CN113350402A - Medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete urination syndrome - Google Patents
Medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete urination syndrome Download PDFInfo
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- CN113350402A CN113350402A CN202110804913.9A CN202110804913A CN113350402A CN 113350402 A CN113350402 A CN 113350402A CN 202110804913 A CN202110804913 A CN 202110804913A CN 113350402 A CN113350402 A CN 113350402A
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- liver
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- micturition
- syndrome
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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Abstract
The invention relates to the field of foods, health-care foods and traditional Chinese medicines, in particular to a medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and inexhaustible syndrome. The feed is prepared from the following raw materials in parts by weight: 20-70 parts of chicory and 30-80 parts of raspberry. The chicory and the raspberry are combined to regulate cold and warm, tonify liver and kidney, warm and nourish kidney yang, ensure that the kidney is normally opened and closed and the liver is cleared, and each herb can obtain good effect and cure diseases after the herbs are used. Chicory soothing the liver and benefiting gallbladder, clearing away heat and toxic materials, and inducing diuresis to alleviate edema; can be used for treating jaundice due to damp-heat pathogen, stomach ache, anorexia, edema, and oliguria. Fructus Rubi has effects of invigorating kidney, stopping nocturnal emission, nourishing liver, improving eyesight, and strengthening yin and yang. Has the effects of soothing liver and regulating stomach, tonifying kidney and warming yang, and securing essence and reducing urination, and has obvious curative effect.
Description
Technical Field
The invention relates to the field of foods, health-care foods and traditional Chinese medicines, in particular to a medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and inexhaustible syndrome.
Technical background:
since 2009, the international urinary control society (ICS) defined the last week of 6 months per year as "world week urinary incontinence (WCW)". Urgency of urination/frequency of urination (OAB) is abbreviated as Overactive blader, and is abbreviated as Overactive bladder. The international urinary control society (ICS) defines OAB as a syndrome characterized by urgency, often accompanied by symptoms of frequency and nocturia, with or without urge incontinence, and the absence of urinary tract infections or other well-defined pathological changes.
In China, the incidence of OAB is high, but the diagnosis rate is low. According to data published in 2011, the total prevalence rate of OAB in China is 6.0%, and the prevalence rate of OAB is obviously increased along with the increase of age, wherein the prevalence rate of OAB in a population over 40 years old is 11.3%, namely more than 1 person in every 10 persons suffers from OAB, and the prevalence rates of OAB in males and females in the same age period are equivalent. In sharp contrast, however, 85% of all OAB patients have not been screened and hospitalized. This also reflects that OAB in China is still a disease that is overlooked by patients.
According to the related survey, the following results are shown: eighty-half of OAB patients have not been hospitalized. In 2011, the LuTS China research project was initiated by three professional institutions of the Chinese medical society urology and surgery (CUA), the Chinese medical society urology and surgery control group (CUCS) and the Chinese urinary bladder overactivity diagnosis and treatment promotion Alliance (OAB-Free Alliance), and the investigation results of the stages I-IV show that: in men or women, over 70% of patients with LUTS present with moderate to severe OAB symptoms when hospitalized. Most patients believe that the symptoms of urgency, frequency, nocturia, urge incontinence, etc. are the older, naturally occurring symptoms.
OAB disease is a serious and non-negligible hazard to patients and their family lives. Data show that the domestic OAB prevalence rate is high, the life quality of patients and family is seriously affected, and the patients can miss the family important time due to OAB symptoms such as urgent micturition, frequent micturition and the like.
For example:
(1) fear of not entering the toilet in time and reduce participation in outing activities
(2) Frequent toilet visits affect activities involving family members, or miss important moments
(3) The frequent toilet use reduces the time for the family to meet, and influences the relationship and emotion of the family and the sexual life of the partner.
(4) When the quantity of nocturia is too much, the sleep quality of the user and a partner is seriously influenced, and even insomnia is caused; the nocturia obviously increases the risk of the occurrence of common chronic diseases such as hypertension and the like and death
(5) Increase the economic burden of the family
A meta-analysis study performed on the family of OAB patients showed that 48% of the family of OAB patients experienced anxiety, worry, embarrassment, and depression due to the patient's OAB symptoms. In addition, according to the family reports of OAB patients, family activities are often affected by OAB symptoms of the patients and cannot enjoy normal lives.
The OAB not only has great influence on the family life of the patient, but also has no negligence on the harm brought by the OAB to the patient. Frequent, urgent, incomplete, nocturnal urination are symptoms that afflict OAB patients, with the greatest effect on the patients 'psychological mood, with 66% of the patients experiencing depression and photophobia and losing confidence, and secondarily on the patients' travel/social activities. The OAB patient frequently goes to the toilet and interferes with normal work, intentionally avoids participating in various social activities in fear of not being able to go to the toilet in time, and wears dark or loose clothes as much as possible so as to hide a used urine pad or cover the occurrence of urinary incontinence and the like, which brings inconvenience to normal work and life, and more importantly, is often misunderstood by others.
For the urethral syndrome, modern Chinese medicine doctors generally consider the deficiency of the origin and the excess of the origin, and the deficiency refers to the deficiency of kidney qi and the deficiency of both spleen and kidney for a long time, so the deficiency of spleen and kidney yang is the main reason. Excess is mainly caused by damp-heat, blood stasis, qi stagnation, etc. Lemna minor recognizes urethral syndrome as having several features: "liver depression and damp-heat are the initiating factors of urethral syndrome; the stagnation of the meridians is an important pathological link in the development of pathological changes; kidney deficiency is the stubborn cause of urethral syndrome; spleen deficiency is the intrinsic basis for the occurrence and development of the disease; the clinical symptoms, tongue coating and pulse conditions of 265 female urethral syndrome patients are observed by Zhang Asia university and other systems, and are divided into 4 symptoms of liver qi stagnation, dampness accumulation in lower energizer, kidney yin deficiency, kidney deficiency and blood stasis, so that the kidney deficiency and blood stasis are more and more, and nearly half of the symptoms are based on the blood stasis on the basis of the kidney deficiency, and the kidney deficiency is considered as the main pathogenesis of the frequent micturition syndrome, the blood stasis is the index, and the damp-heat and liver depression are respectively one of the inducement and the accompanying symptoms of the frequent micturition syndrome. The research also shows that the syndrome of dampness storing lower energizer is mostly related to chronic urinary tract infection; after 225 patients are treated by Zhenghui field and other researches, the' kidney deficiency is considered as the main pathogenesis of the disease, the long-term treatment and the wrong treatment are carried out, the middle-jiao energy is damaged, the deficiency and excess mixed syndrome of spleen and stomach qi deficiency and yin fire internal excess is easy to occur, and the liver and kidney deficiency and the liver depression and qi stagnation are easy to occur when bitter cold clearing and diuresis drugs are used. Deficiency of liver and kidney is usually due to consumption of body fluids and deficiency of yin;
chicory (Cichorium intybus L.) also known as endive, French endive, chicory, coffee, etc., is a perennial plant of the family Cichorium, native to Mediterranean, Central Asia and North Africa, and has been cultivated as early as in ancient Rome and Greece. Chicory is cultivated in europe for many years and has been used for many years as a replacement for leafy vegetables, pasture, sugar-making raw materials and coffee. China also has distribution in Xinjiang, Shandong, inner Mongolia and other places. Chicory is a commonly used medicinal material in Uygur and Mongolian nationalities, and the record of the national medicinal material standard Uygur medicine records that the chicory can be used as a medicine and has slightly bitter, salty and cool properties; collected in the Xinjiang Chinese herbal handbook, the Chinese herbal medicine composition is slightly bitter, salty and cool in nature, has the effects of clearing liver and promoting bile flow, invigorating stomach and promoting digestion, and inducing diuresis to reduce edema, and is used for treating diseases such as damp-heat jaundice, stomachache and anorexia, edema and oliguria and the like. Injection of chicory flowers into animals can excite the central nervous system and enhance cardiac activity; the decoction has antibacterial and astringent effects. The root can improve appetite and promote digestion, and the high concentration infusion can improve gastric secretion without enhancing smooth muscle tone. Seeds have non-specific phytohemagglutinin ". The research and report of the chicory medicinal use are also reported abroad. Research shows that the chicory extract is not only an important source of inulin, chicoric acid, fructose and the like, but also has complex components, and polysaccharides, terpenoids (especially sesquiterpenes), flavonoids, phenolic acid compounds, various vitamins, metal elements and other chemical components are separated from the chicory at present. But also has many physiological activities such as enhancing immunity, anti-inflammatory action, diuresis, lowering cholesterol and blood sugar, etc.
Raspberry is warm in nature, sweet in taste and sour. It enters kidney and bladder meridians. Originally recorded in the book Ben Cao Jing Ji Zhu, it is both medicinal and edible, and was listed in the List of articles issued by the original Ministry of health, which are both food and medicine in 2002. The raspberry has wide pharmacological action and extremely high edible and medicinal values, and is a name of the third generation golden fruit. The raspberry is used as a traditional Chinese medicine for tonifying kidney and strengthening yang, and has the effects of tonifying kidney, securing essence, reducing urination, nourishing liver and improving eyesight. The Chinese pharmacopoeia has the main functions: to tonify kidney, secure essence, reduce urination, nourish liver and improve vision. Can be used for treating spermatorrhea, enuresis, frequent micturition, sexual impotence, premature ejaculation, and dim eyesight. Flavones, anthocyanins, ellagic acid, salicylic acid, vitamins, saccharides, and terpenes are the main active ingredients in Rubi fructus fruit; the raspberry leaves are rich in flavonoids, tea polyphenols, various amino acids, proteins, vitamins and minerals, and have the function of improving immunity; the main chemical components of the raspberry stems are polyphenols and flavonoids, which are main active components with the effects of resisting oxidation and protecting liver.
Disclosure of Invention
The invention aims to provide a medicinal and edible traditional Chinese medicine composition and a preparation for improving urgent micturition, frequent micturition and inexhaustible urine syndrome;
the invention is realized by the following technical scheme:
a medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete urination syndrome is prepared from the following raw materials in parts by weight: 20-70 parts of chicory and 30-80 parts of raspberry.
Further, the feed additive is prepared from the following raw materials in parts by weight: 30-60 parts of chicory and 40-70 parts of raspberry.
Further, the feed additive is prepared from the following raw materials in parts by weight: 44 parts of chicory and 56 parts of raspberry.
Further, the preparation method of the traditional Chinese medicine composition comprises the following steps:
s1: adding 5-30 times of water into herba Cichorii and Rubi fructus, decocting, extracting under reflux at 80-100 deg.C for 5-7 hr, filtering the extractive solution with filter cloth plate frame to obtain mixed medicinal liquid;
s2: concentration: concentrating the obtained mixed liquid medicine to relative density of 0.95-1.3;
s3: preparing medicinal powder: spray drying the concentrated mixed medicinal liquid with atomizer frequency of 15Hz-20Hz and air exhaust temperature of 80-100 deg.C, pulverizing, and sieving with 60-100 mesh sieve to obtain the final product.
Further, the traditional Chinese medicine composition is added with pharmaceutically or physiologically acceptable auxiliary materials, wherein the auxiliary materials are one or more of a filling agent, a flavoring agent, a lubricating agent and a disintegrating agent.
Further, the traditional Chinese medicine composition is prepared into granules, powder, capsules, tablets, pills and liquid formulations.
The invention has the advantages that:
the invention adopts a formula of chicory and raspberry:
the chicory and the raspberry are combined to regulate cold and warm, tonify liver and kidney, warm and nourish kidney yang, ensure that the kidney is normally opened and closed and the liver is cleared, and each herb can obtain good effect and cure diseases after the herbs are used. Chicory soothing the liver and benefiting gallbladder, clearing away heat and toxic materials, and inducing diuresis to alleviate edema; can be used for treating jaundice due to damp-heat pathogen, stomach ache, anorexia, edema, and oliguria. Fructus Rubi has effects of invigorating kidney, stopping nocturnal emission, nourishing liver, improving eyesight, and strengthening yin and yang. Has the effects of soothing liver and regulating stomach, tonifying kidney and warming yang, and securing essence and reducing urination, and has obvious curative effect. The two herbs are combined to make kidney qi full, so that the kidney transforms turbid liquid into clear liquid and turbid liquid again through the qi transformation of its steaming vine, and the turbid liquid is transformed into urine and excreted. The liver regulates qi smoothly, qi circulates water, promoting the distribution of body fluids, and promoting urination. The two herbs have no incompatibility, and are mild in nature. Strengthen the body resistance and consolidate the constitution, remove dampness and eliminate pathogenic factors, take the root and symptoms into consideration and bring out the best in each other. Can be popularized and applied to the diseases caused by kidney-yang deficiency, such as frequent micturition, dysuria, urinary retention, urinary incontinence, enuresis and the like. The health product is prepared by taking chicory and raspberry as main components and extracting effective components by using modern biotechnology, and generates mutual synergistic effect, and the synergistic effect can obviously improve the effects of urgent micturition, frequent micturition and inexhaustible syndrome.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described below clearly and completely, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Normal people urinate 4-6 times in the daytime on average, urinate 0-2 times at night, the urine volume is 200-400 ml every time, and the total urine volume is 1000-2000 ml every day. The frequent micturition refers to the case that the number of urination in day and night exceeds the normal range but the total amount of urination is within the normal range;
frequent micturition, urgent micturition and incomplete micturition at night are common clinical symptoms of the elderly patients and can be caused by various diseases such as prostatic hyperplasia, bladder hypofunction, diabetes, cerebrovascular diseases, neurogenic bladder and the like. The life quality of patients is seriously influenced, the western medicine treatment only has certain curative effect on the patients with prostatic hyperplasia, and has no specific medicine for other reasons and the old patients who frequently urinate, urgently urinate and inexhaustible and frequently urinate at night. For frequent urination, western medicine mainly treats the urinary tract infection with antibiotics, and treats diabetes mellitus with blood sugar control. While western medicine does have some effect on the treatment of acute non-neurological frequency, it does not have a good treatment for chronic non-neurological frequency as well as neurological frequency. Frequent micturition is mainly caused by insecurity of the kidney deficiency, spleen deficiency, weakness in ascending and descending, excessive dispersion and descending of lung qi, stagnation of qi due to depression of the liver, and downward flow of damp-heat.
Kidneys govern water and govern opening and closing to regulate and treat frequent urination, and from kidney governing water and governing opening and closing to regulate and treat frequent urination, it is called "kidneys govern water and viscera and govern body fluids" from Su Wen & inverse regulation theory, which means that kidneys have the functions of governing water metabolism of the whole body and maintaining water balance in the body. The water metabolism of the human body includes two aspects, namely, the body fluid from the food essence with the functions of nourishing and moistening the viscera and tissues is distributed to the whole body; secondly, the turbid liquid after metabolism of the viscera and tissues is discharged out of the body. The water metabolism depends on the function of the kidney to transform qi. The kidney governs opening and closing. When the water is boiled, the water liquid can be discharged; when the body is closed, the water needed by the body can be retained in the body. If the kidney is normally gasified and the opening and closing are proper, the urine excretion is normal. If the kidney governs water, the opening and closing degree will cause disorder of water metabolism. If the patient is closed or opened, scanty urine and edema can be seen; more opening and less closing will result in more urine and frequent urination.
The liver governs smoothing flow of qi and regulating and treating frequent urination, so Su Wen & Ling lan Mi Dian Lun says that the liver is the most important official of the army. The function of the liver in smoothing flow of qi directly affects the smooth regulation of qi activity, and has the functions of smoothing triple energizer and regulating water passage. The distribution and metabolism of body fluids depends on the ascending, descending, exiting and entering of qi, and the stagnation of qi can also lead to the disturbance of the distribution and metabolism of body fluids. In the chapter of Huangdi's Collection of essential questions, the liver governs smoothing flow of water, i.e., frequent urination due to urine retention, difficulty in transforming the liver qi into jueyin, and abnormal urination due to liver qi's smoothing flow of urine, and abnormal flow of liver qi's reversal or ' failure ' of liver qi, there are clouds. For example, many patients have frequent micturition due to stagnation of liver qi due to their personality, stagnation of heat transforming into fire and passing through the kidney, renal occlusion and failure of storage, and bladder failure. Modern famous doctors have thought that the liver meridian of foot jueyin is around the yin apparatus, and the lower Yuan disease is mostly concerned with liver haze. Liver yin is responsible for yang, blood is the primary source, qi is the secondary source, storing blood is used to nourish the body, and qi is used to dredge qi. If liver fails to dredge and defecate, qi stagnation occurs at the beginning and blood stasis occurs for a long time, qi and blood in liver vessel of foot jueyin are lost and qi and blood are not nourished before yin, so that the urinary bladder fails to be contracted and enuresis is not stopped
Therefore, the treatment of urgent micturition, frequent micturition and incomplete urination is mostly selected from the methods of tonifying viscera, regulating qi movement, clearing heat and promoting diuresis, which are good at treating the disease from the lung, spleen and kidney, regulating qi movement, and the spleen and stomach are the acquired root and the source of qi generation; kidneys are the innate root and the root of qi; the lung governs qi, and the three zang organs coordinate in function, so qi of the human body is abundant, and liver qi is smooth, so qi transports water. Among them, kidney-tonifying is the key and liver-soothing is the auxiliary.
Chicory is cool in nature, slightly bitter and salty in flavor, and enters liver, gallbladder and stomach meridians. Has the effects of clearing liver-fire, promoting bile flow, clearing away heat and toxic materials, inducing diuresis, relieving swelling, invigorating stomach, etc. Xinjiang Chinese herbal medicine: clearing heat, promoting urination, promoting bile flow and diminishing inflammation. Can be used for treating icterohepatitis, acute nephritis, and tracheitis. "(Chinese national medical records): clearing away heat and toxic material, inducing diuresis to alleviate edema, and invigorating stomach. Can be used for treating anorexia due to liver fire, nephritis, edema, gastral cavity damp-heat, distending pain, and anorexia. Rohuishan et al dried and pulverized chicory root planted in Changbai mountain area, extracted with water, and made into injection, and observed the change of blood pressure and urine volume of rabbits before and after administration. The result shows that the chicory root water extract has obvious blood pressure reducing effect and diuretic effect, and the blood pressure reducing effect and the diuretic effect are enhanced along with the increase of the dosage.
Rubus coreanus Miq is sweet and sour, and is slightly warm. Enter liver and kidney meridians. It can secure essence and reduce urination, so it is named after tonifying kidney and reducing urination when applied as a drowning device. Rubi fructus has effects of nourishing yin of five internal organs and replenishing vital essence. It is good for kidney-yin conservation because it has the action of directing qi downward. It is recorded in Ben Cao gang mu that raspberry has the functions of tonifying kidney, reducing urination, benefiting essence, strengthening yin, invigorating yang, nourishing liver and improving eyesight, and can be used for tonifying male essence and female children. When the Ming Dynasty physician's Li Zhongcata evaluates Rubi fructus, it is said to be "kidney-strengthening without dryness-heat bias, essence-securing without congealing and astringent. Jin Yu Zhi also. Namely, the raspberry is mild in property, can strengthen the kidney and does not bring dryness-heat; can secure essence and avoid stagnation due to violent potency of the drug. Therefore, raspberry is highly appreciated by ancient physicians in the aspects of tonifying kidney and reducing urination. The materia Medica is in the future: tonifying kidney to secure essence, tonifying liver deficiency to improve vision, treating impotence, and reducing defecation. The book of materia Medica: "covering basin" is a medicine for nourishing true yin, has slightly sour flavor, and can collect and absorb the dissipated yin qi to produce body fluid, so kouzhong 22893 is called tonifying kidney and reducing urination, and it is reasonable to cover the drowning device when taken.
Example 1:
the medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete urination syndrome is prepared from the following raw materials in parts by weight: 45 parts of chicory and 55 parts of raspberry. 5kg each.
Example 2:
the medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete urination syndrome is prepared from the following raw materials in parts by weight: 40 parts of chicory and 60 parts of raspberry. 5kg each.
Example 3:
the medicinal and edible traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete urination syndrome is prepared from the following raw materials in parts by weight: 35 parts of chicory and 65 parts of raspberry. 5kg each.
Example 4:
preparation method
(one) extraction
Weighing chicory and raspberry according to the proportion of each embodiment, putting the chicory and the raspberry into an extraction tank, adding 10 times of water by weight, boiling, extracting under reflux at 100 ℃ for 6 hours, filtering the extracting solution by a filter cloth plate frame until no black residue exists, and concentrating to the relative density of 1.06.
(II) spray drying
Starting a centrifugal fan, and checking the running condition of fan equipment: including whether there is vibration, abnormal sound, peculiar smell etc. of high-speed centrifugal spray drier, whether the temperature of motor and bearing is normal, whether the rag screw is not hard up.
The electric heater is started (steam heating is started firstly), the electric heater is started (the electric heater plays a role in auxiliary heating), and whether electricity is leaked or not is checked (if the electricity is leaked, the control cabinet automatically jumps). Preheating the cylinder body, wherein the preheating temperature is between 160 ℃ and 240 ℃.
The inlet air temperature of the fan is opened and controlled at 160-230 ℃.
Placing a centrifugal spray head, starting the centrifugal spray head, slowly adjusting the frequency of the atomizer to a certain frequency (determining 15HZ-20HZ according to actual conditions), starting a feeding pump when the spray head reaches the highest rotating speed under the frequency condition, and opening an outlet valve of the feeding pump. Meanwhile, the pollinators at the bottom of the cylinder body and the bottom of the cyclone separator are opened to receive materials. When the centrifugal sprayer is continuously produced, the material does not need to be cleaned in each batch, the corrosivity of the material is determined, the centrifugal sprayer does not need to be disassembled when being cleaned, and clean water is pumped by a screw pump for cleaning.
The valve of the centrifugal nozzle is slowly opened to ensure that the blanking amount is increased from small to large, otherwise, the wall sticking phenomenon is generated until the proper requirement is adjusted to keep the air exhaust temperature at a constant of 80-100 ℃.
The dried finished product is collected, in the pollinator at the lower part of the tower body and the lower part of the cyclone separator, the pollinator is required to be exchanged before being full, and when the pollinator is exchanged, the butterfly valve at the upper part must be firstly switched.
After use, the product should be washed by spraying water.
During assembly and disassembly, the main shaft cannot be bent, a plug sheet is used for controlling the gap between the disc and the shell when the spraying disc is assembled, and a nut for fixing the spraying disc must be screwed to prevent loosening and falling
(firstly, turning off steam heating and electric heating for cooling, and turning off a feeding pump (screw pump) for cooling at the same time) when the temperature of an inlet is reduced to 80-100 ℃, the atomizer can be turned off when the temperature is below 80-100 ℃, and the circulating fan can be turned off when the temperature is below 50-80 ℃.
And after spraying, switching the raw material liquid to the solvent, adjusting the frequency of the atomizer to 40-70HZ, spraying for about 8-20 minutes, slowly reducing the rotation speed of the atomizer to about 10-30HZ, and turning off the power supply of the centrifugal nozzle.
And keeping the centrifugal fan running, reducing the temperature in the cyclone spray drying tower to 30-60 ℃, and then closing the power supply of the fan.
And (4) cleaning the centrifugal spray dryer by using a screw pump to pump clean water.
The collected paste powder is sealed in double bags to avoid moisture absorption.
The fluidity of the paste powder is checked, and if the paste powder is too fine, the spraying frequency can be increased.
The collected paste powder should be dissolved in water to check if there is any black spot foreign matter. After confirmation, the mass production is started.
(III) Total mixing
Pulverizing the paste powder, and sieving with 60-100 mesh sieve.
Adding lubricant into the materials, and mixing for 40-60 min,
the double bags are sealed to avoid moisture absorption.
(IV) Dry granulation
The equipment is determined to be clean before dry process, the granules with 14-40 meshes are 100%, and the powder with less than 40 meshes is re-granulated by dry process. Care was taken to reduce losses to ensure yield.
Adding appropriate adjuvants into the above powder or granule, and making into granule, powder, capsule, tablet, pill, liquid, etc., and packaging.
Example 5: the addition amount of water in example 4 was adjusted to 15 times, extraction was performed at 100 ℃ for 7 hours, the mixed liquid medicine was concentrated to a relative density of 1.07, and then spray-dried, pulverized, and granulated to obtain a product.
Example 6: the addition amount of water in the example 4 is adjusted to be 7 times, the extraction is carried out for 6 hours at the temperature of 100 ℃, the mixed liquid medicine is concentrated to the relative density of 1.09, and then the product is obtained by spray drying, crushing and granulating.
Example 7:
a medicine-food homologous traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete micturition syndromes and a preparation thereof are prepared by respectively extracting the traditional Chinese medicines of examples 1-3 with water, concentrating the water extract into thick paste, spray-drying to obtain paste powder, respectively crushing, sieving by 60-100 meshes to obtain extract powder, mixing for 40-60 minutes to obtain mixture powder, adding one or more of a filling agent, a flavoring agent, a lubricating agent, a disintegrating agent and the like according to the required dosage form, mixing, and preparing the mixture into the dosage forms of granules, powder, capsules, tablets, pills, liquid and the like according to the conventional preparation process.
Example of effects:
1. selecting a patient:
28 male patients and 42 female patients who voluntarily receive treatment for frequent micturition syndrome are selected; the age was 55-75 years, and the mean age was 66.2 years. Inclusion criteria were: urinary urgency with or without urge incontinence is greater than or equal to 3 months; urgency with or without urge incontinence for at least 3 times in the last 3 days; no drug is used within 1 month before selection; patients with other urinary system diseases were excluded.
All patients were randomly divided into treatment group and control group, and the patients in each group had no statistical significance (P >0.05) in comparison of general clinical data such as disease type, sex, age, course and disease condition, and were comparable.
2. Method of treatment
Treatment groups: the Chinese medicinal compositions prepared in examples 1-3 were respectively orally taken 2 times/day with warm water after meal.
Control group: the treatment is carried out by using solifenacin succinate tablets, 5mg each time and 1 time/d.
All patients were treated for 2 treatment courses (42d), and the number of urination and the number of acute urinary incontinence in 24h before and after treatment was recorded for each group of patients.
3. Standard of therapeutic effect
The effect is shown: the symptoms and physical signs of the patient such as frequent micturition, urgent micturition and incontinence of urine disappear;
the method has the following advantages: the symptoms and physical signs of the patients such as frequent micturition, urgent micturition and incontinence of urine are obviously improved and still do not return to normal;
and (4) invalidation: the frequency, urgency and incontinence of the urine of the patient are not improved.
4. Results
No withdrawal case and no abscission case exist in the observation period, and two groups in the observation process are serious and have no adverse events; 2 treatment courses (42d) of continuous treatment, 27 cases of obvious effect, 6 cases of effective effect and 2 cases of ineffective effect, and the total effective rate is 94.3 percent.
Clinical efficacy comparison of patients in each group
The results are shown in Table 1.
TABLE 1
| Group of | n | Show effect | Is effective | Invalidation | Total effective rate |
| Treatment group | 35 | 27 | 6 | 2 | 94.3％ |
| Control group | 35 | 14 | 12 | 9 | 74.3％ |
The above examples are only examples to express the specific embodiments of the present invention, and the description thereof is more specific, but not to be construed as limiting the scope of the application of the present invention; it should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (6)
1. A medicine-food homologous traditional Chinese medicine composition for improving urgent micturition, frequent micturition and incomplete urination syndrome is characterized in that: the feed is prepared from the following raw materials in parts by weight: 20-70 parts of chicory and 30-80 parts of raspberry.
2. The Chinese medicinal composition as claimed in claim 1, which is used as both medicine and food for improving urgent micturition, frequent micturition and urine endless syndrome, and is characterized in that: the material is prepared from the following raw materials in parts by weight: 30-60 parts of chicory and 40-70 parts of raspberry.
3. The Chinese medicinal composition as claimed in claim 2, which is used as both medicine and food for improving urgent micturition, frequent micturition and urine endless syndrome, and is characterized in that: the material is prepared from the following raw materials in parts by weight: 44 parts of chicory and 56 parts of raspberry.
4. The Chinese medicinal composition for improving urinary urgency, urinary frequency and inexhaustible syndrome as defined in any one of claims 1 to 3, which is prepared from the following raw materials:
the preparation method of the traditional Chinese medicine composition comprises the following steps:
s1: adding 5-30 times of water into herba Cichorii and Rubi fructus, decocting, extracting under reflux at 80-100 deg.C for 5-7 hr, filtering the extractive solution with filter cloth plate frame to obtain mixed medicinal liquid;
s2: concentration: concentrating the obtained mixed liquid medicine to relative density of 0.95-1.3;
s3: preparing medicinal powder: spray drying the concentrated mixed medicinal liquid with atomizer frequency of 15Hz-20Hz and air exhaust temperature of 80-100 deg.C, pulverizing, and sieving with 60-100 mesh sieve to obtain the final product.
5. The Chinese medicinal composition as food and medicine for improving urgency, frequency and inexhaustible syndrome according to any one of claims 1 to 3, which is characterized in that: the traditional Chinese medicine composition is added with pharmaceutically or physiologically acceptable auxiliary materials, wherein the auxiliary materials are one or more of a filling agent, a flavoring agent, a lubricating agent and a disintegrating agent.
6. The Chinese medicinal composition as claimed in claim 5, which is in the form of granule, powder, capsule, tablet, pill or liquid.
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Non-Patent Citations (1)
| Title |
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| 崔建军: "覆盆子的功效与作用", 《HTTPS://M.BAIDU.COM/BH/M/DETAIL/QR_966250166654734870》 * |
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Application publication date: 20210907 |