CN102406860A - Composition for preventing and treating diabetes, and preparation method and use thereof - Google Patents
Composition for preventing and treating diabetes, and preparation method and use thereof Download PDFInfo
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Abstract
The invention provides a composition for treating and preventing diabetes. The composition comprises the following components: wheat, oat, fagopyrum tataricum, yam, kudzuvine root, coix seed, gordon euryale seed, pumpkin, rivier giantarum rhizome and tuckahoe. More preferably, the composition further comprises green team, Chinese wolfberry, white fungus, gingkgo, lily, sea cucumber and polygonatum odoratum. The invention also provides a preparation method of the composition, which comprises the following steps: drying and sterilizing all raw materials; mixing the raw materials uniformly in a ratio; and grinding. The invention also relates to the use of the composition in the preparation of medicines or foods for treating, preventing and assisting treatment of diabetes.
Description
Technical field
The present invention relates to field of food, be specifically related to a kind of compositions that is used to prevent and treat diabetes.
Background technology
Diabetes are common chronic lifelong diseases of a kind of serious harm health.Modern medicine study proves; The nutrition dietary treatment is the basis of supporting whole treating diabetes system; In treating diabetes and prevention, bringing into play important role; It is with motion, medicine, communication and education and self-monitoring, and " five drive carriage " in the diabetes of the being known as Comprehensive Treatment not only need cooperate collaborative but also can not the phase trans-substitution.Nutrition dietary treatment is wherein most important basic measures, and no matter which kind of Drug therapy no matter state of an illness weight use, and all should adhere to the nutrition dietary treatment for a long time.Present domestic diabetic diet treatment; Mainly be that absorption with the total amount of heat of keeping on a diet is a target; Though have numerous products to emerge, it is poor to exist palatability, nutrition arrangement is unbalanced; The patient can't really adhere to long-term edible problem, so the effect of Diet Therapy also just is difficult to really embody.The diabetes patient is faced with the problem of " difficulty of having a meal " every day, therefore is badly in need of the current demand that a kind of effective means satisfy diabetes patient's health diet, just lets the diabetes patient not only can eat, and can also have enough and eat.Specifically; Let the rising that not only can not cause post-prandial glycemia behind the diabetes patient exactly; Can also play certain blood sugar reducing function; And the characteristics that can combine praxeology provide and both satisfy the patients ' psychological requirement, are more or less the same with the daily meals of average family, again significantly blood sugar lowering, the sugared diet content of control.A large amount of scientific practices and clinical verification show that compositions of the present invention can help the better blood sugar control of diabetics, improve the health status of diabetics comprehensively, are that a kind of effective and feasible Diet Therapy is realized means.
Summary of the invention
The objective of the invention is to the deficiency to prior art, a kind of novel, compositions that obvious results is used for diabetic to take is provided, described compositions does not have toxic and side effects, can eat for a long time.Described compositions comprises following composition: Semen Tritici aestivi, Herba bromi japonici, Radix Et Rhizoma Fagopyri Tatarici, Rhizoma Dioscoreae, Radix Puerariae, Semen Coicis, Semen Euryales, Fructus Cucurbitae moschatae, Rhizoma amorphophalli and Poria.
Further aim of the present invention is to provide said preparation of compositions method.
Another purpose of the present invention is to provide the medicine or the food applications of said compositions.
The specific embodiment
The present invention follows traditional Chinese medical science tradition " integration of edible and medicinal herbs " thought, and is theoretical in conjunction with modern nutriology, and scientific composition can be guaranteed the science of prescription to guarantee the equilibrium of each nutritional labeling in the finished product again.Compositions of the present invention comprises following composition: Semen Tritici aestivi, Herba bromi japonici, Radix Et Rhizoma Fagopyri Tatarici, Rhizoma Dioscoreae, Radix Puerariae, Semen Coicis, Semen Euryales, Fructus Cucurbitae moschatae, Rhizoma amorphophalli and Poria; Better, described compositions can also contain green tea, Fructus Lycii, Tremella, Semen Ginkgo, Bulbus Lilii, Stichopus japonicus and Rhizoma Polygonati Odorati.
Nutritional labeling in the Semen Tritici aestivi mainly concentrates in kind of skin and the aleurone.Comprise two big types of biological active substanceies, i.e. active polysaccharide and phenolic compound, wherein active polysaccharide mainly is meant wheat edible fiber.Dietary fiber can reduce the absorption of passing through the time decreased glucose at small intestinal, slows down the starch hydrolysis, to reducing cholesterolemia, hyperlipidemia, coronary heart disease, and hypertension all has the good preventing effect; Wheat-bran dietary fiber is good to the diabetics action effect that relies on insulin.Also contain compositions such as rich in protein, dietary fiber, vitamin (VB1, VB2, VE) and mineral and oligosaccharide, enzyme (B-amylase, phytase, carboxypeptidase, lipase) and phenolic compound in the Testa Tritici, can satisfy the demand of diabetics to a great extent for nutrition.
Containing rich soluble fiber beta glucan in the Herba bromi japonici kind skin, is the main component of Herba bromi japonici water soluble dietary fiber, has blood sugar lowering, reduces physiological functions such as serum and cholesterol.It is generally acknowledged that its hypoglycemic mechanism is owing to disturbed the metabolism of carbohydrate, has reduced the absorption of external source glucose; Blood glucose and glycometabolic research to diabetes rat show; Avenabeta glucosan can pass through blood fat reducing content; Improve the blood glucose mobile performance, accelerate transport speed and the efficient of carbohydrate content in the process of absorbing, simultaneously to diabetes concurrent hepatic and renal tissue pathological changes the excellent repairing effect is arranged; And can effectively reduce the decomposition of hepatic glycogen, thereby cause blood glucose to reduce.
The main active site of Radix Et Rhizoma Fagopyri Tatarici is a Radix Et Rhizoma Fagopyri Tatarici flavone, and flavone compound mainly comprises rutin, kaempferol, Quercetin etc., can activate pancreatic function, thereby promotes insulin secretion with blood sugar lowering.In addition, contain abundant oleic acid and linoleic acid in the Semen Fagopyri Esculenti.Oleic acid can synthesize arachidonic acid in human body, it has the effect of blood fat reducing, and therefore normal food Semen Fagopyri Esculenti can be prevented and treated diabetes hyperlipaemia.
Rhizoma Dioscoreae is rich in polysaccharide; Can stimulate and regulate functions of immune system; Maurica M. report Rhizoma Dioscoreae extract has hypoglycemic activity to fasted rats and rabbit; Can control the hyperglycemia that alloxan causes, its mechanism of action and Chinese yam polysaccharide can increase insulin secretion, it is relevant to improve impaired beta Cell of islet and removed polyradical etc.Rhizoma Dioscoreae scalable diabetes enteropathy patient blood glucose SP concentration, VIP concentration make it to be tending towards normal level, help keeping of diabetes enteropathy patient intestinal normal configuration and function; Simultaneously, Rhizoma Dioscoreae and insulin share and can also pass through picked-up and the utilization of nerve-hormone-immunological network adjusting enhancing surrounding tissue cell to glucose, improve peripheral tissues's insulin resistant, thus blood sugar lowering.
The puerarin that Radix Puerariae contains has good hypoglycemic activity, and mechanism is to promote the reparation and the regeneration of damaging cells, strengthens the islet secretion function, also improves the body environment with its YIN nourishing and the production of body fluid promoting, and it is relevant to strengthen tissue target cell insulin receptor sensitivity.Puerarin also has certain therapeutical effect to complication such as diabetic nephropathy, diabetes high blood viscosity disease, diabetic renal papillary necrosis, diabetic peripheral neuropathy, diabetes and coronary heart disease, myocardial infarctions.
Semen Coicis property slightly sweet flavor is slightly cold, and is the article of the medicine-food two-purpose of tonifying the lung spleen invigorating, promoting urination to remove dampness.Pharmacological research shows that the compositions such as Semen Coicis polysaccharide, Semen Coicis oil and Coixol in the Semen Coicis have remarkable blood sugar reducing function.Research shows that the Semen Coicis polysaccharide can significantly reduce the blood glucose of normal and hyperglycemia model mice, causes rat Langerhans islet β cell injury to alloxan and has the significant protection effect.The Semen Coicis polysaccharide can reduce the blood lactate level, improves impaired glucose tolerance, increases the storage of liver, muscle glycogen, increases the activity of glucokinase, to improve carbohydrate metabolism disturbance.Semen Coicis is particularly useful for obese diabetic with the hyperpietic.
Nutritional labelings such as Semen Euryales rich in proteins, fat, calcium, phosphorus, ferrum, thiamine, riboflavin, nicotinic acid, ascorbic acid and micro-carotene, tocopherol, aminoacid.The traditional Chinese medical science think Semen Euryales property flat, sweet puckery, hold back admittedly, spleen invigorating dehumidifying, kidney tonifying spermatogenesis, effects such as nourishing blood to tranquillize the mind, hemostasis leukorrhagia stopping, often eating Semen Euryales has good improvement effect to diabetes patient's frequent micturition.
Fructus Cucurbitae moschatae and starch food mix when eating, and can improve the viscosity of gastric content, and regulate the trap of gastric food, and the saccharide absorption is slowed down, thereby have postponed the time of gastric food emptying.Pectin in the Fructus Cucurbitae moschatae can form a kind of spawn in intestinal, make the molecule of digestive enzyme and nutrient substance can not uniform mixing, has delayed digestion and the absorption of intestinal to nutrient substance, thereby has effectively controlled blood sugar increasing after meal.Contain abundant cobalt, zinc, manganese and chromium in the Fructus Cucurbitae moschatae, these trace element have the insulin function of improvement, promote effects such as saccharide and proteinic metabolism.In addition; Squash polyoses also can significantly increase the diabetes rat insulin content, reduces fasting blood sugar, and the blood sugar reducing function that polysaccharide is described mainly is through stimulating islet cells to increase secretion of insulin; Through the effect of insulin to maincenter and periphery; Promptly promote anabolism, suppress catabolism, thereby play the effect of blood sugar lowering.
The contained Rhizoma amorphophalli glucomannan (KGM) of Rhizoma amorphophalli is a kind of good diet fiber, and water absorption is extremely strong, has the characteristics of low in calories, low fat and high fiber.The KGM molecular weight is high, and viscosity is big, has improved the viscosity of chyme in the gastrovascular cavity, prolongs the holdup time in gastral cavity, reduces the food nutrition material to the intestinal wall diffusion velocity, delays the food digestion process.KGM can control agent in the insulin balance, obviously descend and postpone with the post-prandial glycemia peak value, thereby alleviate the insulin burden, the promotion diabetes patient is in benign recurrent state.KGM can not be digested by digestive enzyme, and heat own is extremely low, can prolong the gastric emptying time; Increase satiety, reduce the speed of intestinal glucose absorption, so its total amount of heat of can the control of diabetes people taking in; Blood sugar lowering content has to alleviate diabetes patient's hunger pangs.KGM can ferment at colonic, produces the propionate that is absorbed by the body, and cell cultured supernatant is quickened glycolysis, increases the utilization of glucose; KGM can influence the release of gastrointestinal hormone, can reduce free fatty acid levels in the blood, improves the sensitivity of insulin, and carbohydrate tolerance is reduced.
The Poria Main Ingredients and Appearance is a pachyman, belongs to soluble dietary fiber.Clinical trial shows that Poria has certain hypoglycemic effect to the type ii diabetes patient.Test and Selection is type ii diabetes patient 13 examples more than 60 years old; Give Poria 50 grams for each person every day, be made into steamed bread, divide edible sooner or later; Edible 7 days altogether; Before and after the determination test on an empty stomach and post-prandial glycemia, the result show fasting glucose tried before for (8.76 ± 2.04) mM/liter, tried the back for (7.94 ± 1.45) mM/liter; Before two hours after the meal blood glucose is tried for (13.71 ± 2.49) mM/liter, tried the back for (11.69 ± 2.19) mM/liter.
Green tea is rich in tea polyphenols and tea polysaccharide.Tea polyphenols has antioxidation, and through improving the body anti-oxidation function, remove the polyradical of crossing that produces in the body, protection β-islet cells is avoided the free radical infringement.Tea polysaccharide then can be protected the secretory activity that stimulates islet cells, and hepatic glycogen is rolled up.Tea polysaccharide has the effect similar with insulin aspect carbohydrate metabolism, and can delay or slow down sugared digestion and absorption at intestinal, reduces the lasting rising trend of post-prandial glycemia, improves carbohydrate tolerance, thereby stablizes blood glucose.
Fructus Lycii contains compositions such as LBP, several amino acids, trace element, vitamin, taurine, effect such as have nourishing kidney, lung moistening, tonifying liver, make eye bright, lengthen one's life.LBP all has hypoglycemic activity to normal and diabetes model animal.Can obviously reduce the hyperglycemia mouse blood sugar, and damage has protective effect to insulin.Pure article LBP reaches 100% to the effective percentage of experimental alloxan diabetes rabbit test, and glucose tolerance curve obviously descends.Research shows that also various dose Fructus Lycii decocting liquid all has the effect that reduces T-CHOL, triglyceride, low-density lipoprotein cholesterol in the blood, and is evident in efficacy to diabetes and hyperlipidemia complications person.
The Tremella heat is lower, contains rich in amino acid, colloid and organophosphor etc. again to human body beneficial's composition.The main active of Tremella is a tremella polysaccharide, and tremella polysaccharide has a lot of pharmacological actions, like conciliator's body immunity function, antitumor, radioprotective and anti-ageing waiting for a long time.Zoopery finds that tremella polysaccharide can be with extending to 8-12 hour from 3-4 hour action time in animal body with insulin.The patients with diabetes mellitus Tremella has the effect that blood glucose rises that delays.
Bulbus Lilii polysaccharide can be repaired β-islet cells, strengthens the excreting insulin function and reduce the adrenocortical hormone secretion, and promotes that blood glucose is converted into glycogen in the liver, and above synergy reduces blood glucose.The experiment proof; Bulbus Lilii dietary fiber can suppress the mouse blood sugar rising that exogenous glucose causes; Suppress the glycogenolysis that epinephrine promoted, be beneficial to the anabolic effect of glycogen, weakened the islet cells damage; Recover impaired islets of langerhans 26S Proteasome Structure and Function, thereby suppress the rising of post-prandial glycemia.
The main active substances of Semen Ginkgo is ginkgetin and bilobalide, and experiment shows can make alloxan diabetes rats blood glucose descend, and serum insulin raises.Ginkgetin is blood sugar lowering and blood lipid level significantly, and insulin sensitivity index is provided, and antioxidant ability of organism can significantly be provided, thereby reduces the infringement of peroxidating product type metabolic by-product to body.Research also finds, ginkgetin has and alleviates the hepar damnification that causes because of high sugar, high fat diet and the effect of pathological changes.
The trace element vanadium that contains needed by human in the Stichopus japonicus, the research proof, vanadium has the para-insulin effect.Diabetics ubiquity magnesium deficiency phenomenon, and low magnesium is one of pathogenic factor of hypoinsulinism, then contains abundant magnesium elements in the Stichopus japonicus.
The Rhizoma Polygonati Odorati nature and flavor are sweet flat, have yin nourishing, moisturize, relieving restlessness, the effect of quenching the thirst.Classify it as top grade medicine in the Shennong's Herbal.Animal test results shows that fragrant solomonseal rhizome polyoses has certain inhibitory action to the destruction of the caused beta Cell of islet of alloxan, can reduce the blood glucose of diabetic mice.Show that also fragrant solomonseal rhizome polyoses has some improvement to the blood lipid level disorder that alloxan causes; Particularly triglyceride levels has tangible reduction, and this prompting fragrant solomonseal rhizome polyoses possibly have certain therapeutical effect to the diabetic complication that is caused that raises because of blood fat.
The weight portion of each composition is respectively in the compositions according to the invention: 50～90 parts of Semen Tritici aestivis are preferably 60～80 parts; 1～10 part of Herba bromi japonici is preferably 3～5 parts; 1～10 part of Radix Et Rhizoma Fagopyri Tatarici is preferably 3～5 parts; 1～10 part of Rhizoma Dioscoreae is preferably 3～5 parts; 1～10 part of Radix Puerariae is preferably 2～5 parts; 1～10 part of Semen Coicis is preferably 2～5 parts; 1～10 part of Semen Euryales is preferably 2～5 parts; 0.1～5 part in Fructus Cucurbitae moschatae is preferably 1～2 part; 0.1～5 part of Rhizoma amorphophalli is preferably 1～2 part; 0.1～5 part in Poria is preferably 1～2 part; 0.1～2 part of green tea is preferably 0.5～1 part; 0.1～2 part of Fructus Lycii is preferably 0.3～0.5 part; 0.1～2 part in Tremella is preferably 0.3～0.5 part; 0.1～2 part of Semen Ginkgo is preferably 0.3～0.5 part; 0.1～2 part of Bulbus Lilii is preferably 0.2～0.5 part; 0.1～2 part of Stichopus japonicus is preferably 0.2～0.5 part; 0.1～2 part of Rhizoma Polygonati Odorati is preferably 0.2～0.5 part.
Wherein, the main active of Semen Tritici aestivi, Herba bromi japonici and Radix Et Rhizoma Fagopyri Tatarici blood sugar lowering all presents the rule that reduces gradually to the center from the periphery, and promptly outer field nutritional labeling is the highest, inwardly reduces gradually, and is minimum to core.For guaranteeing that its active component do not suffer a loss, the mode of preferably selecting for use the raw grain of not peeling directly to pulverize is processed.Described Semen Tritici aestivi is preferably selected the strong gluten wheat of National standard good quality wheat-strong gluten wheat national standard (GB/T17892-1999) for use.
Compositions of the present invention can adopt the method that comprises the steps to prepare: after whole raw material drying sterilizations, mix in proportion, pulverizing promptly gets.Wherein said baking temperature can be 80～130 ℃, is preferably 80～100 ℃, most preferably is 80 ℃; Be 1～10 hour drying time, is preferably 2～6 hours, more preferably 3 hours.The raw grain and the Chinese crude drug of decortication do not contain a large amount of dietary fibers with physiologically active; In order to make described compositions mouthfeel better; Can adopt superfine communication technique that raw material pulverizing is arrived fineness less than 150 orders; Preferred fineness is less than 200 orders, and more preferably below 300 orders, wherein said order number adopts CNS.
The compositions of preparation contains multiple physiologically active ingredients with hypoglycemic effect such as dietary fiber, ginkgetin, tremella polysaccharide, pachyman, Bulbus Lilii polysaccharide, LBP, tea polyphenols, puerarin as stated above; Can guarantee that post-prandial glycemia is normal; Eliminate hunger sensation, improve compliance rate.Contain rich nutrient substances such as zinc, selenium, calcium, magnesium, manganese, copper, vanadium, cobalt, vitamin B complex, protein, aminoacid simultaneously, can replenish the nutrition that is prone to loss, reach the endotrophic balance, enhancing immunity and resistance.Functional component cooperatively interacts, and synergism promptly on the basis of whole synthesis property adjusting, is regulated targetedly, thereby reaches stable blood glucose fluctuation, blood lipid regulation blood pressure, the final purpose that complication prevention produces.
Compositions of the present invention can be used for treatment of diabetes, prevention and auxiliary treatment.
Compositions safety of the present invention, nontoxic can be used as food consumption.
Compositions of the present invention is used simple, need not to add other additive and can make steamed bread, fine dried noodles in a conventional manner, and varieties of food items such as medicated porridge, cake supply the diabetes patient daily edible.Certainly, can also adopt the conventional method for preparing in this area, described compositions processed the instant food of instant nourishing powder and other state food rules and regulations etc.
The test of Test Example 1 present composition hypoglycemic effect
Nutriology Dept. adopts 100 routine diabetes patient's clinical observations that the compositions (excellent Tang supports plain) of the embodiment of the invention 1 is carried out through the Shandong Prov. Hospital, and patient's post-prandial glycemia has obvious decline than before.Concrete test situation is following:
1 material and method
1.1 experimental subject and grouping random selection are in the same period moved in person in middle and old age's type ii diabetes patient 100 examples in endocrine ward, Shandong Prov. Hospital, male 55 examples, and women 45 examples, the age, build was fat partially at 40～78 years old.Selected case all meets China's diabetology meeting diagnostic criteria in 1999: symptom adds fasting glucose >=7.0mmol/L or random blood sugar >=11.1mmol/L.Judge patient's build with BMI (constitutional index), BMI >=24 are overweight, and selected patient's BMI is all in this scope.
Patient's fasting blood sugar when 1.2 investigation content and method measurement are admitted to hospital, 2 hours after the meal blood glucose values and body weight value.Be admitted to hospital and detected These parameters in back 10 days more respectively, to observe its front and back variation and to write down its subjective feeling these prescription meals.
1.3 grouping intervening measure
1.31 divide into groups 100 routine patients are divided into three groups of A (nutrition treatment education group), B (" excellent Tang supports plain " group), C (" excellent Tang supports plain " adds the education group), each group is respectively 20,40,40 examples.
1.32 intervening measure A group is nutrition treatment education group; Account for 55%～65% according to patient's individual instances (difference that comprises height, body weight, age, physical exertion) according to carbohydrate wherein; Protein accounts for 10%～20%; Fat accounts for 20%～30% ratio and is respectively the patient and formulates Diet Therapy meal, and carries out diet guide.The B group is organized for " excellent Tang is foster plain ", promptly when the patient takes in the heat ratio usually, gives the excellent Tang of 50g when treatment is eaten middle evening and supports plain all the other staple foods of prescription flour replacement 50g.The C group gives to be aided with the intervention of B group equivalent means after patient's nutrition guide for " excellent Tang supports plain " adds the education group.
1.4 all through SPSS16.0 statistical software analyzing and processing in addition, the result representes with
statistical procedures gained data.
2 results
2.1 the variation A of fasting glucose, B, C are intervening the enforcement front and back for three groups, fasting blood sugar all descends to some extent.
The B group is compared with the A group, the C group is compared with the A group, and difference all has statistical significance (p＜0.05), sees table 1.
Table 1 fasting glucose experimental result (
)
* be to compare P＜0.05 with the A group
2.2 changes of blood glucose A, B, C were intervening the enforcement front and back for three groups in 2 hours after the meal, blood glucose value all descended to some extent in 2 hours after the meal.Wherein the B group is compared with the A group, C organizes compares with the A group, and difference all has statistical significance (p＜0.01), sees table 2.
Table 2 is 2h blood glucose (
) after the meal
* compares P＜0.01 with the A group
2.3 the variation of body weight is originally tested selected patient's average body weight average about 75kg, the tenth day flat comparing to some extent of body heavy water of weight in patients level and test back descends before the experiment, but changes little (p＞0.05), difference not statistically significant.
Table 3 body weight (
)
2.4 patient's subjective feeling uses the different situations after plain prescription meals are supported by excellent Tang according to the patient, and subjective feeling is divided into relatively poor, general, good, fine four grades.Can find out that by table 4 most patients are more satisfied to these prescription meals.
Table 4 subjective feeling
Conclusion: the type ii diabetes patient select for use prescription meals " excellent Tang support plain " especially select for use " excellent Tang supports plain " and in addition the nutrition education intervention 2 hours after the meal blood glucose of control and fasting glucose are had positive role.
Confirm that through further experiment the compositions of embodiment of the invention 2-7 also has and " excellent Tang supports plain " similar hypoglycemic activity.This explains that compositions of the present invention all has hypoglycemic activity preferably.
Test Example 2 present composition toxicity tests
This test is carried out the oral acute toxic test of rat (Acute oral toxicity study) with substances (compositions of the embodiment of the invention 1, promptly excellent Tang supports plain).The laboratory animal that this test is used is 5 male and 5 female Sprague-Dawley strain rats.All rats of duration of test are all raised the Experimental Animal Center in State-Run Yangming University.During test plain powder is supported by excellent Tang and give all test rats with the throwing of oral pipe hello mode single, throwing and giving dosage is the 5000mg/kg body weight.Pipe feed to be thrown and to be given after excellent Tang supports plain powder, and continuous 14 days observed and recorded rats are taken place dead or manifest the situation of clinical symptoms.In addition, all rats of duration of test all can normally increase weight.During off-test, all rats are dissected and the naked eyes lesion examining, the result shows that not having any and excellent Tang of discovery supports the relevant naked eyes pathological changes of plain powder.Therefore, under this EXPERIMENTAL DESIGN condition the oral half lethal dose of rat of [plain powder is supported by excellent Tang] (median lethal dose is LD50) greater than 5000mg/kg.
Test procedure:
1. every rat is carried out labelling with the earmarking mode.Before the foster plain powder of excellent Tang was given in throwing, all rats all need pass through feed overnight.
2. marginal test (limit test): during test plain powder is supported by the excellent Tang of 15000mg and be dissolved in the 60ml reverse osmosis water and be mixed with aqueous solution.Plain amidin is supported by freshly prepared excellent Tang give all test rats with the throwing of oral pipe hello mode single, throwing and giving dosage is 5000mg/kg, and throwing and giving volume then is 20ml/kg.
Respectively throwing give excellent Tang support plain powder before, test the 7th day and test the body weight of measuring all test rats on the 14th day.
4. pipe feed to be thrown and to be given after excellent Tang supports plain powder, by continuous 14 days of veterinarian, every day 2 times all test rats is carried out clinical observation.
5. during the clinical observation, death takes place or manifests the situation of signs of toxicity in itemized record test rat, and the time of itemized record symptom generation and recovery situation.In addition, dead rat all need be dissected and the macropathology inspection during the clinical observation.
6. (the 15th day) during off-test with after sucking 100% carbon dioxide mode euthanasia, carried out pathological anatomy and macropathology inspection with all survival rats.
Result of the test:
1, it is as shown in table 1 that dosage is given in the foster plain powder throwing of test rat body weight and excellent Tang.
2, all test rat orals clothes are thrown and are given excellent Tang and support behind the plain powder all acomia life and death situation (table 2) of dying.
3, test is the 15th day, and all survival rats are all carried out pathological anatomy and macropathology inspection.The result shows that not having discovery supports the relevant naked eyes pathological changes (table 3) of plain powder with excellent Tang.
Table 1 duration of test rat body weight changes
Body weight change=15th day body weight-first day body weight
Table 2 clinical observation result
Clinical symptoms
Number of animals 30 4 Day Day Day Day Day Day Day Day Day Day Day Day Day
mins?hours?2 3 4 5 6 7 8 9 10 11 12 13 14
Male
01008F01-01M N N ?N N N N N N N N N N N N N
01008F01-02M N N ?N N N N N N N N N N N N N
01008F01-03M N N ?N N N N N N N N N N N N N
01008F01-04M N N ?N N N N N N N N N N N N N
01008F01-05M N N ?N N N N N N N N N N N N N
Female
01008F01-06M N N ?N N N N N N N N N N N N N
01008F01-07M N N ?N N N N N N N N N N N N N
01008F01-08M N N ?N N N N N N N N N N N N N
01008F01-09M N N ?N N N N N N N N N N N N N
01008F01-10M N N ?N N N N N N N N N N N N N
N: normal
Table 3: macropathology check result
Number of animals dosage naked eyes pathological changes
The male discovery naked eyes pathological changes relevant with substances
01008F01-01M does not find the naked eyes pathological changes relevant with substances
01008F01-02M does not find the naked eyes pathological changes relevant with substances
01008F01-03M 5000mg/kg does not find the naked eyes pathological changes relevant with substances
01008F01-04M does not find the naked eyes pathological changes relevant with substances
01008F01-05M does not find the naked eyes pathological changes relevant with substances
The female discovery naked eyes pathological changes relevant with substances
01008F01-06M 5000mg/kg does not find the naked eyes pathological changes relevant with substances
01008F01-07M does not find the naked eyes pathological changes relevant with substances
01008F01-08M does not find the naked eyes pathological changes relevant with substances
01008F01-09M does not find the naked eyes pathological changes relevant with substances
01008F01-10M does not find the naked eyes pathological changes relevant with substances
Sum up:
This test is thrown the foster plain powder of excellent Tang and is given Sprague-Dawley strain rat with the oral pipe mode of feeding, throwing and giving dosage is the 5000mg/kg body weight.Result of the test shows that all test rats all survive to off-test after the foster plain powder of excellent Tang is given in throwing.Duration of test, all rats all can normally increase weight.In addition, dissection and macropathology check result show that not having any and excellent Tang of discovery supports the relevant naked eyes pathological changes of plain powder.Therefore this test result is pointed out under this EXPERIMENTAL DESIGN condition excellent Tang to support the oral half lethal dose of rat of plain powder (median lethal dose is LD50) greater than 5000mg/kg.
Confirm further that through experiment the compositions of embodiment of the invention 2-7 is under similar experiment condition, the oral median lethal dose(LD 50) of rat is supported plain powder group with excellent Tang and is had similar experimental result all greater than 5000mg/kg.
Embodiment
Adopt concrete embodiment that the present invention is further described below, but not as limitation of the present invention.
Embodiment 1
List of ingredients
Composition weight (g) composition weight (g)
Semen Tritici aestivi 60 Rhizoma amorphophallis 2
Herba bromi japonici 5 green tea 1
Radix Et Rhizoma Fagopyri Tatarici 5 Fructus Lyciis 0.5
Rhizoma Dioscoreae 5 Tremella 0.5
Radix Puerariae 5 Semen Ginkgoes 0.5
Semen Coicis 5 Bulbus Liliies 0.5
Semen Euryales 5 Rhizoma Polygonati Odorati 0.5
Fructus Cucurbitae moschatae 2 Stichopus japonicuss 0.5
Poria 2
Take by weighing each raw material by list of ingredients, 80 ℃ dry 3 hours down, mix homogeneously is laggard goes into super micron mill and carries out micronizing, fineness reaches 300 orders, discharging obtains finished product.
Embodiment 2
Composition weight (g) composition weight (g)
Semen Tritici aestivi 80 Rhizoma amorphophallis 1
Herba bromi japonici 3 green tea 0.5
Radix Et Rhizoma Fagopyri Tatarici 3 Fructus Lyciis 0.3
Rhizoma Dioscoreae 3 Tremella 0.3
Radix Puerariae 2 Semen Ginkgoes 0.3
Semen Coicis 2 Bulbus Liliies 0.2
Semen Euryales 2 Rhizoma Polygonati Odorati 0.2
Poria 1 Stichopus japonicus 0.2
Fructus Cucurbitae moschatae 1
Take by weighing each raw material by list of ingredients, 80 ℃ dry 10 hours down, mix homogeneously is laggard goes into super micron mill and carries out micronizing, fineness reaches 200, discharging obtains finished product.
Embodiment 3
Composition weight (g) composition weight (g)
Semen Tritici aestivi 70 Rhizoma amorphophallis 1.5
Herba bromi japonici 4 green tea 0.75
Radix Et Rhizoma Fagopyri Tatarici 4 Fructus Lyciis 0.4
Rhizoma Dioscoreae 4 Tremella 0.4
Radix Puerariae 3.5 Semen Ginkgoes 0.4
Semen Coicis 3.5 Bulbus Liliies 0.35
Semen Euryales 3.5 Rhizoma Polygonati Odorati 0.35
Fructus Cucurbitae moschatae 1.5 Stichopus japonicuss 0.35
Poria 1.5
Take by weighing each raw material by list of ingredients, 90 ℃ dry 2 hours down, mix homogeneously is laggard goes into super micron mill and carries out micronizing, fineness reaches 200 orders, discharging obtains finished product.
Embodiment 4
Composition weight (g) composition weight (g)
Semen Tritici aestivi 50 Rhizoma amorphophallis 5
Herba bromi japonici 10 green tea 2
Radix Et Rhizoma Fagopyri Tatarici 10 Fructus Lyciis 2
Rhizoma Dioscoreae 10 Tremella 2
Radix Puerariae 10 Semen Ginkgoes 2
Semen Coicis 10 Bulbus Liliies 2
Semen Euryales 10 Rhizoma Polygonati Odorati 2
Fructus Cucurbitae moschatae 5 Stichopus japonicuss 2
Poria 5
Take by weighing each raw material by list of ingredients, 80 ℃ dry 6 hours down, mix homogeneously is laggard goes into super micron mill and carries out micronizing, fineness reaches 150 orders, discharging obtains finished product.
Embodiment 5
Composition weight (g) composition weight (g)
Semen Tritici aestivi 90 Rhizoma amorphophallis 0.1
Herba bromi japonici 1 green tea 0.1
Radix Et Rhizoma Fagopyri Tatarici 1 Fructus Lycii 0.1
Rhizoma Dioscoreae 1 Tremella 0.1
Radix Puerariae 1 Semen Ginkgo 0.1
Semen Coicis 1 Bulbus Lilii 0.1
Semen Euryales 1 Rhizoma Polygonati Odorati 0.1
Fructus Cucurbitae moschatae 0.1 Stichopus japonicus 0.1
Poria 0.1
Take by weighing each raw material by list of ingredients, 100 ℃ dry 2 hours down, mix homogeneously is laggard goes into super micron mill and carries out micronizing, fineness reaches 250 orders, discharging obtains finished product.
Embodiment 6
Composition weight (g) composition weight (g)
Semen Tritici aestivi 90 Semen Coiciss 1
Herba bromi japonici 1 Semen Euryales 1
Radix Et Rhizoma Fagopyri Tatarici 1 Fructus Cucurbitae moschatae 0.1
Rhizoma Dioscoreae 1 Poria 0.1
Radix Puerariae 1 Rhizoma amorphophalli 0.1
Take by weighing each raw material by list of ingredients, 80 ℃ dry 3 hours down, mix homogeneously is laggard goes into super micron mill and carries out micronizing, fineness reaches 300 orders, discharging obtains finished product.
Embodiment 7
Composition weight (g) composition weight (g)
Semen Tritici aestivi 50 Semen Coiciss 10
Herba bromi japonici 10 Semen Euryaless 10
Radix Et Rhizoma Fagopyri Tatarici 10 Fructus Cucurbitae moschataes 5
Rhizoma Dioscoreae 10 Poria 5
Radix Puerariae 10 Rhizoma amorphophallis 5
Take by weighing each raw material by list of ingredients, 95 ℃ dry 4 hours down, mix homogeneously is laggard goes into super micron mill and carries out micronizing, fineness reaches 250 orders, discharging obtains finished product.
Claims (15)
1. compositions that is used to treat with prevent diabetes, it comprises following composition: Semen Tritici aestivi, Herba bromi japonici, Radix Et Rhizoma Fagopyri Tatarici, Rhizoma Dioscoreae, Radix Puerariae, Semen Coicis, Semen Euryales, Fructus Cucurbitae moschatae, Rhizoma amorphophalli and Poria.
2. compositions according to claim 1 also comprises green tea, Fructus Lycii, Tremella, Semen Ginkgo, Bulbus Lilii, Stichopus japonicus and Rhizoma Polygonati Odorati.
3. compositions according to claim 1 is characterized in that described Semen Tritici aestivi, Herba bromi japonici and Radix Et Rhizoma Fagopyri Tatarici select the raw grain of not peeling for use.
4. according to any described compositions of claim 1～3, it is characterized in that described Semen Tritici aestivi selects the strong gluten wheat of National standard for use.
5. compositions according to claim 1, the weight portion of said each composition is following: 0.1～5 part in 50～90 parts of Semen Tritici aestivis, 1～10 part of Herba bromi japonici, 1～10 part of Radix Et Rhizoma Fagopyri Tatarici, 1～10 part of Rhizoma Dioscoreae, 1～10 part of Radix Puerariae, 1～10 part of Semen Coicis, 1～10 part of Semen Euryales, 0.1～5 part in Fructus Cucurbitae moschatae, 0.1～5 part of Rhizoma amorphophalli and Poria.
6. compositions according to claim 5, the weight portion of said each composition is following: 1～2 part in 60～80 parts of Semen Tritici aestivis, 3～5 parts of Herba bromi japonicis, 3～5 parts of Radix Et Rhizoma Fagopyri Tataricis, 3～5 parts of Rhizoma Dioscoreaes, 2～5 parts of Radix Puerariaes, 2～5 parts of Semen Coiciss, 2～5 parts of Semen Euryaless, 1～2 part in Fructus Cucurbitae moschatae, 1～2 part of Rhizoma amorphophalli and Poria.
7. according to claim 2 or 3 described compositionss, the weight portion of said each composition is following: 0.1～2 part of 50～90 parts of Semen Tritici aestivis, 1～10 part of Herba bromi japonici, 1～10 part of Radix Et Rhizoma Fagopyri Tatarici, 1～10 part of Rhizoma Dioscoreae, 1～10 part of Radix Puerariae, 1～10 part of Semen Coicis, 1～10 part of Semen Euryales, 0.1～5 part in Fructus Cucurbitae moschatae, 0.1～5 part of Rhizoma amorphophalli, 0.1～5 part in Poria, 0.1～2 part of green tea, 0.1～2 part of Fructus Lycii, 0.1～2 part in Tremella, 0.1～2 part of Semen Ginkgo, 0.1～2 part of Bulbus Lilii, 0.1～2 part of Stichopus japonicus and Rhizoma Polygonati Odorati.
8. compositions according to claim 4, the weight portion of said each composition is following: 0.1～2 part of 50～90 parts of Semen Tritici aestivis, 1～10 part of Herba bromi japonici, 1～10 part of Radix Et Rhizoma Fagopyri Tatarici, 1～10 part of Rhizoma Dioscoreae, 1～10 part of Radix Puerariae, 1～10 part of Semen Coicis, 1～10 part of Semen Euryales, 0.1～5 part in Fructus Cucurbitae moschatae, 0.1～5 part of Rhizoma amorphophalli, 0.1～5 part in Poria, 0.1～2 part of green tea, 0.1～2 part of Fructus Lycii, 0.1～2 part in Tremella, 0.1～2 part of Semen Ginkgo, 0.1～2 part of Bulbus Lilii, 0.1～2 part of Stichopus japonicus and Rhizoma Polygonati Odorati.
9. compositions according to claim 7, the weight portion of said each composition is following: 0.2～0.5 part of 60～80 parts of Semen Tritici aestivis, 3～5 parts of Herba bromi japonicis, 3～5 parts of Radix Et Rhizoma Fagopyri Tataricis, 3～5 parts of Rhizoma Dioscoreaes, 2～5 parts of Radix Puerariaes, 2～5 parts of Semen Coiciss, 2～5 parts of Semen Euryaless, 1～2 part in Fructus Cucurbitae moschatae, 1～2 part of Rhizoma amorphophalli, 1～2 part in Poria, 0.5～1 part of green tea, 0.3～0.5 part of Fructus Lycii, 0.3～0.5 part in Tremella, 0.3～0.5 part of Semen Ginkgo, 0.2～0.5 part of Bulbus Lilii, 0.2～0.5 part of Stichopus japonicus and Rhizoma Polygonati Odorati.
10. compositions according to claim 8, the weight portion of said each composition is following: 0.2～0.5 part of 60～80 parts of Semen Tritici aestivis, 3～5 parts of Herba bromi japonicis, 3～5 parts of Radix Et Rhizoma Fagopyri Tataricis, 3～5 parts of Rhizoma Dioscoreaes, 2～5 parts of Radix Puerariaes, 2～5 parts of Semen Coiciss, 2～5 parts of Semen Euryaless, 1～2 part in Fructus Cucurbitae moschatae, 1～2 part of Rhizoma amorphophalli, 1～2 part in Poria, 0.5～1 part of green tea, 0.3～0.5 part of Fructus Lycii, 0.3～0.5 part in Tremella, 0.3～0.5 part of Semen Ginkgo, 0.2～0.5 part of Bulbus Lilii, 0.2～0.5 part of Stichopus japonicus and Rhizoma Polygonati Odorati.
11. one kind is used for preparing any described method for compositions of claim 1～10, it comprises the steps: to mix in proportion after whole raw material drying sterilizations, pulverizes promptly to get.
12. method according to claim 11 is characterized in that, described pulverizing be adopt superfine grinding method with raw material pulverizing to fineness less than 150 orders.
13. a food that is used for treatment of diabetes, prevention and auxiliary treatment is characterized in that it contains any described compositions among the claim 1-10.
14. food according to claim 13 is steamed bread, fine dried noodles, medicated porridge, cake, instant nourishing powder or instant food.
15. be used for the medicine or the Application in Food of treatment of diabetes, prevention and auxiliary treatment in preparation according to any described compositions or claim 13 or 14 described food in the claim 1～10.
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Inventor after: Ma Fang Inventor after: Liu Qiusheng Inventor after: Yang Xiaoqiang Inventor after: Liu Lei Inventor after: Liu Jingheng Inventor before: The inventor has waived the right to be mentioned |
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Owner name: BY-HEALTH CO., LTD. Free format text: FORMER OWNER: BEIJING SINANCON BIOTECHNOLOGY CO., LTD. Effective date: 20150113 |
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Effective date of registration: 20150113 Address after: 519040 Guangdong province Zhuhai Sanzao Science and Technology Industrial Park Road No. 19 stars Patentee after: By-Health Co., Ltd. Address before: 102208, Beijing, Changping District Huilongguan West Street, 118 dragon Crown Building, block A, 411 Patentee before: Beijing Sinancon Biotechnology Co.,Ltd. |