CN103254183A - 阿法替尼的制备方法 - Google Patents
阿法替尼的制备方法 Download PDFInfo
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- CN103254183A CN103254183A CN2013101735049A CN201310173504A CN103254183A CN 103254183 A CN103254183 A CN 103254183A CN 2013101735049 A CN2013101735049 A CN 2013101735049A CN 201310173504 A CN201310173504 A CN 201310173504A CN 103254183 A CN103254183 A CN 103254183A
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Application Number | Priority Date | Filing Date | Title |
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CN201310173504.9A CN103254183B (zh) | 2013-05-10 | 2013-05-10 | 阿法替尼的制备方法 |
PCT/CN2014/076536 WO2014180271A1 (zh) | 2013-05-10 | 2014-04-30 | 阿法替尼及其中间体的制备方法 |
US14/957,607 US9845315B2 (en) | 2013-05-10 | 2015-12-03 | Method for preparing Afatinib and intermediate thereof |
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CN201310173504.9A CN103254183B (zh) | 2013-05-10 | 2013-05-10 | 阿法替尼的制备方法 |
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CN103254183A true CN103254183A (zh) | 2013-08-21 |
CN103254183B CN103254183B (zh) | 2015-11-11 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103755688A (zh) * | 2013-12-24 | 2014-04-30 | 江苏奥赛康药业股份有限公司 | 一种阿法替尼化合物的制备方法 |
WO2014180271A1 (zh) * | 2013-05-10 | 2014-11-13 | 苏州明锐医药科技有限公司 | 阿法替尼及其中间体的制备方法 |
CN104478863A (zh) * | 2014-12-23 | 2015-04-01 | 康伯莱(天津)药物研发有限责任公司 | 一种阿法替尼的制备方法 |
WO2016185485A3 (en) * | 2015-05-18 | 2017-01-19 | Msn Laboratories Private Limited | Process for the preparation of n-[4-[(3-chloro-4-fluoro phenyl) amino]-7-[[(3s)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4- (dimethyl amino)-(2e)-2-butenamide (2z)-2-butenedioate (1 :2) and its polymorphs thereof |
Citations (4)
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WO2003094921A2 (de) * | 2002-05-11 | 2003-11-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von hemmern der egfr-vermittelten signaltransduktion zur behandlung von gutartiger prostatahyperplasie (bph)/prostatahypertrophie |
CN1481370A (zh) * | 2000-12-20 | 2004-03-10 | ���ָ��Ӣ��ķ�������Ϲ�˾ | 喹唑啉衍生物,含该化合物的药物组合物,其用途及其制备方法 |
WO2007085638A1 (en) * | 2006-01-26 | 2007-08-02 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
WO2012122058A2 (en) * | 2011-03-04 | 2012-09-13 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compound and methods of use |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1481370A (zh) * | 2000-12-20 | 2004-03-10 | ���ָ��Ӣ��ķ�������Ϲ�˾ | 喹唑啉衍生物,含该化合物的药物组合物,其用途及其制备方法 |
WO2003094921A2 (de) * | 2002-05-11 | 2003-11-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von hemmern der egfr-vermittelten signaltransduktion zur behandlung von gutartiger prostatahyperplasie (bph)/prostatahypertrophie |
WO2007085638A1 (en) * | 2006-01-26 | 2007-08-02 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
WO2012122058A2 (en) * | 2011-03-04 | 2012-09-13 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compound and methods of use |
Non-Patent Citations (2)
Title |
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CATERINA CARMI,等: "Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 55, no. 5, 26 February 2012 (2012-02-26), pages 2251 - 2264 * |
季兴,等: "拉帕替尼的合成", 《中国医药工业杂志》, vol. 40, no. 11, 10 November 2009 (2009-11-10), pages 801 - 804 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014180271A1 (zh) * | 2013-05-10 | 2014-11-13 | 苏州明锐医药科技有限公司 | 阿法替尼及其中间体的制备方法 |
CN103755688A (zh) * | 2013-12-24 | 2014-04-30 | 江苏奥赛康药业股份有限公司 | 一种阿法替尼化合物的制备方法 |
CN103755688B (zh) * | 2013-12-24 | 2015-11-18 | 江苏奥赛康药业股份有限公司 | 一种阿法替尼化合物的制备方法 |
CN104478863A (zh) * | 2014-12-23 | 2015-04-01 | 康伯莱(天津)药物研发有限责任公司 | 一种阿法替尼的制备方法 |
WO2016185485A3 (en) * | 2015-05-18 | 2017-01-19 | Msn Laboratories Private Limited | Process for the preparation of n-[4-[(3-chloro-4-fluoro phenyl) amino]-7-[[(3s)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4- (dimethyl amino)-(2e)-2-butenamide (2z)-2-butenedioate (1 :2) and its polymorphs thereof |
US10550107B2 (en) | 2015-05-18 | 2020-02-04 | Msn Laboratories Private Limited | Process for the preparation of N-[4-[(3-chloro-4-fluoro phenyl) amino]-7-[[(3s-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) and its polymorphs thereof |
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Effective date of registration: 20200513 Address after: 210000 Qinhuai Avenue 288, Yongyang Street, Lishui District, Nanjing City, Jiangsu Province Patentee after: Nanjing xunyin Seismic Technology Co., Ltd Address before: 215000 Jiangsu Province, Suzhou City Industrial Park Commercial Plaza Building 1 room 1305 Lianfeng Co-patentee before: Xu Xuenong Patentee before: SUZHOU MIRACPHARMA TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20200923 Address after: 244000 Huayuan Road, Tongling, Anhui, No. 192 on the first floor Patentee after: Tongling Shangdong hi tech Innovation Co., Ltd Address before: 210000 Qinhuai Avenue 288, Yongyang Street, Lishui District, Nanjing City, Jiangsu Province Patentee before: Nanjing xunyin Seismic Technology Co.,Ltd. |