CN103025740B - 蛋白酪氨酸激酶活性的抑制剂及其治疗眼科疾病的用途 - Google Patents
蛋白酪氨酸激酶活性的抑制剂及其治疗眼科疾病的用途 Download PDFInfo
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- GKTQKQTXHNUFSP-UHFFFAOYSA-N thieno[3,4-c]pyrrole-4,6-dione Chemical compound S1C=C2C(=O)NC(=O)C2=C1 GKTQKQTXHNUFSP-UHFFFAOYSA-N 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N thiocyanic acid Chemical compound SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229940108519 trasylol Drugs 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32480310P | 2010-04-16 | 2010-04-16 | |
| US61/324,803 | 2010-04-16 | ||
| PCT/CA2011/000390 WO2011127565A1 (en) | 2010-04-16 | 2011-04-08 | Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103025740A CN103025740A (zh) | 2013-04-03 |
| CN103025740B true CN103025740B (zh) | 2015-07-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201180029735.1A Expired - Fee Related CN103025740B (zh) | 2010-04-16 | 2011-04-08 | 蛋白酪氨酸激酶活性的抑制剂及其治疗眼科疾病的用途 |
| CN2011800297313A Pending CN102947315A (zh) | 2010-04-16 | 2011-04-08 | 蛋白酪氨酸激酶活性抑制剂 |
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| CN2011800297313A Pending CN102947315A (zh) | 2010-04-16 | 2011-04-08 | 蛋白酪氨酸激酶活性抑制剂 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2495044C2 (ru) * | 2007-08-29 | 2013-10-10 | Метилджен Инк. | Ингибиторы активности протеинтирозинкиназы |
| EP2262815A4 (en) * | 2008-03-05 | 2012-04-11 | Methylgene Inc | Inhibitors of protein intolerance activity |
| JP2013525286A (ja) * | 2010-04-16 | 2013-06-20 | メチルジーン・インコーポレイテッド | タンパク質チロシンキナーゼ活性の阻害剤 |
| US20130090327A1 (en) * | 2011-09-30 | 2013-04-11 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
| US20130096088A1 (en) * | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
| US20130096135A1 (en) * | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Selected Inhibitors of Protein Tyrosine Kinase Activity |
| ES2593533T3 (es) | 2011-12-15 | 2016-12-09 | Pfizer Limited | Derivados de sulfonamida |
| US10544117B2 (en) | 2014-09-10 | 2020-01-28 | Temple University—Of the Commonwealth System of Higher Education | 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
| US20180221365A1 (en) * | 2015-05-12 | 2018-08-09 | Temple University-Of The Commonwealth System Of Higher Education | Novel sigma-2 receptor binders and their method of use |
| CN108530464B (zh) * | 2017-03-02 | 2020-10-27 | 深圳海王医药科技研究院有限公司 | 一种多靶点激酶抑制剂 |
Citations (7)
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|---|---|---|---|---|
| CA2603125A1 (en) * | 2005-03-28 | 2006-10-05 | Kirin Pharma Kabushiki Kaisha | Thienopyridine derivative, quinoline derivatives,and quinazoline derivatives, having c-met autophosphorylation inhibiting activity |
| CN1856498A (zh) * | 2003-07-24 | 2006-11-01 | 艾博特公司 | 噻吩并吡啶和呋喃并吡啶激酶抑制剂 |
| CA2605680A1 (en) * | 2005-04-27 | 2006-11-02 | Amgen Inc. | Substituted amide derivatives as protein kinase inhibitors |
| US20070004675A1 (en) * | 2005-05-20 | 2007-01-04 | Methylgene, Inc. | Inhibitors of VEGF receptor and HGF receptor signaling |
| CA2608726A1 (en) * | 2005-05-20 | 2007-05-18 | Methylgene Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
| WO2009026717A1 (en) * | 2007-08-29 | 2009-03-05 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
| WO2009109035A1 (en) * | 2008-03-05 | 2009-09-11 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2438017T3 (es) * | 2004-07-30 | 2014-01-15 | Methylgene Inc. | Inhibidores de la señalización del receptor del VEGF y del receptor del HGF |
| US8907091B2 (en) | 2007-08-29 | 2014-12-09 | Methylgene Inc. | Processes and intermediates for preparing fused heterocyclic kinase inhibitors |
| JP2013525286A (ja) * | 2010-04-16 | 2013-06-20 | メチルジーン・インコーポレイテッド | タンパク質チロシンキナーゼ活性の阻害剤 |
| US20130096088A1 (en) * | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
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2011
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- 2011-04-08 CA CA2796008A patent/CA2796008A1/en not_active Abandoned
- 2011-04-08 UA UAA201211687A patent/UA108878C2/ru unknown
- 2011-04-08 MX MX2012012032A patent/MX2012012032A/es not_active Application Discontinuation
- 2011-04-08 US US13/082,944 patent/US8455484B2/en not_active Expired - Fee Related
- 2011-04-08 AR ARP110101191A patent/AR080871A1/es unknown
- 2011-04-08 US US13/082,923 patent/US8906852B2/en not_active Expired - Fee Related
- 2011-04-08 EP EP20110768305 patent/EP2563794A4/en not_active Withdrawn
- 2011-04-08 AR ARP110101195A patent/AR080875A1/es unknown
- 2011-04-08 CA CA2796054A patent/CA2796054A1/en not_active Abandoned
- 2011-04-08 NZ NZ602948A patent/NZ602948A/en not_active IP Right Cessation
- 2011-04-08 CN CN201180029735.1A patent/CN103025740B/zh not_active Expired - Fee Related
- 2011-04-08 CN CN2011800297313A patent/CN102947315A/zh active Pending
- 2011-04-08 KR KR1020127029841A patent/KR20130100234A/ko not_active Application Discontinuation
- 2011-04-08 MY MYPI2012004621A patent/MY157319A/en unknown
- 2011-04-08 EA EA201291055A patent/EA201291055A1/ru unknown
- 2011-04-08 WO PCT/CA2011/000390 patent/WO2011127565A1/en active Application Filing
- 2011-04-08 EA EA201291052A patent/EA201291052A1/ru unknown
- 2011-04-08 TW TW100112307A patent/TW201204734A/zh unknown
- 2011-04-08 JP JP2013504075A patent/JP2013523846A/ja not_active Ceased
- 2011-04-08 TW TW100112308A patent/TW201204735A/zh unknown
- 2011-04-08 SG SG2012076733A patent/SG184883A1/en unknown
- 2011-04-08 AU AU2011241422A patent/AU2011241422B2/en not_active Ceased
- 2011-04-08 AU AU2011241420A patent/AU2011241420B2/en not_active Ceased
- 2011-04-08 KR KR1020127030161A patent/KR20130058006A/ko not_active Application Discontinuation
- 2011-04-08 EP EP11768307.8A patent/EP2563795A4/en not_active Withdrawn
- 2011-04-08 NZ NZ602954A patent/NZ602954A/en not_active IP Right Cessation
- 2011-04-08 WO PCT/CA2011/000394 patent/WO2011127567A1/en active Application Filing
- 2011-04-08 SG SG2012076725A patent/SG184882A1/en unknown
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2012
- 2012-10-05 ZA ZA2012/07482A patent/ZA201207482B/en unknown
- 2012-10-09 ZA ZA2012/07557A patent/ZA201207557B/en unknown
- 2012-11-15 CO CO12207310A patent/CO6630193A2/es active IP Right Grant
- 2012-11-15 CO CO12207317A patent/CO6640224A2/es active IP Right Grant
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2014
- 2014-06-18 US US14/308,408 patent/US20140315801A1/en not_active Abandoned
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| CN1856498A (zh) * | 2003-07-24 | 2006-11-01 | 艾博特公司 | 噻吩并吡啶和呋喃并吡啶激酶抑制剂 |
| CA2603125A1 (en) * | 2005-03-28 | 2006-10-05 | Kirin Pharma Kabushiki Kaisha | Thienopyridine derivative, quinoline derivatives,and quinazoline derivatives, having c-met autophosphorylation inhibiting activity |
| CA2605680A1 (en) * | 2005-04-27 | 2006-11-02 | Amgen Inc. | Substituted amide derivatives as protein kinase inhibitors |
| US20070004675A1 (en) * | 2005-05-20 | 2007-01-04 | Methylgene, Inc. | Inhibitors of VEGF receptor and HGF receptor signaling |
| CA2608726A1 (en) * | 2005-05-20 | 2007-05-18 | Methylgene Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
| WO2009026717A1 (en) * | 2007-08-29 | 2009-03-05 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
| WO2009109035A1 (en) * | 2008-03-05 | 2009-09-11 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
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