CN103153300A - 杂芳基化合物和其用途 - Google Patents
杂芳基化合物和其用途 Download PDFInfo
- Publication number
- CN103153300A CN103153300A CN2011800492087A CN201180049208A CN103153300A CN 103153300 A CN103153300 A CN 103153300A CN 2011800492087 A CN2011800492087 A CN 2011800492087A CN 201180049208 A CN201180049208 A CN 201180049208A CN 103153300 A CN103153300 A CN 103153300A
- Authority
- CN
- China
- Prior art keywords
- group
- membered
- nitrogen
- sulfur
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C1C2C=C*C12 Chemical compound C1C2C=C*C12 0.000 description 38
- YKHHVRCRJHPQCE-UHFFFAOYSA-N NC(c1c(Nc2nc(CN3CCOCC3)ccc2)[s]c(-c2ccnc(N3CCNCC3)c2)c1)=O Chemical compound NC(c1c(Nc2nc(CN3CCOCC3)ccc2)[s]c(-c2ccnc(N3CCNCC3)c2)c1)=O YKHHVRCRJHPQCE-UHFFFAOYSA-N 0.000 description 3
- ZUOCPGVWHCZSTJ-UHFFFAOYSA-N C/C=[O]/C(c1c(Cc(cc2)cc(Cl)c2Cl)nc(N2CCOCC2)[s]1)=O Chemical compound C/C=[O]/C(c1c(Cc(cc2)cc(Cl)c2Cl)nc(N2CCOCC2)[s]1)=O ZUOCPGVWHCZSTJ-UHFFFAOYSA-N 0.000 description 1
- KWKBJBKDZGMUQU-UHFFFAOYSA-N CC(Nc1nccc(-c2nc(Cc3cc(cccc4)c4cc3)c(C(O)=O)[s]2)c1)=O Chemical compound CC(Nc1nccc(-c2nc(Cc3cc(cccc4)c4cc3)c(C(O)=O)[s]2)c1)=O KWKBJBKDZGMUQU-UHFFFAOYSA-N 0.000 description 1
- GJXGSHVNQRFCGM-UHFFFAOYSA-N CC(c1c(Nc2cccc(CN3CCOCC3)n2)[s]c(-c2ccncc2)c1)=O Chemical compound CC(c1c(Nc2cccc(CN3CCOCC3)n2)[s]c(-c2ccncc2)c1)=O GJXGSHVNQRFCGM-UHFFFAOYSA-N 0.000 description 1
- SOLAXWLZSNEHEW-UHFFFAOYSA-N CC1(CN2CCOCC2)NC(Nc([s]c(-c2ccncc2)c2)c2C(N)=O)=CC=C1 Chemical compound CC1(CN2CCOCC2)NC(Nc([s]c(-c2ccncc2)c2)c2C(N)=O)=CC=C1 SOLAXWLZSNEHEW-UHFFFAOYSA-N 0.000 description 1
- SIZOQCVNAJBQQO-JAIQZWGSSA-N CCN(CCOC)c1nc(Cc(cc2)cc(Cl)c2Cl)c(/C=N\C)[s]1 Chemical compound CCN(CCOC)c1nc(Cc(cc2)cc(Cl)c2Cl)c(/C=N\C)[s]1 SIZOQCVNAJBQQO-JAIQZWGSSA-N 0.000 description 1
- WJCNBZGTWRRQMB-UHFFFAOYSA-N CCOC(c1c(Cc(cc2)ccc2Cl)nc(-c2ccncc2)[s]1)=O Chemical compound CCOC(c1c(Cc(cc2)ccc2Cl)nc(-c2ccncc2)[s]1)=O WJCNBZGTWRRQMB-UHFFFAOYSA-N 0.000 description 1
- SRZBHUBTUHPBDP-UHFFFAOYSA-N CCc1cnn[nH]1 Chemical compound CCc1cnn[nH]1 SRZBHUBTUHPBDP-UHFFFAOYSA-N 0.000 description 1
- URNMXNVOLWQODN-UHFFFAOYSA-N COC(c1c(-c2ccccc2)[s]c(N2CCOCC2)c1C(OC)=O)=O Chemical compound COC(c1c(-c2ccccc2)[s]c(N2CCOCC2)c1C(OC)=O)=O URNMXNVOLWQODN-UHFFFAOYSA-N 0.000 description 1
- OVTQFPYUZUVKBA-UHFFFAOYSA-N COC(c1c(-c2nnc[nH]2)[s]c(-c2ccncc2)c1)c(cc1)ccc1Cl Chemical compound COC(c1c(-c2nnc[nH]2)[s]c(-c2ccncc2)c1)c(cc1)ccc1Cl OVTQFPYUZUVKBA-UHFFFAOYSA-N 0.000 description 1
- LIRLOKQRIUYQTA-UHFFFAOYSA-N COC(c1c(C(c2ccccc2)=O)[s]c(N2CCOCC2)c1C(OC)=O)=O Chemical compound COC(c1c(C(c2ccccc2)=O)[s]c(N2CCOCC2)c1C(OC)=O)=O LIRLOKQRIUYQTA-UHFFFAOYSA-N 0.000 description 1
- KMHLYFVZYMSJIL-UHFFFAOYSA-N COC(c1c(N2CCOCC2)[s]c(N2CCOCC2)c1C(OC)=O)=O Chemical compound COC(c1c(N2CCOCC2)[s]c(N2CCOCC2)c1C(OC)=O)=O KMHLYFVZYMSJIL-UHFFFAOYSA-N 0.000 description 1
- GVSNQMFKEPBIOY-UHFFFAOYSA-N Cc1cnn[nH]1 Chemical compound Cc1cnn[nH]1 GVSNQMFKEPBIOY-UHFFFAOYSA-N 0.000 description 1
- FVMDFYCKIGUQIF-UHFFFAOYSA-N ClC1C(Cl)=CC=C(CC2N=C(N3CCOCC3)SC2Cc2nnn[nH]2)C1 Chemical compound ClC1C(Cl)=CC=C(CC2N=C(N3CCOCC3)SC2Cc2nnn[nH]2)C1 FVMDFYCKIGUQIF-UHFFFAOYSA-N 0.000 description 1
- WPIAFMNBUIVCHE-UHFFFAOYSA-N N#Cc1c(N2CCOCC2)[s]c(C(O)=O)c1-c1c[s]cc1 Chemical compound N#Cc1c(N2CCOCC2)[s]c(C(O)=O)c1-c1c[s]cc1 WPIAFMNBUIVCHE-UHFFFAOYSA-N 0.000 description 1
- YKLGVQWNURXADG-UHFFFAOYSA-N N#Cc1c(N2CCOCC2)[s]c(C(O)=O)c1CN(C=Nc1c2cccc1)C2=O Chemical compound N#Cc1c(N2CCOCC2)[s]c(C(O)=O)c1CN(C=Nc1c2cccc1)C2=O YKLGVQWNURXADG-UHFFFAOYSA-N 0.000 description 1
- RTXBUFWQVLJPNK-UHFFFAOYSA-N NC(c1c(Cc(cc2)ccc2Cl)nc(-c2ccncc2)[s]1)=N Chemical compound NC(c1c(Cc(cc2)ccc2Cl)nc(-c2ccncc2)[s]1)=N RTXBUFWQVLJPNK-UHFFFAOYSA-N 0.000 description 1
- FNWNUKZTPIQCKI-UHFFFAOYSA-N NC(c1c(Nc2cccc(CN3CCOCC3)n2)[s]c(-c2ccncc2)c1)=O Chemical compound NC(c1c(Nc2cccc(CN3CCOCC3)n2)[s]c(-c2ccncc2)c1)=O FNWNUKZTPIQCKI-UHFFFAOYSA-N 0.000 description 1
- SPLQRGONDJIJDF-UHFFFAOYSA-N Nc1nccc(-c2nc(Cc3cc(cccc4)c4cc3)c(C(O)=O)[s]2)c1 Chemical compound Nc1nccc(-c2nc(Cc3cc(cccc4)c4cc3)c(C(O)=O)[s]2)c1 SPLQRGONDJIJDF-UHFFFAOYSA-N 0.000 description 1
- RXTZNEGXSYZJAH-UHFFFAOYSA-N O=C1NC(c2c(Cc(cc3)ccc3Cl)nc(-c3ccncc3)[s]2)=NC=C1 Chemical compound O=C1NC(c2c(Cc(cc3)ccc3Cl)nc(-c3ccncc3)[s]2)=NC=C1 RXTZNEGXSYZJAH-UHFFFAOYSA-N 0.000 description 1
- QMNUDYFKZYBWQX-UHFFFAOYSA-N O=C1NC=Nc2ccccc12 Chemical compound O=C1NC=Nc2ccccc12 QMNUDYFKZYBWQX-UHFFFAOYSA-N 0.000 description 1
- KNBTVYYCIABTLI-UHFFFAOYSA-N OC(c1c(-c2nnc[nH]2)[s]c(-c2ccncc2)c1)c(cc1)ccc1Cl Chemical compound OC(c1c(-c2nnc[nH]2)[s]c(-c2ccncc2)c1)c(cc1)ccc1Cl KNBTVYYCIABTLI-UHFFFAOYSA-N 0.000 description 1
- YUIOPHXTILULQC-UHFFFAOYSA-N OC1SCC(O)SC1 Chemical compound OC1SCC(O)SC1 YUIOPHXTILULQC-UHFFFAOYSA-N 0.000 description 1
- QXIWHJLTDZMJIA-UHFFFAOYSA-N OCc1c(Cc(cc2)cc(Cl)c2Cl)nc(N2CCOCC2)[s]1 Chemical compound OCc1c(Cc(cc2)cc(Cl)c2Cl)nc(N2CCOCC2)[s]1 QXIWHJLTDZMJIA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
- C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
- C07D293/04—Five-membered rings
- C07D293/06—Selenazoles; Hydrogenated selenazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37259410P | 2010-08-11 | 2010-08-11 | |
| US61/372,594 | 2010-08-11 | ||
| US201161438375P | 2011-02-01 | 2011-02-01 | |
| US61/438,375 | 2011-02-01 | ||
| PCT/US2011/047407 WO2012021696A1 (en) | 2010-08-11 | 2011-08-11 | Heteroaryls and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103153300A true CN103153300A (zh) | 2013-06-12 |
Family
ID=45567940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800492087A Pending CN103153300A (zh) | 2010-08-11 | 2011-08-11 | 杂芳基化合物和其用途 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US8796268B2 (enExample) |
| EP (1) | EP2603214A4 (enExample) |
| JP (1) | JP2013536193A (enExample) |
| KR (1) | KR20130098334A (enExample) |
| CN (1) | CN103153300A (enExample) |
| AR (1) | AR082665A1 (enExample) |
| AU (1) | AU2011289377A1 (enExample) |
| BR (1) | BR112013003358A2 (enExample) |
| CA (1) | CA2807971A1 (enExample) |
| CL (1) | CL2013000417A1 (enExample) |
| CO (1) | CO6690755A2 (enExample) |
| CR (1) | CR20130084A (enExample) |
| DO (1) | DOP2013000034A (enExample) |
| EA (1) | EA201390214A1 (enExample) |
| EC (1) | ECSP13012485A (enExample) |
| MA (1) | MA34797B1 (enExample) |
| MX (1) | MX2013001660A (enExample) |
| NZ (1) | NZ607087A (enExample) |
| PE (1) | PE20131304A1 (enExample) |
| PH (1) | PH12013500274A1 (enExample) |
| SG (2) | SG10201506238SA (enExample) |
| TW (1) | TW201217365A (enExample) |
| UY (1) | UY33554A (enExample) |
| WO (1) | WO2012021696A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109810071A (zh) * | 2019-03-28 | 2019-05-28 | 中国科学院成都生物研究所 | 一种miRNA生物合成抑制剂 |
| CN109970703A (zh) * | 2019-05-08 | 2019-07-05 | 玉林师范学院 | 1,3-杂环取代芳香酮的制备方法及应用 |
| WO2022083687A1 (zh) * | 2020-10-21 | 2022-04-28 | 南京明德新药研发有限公司 | 硒杂环类化合物及其应用 |
| WO2023202706A1 (zh) * | 2022-04-21 | 2023-10-26 | 南京明德新药研发有限公司 | 硒杂环类化合物的盐型和晶型及其应用 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009094224A1 (en) | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9139589B2 (en) | 2009-01-30 | 2015-09-22 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| EP2603216A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
| WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| TW201217365A (en) | 2010-08-11 | 2012-05-01 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| UY33671A (es) | 2010-10-13 | 2012-04-30 | Millenium Pharmaceuticals Inc | Heteroarilos y sus usos |
| MX2014000514A (es) | 2011-07-15 | 2014-02-19 | Basf Se | Metodos plaguicidas que utilizan compuestos de 3 - piridil tiazol sustituido y derivados para combatir las plagas de animales i. |
| SG11201406759YA (en) | 2012-04-26 | 2014-11-27 | Bristol Myers Squibb Co | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| BR112014026643B1 (pt) | 2012-04-26 | 2023-03-07 | Universite De Montreal | Derivados de imidazotiadiazol e imidazopirazina como inibidores de receptor 4 ativado por protease (par4) para o tratamento de agregação de plaqueta, seus usos e composição farmacêutica |
| MX2014012741A (es) | 2012-04-26 | 2015-04-13 | Bristol Myers Squibb Co | Derivados de imidazotiadiazol e imidazopirazina como inhibidores del receptor 4 activado de proteasa (par4) para tratamiento de agregacion plaquetaria. |
| US9737521B2 (en) | 2012-11-08 | 2017-08-22 | Rhizen Pharmaceuticals Sa | Pharmaceutical compositions containing a PDE4 inhibitor and a PI3 delta or dual PI3 delta-gamma kinase inhibitor |
| NO2944633T3 (enExample) * | 2012-11-14 | 2018-06-30 | ||
| BR112015015503A2 (pt) | 2012-12-27 | 2017-07-11 | Basf Se | composto substituído, composição veterinária, utilização de um composto, método para o controle de pragas de invertebrados e para o tratamento ou proteção de um animal e material de propagação do vegetal |
| US10202373B2 (en) | 2014-01-14 | 2019-02-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| MX2016009135A (es) | 2014-01-14 | 2016-10-05 | Millennium Pharm Inc | Heteroarilos y usos de estos. |
| AU2020406139A1 (en) | 2019-12-20 | 2022-06-30 | Bayer Aktiengesellschaft | Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof |
| CN119504592B (zh) * | 2024-11-19 | 2025-07-29 | 深圳智微通科技有限公司 | 3-氨基-5-(4-苯氧基苯基)-4-氰基-1h-吡唑的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009094224A1 (en) * | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
| US20100075951A1 (en) * | 2008-06-19 | 2010-03-25 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE581861A (enExample) | 1958-08-20 | |||
| US3852293A (en) | 1972-06-21 | 1974-12-03 | Uniroyal Inc | 4-phenyl-2-(3-pyridyl)-thiazole carboxamides |
| US3821384A (en) | 1972-10-06 | 1974-06-28 | Uniroyal Inc | Pharmaceutical compositions containing a4-aryl-2-(3-pyridyl)thiazole and methods of using same |
| DE3021590A1 (de) | 1980-06-09 | 1981-12-17 | Hoechst Ag, 6000 Frankfurt | 4-halogen-5-(halogenmethyl-phenyl)-oxazol-derivate, ein verfahren zu ihrer herstellung und sie enthaltenden strahlungsempfindliche massen |
| DD275870A1 (de) | 1988-09-27 | 1990-02-07 | Univ Leipzig | Verfahren zur herstellung von in 5-position verschiedenartig substituierten 3-aminothiophen-4-carbonitrilen |
| PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| US6268308B1 (en) | 1996-08-27 | 2001-07-31 | Syngenta Crop Protection, Inc. | Herbicidal S-substituted 1,2,4,6-thiatriazines |
| JPH1087490A (ja) | 1996-09-10 | 1998-04-07 | Sagami Chem Res Center | インターロイキン6生産抑制剤、骨吸収抑制剤、抗骨粗鬆症剤、及びチアゾール化合物 |
| PT853083E (pt) | 1997-01-06 | 2001-12-28 | Pfizer | Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica |
| ES2167882T3 (es) | 1997-04-24 | 2002-05-16 | Dow Agrosciences Llc | 3-(fenil sustituido)-5-(tienil o furil)-1,2,4-triazoles pesticidas. |
| EP1097147A4 (en) | 1998-07-10 | 2001-11-21 | Merck & Co Inc | NEW ANGIOGENESIS INHIBITORS |
| DE19858192A1 (de) | 1998-12-17 | 2000-06-21 | Aventis Cropscience Gmbh | 4-Trifluormethyl-3-oxazolylpyridine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
| CO5170501A1 (es) | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
| EP1251848B1 (en) | 2000-01-18 | 2004-06-23 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US6642227B2 (en) | 2001-04-13 | 2003-11-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases |
| ATE402164T1 (de) | 2001-04-26 | 2008-08-15 | Eisai R&D Man Co Ltd | Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon |
| US7405235B2 (en) | 2001-05-04 | 2008-07-29 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| CN100502863C (zh) | 2001-08-13 | 2009-06-24 | 詹森药业有限公司 | 2,4,5-三取代噻唑衍生物和它们的抗炎活性 |
| DE60228098D1 (de) | 2001-09-05 | 2008-09-18 | Smithkline Beecham Plc | Pyridin-substituierte furanderivate als raf-kinase inhibitoren |
| JP2005532983A (ja) | 2001-09-26 | 2005-11-04 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | C17,20リアーゼ阻害剤としての3‐ピリジルもしくは4‐イソキノリニルチアゾール |
| US20040198773A1 (en) | 2001-09-26 | 2004-10-07 | Barry Hart | Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors |
| AR039555A1 (es) | 2001-11-08 | 2005-02-23 | Upjohn Co | Derivados n,n'-sustituidos de 1,3-diamino-2-hidroxipropano |
| MXPA05001544A (es) | 2002-08-08 | 2005-04-19 | Smithkline Beecham Corp | Compuestos de tiofeno. |
| EP1534680B1 (en) | 2002-08-14 | 2012-02-22 | Pharmaco Investments, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| US20050004122A1 (en) | 2002-08-14 | 2005-01-06 | Brown Bradley B. | Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use |
| EP1605946B1 (en) * | 2003-03-25 | 2008-05-28 | Vertex Pharmaceuticals Incorporated | Thiazoles useful as inhibitors of protein kinases |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| US6984652B2 (en) | 2003-09-05 | 2006-01-10 | Warner-Lambert Company Llc | Gyrase inhibitors |
| GB0324653D0 (en) * | 2003-10-22 | 2003-11-26 | Syngenta Participations Ag | Fungicides |
| JP2007517886A (ja) * | 2004-01-09 | 2007-07-05 | スミスクライン・ビーチャム・コーポレイション | 新規な化学化合物 |
| JP2007519753A (ja) | 2004-01-30 | 2007-07-19 | スミスクライン ビーチャム コーポレーション | 化合物 |
| WO2005095386A1 (en) | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| WO2006078287A2 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
| GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| JP2008524329A (ja) | 2004-12-21 | 2008-07-10 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| CA2594477C (en) | 2005-01-21 | 2016-07-12 | Astex Therapeutics Limited | Pharmaceutical compounds |
| GB0503962D0 (en) | 2005-02-25 | 2005-04-06 | Kudos Pharm Ltd | Compounds |
| CN1834095B (zh) | 2005-03-18 | 2011-04-20 | 中国科学院上海药物研究所 | 一类非核苷类抗病毒抑制剂及其制备方法和用途 |
| KR20070120963A (ko) | 2005-03-21 | 2007-12-26 | 일라이 릴리 앤드 캄파니 | 이미다조피리다진 화합물 |
| GB0508471D0 (en) | 2005-04-26 | 2005-06-01 | Celltech R&D Ltd | Therapeutic agents |
| GB0508472D0 (en) | 2005-04-26 | 2005-06-01 | Glaxo Group Ltd | Compounds |
| DE102005000046A1 (de) | 2005-04-28 | 2006-11-02 | Voith Patent Gmbh | Maschine zur Herstellung einer Faserstoffbahn |
| EP1910307A1 (en) | 2005-06-27 | 2008-04-16 | Exelixis, Inc. | Pyrazole based lxr modulators |
| WO2007043400A1 (ja) | 2005-10-07 | 2007-04-19 | Kissei Pharmaceutical Co., Ltd. | 含窒素芳香族複素環化合物およびそれを含有する医薬組成物 |
| JP2007197324A (ja) | 2006-01-23 | 2007-08-09 | Toray Ind Inc | 2,4,5−置換−1,3−アゾール誘導体 |
| HRP20130058T1 (hr) | 2006-01-24 | 2013-02-28 | Eli Lilly & Company | Indolsulfonamidni modulatori progesteronskih receptora |
| US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
| NZ572202A (en) | 2006-03-27 | 2012-05-25 | Nerviano Medical Sciences Srl | Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors |
| BRPI0710874A2 (pt) | 2006-04-26 | 2012-02-14 | Hoffmann La Roche | compostos de tienopirimidina, processos de produção dos referidos compostos, composições farmacêuticas contendo os mesmos, kit, produto, e usos dos compostos |
| US20090076009A1 (en) | 2006-05-03 | 2009-03-19 | Arnould Jean-Claude Retired | Thiazole derivatives and their use as anti-tumour agents |
| CN101484447A (zh) | 2006-05-23 | 2009-07-15 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的噻吩-甲酰胺类 |
| WO2007138110A2 (en) | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
| US20080021217A1 (en) | 2006-07-20 | 2008-01-24 | Allen Borchardt | Heterocyclic inhibitors of rho kinase |
| US20100143499A1 (en) | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| EP2385050A1 (en) | 2006-08-14 | 2011-11-09 | Schering Corporation | A process for preparing a substituted oxazole |
| US20090093452A1 (en) | 2006-08-24 | 2009-04-09 | Pfizer Inc. | Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives |
| MX2009002046A (es) | 2006-08-24 | 2009-03-06 | Astrazeneca Ab | Derivados de morfolino pirimidina utiles en el tratamiento de trastornos proliferativos. |
| CA2662000C (en) | 2006-09-20 | 2013-01-08 | Eli Lilly And Company | Thiophene pyrazolopyrimidine compounds |
| JP2010511682A (ja) | 2006-12-04 | 2010-04-15 | アストラゼネカ アクチボラグ | 抗菌性の多環系尿素化合物 |
| WO2008083070A1 (en) | 2006-12-29 | 2008-07-10 | Neurogen Corporation | Crf1 receptor ligands comprising fused bicyclic heteroaryl moieties |
| GB0701426D0 (en) | 2007-01-25 | 2007-03-07 | Univ Sheffield | Compounds and their use |
| CA2677264C (en) | 2007-02-02 | 2021-11-30 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| US8420690B2 (en) | 2007-02-07 | 2013-04-16 | Glaxosmithkline Llc | Inhibitors of Akt activity |
| UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| CL2008001234A1 (es) | 2007-04-30 | 2008-09-22 | Genentech Inc | Compuestos derivados de heterociclos nitrogenados, inhibidores de las proteinas de apoptosis; y uso en el tratamiento del cancer. |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| WO2008157273A1 (en) | 2007-06-14 | 2008-12-24 | Smithkline Beecham Corporation | Chemical compounds |
| ES2395581T3 (es) * | 2007-06-20 | 2013-02-13 | Merck Sharp & Dohme Corp. | Inhibidores de quinasas janus |
| WO2009006577A2 (en) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting ezh2 |
| US8338623B2 (en) * | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
| WO2009040730A2 (en) | 2007-09-24 | 2009-04-02 | Actelion Pharmaceuticals Ltd | Pyrrolidines and piperidines as orexin receptor antagonists |
| CA2704711C (en) | 2007-09-24 | 2016-07-05 | Genentech, Inc. | Thiazolopyrimidine p13k inhibitor compounds and methods of use |
| WO2009049028A1 (en) | 2007-10-09 | 2009-04-16 | Targegen Inc. | Pyrrolopyrimidine compounds and their use as janus kinase modulators |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| PL2276767T3 (pl) | 2008-03-31 | 2014-09-30 | Genentech Inc | Związki benzopiranowe i benzoksepinowe będące inhibitorami pi3k oraz metody ich stosowania |
| GB0805818D0 (en) | 2008-03-31 | 2008-04-30 | Ucb Pharma Sa | Therapeutic agents |
| JP2011525931A (ja) | 2008-06-26 | 2011-09-29 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Akt活性の阻害剤 |
| GB0812309D0 (en) | 2008-07-03 | 2008-08-13 | Ucb Pharma Sa | Therapeutic agents |
| TWI404025B (zh) * | 2008-07-08 | 2013-08-01 | Innolux Corp | 液晶面板驅動方法及液晶顯示器 |
| US8420695B2 (en) * | 2008-07-09 | 2013-04-16 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| JP5698666B2 (ja) | 2008-08-04 | 2015-04-08 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Faahの阻害剤として有用なオキサゾール誘導体 |
| KR20110098908A (ko) | 2008-11-11 | 2011-09-02 | 엑스커버리 홀딩 컴퍼니 엘엘씨 | PI3K/mTOR 키나제 억제제 |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| WO2010080873A1 (en) | 2009-01-08 | 2010-07-15 | Glaxo Group Limited | Oxazoles as modulators of chemokine receptors |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US9139589B2 (en) | 2009-01-30 | 2015-09-22 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| MX2011012037A (es) | 2009-05-13 | 2012-02-28 | Amgen Inc | Compuestos de heteroarilo como inhibidores de pikk. |
| US20110021531A1 (en) | 2009-07-27 | 2011-01-27 | Chobanian Harry | Oxazole derivatives useful as inhibitors of faah |
| JP2012254939A (ja) | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
| US8722660B2 (en) * | 2010-02-17 | 2014-05-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| EP2603216A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
| TW201217365A (en) | 2010-08-11 | 2012-05-01 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| UY33671A (es) | 2010-10-13 | 2012-04-30 | Millenium Pharmaceuticals Inc | Heteroarilos y sus usos |
| WO2013096642A1 (en) | 2011-12-23 | 2013-06-27 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
-
2011
- 2011-08-11 TW TW100128796A patent/TW201217365A/zh unknown
- 2011-08-11 AR ARP110102929A patent/AR082665A1/es unknown
- 2011-08-11 US US13/207,753 patent/US8796268B2/en active Active
- 2011-08-11 UY UY0001033554A patent/UY33554A/es not_active Application Discontinuation
- 2011-08-11 CA CA2807971A patent/CA2807971A1/en not_active Abandoned
- 2011-08-11 SG SG10201506238SA patent/SG10201506238SA/en unknown
- 2011-08-11 MA MA35714A patent/MA34797B1/fr unknown
- 2011-08-11 EA EA201390214A patent/EA201390214A1/ru unknown
- 2011-08-11 PH PH1/2013/500274A patent/PH12013500274A1/en unknown
- 2011-08-11 PE PE2013000258A patent/PE20131304A1/es not_active Application Discontinuation
- 2011-08-11 EP EP11817031.5A patent/EP2603214A4/en not_active Withdrawn
- 2011-08-11 SG SG2013009964A patent/SG187795A1/en unknown
- 2011-08-11 MX MX2013001660A patent/MX2013001660A/es not_active Application Discontinuation
- 2011-08-11 KR KR1020137006232A patent/KR20130098334A/ko not_active Withdrawn
- 2011-08-11 JP JP2013524226A patent/JP2013536193A/ja active Pending
- 2011-08-11 US US13/207,696 patent/US8796271B2/en active Active
- 2011-08-11 NZ NZ607087A patent/NZ607087A/en not_active IP Right Cessation
- 2011-08-11 CN CN2011800492087A patent/CN103153300A/zh active Pending
- 2011-08-11 AU AU2011289377A patent/AU2011289377A1/en not_active Abandoned
- 2011-08-11 WO PCT/US2011/047407 patent/WO2012021696A1/en not_active Ceased
- 2011-08-11 BR BR112013003358A patent/BR112013003358A2/pt not_active IP Right Cessation
-
2013
- 2013-02-11 DO DO2013000034A patent/DOP2013000034A/es unknown
- 2013-02-11 CL CL2013000417A patent/CL2013000417A1/es unknown
- 2013-02-25 CR CR20130084A patent/CR20130084A/es unknown
- 2013-03-07 CO CO13046171A patent/CO6690755A2/es not_active Application Discontinuation
- 2013-03-11 EC ECSP13012485 patent/ECSP13012485A/es unknown
-
2014
- 2014-07-29 US US14/445,376 patent/US20150175563A1/en not_active Abandoned
- 2014-07-29 US US14/445,373 patent/US20150175593A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009094224A1 (en) * | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
| US20100075951A1 (en) * | 2008-06-19 | 2010-03-25 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109810071A (zh) * | 2019-03-28 | 2019-05-28 | 中国科学院成都生物研究所 | 一种miRNA生物合成抑制剂 |
| CN109970703A (zh) * | 2019-05-08 | 2019-07-05 | 玉林师范学院 | 1,3-杂环取代芳香酮的制备方法及应用 |
| WO2022083687A1 (zh) * | 2020-10-21 | 2022-04-28 | 南京明德新药研发有限公司 | 硒杂环类化合物及其应用 |
| CN116390922A (zh) * | 2020-10-21 | 2023-07-04 | 南京明德新药研发有限公司 | 硒杂环类化合物及其应用 |
| WO2023202706A1 (zh) * | 2022-04-21 | 2023-10-26 | 南京明德新药研发有限公司 | 硒杂环类化合物的盐型和晶型及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2807971A1 (en) | 2012-02-16 |
| MA34797B1 (fr) | 2014-01-02 |
| US20150175593A1 (en) | 2015-06-25 |
| EP2603214A1 (en) | 2013-06-19 |
| US8796271B2 (en) | 2014-08-05 |
| JP2013536193A (ja) | 2013-09-19 |
| PE20131304A1 (es) | 2013-11-14 |
| US20120172345A1 (en) | 2012-07-05 |
| NZ607087A (en) | 2015-05-29 |
| EA201390214A1 (ru) | 2013-07-30 |
| EP2603214A4 (en) | 2013-12-18 |
| CL2013000417A1 (es) | 2014-01-10 |
| US20150175563A1 (en) | 2015-06-25 |
| AR082665A1 (es) | 2012-12-26 |
| BR112013003358A2 (pt) | 2016-07-12 |
| US20120178723A1 (en) | 2012-07-12 |
| AU2011289377A1 (en) | 2013-03-07 |
| SG187795A1 (en) | 2013-03-28 |
| US8796268B2 (en) | 2014-08-05 |
| UY33554A (es) | 2012-02-29 |
| WO2012021696A1 (en) | 2012-02-16 |
| CO6690755A2 (es) | 2013-06-17 |
| KR20130098334A (ko) | 2013-09-04 |
| TW201217365A (en) | 2012-05-01 |
| DOP2013000034A (es) | 2013-03-31 |
| PH12013500274A1 (en) | 2013-03-04 |
| CR20130084A (es) | 2013-05-29 |
| SG10201506238SA (en) | 2015-09-29 |
| ECSP13012485A (es) | 2015-02-28 |
| MX2013001660A (es) | 2013-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103153300A (zh) | 杂芳基化合物和其用途 | |
| CN100360538C (zh) | 噻吩并嘧啶化合物及其用途 | |
| TWI680970B (zh) | 可做為sumo活化酵素抑制劑之雜芳基化合物 | |
| TWI457333B (zh) | 嗒酮化合物 | |
| CN106220614B (zh) | 吡啶酮/吡嗪酮、其制备方法及使用方法 | |
| CN105924437B (zh) | 作为iii型受体酪氨酸激酶抑制剂的化合物 | |
| WO2020239077A1 (zh) | 含氮杂环类衍生物调节剂、其制备方法和应用 | |
| CN107253963A (zh) | 吡啶酮和氮杂吡啶酮化合物及使用方法 | |
| CN106573937B (zh) | 作为fshr调节剂的吡唑化合物及其用途 | |
| CN113166065A (zh) | 用于治疗与nlrp活性相关的病症的化合物和组合物 | |
| US9062038B2 (en) | Heteroaryls and uses thereof | |
| WO2013064068A1 (zh) | 噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用 | |
| CN106458996A (zh) | 作为p97复合物的抑制剂的稠合嘧啶 | |
| KR20100137551A (ko) | 벤조피란 및 벤족세핀 pi3k 저해제 화합물 및 이의 사용 방법 | |
| TW201524958A (zh) | 用作轉染期間重排抑制劑之新穎化合物 | |
| WO2024140714A1 (zh) | Wrn抑制剂 | |
| CN103237450A (zh) | 杂芳基化合物和其用途 | |
| WO2024083208A1 (zh) | Kif18a蛋白抑制剂 | |
| JP2022517110A (ja) | がん治療に用いるためのnlrp3モジュレーターとしての置換キナゾリン | |
| CN109923117A (zh) | 使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗 | |
| CN110049979A (zh) | 布罗莫结构域抑制剂 | |
| CN115703738A (zh) | 含2-芳杂环取代的脲类化合物、其制备方法和用途 | |
| JP7721167B2 (ja) | 新規な選択的flt3阻害剤としての1h-イミダゾ[4,5-h]キナゾリン化合物 | |
| TWI707853B (zh) | 1,2-二氫-1,6-萘啶類衍生物、其製備方法、其藥物組合物及其在醫藥上的用途 | |
| HK1243417B (zh) | 吡啶酮和氮杂吡啶酮化合物及使用方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130612 |