CN103153297A - 类萜类似物及其用于治疗神经病症的用途 - Google Patents
类萜类似物及其用于治疗神经病症的用途 Download PDFInfo
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- CN103153297A CN103153297A CN2011800498172A CN201180049817A CN103153297A CN 103153297 A CN103153297 A CN 103153297A CN 2011800498172 A CN2011800498172 A CN 2011800498172A CN 201180049817 A CN201180049817 A CN 201180049817A CN 103153297 A CN103153297 A CN 103153297A
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- diene
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- 0 CC(CCCC=C(C)**)(C**)N Chemical compound CC(CCCC=C(C)**)(C**)N 0.000 description 4
- DCPQHJVJESEDIF-VQHVLOKHSA-N CC(C)=CCC/C(/C)=C/C(C(F)(F)F)(C(F)(F)F)O Chemical compound CC(C)=CCC/C(/C)=C/C(C(F)(F)F)(C(F)(F)F)O DCPQHJVJESEDIF-VQHVLOKHSA-N 0.000 description 1
- IONXCPZMDZYBPG-ZRDIBKRKSA-N CC(C)=CCC/C(/C)=C/C(CCCO)N Chemical compound CC(C)=CCC/C(/C)=C/C(CCCO)N IONXCPZMDZYBPG-ZRDIBKRKSA-N 0.000 description 1
- MCOIJKSGRQZRMY-JQIJEIRASA-N CC(C)=CCC/C(/C)=C/C(CCCO)N(C(c1c2cccc1)=O)C2=O Chemical compound CC(C)=CCC/C(/C)=C/C(CCCO)N(C(c1c2cccc1)=O)C2=O MCOIJKSGRQZRMY-JQIJEIRASA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
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- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/21—Monoamines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/15—Unsaturated ethers containing only non-aromatic carbon-to-carbon double bonds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/164—Unsaturated ethers containing six-membered aromatic rings
- C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38263510P | 2010-09-14 | 2010-09-14 | |
| US61/382,635 | 2010-09-14 | ||
| PCT/CA2011/050562 WO2012034232A1 (en) | 2010-09-14 | 2011-09-14 | Terpenoid analogues and uses thereof for treating neurological conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103153297A true CN103153297A (zh) | 2013-06-12 |
Family
ID=45830903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800498172A Pending CN103153297A (zh) | 2010-09-14 | 2011-09-14 | 类萜类似物及其用于治疗神经病症的用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130267571A1 (https=) |
| EP (1) | EP2616056A4 (https=) |
| JP (2) | JP2013538218A (https=) |
| CN (1) | CN103153297A (https=) |
| CA (1) | CA2811241A1 (https=) |
| WO (1) | WO2012034232A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107935815A (zh) * | 2016-10-13 | 2018-04-20 | 浙江蓝天环保高科技股份有限公司 | 一种制备,1,1,3,3,3‑六氟‑2‑甲基‑2‑丙醇的方法 |
| CN109867659A (zh) * | 2017-12-04 | 2019-06-11 | 江苏恒瑞医药股份有限公司 | 苯并哌啶类衍生物的制备方法 |
| CN115583875A (zh) * | 2022-09-28 | 2023-01-10 | 联化科技(台州)有限公司 | 在连续流反应器中将烯丙型醇氧化为α,β-不饱和醛酮的方法 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008095297A1 (en) | 2007-02-06 | 2008-08-14 | Origin Biomed Inc. | Composition comprising terpene compounds and methods for inhibiting nerve transmission |
| CA2732784C (en) | 2008-08-13 | 2018-09-18 | Neuroquest Inc. | Compositions comprising terpene compounds for treating negative sensory phenomena |
| US20130085283A1 (en) * | 2011-10-04 | 2013-04-04 | Coyote Pharmaceuticals, Inc. | Geranylgeranylacetone derivatives |
| CN119264026A (zh) * | 2024-10-03 | 2025-01-07 | 西北大学 | 机械光激发合成环状磺酰胺和磺酰烯烃的方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017695A1 (en) * | 1992-03-12 | 1993-09-16 | Smooth Contours, Inc. | Diagnosis and treatment of various neuralgias |
| WO2007095631A2 (en) * | 2006-02-15 | 2007-08-23 | The Regents Of The University Of California | New drug delivery system for crossing the blood brain barrier |
| WO2008108825A2 (en) * | 2006-10-10 | 2008-09-12 | Burnham Institute For Medical Research | Neuroprotective compositions and methods |
| WO2010017626A1 (en) * | 2008-08-13 | 2010-02-18 | Origin Biomed Inc. | Compositions comprising terpene compounds for treating negative sensory phenomena |
| CN101677973A (zh) * | 2007-02-06 | 2010-03-24 | 奥里金生物医学股份有限公司 | 用于抑制神经传导的包括萜烯化合物的组合物以及方法 |
| WO2010057295A1 (en) * | 2008-11-18 | 2010-05-27 | Origin Biomed Inc. | Homeopathic composition comprising hypericum perforatum extract and essential oils for the treatment of neuropathic pain |
-
2011
- 2011-09-14 CN CN2011800498172A patent/CN103153297A/zh active Pending
- 2011-09-14 JP JP2013528482A patent/JP2013538218A/ja active Pending
- 2011-09-14 US US13/822,826 patent/US20130267571A1/en not_active Abandoned
- 2011-09-14 WO PCT/CA2011/050562 patent/WO2012034232A1/en not_active Ceased
- 2011-09-14 CA CA2811241A patent/CA2811241A1/en not_active Abandoned
- 2011-09-14 EP EP11824405.2A patent/EP2616056A4/en not_active Withdrawn
-
2016
- 2016-08-05 JP JP2016154978A patent/JP2017008076A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017695A1 (en) * | 1992-03-12 | 1993-09-16 | Smooth Contours, Inc. | Diagnosis and treatment of various neuralgias |
| WO2007095631A2 (en) * | 2006-02-15 | 2007-08-23 | The Regents Of The University Of California | New drug delivery system for crossing the blood brain barrier |
| WO2008108825A2 (en) * | 2006-10-10 | 2008-09-12 | Burnham Institute For Medical Research | Neuroprotective compositions and methods |
| CN101677973A (zh) * | 2007-02-06 | 2010-03-24 | 奥里金生物医学股份有限公司 | 用于抑制神经传导的包括萜烯化合物的组合物以及方法 |
| WO2010017626A1 (en) * | 2008-08-13 | 2010-02-18 | Origin Biomed Inc. | Compositions comprising terpene compounds for treating negative sensory phenomena |
| WO2010057295A1 (en) * | 2008-11-18 | 2010-05-27 | Origin Biomed Inc. | Homeopathic composition comprising hypericum perforatum extract and essential oils for the treatment of neuropathic pain |
Non-Patent Citations (1)
| Title |
|---|
| ABENA ET AL.: "COMPARATIVE CHEMICAL AND ANALGESIC PROPERTIES OF ESSENTIAL OILS OF CYMBOPOGON NARDUS (L) RENDLE OF BENIN AND CONGO", 《AFR. J. TRAD. CAM》, vol. 4, no. 2, 31 December 2007 (2007-12-31), pages 267 - 272, XP002719042 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107935815A (zh) * | 2016-10-13 | 2018-04-20 | 浙江蓝天环保高科技股份有限公司 | 一种制备,1,1,3,3,3‑六氟‑2‑甲基‑2‑丙醇的方法 |
| CN109867659A (zh) * | 2017-12-04 | 2019-06-11 | 江苏恒瑞医药股份有限公司 | 苯并哌啶类衍生物的制备方法 |
| CN115583875A (zh) * | 2022-09-28 | 2023-01-10 | 联化科技(台州)有限公司 | 在连续流反应器中将烯丙型醇氧化为α,β-不饱和醛酮的方法 |
| CN115583875B (zh) * | 2022-09-28 | 2023-12-01 | 联化科技(台州)有限公司 | 在连续流反应器中将烯丙型醇氧化为α,β-不饱和醛酮的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2811241A1 (en) | 2012-03-22 |
| US20130267571A1 (en) | 2013-10-10 |
| JP2017008076A (ja) | 2017-01-12 |
| EP2616056A4 (en) | 2014-03-12 |
| WO2012034232A1 (en) | 2012-03-22 |
| JP2013538218A (ja) | 2013-10-10 |
| EP2616056A1 (en) | 2013-07-24 |
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