridians. The Chinese pharmacopoeia (2020 edition) carries the functions of clearing liver and promoting bile flow, invigorating stomach and promoting digestion, and inducing diuresis and reducing edema. Can be used for treating stomach ache, anorexia, edema and oliguria. It can assist Poria to strengthen the spleen and stomach, promote diuresis and remove dampness, and can be used as monarch drug. Poria cocos, sweet, bland and neutral. It enters heart, spleen and kidney meridians. Shen nong Ben Cao Jing (Shen nong's herbal classic) means that: 'diuresis promoting'. Long-term administration of the product can relieve soul, nourish mind, prevent hunger, and prolong life. "Shibuzhai medical book" Yun: "Fu Ling is a Chinese herb, which is used as the main herb for treating phlegm, but also water can move water. The phlegm moving and dampness moving, but the tuckahoe also moves and dampness moves. The actions of benefiting water and eliminating dampness, invigorating spleen and calming heart are provided. The spleen is the acquired root. Poria cocos, is a ministerial drug for its use, because it has the effects of invigorating the spleen and stomach, and excreting damp-turbidity.
Both herbs can tonify spleen and dispel dampness, and can guide water to flow downward and activate bladder, but Poria is neutral in property in tonifying spleen and eliminating dampness; cichorium intybus is cold in nature and good at purging heat from kidney and bladder to remove damp-heat in lower energizer. The two herbs have the actions of inducing diuresis and excreting dampness, and can surpass heat, so they are indicated for the treatment of edema, dysuria and diarrhea due to retention of water-dampness in lower energizer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described below clearly and completely, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
"glycolipid metabolic disease" refers to a disease characterized by disorder of metabolism of sugar and lipid, and clinically characterized by single or combined occurrence of diseases such as obesity, hyperglycemia, hyperlipidemia, fatty liver and atherosclerosis. Clinically, for various metabolic disorders, two or more drugs are often administered simultaneously to reduce the levels of Triglyceride (TG) and blood glucose (Glu), which are not economical and may cause many unexpected side effects.
Traditional Chinese medicine has no disease name of 'glycolipid metabolic disease', mostly belongs to the categories of 'diabetes', 'phlegm turbidity' and 'blood stasis', and is a group of syndromes caused by dysfunction of viscera and loss of body fluid in transportation and transformation. Modern researchers believe that blood sugar, blood fat and nutrient, blood and body fluids are quite similar and are the essence and micro substances generated by food essence. The basic pathogenesis of glycolipid metabolic diseases is that qi and blood circulation is not smooth and the distribution of food essence is abnormal under pathological conditions, so that phlegm turbidity and blood stasis are generated to block viscera and meridians. Modern people like to eat fat, sweet and thick taste, and improper diet is the initiating factor of the onset of glycolipid metabolic diseases. For instance, the theory of Su Wen and Tong appraise of deficiency and excess states, it is said that the disease of sorghum is also found in the case of the fat and the honour. The literature of Su Wen & Qi Bing Lun (treatise on Su Wen & Qi disease) says that the qi of people with fertilizer is overflowed and becomes diabetes because people with fertilizer are full of heat and sweet taste. Li Gao also mentions in the treatise on the spleen and stomach: "five flavors do not impair the normal condition when they are too much, but rather they are like to eat. Overeating the food with fat, sweet and thick flavor can damage the spleen and stomach, resulting in dysfunction of food essence in transportation and transformation, failure of food essence to distribute, and failure of liver-qi to nourish the liver-qi can lead to deficiency of liver-qi or dysfunction of liver-qi, which can further aggravate dysfunction of spleen in transportation and transformation. Therefore, liver dysfunction in smoothing flow of qi and spleen dysfunction in transportation and transportation are the key pathogenesis of the disease. Therefore, under the guidance of the theory of 'liver and spleen correlation' in the traditional Chinese medicine, the prevention and treatment effect of the liver-soothing and spleen-strengthening method on the glycolipid metabolic diseases is deeply discussed, and the new idea of preventing and treating the glycolipid metabolic diseases by combining the traditional Chinese medicine and the western medicine is developed.
Example 1:
a medicine and food dual-purpose traditional Chinese medicine composition for reducing blood sugar and blood fat is prepared from the following raw materials in parts by weight: 35 parts of chicory and 65 parts of tuckahoe, and each part is 5 kg.
Example 2:
a medicine and food dual-purpose traditional Chinese medicine composition for reducing blood sugar and blood fat is prepared from the following raw materials in parts by weight: 30 parts of chicory and 70 parts of tuckahoe, each 5 kg.
Example 3:
a medicine and food dual-purpose traditional Chinese medicine composition for reducing blood sugar and blood fat is prepared from the following raw materials in parts by weight: 40 parts of chicory and 60 parts of tuckahoe, each 5 kg.
Example 4: preparation method
(one) extraction
Weighing chicory and poria cocos according to the proportion of each embodiment, putting into a tank, adding 10 times of water, boiling, extracting under reflux at 100 ℃ for 5 hours, filtering the extracting solution by using a filter cloth plate frame until no black residue exists, and concentrating to the relative density of 1.05.
(II) spray drying
Starting a centrifugal fan, and checking the running condition of fan equipment: including whether there is vibration, abnormal sound, peculiar smell etc. of high-speed centrifugal spray drier, whether the temperature of motor and bearing is normal, whether the rag screw is not hard up.
The electric heater is started (steam heating is started firstly), the electric heater is started (the electric heater plays a role in auxiliary heating), and whether electricity is leaked or not is checked (if the electricity is leaked, the control cabinet automatically jumps). Preheating the cylinder body at the temperature of between 150 ℃ and 250 ℃.
The air inlet temperature of the fan is opened and controlled to be 150-250 ℃.
Placing a centrifugal spray head, starting the centrifugal spray head, slowly adjusting the frequency of the atomizer to a certain frequency (determining 15HZ-20HZ according to actual conditions), starting a feeding pump when the spray head reaches the highest rotating speed under the frequency condition, and opening an outlet valve of the feeding pump. Meanwhile, the pollinators at the bottom of the cylinder body and the bottom of the cyclone separator are opened to receive materials. When the centrifugal sprayer is continuously produced, the material does not need to be cleaned in each batch, the corrosivity of the material is determined, the centrifugal sprayer does not need to be disassembled when being cleaned, and clean water is pumped by a screw pump for cleaning.
The valve of the centrifugal nozzle is slowly opened to ensure that the blanking amount is increased from small to large, otherwise, the wall sticking phenomenon is generated until the proper requirement is adjusted to keep the air exhaust temperature at a constant of 80-100 ℃.
The dried finished product is collected, in the pollinator at the lower part of the tower body and the lower part of the cyclone separator, the pollinator is required to be exchanged before being full, and when the pollinator is exchanged, the butterfly valve at the upper part must be firstly switched.
After use, the product should be washed by spraying water.
During assembly and disassembly, the main shaft cannot be bent, a plug sheet is used for controlling the gap between the disc and the shell when the spraying disc is assembled, and a nut for fixing the spraying disc must be screwed to prevent loosening and falling
(firstly, turning off steam heating and electric heating for cooling, and turning off a feeding pump (screw pump) for cooling at the same time) when the temperature of an inlet is reduced to 80-100 ℃, the atomizer can be turned off when the temperature is below 80-100 ℃, and the circulating fan can be turned off when the temperature is below 50-80 ℃.
And after spraying, switching the raw material liquid to the solvent, adjusting the frequency of the atomizer to 40-70HZ, spraying for about 8-20 minutes, slowly reducing the rotation speed of the atomizer to about 10-30HZ, and turning off the power supply of the centrifugal nozzle.
And keeping the centrifugal fan running, reducing the temperature in the cyclone spray drying tower to 30-60 ℃, and then closing the power supply of the fan.
And (4) cleaning the centrifugal spray dryer by using a screw pump to pump clean water.
The collected paste powder is sealed in double bags to avoid moisture absorption.
The fluidity of the paste powder is checked, and if the paste powder is too fine, the spraying frequency can be increased.
The collected paste powder should be dissolved in water to check if there is any black spot foreign matter. After confirmation, the mass production is started.
(III) Total mixing
Pulverizing the paste powder, sieving with 60-100 mesh sieve, adding filler, and sieving.
Adding lubricant into the materials, and mixing for 45 minutes,
the double bags are sealed to avoid moisture absorption.
(IV) Dry granulation
The equipment is determined to be clean before dry process, the granules with 14-40 meshes are 100%, and the powder with less than 40 meshes is re-granulated by dry process. Care was taken to reduce losses to ensure yield.
Adding appropriate adjuvants into the above powder or granule, and making into granule, powder, capsule, tablet, pill, liquid, etc., and packaging.
Example 5: the addition amount of water in example 4 was adjusted to 20 times, extraction was performed at 100 ℃ for 8 hours, the mixed liquid medicine was concentrated to a relative density of 1.07, and then spray-dried, pulverized, and granulated to obtain a product.
Example 6: the addition amount of water in the example 4 is adjusted to 5 times, the extraction is carried out for 6 hours at 100 ℃, the mixed liquid medicine is concentrated to the relative density of 1.1, and then the product is obtained by spray drying, crushing and granulating.
Case 1: old, female, age 75, with fasting blood glucose checked half a year ago: 7.01mmol/L, total cholesterol 5.16mmol/L, diagnosed as "T2 DM", the patient denied family history of hypertension, diabetes. The life style intervention is carried out, and 1 dose of chicory and tuckahoe soup (12 g of chicory and 22g of tuckahoe) is orally taken every day by decocting with water, is taken 2 times in the morning and at night, and is not treated by other medicines. Low fat low sugar diet was ordered. After 3 months, the fasting blood is 5.67mmol/L, and the total cholesterol is 4.44 mmol/L. Order to adhere to a low-fat, low-sugar diet. The blood fat and blood sugar level is rechecked at regular intervals. The blood sugar and blood fat levels are stable after 3 months of follow-up visit.
Case 2: in Liji, male, 48 years old, total cholesterol was checked to be 7.19mmol/L, low density lipoprotein was checked to be 4.84, and fasting blood glucose was checked to be 4.93mmol/L in 12 months of 2020. Diagnosing mixed hyperlipidemia. The life style intervention is carried out, and 1 dose of chicory and poria cocos decoction (10 g of chicory and 20g of poria cocos) is orally taken every day by decocting with water, is taken 2 times in the morning and at night, and is not treated by other medicines. Low fat low sugar diet was ordered. After 3 months, the total cholesterol is 3.5mmol/L, the low density lipoprotein is 1.58, and the fasting blood glucose is 4.51 mmol/L. Order to adhere to a low-fat, low-sugar diet. The blood fat and blood sugar level is rechecked at regular intervals. The blood sugar and blood fat levels are stable after 3 months of follow-up visit.
The above examples are only examples to express the specific embodiments of the present invention, and the description thereof is more specific, but not to be construed as limiting the scope of the application of the present invention; it should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (6)
1. A medicine and food dual purpose Chinese medicinal composition for reducing blood sugar and blood fat is characterized in that: the feed is prepared from the following raw materials in parts by weight: 10-70 parts of chicory and 30-90 parts of poria cocos.
2. The dual-purpose Chinese medicinal composition as food and medicine for reducing blood sugar and blood fat according to claim 1, which is characterized in that: the feed is prepared from the following raw materials in parts by weight: 25-55 parts of chicory and 45-75 parts of poria cocos.
3. The dual-purpose Chinese medicinal composition as food and medicine for reducing blood sugar and blood fat according to claim 1, which is characterized in that: the feed is prepared from the following raw materials in parts by weight: 34 parts of chicory and 66 parts of poria cocos.
4. The dual-purpose Chinese medicinal composition as food and medicine for reducing blood sugar and blood fat according to any one of claims 1 to 3, which is characterized in that: the preparation method of the traditional Chinese medicine composition comprises the following steps:
s1: adding 4-30 times of water into herba Cichorii and Poria, decocting, extracting under reflux at 100 deg.C for 5-8 hr, filtering the extractive solution with filter cloth plate frame to obtain mixed medicinal liquid;
s2: concentration: concentrating the obtained mixed liquid medicine to relative density of 1.0-1.3;
s3: preparing medicinal powder: spray drying the concentrated mixed medicinal liquid with atomizer frequency of 15Hz-20Hz and air exhaust temperature of 80-100 deg.C, pulverizing, and sieving with 60-100 mesh sieve to obtain the final product.
5. The dual-purpose Chinese medicinal composition as food and medicine for reducing blood sugar and blood fat according to any one of claims 1 to 3, which is characterized in that: the traditional Chinese medicine composition is added with pharmaceutically or physiologically acceptable auxiliary materials, wherein the auxiliary materials are one or more of fillers, flavoring agents, lubricants, disintegrating agents and the like.
6. The dual-purpose Chinese medicinal composition as food and medicine for reducing blood sugar and blood fat according to claim 5, wherein the Chinese medicinal composition is prepared into granules, powder, capsules, tablets, pills and liquid.
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