CN103079563B - 作为食欲素受体拮抗剂的脯氨酸磺酰胺衍生物 - Google Patents

作为食欲素受体拮抗剂的脯氨酸磺酰胺衍生物 Download PDF

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Publication number
CN103079563B
CN103079563B CN201180040497.4A CN201180040497A CN103079563B CN 103079563 B CN103079563 B CN 103079563B CN 201180040497 A CN201180040497 A CN 201180040497A CN 103079563 B CN103079563 B CN 103079563B
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China
Prior art keywords
phenyl
pyrrolidine
methoxy
amide
disorders
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Expired - Fee Related
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CN201180040497.4A
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English (en)
Chinese (zh)
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CN103079563A (zh
Inventor
克里斯多夫·博斯
克莉丝汀·普罗奇
约翰·加特菲尔德
马库斯·盖得
比比安·海德曼
蒂埃里·西弗朗
约迪·T·威廉姆斯
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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Publication of CN103079563A publication Critical patent/CN103079563A/zh
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CN201180040497.4A 2010-08-24 2011-08-23 作为食欲素受体拮抗剂的脯氨酸磺酰胺衍生物 Expired - Fee Related CN103079563B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/IB2010/053799 2010-08-24
IB2010053799 2010-08-24
IBPCT/IB2010/053799 2010-08-24
PCT/IB2011/053693 WO2012025877A1 (en) 2010-08-24 2011-08-23 Proline sulfonamide derivatives as orexin receptor antagonists

Publications (2)

Publication Number Publication Date
CN103079563A CN103079563A (zh) 2013-05-01
CN103079563B true CN103079563B (zh) 2015-07-08

Family

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Family Applications (1)

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CN201180040497.4A Expired - Fee Related CN103079563B (zh) 2010-08-24 2011-08-23 作为食欲素受体拮抗剂的脯氨酸磺酰胺衍生物

Country Status (9)

Country Link
US (3) US8895606B2 (cg-RX-API-DMAC7.html)
EP (1) EP2608787B1 (cg-RX-API-DMAC7.html)
JP (1) JP5744203B2 (cg-RX-API-DMAC7.html)
KR (1) KR101802726B1 (cg-RX-API-DMAC7.html)
CN (1) CN103079563B (cg-RX-API-DMAC7.html)
CA (1) CA2807000C (cg-RX-API-DMAC7.html)
ES (1) ES2769607T3 (cg-RX-API-DMAC7.html)
TW (1) TW201209037A (cg-RX-API-DMAC7.html)
WO (1) WO2012025877A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5744203B2 (ja) 2010-08-24 2015-07-08 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン受容体拮抗薬としてのプロリンスルフォンアミド誘導体
CN104334544B (zh) 2012-06-04 2016-10-19 埃科特莱茵药品有限公司 苯并咪唑脯氨酸衍生物
SI3077389T1 (en) 2013-12-03 2018-01-31 Idorsia Pharmaceuticals Ltd (S) - (2- (6-CHLORO-7-METHYL-1 H-BENZO (D) IMIDAZOL-2-YL) -2-METHYLPYROLIDIN-1-YL (5-METHOXY-2- (2H- , 2,3-TRIAZOL-2-IL) PHENYL) METHANONE AND ITS USE AS ANTAGONISTS OF OREXIN RECEPTOR
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
CA2930053A1 (en) 2013-12-04 2015-06-11 Actelion Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
WO2021207678A1 (en) * 2020-04-09 2021-10-14 Arizona Board Of Regents On Behalf Of The University Of Arizona Kappa opioid receptor antagonists for treating pain-related sleep disorders
EP4356909A1 (en) * 2022-10-17 2024-04-24 Selabtec Sciences, SLU 1-(sulfonyl)-n-phenylpyrrolidine-2-carboxamides derivatives and use thereof
WO2025224168A1 (en) 2024-04-24 2025-10-30 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators

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JPS5581857A (en) 1978-12-15 1980-06-20 Kyowa Hakko Kogyo Co Ltd Modifier of citrus fruit
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CN1898227A (zh) 2003-12-22 2007-01-17 安斯泰来制药有限公司 作为前列腺素e2激动剂或拮抗剂的鸟氨酸衍生物
CN1926109B (zh) 2004-03-01 2011-04-13 埃科特莱茵药品有限公司 经取代的1,2,3,4-四氢异喹啉衍生物
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PE20091010A1 (es) 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
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JP5744203B2 (ja) 2010-08-24 2015-07-08 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン受容体拮抗薬としてのプロリンスルフォンアミド誘導体
CN104334544B (zh) 2012-06-04 2016-10-19 埃科特莱茵药品有限公司 苯并咪唑脯氨酸衍生物

Also Published As

Publication number Publication date
TW201209037A (en) 2012-03-01
CN103079563A (zh) 2013-05-01
EP2608787B1 (en) 2019-11-20
US9211279B2 (en) 2015-12-15
CA2807000C (en) 2018-12-04
JP2013538206A (ja) 2013-10-10
US9000029B2 (en) 2015-04-07
US20150246021A1 (en) 2015-09-03
US8895606B2 (en) 2014-11-25
KR20130110160A (ko) 2013-10-08
KR101802726B1 (ko) 2017-11-29
EP2608787A1 (en) 2013-07-03
JP5744203B2 (ja) 2015-07-08
ES2769607T3 (es) 2020-06-26
WO2012025877A1 (en) 2012-03-01
CA2807000A1 (en) 2012-03-01
US20130150424A1 (en) 2013-06-13
US20150057328A1 (en) 2015-02-26

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Effective date of registration: 20171108

Address after: Swiss A Skei Weil

Patentee after: ACTELION PHARMACEUTICALS LTD.

Address before: Swiss A Skei Weil

Patentee before: Actelion Pharmaceuticals Ltd.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150708