CN103314296A - 用于检测针对靶抗体的中和抗体的双功能体外靶结合测定 - Google Patents

用于检测针对靶抗体的中和抗体的双功能体外靶结合测定 Download PDF

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Publication number
CN103314296A
CN103314296A CN2011800490310A CN201180049031A CN103314296A CN 103314296 A CN103314296 A CN 103314296A CN 2011800490310 A CN2011800490310 A CN 2011800490310A CN 201180049031 A CN201180049031 A CN 201180049031A CN 103314296 A CN103314296 A CN 103314296A
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CN
China
Prior art keywords
antibody
mark
target
polyhistidine
specificity
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Pending
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CN2011800490310A
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English (en)
Chinese (zh)
Inventor
X.C.陈
F.奇沃利
S.古普塔
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Amgen Inc
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Amgen Inc
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CN103314296A publication Critical patent/CN103314296A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
CN2011800490310A 2010-08-10 2011-08-10 用于检测针对靶抗体的中和抗体的双功能体外靶结合测定 Pending CN103314296A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37243210P 2010-08-10 2010-08-10
US61/372432 2010-08-10
PCT/US2011/047289 WO2012021648A1 (en) 2010-08-10 2011-08-10 Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies

Publications (1)

Publication Number Publication Date
CN103314296A true CN103314296A (zh) 2013-09-18

Family

ID=44630491

Family Applications (1)

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CN2011800490310A Pending CN103314296A (zh) 2010-08-10 2011-08-10 用于检测针对靶抗体的中和抗体的双功能体外靶结合测定

Country Status (12)

Country Link
US (1) US20140072983A1 (ja)
EP (1) EP2603794A1 (ja)
JP (1) JP2013535692A (ja)
KR (1) KR20130097747A (ja)
CN (1) CN103314296A (ja)
AU (1) AU2011289426A1 (ja)
CA (1) CA2807673A1 (ja)
CL (1) CL2013000411A1 (ja)
EA (1) EA201370030A1 (ja)
MX (1) MX2013001632A (ja)
SG (1) SG187787A1 (ja)
WO (1) WO2012021648A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104459108A (zh) * 2014-11-19 2015-03-25 天津大学 一种多肽分子定向固定抗体的免疫检测材料及其制备方法
CN110088625A (zh) * 2016-12-21 2019-08-02 豪夫迈·罗氏有限公司 用于确定抗体或配体结合和功能的测定法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201602979RA (en) * 2013-10-17 2016-05-30 Univ Singapore Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors
US10144770B2 (en) * 2013-10-17 2018-12-04 National University Of Singapore Chimeric receptors and uses thereof in immune therapy
CN108562573B (zh) * 2018-04-20 2020-01-03 青岛大学 一种基于二碳化三钛二维金属碳化物催化鲁米诺电化学发光探针的生物传感器及制备方法
US20220283185A1 (en) * 2019-08-27 2022-09-08 University Of Southern California Assays for detecting and quantifying a biomarker of pericyte injury

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104459108A (zh) * 2014-11-19 2015-03-25 天津大学 一种多肽分子定向固定抗体的免疫检测材料及其制备方法
CN110088625A (zh) * 2016-12-21 2019-08-02 豪夫迈·罗氏有限公司 用于确定抗体或配体结合和功能的测定法
CN110088625B (zh) * 2016-12-21 2023-11-03 豪夫迈·罗氏有限公司 用于确定抗体或配体结合和功能的测定法

Also Published As

Publication number Publication date
WO2012021648A1 (en) 2012-02-16
US20140072983A1 (en) 2014-03-13
SG187787A1 (en) 2013-03-28
EA201370030A1 (ru) 2013-06-28
EP2603794A1 (en) 2013-06-19
JP2013535692A (ja) 2013-09-12
KR20130097747A (ko) 2013-09-03
CL2013000411A1 (es) 2013-11-08
CA2807673A1 (en) 2012-02-16
MX2013001632A (es) 2013-06-05
AU2011289426A1 (en) 2013-02-28

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Application publication date: 20130918