CN103026230B - 共偶联以控制免疫测定中试剂的反应性 - Google Patents

共偶联以控制免疫测定中试剂的反应性 Download PDF

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Publication number
CN103026230B
CN103026230B CN201180036074.5A CN201180036074A CN103026230B CN 103026230 B CN103026230 B CN 103026230B CN 201180036074 A CN201180036074 A CN 201180036074A CN 103026230 B CN103026230 B CN 103026230B
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reagent
antibody
microspheres
reagents
signal
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Expired - Fee Related
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Chinese (zh)
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CN103026230A (zh
Inventor
哈罗德·贝克
米夏埃拉·奥夫梅耶
谢里·邓巴
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Luminex Corp
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Luminex Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)
CN201180036074.5A 2010-07-23 2011-07-22 共偶联以控制免疫测定中试剂的反应性 Expired - Fee Related CN103026230B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36728110P 2010-07-23 2010-07-23
US61/367,281 2010-07-23
PCT/US2011/045053 WO2012012748A2 (en) 2010-07-23 2011-07-22 Co-coupling to control reactivity of reagents in immunoassays

Publications (2)

Publication Number Publication Date
CN103026230A CN103026230A (zh) 2013-04-03
CN103026230B true CN103026230B (zh) 2015-01-14

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CN201180036074.5A Expired - Fee Related CN103026230B (zh) 2010-07-23 2011-07-22 共偶联以控制免疫测定中试剂的反应性

Country Status (9)

Country Link
US (2) US20120021944A1 (https=)
EP (1) EP2596354B1 (https=)
JP (1) JP5813111B2 (https=)
KR (1) KR101866844B1 (https=)
CN (1) CN103026230B (https=)
AU (1) AU2011280967B2 (https=)
BR (1) BR112013001642A8 (https=)
CA (1) CA2806306A1 (https=)
WO (1) WO2012012748A2 (https=)

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Publication number Priority date Publication date Assignee Title
JP6479799B2 (ja) * 2013-08-13 2019-03-06 アンテオ テクノロジーズ プロプライエタリー リミテッドＡｎｔｅｏ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｐｔｙ Ｌｔｄ 粒子への分子の接合
WO2015106226A2 (en) * 2014-01-10 2015-07-16 University Of Rochester Diagnostic device and method for detection of staphylococcus infection
ES2732476T3 (es) * 2014-10-30 2019-11-22 Univ Erasmus Med Ct Rotterdam Reactivos, métodos y kits para el diagnóstico de inmunodeficiencias primarias
JP6218916B1 (ja) * 2016-12-28 2017-10-25 Jsr株式会社 磁性粒子分散液
CN110187132A (zh) * 2019-05-14 2019-08-30 太原瑞盛生物科技有限公司 一种检测促甲状腺激素的分析方法
CN111879946A (zh) * 2020-07-28 2020-11-03 江苏扬新生物医药有限公司 一种多指标快速检测荧光免疫层析试剂盒

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WO1996010992A1 (en) * 1994-10-10 1996-04-18 University Of Nottingham Preparation of protein microspheres, films and coatings
US20010026920A1 (en) * 2000-02-25 2001-10-04 Mark Chandler Internal standards and controls for multiplexed assay
CN1636136A (zh) * 2001-12-28 2005-07-06 生物芯片溶液有限公司 利用特殊用途的随机粒子阵列的多分析物分子分析
CN1820201A (zh) * 2003-05-26 2006-08-16 佰赛泰克斯公司 使用微球体检测和多重定量样品中分析物的方法
CN101133328A (zh) * 2004-12-31 2008-02-27 健泰科生物技术公司 检测非人血清中的人抗体
WO2008036802A2 (en) * 2006-09-21 2008-03-27 Prometheus Laboratories Inc. Antibody-based arrays for detecting multiple signal transducers in rare circulating cells
CN101545912A (zh) * 2008-03-25 2009-09-30 北京科美东雅生物技术有限公司 胰岛素微孔板式磁颗粒化学发光免疫分析测定试剂盒及其制备方法
WO2010054385A2 (en) * 2008-11-10 2010-05-14 Luminex Corporation Method and system for manufacture and use of macroporous beads in a multiplex assay

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NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
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US4357311A (en) * 1980-10-03 1982-11-02 Warner-Lambert Company Substrate for immunoassay and means of preparing same
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WO1988007670A2 (en) * 1987-03-27 1988-10-06 Chimerix Corporation Time-resolved fluorescence apparatus and immunoassay
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812414A (en) * 1987-09-18 1989-03-14 Eastman Kodak Company Immunoreactive reagent particles having tracer, receptor molecules and protein of pI less than 6
WO1996010992A1 (en) * 1994-10-10 1996-04-18 University Of Nottingham Preparation of protein microspheres, films and coatings
US20010026920A1 (en) * 2000-02-25 2001-10-04 Mark Chandler Internal standards and controls for multiplexed assay
CN1636136A (zh) * 2001-12-28 2005-07-06 生物芯片溶液有限公司 利用特殊用途的随机粒子阵列的多分析物分子分析
CN1820201A (zh) * 2003-05-26 2006-08-16 佰赛泰克斯公司 使用微球体检测和多重定量样品中分析物的方法
CN101133328A (zh) * 2004-12-31 2008-02-27 健泰科生物技术公司 检测非人血清中的人抗体
WO2008036802A2 (en) * 2006-09-21 2008-03-27 Prometheus Laboratories Inc. Antibody-based arrays for detecting multiple signal transducers in rare circulating cells
CN101545912A (zh) * 2008-03-25 2009-09-30 北京科美东雅生物技术有限公司 胰岛素微孔板式磁颗粒化学发光免疫分析测定试剂盒及其制备方法
WO2010054385A2 (en) * 2008-11-10 2010-05-14 Luminex Corporation Method and system for manufacture and use of macroporous beads in a multiplex assay

Also Published As

Publication number Publication date
AU2011280967B2 (en) 2014-09-11
WO2012012748A2 (en) 2012-01-26
BR112013001642A2 (pt) 2016-05-24
US20120021944A1 (en) 2012-01-26
EP2596354A2 (en) 2013-05-29
JP5813111B2 (ja) 2015-11-17
JP2013532821A (ja) 2013-08-19
CA2806306A1 (en) 2012-01-26
WO2012012748A3 (en) 2012-05-10
BR112013001642A8 (pt) 2016-10-11
EP2596354B1 (en) 2017-04-12
KR20130090892A (ko) 2013-08-14
EP2596354A4 (en) 2013-12-25
AU2011280967A1 (en) 2013-01-31
US20140024556A1 (en) 2014-01-23
CN103026230A (zh) 2013-04-03
KR101866844B1 (ko) 2018-06-14

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