CN103293262A - 一种利用离子色谱法检测叔丁基肼盐酸盐的方法 - Google Patents
一种利用离子色谱法检测叔丁基肼盐酸盐的方法 Download PDFInfo
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- CN103293262A CN103293262A CN2013101814426A CN201310181442A CN103293262A CN 103293262 A CN103293262 A CN 103293262A CN 2013101814426 A CN2013101814426 A CN 2013101814426A CN 201310181442 A CN201310181442 A CN 201310181442A CN 103293262 A CN103293262 A CN 103293262A
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- butyl group
- salt hydrochlorate
- hydrazonium salt
- ion chromatography
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- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000004255 ion exchange chromatography Methods 0.000 title claims abstract description 20
- DDPWVABNMBRBFI-UHFFFAOYSA-N tert-butylhydrazine;hydron;chloride Chemical compound Cl.CC(C)(C)NN DDPWVABNMBRBFI-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004458 analytical method Methods 0.000 claims abstract description 18
- 238000010812 external standard method Methods 0.000 claims abstract description 9
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 87
- 150000003839 salts Chemical class 0.000 claims description 75
- 239000000523 sample Substances 0.000 claims description 61
- 150000002500 ions Chemical class 0.000 claims description 30
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 claims description 18
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 13
- 125000002091 cationic group Chemical group 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 10
- 239000012086 standard solution Substances 0.000 claims description 7
- 238000001724 coherent Stokes Raman spectroscopy Methods 0.000 claims description 6
- 239000012488 sample solution Substances 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 238000012113 quantitative test Methods 0.000 claims description 5
- 238000005277 cation exchange chromatography Methods 0.000 claims description 4
- 238000004364 calculation method Methods 0.000 claims description 2
- -1 Dionex ion Chemical class 0.000 abstract description 7
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 20
- 239000012452 mother liquor Substances 0.000 description 16
- 239000012085 test solution Substances 0.000 description 15
- 238000004587 chromatography analysis Methods 0.000 description 9
- 229910021642 ultra pure water Inorganic materials 0.000 description 8
- 239000012498 ultrapure water Substances 0.000 description 8
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 3
- 238000001212 derivatisation Methods 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 238000002203 pretreatment Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 239000005917 Methoxyfenozide Substances 0.000 description 2
- 208000002474 Tinea Diseases 0.000 description 2
- 241000893966 Trichophyton verrucosum Species 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- QCAWEPFNJXQPAN-UHFFFAOYSA-N methoxyfenozide Chemical compound COC1=CC=CC(C(=O)NN(C(=O)C=2C=C(C)C=C(C)C=2)C(C)(C)C)=C1C QCAWEPFNJXQPAN-UHFFFAOYSA-N 0.000 description 2
- 239000010413 mother solution Substances 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 101710082795 30S ribosomal protein S17, chloroplastic Proteins 0.000 description 1
- 239000005887 Chromafenozide Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000005663 Pyridaben Substances 0.000 description 1
- 239000005937 Tebufenozide Substances 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WARCRYXKINZHGQ-UHFFFAOYSA-N benzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1 WARCRYXKINZHGQ-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- HPNSNYBUADCFDR-UHFFFAOYSA-N chromafenozide Chemical compound CC1=CC(C)=CC(C(=O)N(NC(=O)C=2C(=C3CCCOC3=CC=2)C)C(C)(C)C)=C1 HPNSNYBUADCFDR-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- CNKHSLKYRMDDNQ-UHFFFAOYSA-N halofenozide Chemical compound C=1C=CC=CC=1C(=O)N(C(C)(C)C)NC(=O)C1=CC=C(Cl)C=C1 CNKHSLKYRMDDNQ-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- DWFZBUWUXWZWKD-UHFFFAOYSA-N pyridaben Chemical compound C1=CC(C(C)(C)C)=CC=C1CSC1=C(Cl)C(=O)N(C(C)(C)C)N=C1 DWFZBUWUXWZWKD-UHFFFAOYSA-N 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- QYPNKSZPJQQLRK-UHFFFAOYSA-N tebufenozide Chemical compound C1=CC(CC)=CC=C1C(=O)NN(C(C)(C)C)C(=O)C1=CC(C)=CC(C)=C1 QYPNKSZPJQQLRK-UHFFFAOYSA-N 0.000 description 1
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CN201310181442.6A CN103293262B (zh) | 2013-05-16 | 2013-05-16 | 一种利用离子色谱法检测叔丁基肼盐酸盐的方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104820056A (zh) * | 2015-05-14 | 2015-08-05 | 吉林化工学院 | 一种柱前衍生化-高效液相色谱法测定叔丁基肼盐酸盐的方法 |
CN109682921A (zh) * | 2019-01-15 | 2019-04-26 | 通化东宝药业股份有限公司 | 一种游离肼的检测方法及其在磷酸西格列汀原料药杂质检测中的应用 |
CN111426762A (zh) * | 2020-03-31 | 2020-07-17 | 湖北航天化学技术研究所 | 一氨基胍硝酸盐和二氨基胍硝酸盐含量的测定方法 |
CN111579707A (zh) * | 2020-05-29 | 2020-08-25 | 山东省分析测试中心 | 一种检测阳离子醚化剂中三甲胺盐酸盐的方法及应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1271727A (zh) * | 2000-04-14 | 2000-11-01 | 南开大学 | 双硫酰肼类化合物及其应用 |
WO2012036997A1 (en) * | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
-
2013
- 2013-05-16 CN CN201310181442.6A patent/CN103293262B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1271727A (zh) * | 2000-04-14 | 2000-11-01 | 南开大学 | 双硫酰肼类化合物及其应用 |
WO2012036997A1 (en) * | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
Non-Patent Citations (2)
Title |
---|
ALEXANDER D.SMOLENKOV: "Direct liquid chromatographic determination of hydrazines:A review", 《TALANTA》 * |
李荣坡 等: "抑食肼的合成工艺研究", 《上海化工》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104820056A (zh) * | 2015-05-14 | 2015-08-05 | 吉林化工学院 | 一种柱前衍生化-高效液相色谱法测定叔丁基肼盐酸盐的方法 |
CN109682921A (zh) * | 2019-01-15 | 2019-04-26 | 通化东宝药业股份有限公司 | 一种游离肼的检测方法及其在磷酸西格列汀原料药杂质检测中的应用 |
CN111426762A (zh) * | 2020-03-31 | 2020-07-17 | 湖北航天化学技术研究所 | 一氨基胍硝酸盐和二氨基胍硝酸盐含量的测定方法 |
CN111426762B (zh) * | 2020-03-31 | 2022-04-12 | 湖北航天化学技术研究所 | 一氨基胍硝酸盐和二氨基胍硝酸盐含量的测定方法 |
CN111579707A (zh) * | 2020-05-29 | 2020-08-25 | 山东省分析测试中心 | 一种检测阳离子醚化剂中三甲胺盐酸盐的方法及应用 |
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