CN103638223A - Compound preparation capsule for reducing blood fat - Google Patents
Compound preparation capsule for reducing blood fat Download PDFInfo
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- CN103638223A CN103638223A CN201310685631.7A CN201310685631A CN103638223A CN 103638223 A CN103638223 A CN 103638223A CN 201310685631 A CN201310685631 A CN 201310685631A CN 103638223 A CN103638223 A CN 103638223A
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- rhizoma alismatis
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Abstract
The invention discloses a compound preparation capsule for reducing blood fat. According to a prescription, the compound preparation capsule comprises the following traditional Chinese medicine extractives in percentage by weight: 15-30% of the root of kudzu vine, 15-30% of semen cassia, 15-30% of rhizoma alismatis and 20-40% of poria cocos; the final internal content of the capsule comprises the following traditional Chinese medicine extractives and other components in percentage by weight: 60-80% of traditional Chinese medicine extractives, 15-40% of natto powder and 4.4% of starch. A preparation method of the compound preparation capsule for reducing blood fat comprises the steps of selecting the root of kudzu vine, the semen cassia, the rhizoma alismatis and the poria cocos carefully; washing, decocting, drying and crushing; then evenly mixing with the natto powder and the starch; and filling and packaging to obtain the prepared capsule product. In the compound preparation capsule for reducing blood fat, the cholesterol CHOL is reduced by 11.03%, the triglyceride TG is reduced by 19.9%; the effective rate of the compound preparation capsule is 75-94.4%; the compound preparation capsule has a good effect of reducing blood fat.
Description
Technical field
The present invention relates to a kind of compound preparation with blood fat reducing function, relate in particular to the compound preparation capsule of a kind of natto powder and Chinese medicine extract.
Background technology
Along with people's eating patterns and lifestyle change, the crowd of Hyperlipidemia is more and more huger, the hazardness that hyperlipidemia can cause severe cardiovascular disease, by more people's understanding, is thirsted for the pursuit that a kind of good blood fat reducing health products having no side effect becomes people with hyperlipidemia.
Radix Puerariae is one of article of Ministry of Public Health issue " being food and medicine ", is rich in flavone compound, has good hypolipemic function.
Semen Cassiae is one of article of Ministry of Public Health issue " being food and medicine ", and pharmacological experiment proves: Semen Cassiae has the effect of blood pressure lowering, blood fat reducing.
Rhizoma Alismatis is one of article of Ministry of Public Health issue " can be used for health food ", and medical research shows: Rhizoma Alismatis has the effect of obvious reduction human serum T-CHOL and triacylglycerol content.
Poria is one of article of Ministry of Public Health issue " being food and medicine ", and Poria is rich in the nutrient substance such as polysaccharide, aminoacid, has the effect of blood sugar lowering, blood fat reducing simultaneously.
Natto is a kind of safety food, contains and has bioactive nattokinase, and nattokinase has direct thrombolytic effect.Experiment showed, that natto can suppress the LDL oxidation in blood, effectively reduces the concentration of cholesterol and triacylglycerol.
Summary of the invention
The present invention will provide a kind of compound preparation capsule with good blood fat reducing function.
Technical scheme of the present invention is: a kind of compound preparation capsule of blood fat reducing, comprise Chinese crude drug extract, frozen dried natto powder and starch, and wherein said capsule is by weight ratio: Chinese crude drug extract 60%～80%, frozen dried natto powder 15%～40%, starch 4.4%; Described Chinese crude drug extract is the extract of Radix Puerariae, Semen Cassiae, Rhizoma Alismatis and Poria, its Chinese crude drug meter that feeds intake by weight ratio: Radix Puerariae, Semen Cassiae, Rhizoma Alismatis each 15%～30%, Poria 20%～40%; Described Chinese crude drug extract is that Radix Puerariae, Semen Cassiae, Rhizoma Alismatis, Poria is selected, clean, through decocting, dry, pulverize and obtain.
Preferred version of the present invention is: above-mentioned Chinese crude drug extract powder 68.9%, and frozen dried natto powder 26.7%, starch proportion is 4.4%; The ingredient proportion of each medical material of Chinese crude drug extract is: Radix Puerariae 25.5%, Semen Cassiae 25.5%, Rhizoma Alismatis 25.5%, Poria 23.5%.
Radix Puerariae is the dry root of legume pueraria lobata, contains multiple flavones ingredient.Its contained flavone compound has effect for reducing blood fat, can reduce serum cholesterol, reduces glyceric acid, is used for the treatment of hyperlipidemia and has curative effect significantly.
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae and little Semen Cassiae, containing anthraquinone analog compounds such as emodin, chrysophanols, in addition containing nutrient substance such as protein, sitosterol, aminoacid.Medical experiment shows: Semen Cassiae can reduce the content of glycerol three acid in plasma cholesterol, glycerol three acid and liver.
Rhizoma Alismatis is the dry tuber that Alismataceae is planted Rhizoma Alismatis, is rich in alisol ester type compound, also the element such as sugary and potassium, calcium, magnesium.Medical experiment shows: in Rhizoma Alismatis, part composition has the effect of significant blood fat reducing.Zoopery demonstration, the acetas of Alisol A, C can make the cholesterol in blood decline more than 50%.Can also suppress the absorption of cholesterol simultaneously.
Poria is the dry sclerotia of porous strain Poria.Poria is containing triterpenes, polysaccharide multiple compounds.Medical experiment proof Poria has good health-care effect to people's Cardiovascular System.
Natto is traditional food, by cryodesiccated natto, has retained the wherein biological activity of nattokinase.Nattokinase is thrombus directly, and to thrombosis long action time, nattokinase can also stimulate vascular endothelial cell to produce endogenous t-PA apart from directly thrombolytic effect is outer, swashs in vivo urine hormone proenzyme and changes urokinase into, the inhibitory enzyme (PAI of reduction and inactivation plasminogen activator
1) regulate the modes such as fibrinolysis activity to realize human body oneself physiology thrombolytic.Zoopery confirms: natto can suppress the LDL oxidation in blood, effectively reduces the concentration of T-CHOL and triglycerin acid.
This capsule is checked through Hubei Province Disease Control and Prevention Center, playing result is arsenic (mg/kg is in As) < 0.10, plumbous (mg/kg is in Pb) < 0.14, hydrargyrum (mg/kg is in Hg) < 0.010, coliform (MPN/100g) < 3, pathogenic bacterium do not detect.Poor program of test basis < < food safety toxicology and method > > GB1519394.
The Kunming mouse per os acute toxicity of this capsule to two kinds of sexes, in 24 hours, the 3 hours continuous gavages in interval are twice, total gavage metering reaches 100g/kg bw and without animal dead and any poisoning symptom, occurs in mono-week, by acute toxicity classification, and nontoxic grade of class material of this tested material.Three mutagenic test results are all negative.
This product is selected natural Radix Puerariae, Semen Cassiae, Rhizoma Alismatis, Poria and is raw material with the natto that Semen Glycines fermentation makes, and belongs to the nontoxic food of All Pure Nature, and in capsule, filling thing is brown color powder, has natto fragrance.This product is taken through volunteer,
Every contains content 450mg, and consumption is every day twice, each two.Cholesterol CHOL decline 11.03%, the sour TG of glycerol three decline 19.9%; Effective percentage 75%～94.4%; There is good blood fat reducing function.
This capsule has the function of blood fat reducing, the person that is applicable to Hyperlipidemia, and children should not take.
The specific embodiment
Embodiment 1
By four Chinese medicine material Radix Puerariae 25.5% by weight, Semen Cassiae 25.5%, Rhizoma Alismatis 25.5%, Poria 23.5% feeds intake, through decocting, filter, concentrated, dry, standby after pulverizing.
Extract powder 77.8% by weight, adds frozen dried natto powder 17.8%, starch 4.4%, and after fully mixing, filled capsules, test package warehouse-in.
Natto Indian buead capsule is for the effect of blood fat reducing.
Test-meal total number of persons 36 people, male's 20 examples, women's 16 examples, age 18-65 year.
Test-meal method
Take sample by recommended dose every day, takes continuously 60 days, do not change original dietary habit, normal diet during test-meal.
Test-meal dosage is every twice-daily, each two (every 450mg).
Observation index, when test-meal starts and finish, each surveys once every observation index.
Effect index, cholesterol (CHOL), glycerol three acid (TG)
Result is judged
CHOL reduces > 10%, and TG reduces > 15%, and each functional observation index experiment front and rear body body comparison, can judge that this index is positive.
Serum cholesterol, the positive judgement of the sour binomial index of glycerol three given the test agent have blood fat reducing function.
Take the index analysis result after natto Indian buead capsule
| Test-meal number | Efficiently individual quantity | Effective percentage |
| 36 | 28 | 77.8% |
Embodiment 2
By four Chinese medicine material Radix Puerariae 25.5% by weight, Semen Cassiae 25.5%, Rhizoma Alismatis 25.5%, Poria 23.5% feeds intake, through decocting, filter, concentrated, dry, standby after pulverizing.
Said extracted thing powder 68.9%, adds frozen dried natto powder 26.7% by weight, starch 4.4%, and after fully mixing, filled capsules, test package warehouse-in.
Test-meal experiment is with embodiment 1
Take the index analysis result after natto Indian buead capsule
| Test-meal number | Efficiently individual quantity | Effective percentage |
| 36 | 34 | 94.4% |
Embodiment 3
By four Chinese medicine material Radix Puerariae 25.5% by weight, Semen Cassiae 25.5%, Rhizoma Alismatis 25.5%, Poria 23.5% feeds intake, standby through decocting, filter, concentrate, be dried, pulverizing.
Said extracted thing powder 60%, adds frozen dried natto powder 35.6% by weight, starch 4.4%, and after fully mixing, filled capsules, test package warehouse-in.
Test-meal experiment is with embodiment 1
Take the index analysis result after natto Indian buead capsule
| Test-meal number | Efficiently individual quantity | Effective percentage |
| 36 | 28 | 77.8% |
Embodiment 4
By four Chinese medicine material Radix Puerariae 19.6% by weight, Semen Cassiae 19.6%, Rhizoma Alismatis 19.6%, Poria 41.2% feeds intake, standby through decocting, filter, concentrate, be dried, pulverizing.
Said extracted thing powder 77.8%, adds frozen dried natto powder 17.8% by weight, starch 4.4%, and after fully mixing, filled capsules, test package warehouse-in.
Test-meal experiment is with embodiment 1
Take the index analysis result after natto Indian buead capsule
| Test-meal number | Efficiently individual quantity | Effective percentage |
| 36 | 27 | 75% |
Embodiment 5
By four Chinese medicine material Radix Puerariae 19.6% by weight, Semen Cassiae 19.6%, Rhizoma Alismatis 19.6%, Poria 41.2% feeds intake, standby through decocting, filter, concentrate, be dried, pulverizing.
Said extracted thing powder 68.9%, adds frozen dried natto powder 26.7% by weight, starch 4.4%, and after fully mixing, filled capsules, test package warehouse-in.
Test-meal experiment is with embodiment 1
Take the index analysis result after natto Indian buead capsule
| Test-meal number | Efficiently individual quantity | Effective percentage |
| 36 | 32 | 88.9% |
Embodiment 6
By four Chinese medicine material Radix Puerariae 19.6% by weight, Semen Cassiae 19.6%, Rhizoma Alismatis 19.6%, Poria 41.2% feeds intake, standby through decocting, filter, concentrate, be dried, pulverizing.
Said extracted thing powder 60%, adds frozen dried natto powder 25.6% by weight, starch 4.4%, and after fully mixing, filled capsules, test package warehouse-in.
Test-meal experiment is with embodiment 1
Take the index analysis result after natto Indian buead capsule
| Test-meal number | Efficiently individual quantity | Effective percentage |
| 36 | 29 | 80.6% |
General physical examination: the situations such as experimenter's spirit, sleep, diet, defecation are without extremely, and explanation has no adverse effects.
Take before and after natto Indian buead capsule, routine blood test (RBC, WBC, HBC) liver function, renal function all, without abnormal, have no adverse effects.
Take before and after natto Indian buead capsule, Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest check, all, without abnormal, have no adverse effects.
Conclusion: natto Indian buead capsule Chinese crude drug used is all " being food and medicine " or the article of " can be used for health food " that Ministry of Public Health is announced, and natto is traditional food, safe and reliable.The blood fat reducing function that experiment showed, the 2nd routine proportioning by above-mentioned 6 groups of human experiments is best.
The sample making with above-mentioned formula 2, human experiment experiment is organized and implemented functional observation by Hunan Province Disease Control and Prevention Center.
Sample: sample is provided by Hubei McKesson Bioisystech Co., Ltd for No. 1, No. 2, is capsule formulation, 450mg/ grain, both outer officials, taste are basic identical, and one of them is natto Indian buead capsule, and another is placebo.The oral recommended dose of human body is every day 2 times, each 2.
Experimenter is not sex-limited not, and the age is 18-65 year.Blood sampling be >=5.2mol/L of twice, twice T-CHOL or glycerol three acid >=1.65mol/L in half a year, dyslipidemia, without obvious brain, the heart, liver, lung, kidney, Hematological Diseases, without Long-term taking medicine history, voluntary tested assurance coordinates.
Adopt two kinds of control design between self and group.By experimenter's blood lipid level, be divided at random natto Indian buead capsule test-meal combination placebo group.
Test-meal group 5 examples, matched group 5 examples.Test-meal group male/female is 38/13, and the age is 39.71 ± 6.19 years old; Matched group male/female is 41/10, and the age is 39.73 ± 6.73 years old.
CHOL, the horizontal situation of change of TG table 1, table 2, table 3 before and after test-meal test.Before experiment, matched group and test-meal group change of serum C HOL, the comparison of TG level, no significant difference (P > 0.05), has comparability between indicating two groups.After the test-meal of test-meal group, CHOL, TG and test-meal are front compares, and difference has significance (P < 0.05), after the test-meal of indication test-meal group, after CHOL, TG and matched group test, compares, and difference has significance (P < 0.05).After test-meal, HDL-C level has no obvious change (P > 0.05).
Change of serum C HOL, TG, HDL-C level (table 1) before test-meal experiment
CHOL, TG, HDL-C level (table 2) before and after test-meal experiment
* with tested front relatively P < 0.05; # and matched group be P < 0.05 relatively
Change of serum C HOL, TG, HDL-C situation of change (table 3) before and after test-meal experiment
Conclusion:
Adopt counter point between own control and group, the volunteer that selection meets experiment condition took tested material after 60 days, result shows: take after the test-meal of natto Indian buead capsule experimental group before CHOL, TG and test-meal relatively, difference has significance (P < 0.05), after test-meal, declines more respectively 11.03%, 19.93% before CHOL, TG and test-meal; After the test-meal of test-meal group, after CHOL, TG and matched group test, compare, difference has significance (P < 0.05); After test-meal, test-meal group HDL-C and matched group comparing difference are without significance (P > 0.05).According to the check of < < health food and assessment technique standard > > (version in 2003) evaluation criterion, prompting given the test agent has good hypolipemic function effect.
Claims (2)
1. for a compound preparation capsule for blood fat reducing, comprise Chinese crude drug extract, frozen dried natto powder and starch, wherein said capsule is by weight ratio: Chinese crude drug extract 60%～80%, frozen dried natto powder 15%～40%, starch 4.4%; Described Chinese crude drug extract is the extract of Radix Puerariae, Semen Cassiae, Rhizoma Alismatis and Poria, its Chinese crude drug meter that feeds intake by weight ratio: Radix Puerariae, Semen Cassiae, Rhizoma Alismatis each 15%～30%, Poria 20%～40%; Described Chinese crude drug extract is that Radix Puerariae, Semen Cassiae, Rhizoma Alismatis, Poria is selected, clean, through decocting, dry, pulverize and obtain.
2. compound preparation capsule as claimed in claim 1, is characterized in that, described Chinese crude drug extract powder 68.9%, and frozen dried natto powder 26.7%, starch proportion is 4.4%; The ingredient proportion of described each medical material of Chinese crude drug extract is: Radix Puerariae 25.5%, Semen Cassiae 25.5%, Rhizoma Alismatis 25.5%, Poria 23.5%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310685631.7A CN103638223A (en) | 2013-12-16 | 2013-12-16 | Compound preparation capsule for reducing blood fat |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310685631.7A CN103638223A (en) | 2013-12-16 | 2013-12-16 | Compound preparation capsule for reducing blood fat |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385990A (en) * | 2013-08-13 | 2013-11-13 | 吴中区胥口精益生物医药研究所 | Rhizoma alismatis essence and preparation method thereof |
Citations (1)
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| CN101121007A (en) * | 2006-08-08 | 2008-02-13 | 西安汇源科技开发有限公司 | Natto capsule and its preparation method |
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- 2013-12-16 CN CN201310685631.7A patent/CN103638223A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101121007A (en) * | 2006-08-08 | 2008-02-13 | 西安汇源科技开发有限公司 | Natto capsule and its preparation method |
Non-Patent Citations (4)
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| 吴杰忱等: "纳豆和纳豆激酶在预防和治疗疾病中的作用", 《黑龙江医药》 * |
| 施溯筠: "茯苓醇提取物对高脂血症小鼠的血脂和NO水平的影响", 《华西药学杂志》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385990A (en) * | 2013-08-13 | 2013-11-13 | 吴中区胥口精益生物医药研究所 | Rhizoma alismatis essence and preparation method thereof |
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Application publication date: 20140319 |