CN103154742B - 用于鉴定高风险冠状动脉疾病患者的脂质组学标志 - Google Patents

用于鉴定高风险冠状动脉疾病患者的脂质组学标志 Download PDF

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CN103154742B
CN103154742B CN201180035877.9A CN201180035877A CN103154742B CN 103154742 B CN103154742 B CN 103154742B CN 201180035877 A CN201180035877 A CN 201180035877A CN 103154742 B CN103154742 B CN 103154742B
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lipid
total
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apolipoprotein
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CN103154742A (zh
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R·拉克松恩
K·埃克罗斯
R·霍尔姆
M·詹尼斯
R·卡塔恩
K·塔拉索夫
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Zora Biosciences Oy
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • G01N2405/06—Glycophospholipids, e.g. phosphatidyl inositol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180035877.9A 2010-06-20 2011-06-20 用于鉴定高风险冠状动脉疾病患者的脂质组学标志 Active CN103154742B (zh)

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EP10006399.9 2010-06-20
EP10006399 2010-06-20
US35667510P 2010-06-21 2010-06-21
US61/356,675 2010-06-21
PCT/EP2011/060253 WO2011161062A2 (en) 2010-06-20 2011-06-20 Lipidomic biomarkers for identification of high-risk coronary artery disease patients

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CN201711362402.6A Active CN108445241B (zh) 2010-06-20 2011-06-20 用于鉴定高风险冠状动脉疾病患者的脂质组学标志

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US (5) US9201080B2 (https=)
EP (2) EP3293522A3 (https=)
JP (2) JP6262529B2 (https=)
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EP2592423A1 (en) 2011-11-08 2013-05-15 Zora Biosciences OY Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment
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CN104063570B (zh) * 2013-03-20 2017-06-16 中国科学院大连化学物理研究所 一种脂质代谢网络动态研究的方法
KR101594515B1 (ko) * 2013-12-24 2016-02-16 연세대학교 산학협력단 혈장 대사체를 이용한 제2형 당뇨병 진단 키트
CN106457090B (zh) 2014-04-10 2020-09-29 Mep马解决方案有限责任公司 粪便中寄生虫卵的定量方法
US9347960B2 (en) * 2014-06-16 2016-05-24 Zora Biosciences, Oy Ceramides and their use in diagnosing CVD
CN108027354B (zh) * 2015-08-20 2021-01-08 深圳华大生命科学研究院 冠心病的生物标志物
US10184932B2 (en) 2015-12-07 2019-01-22 Zora Biosciences Oy Use of ceramides and LPLs in diagnosing CVD
CN105424841B (zh) * 2015-12-25 2017-11-03 齐炼文 用于诊断冠状动脉粥样硬化的代谢标志物
CN105486773A (zh) * 2015-12-25 2016-04-13 齐炼文 用于诊断冠心病的代谢标志物
CN105628809B (zh) * 2015-12-25 2018-04-03 中国药科大学 用于诊断区分冠状动脉粥样硬化和冠心病的代谢标志物
CN105445408B (zh) * 2016-01-25 2018-06-12 齐炼文 诊断区分冠状动脉粥样硬化和稳定型心绞痛的代谢标志物
CN109870536B (zh) * 2017-12-05 2021-08-10 中国科学院大连化学物理研究所 一种基于液相色谱-质谱联用的高覆盖脂质组学分析方法
CN108037275A (zh) * 2017-12-14 2018-05-15 北京豪思生物科技有限公司 一种用于评估冠状动脉疾病的试剂盒
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US20240003921A1 (en) * 2020-10-16 2024-01-04 Indian Institute Of Science A lipid based indicator for cardiovascular disorder
CN112305124B (zh) * 2020-10-30 2022-03-04 河北医科大学第二医院 一种生物标志物及其在疾病诊断中的应用
CN112147344B (zh) * 2020-10-30 2021-07-13 河北医科大学第二医院 动脉粥样硬化性脑梗死的代谢标志物及其在诊疗中的应用
CN112305119B (zh) * 2020-10-30 2021-08-17 河北医科大学第二医院 动脉粥样硬化性脑梗死的生物标志物及其应用
EP4043884A1 (en) * 2021-02-10 2022-08-17 Eberhard-Karls-Universität Tübingen Medium-chain fatty acyls and phospholipids as biomarkers for cardiovascular diseases
CN113533754A (zh) * 2021-07-12 2021-10-22 北京市心肺血管疾病研究所 神经酰胺在制备用于评估高血压患者发生不良事件风险的试剂盒中的应用
CN114791459B (zh) * 2022-03-29 2023-02-14 浙江苏可安药业有限公司 用于检测肺结核的血清代谢标志物及其试剂盒
CN117589897A (zh) * 2023-11-09 2024-02-23 首都医科大学附属北京朝阳医院 冠心病血清学预警生物标志物、检测试剂及试剂盒

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CA2801459C (en) 2018-04-24
US20180067138A1 (en) 2018-03-08
WO2011161062A3 (en) 2012-06-28
US12270816B2 (en) 2025-04-08
US20130216560A1 (en) 2013-08-22
US9841431B2 (en) 2017-12-12
US10955427B2 (en) 2021-03-23
US10261101B2 (en) 2019-04-16
EP3293522A2 (en) 2018-03-14
EP2583107A2 (en) 2013-04-24
US20200003794A1 (en) 2020-01-02
US9201080B2 (en) 2015-12-01
WO2011161062A2 (en) 2011-12-29
CN103154742A (zh) 2013-06-12
EP3293522A3 (en) 2018-05-02
JP6262529B2 (ja) 2018-01-17
CN108445241B (zh) 2021-11-02
US20210239719A1 (en) 2021-08-05
CN108445241A (zh) 2018-08-24
JP2017129592A (ja) 2017-07-27
JP2013531238A (ja) 2013-08-01
JP6605521B2 (ja) 2019-11-13
US20160025751A1 (en) 2016-01-28
CA2801459A1 (en) 2011-12-29

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