CN102993306B - 高亲和力抗人类IgE抗体 - Google Patents
高亲和力抗人类IgE抗体 Download PDFInfo
- Publication number
- CN102993306B CN102993306B CN201210316908.4A CN201210316908A CN102993306B CN 102993306 B CN102993306 B CN 102993306B CN 201210316908 A CN201210316908 A CN 201210316908A CN 102993306 B CN102993306 B CN 102993306B
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- Prior art keywords
- antibody
- ser
- thr
- gly
- ala
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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Landscapes
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| CN2004800070117A Expired - Lifetime CN1771338B (zh) | 2003-02-01 | 2004-02-02 | 高亲和力抗人类IgE抗体 |
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| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US20060234296A1 (en) * | 2003-02-01 | 2006-10-19 | Sanjaya Singh | Method for generating high affinity antibodies |
| WO2004070010A2 (en) * | 2003-02-01 | 2004-08-19 | Tanox, Inc. | A method for generating high affinity antibodies |
| EP3718564B1 (en) | 2003-12-23 | 2023-10-11 | Genentech, Inc. | Novel anti-il 13 antibodies and uses thereof |
| KR101365375B1 (ko) * | 2004-02-02 | 2014-02-19 | 타녹스 인코퍼레이티드 | 신규한 ＩｇＥ 에피토프의 확인 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| WO2006055704A2 (en) * | 2004-11-17 | 2006-05-26 | Curagen Corporation | Antibodies directed to ten-m proteins and uses thereof |
| WO2007041171A2 (en) * | 2005-09-29 | 2007-04-12 | Medimmune, Inc. | Method of identifying membrane lg specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| AR065368A1 (es) | 2007-02-15 | 2009-06-03 | Astrazeneca Ab | Anticuerpos para moleculas de ige |
| ES2478242T3 (es) | 2007-03-22 | 2014-07-21 | Genentech, Inc. | Anticuerpos anti IgE apoptóticos que se unen con el IgE unido a membrana |
| DE102007052281A1 (de) * | 2007-11-02 | 2009-05-07 | Zenteris Gmbh | Einschritt-Multiplex-Immuntest |
| US20100248971A1 (en) | 2007-12-03 | 2010-09-30 | Takashi Inagaki | Process for antibody production |
| US20130338038A1 (en) | 2007-12-21 | 2013-12-19 | Pdl Biopharma, Inc. | Method of screening complex protein libraries to identify altered properties |
| CN101230103B (zh) * | 2008-03-25 | 2011-09-07 | 中国医药集团总公司四川抗菌素工业研究所 | 一全人源重组抗-IgE抗体 |
| ES2927192T3 (es) | 2008-09-17 | 2022-11-03 | Xencor Inc | Nuevas composiciones y métodos para tratar trastornos mediados por IgE |
| ES2615881T3 (es) | 2009-05-07 | 2017-06-08 | Stallergenes | Uso de inmunoglobulinas igg1 y/o de ligandos del receptor cd32 para el tratamiento de enfermedades y manifestaciones inflamatorias por vía mucosa. |
| DK2494356T3 (en) | 2009-10-26 | 2017-05-15 | Genentech Inc | ASSAYS FOR THE DETECTION OF ANTIBODIES SPECIFIC TO THERAPEUTIC ANTI-IGE ANTIBODIES AND THEIR USE OF ANAPHYLAXY |
| JP2013523153A (ja) * | 2010-04-07 | 2013-06-17 | アッヴィ・インコーポレイテッド | ＴＮＦ−α結合タンパク質 |
| AR089434A1 (es) | 2011-12-23 | 2014-08-20 | Genentech Inc | Procedimiento para preparar formulaciones con alta concentracion de proteinas |
| CA2863066A1 (en) | 2012-01-31 | 2013-08-08 | Genentech, Inc. | Anti-ig-e m1' antibodies and methods using same |
| NZ701915A (en) | 2012-05-18 | 2016-11-25 | Genentech Inc | High-concentration monoclonal antibody formulations |
| KR102307248B1 (ko) | 2012-08-21 | 2021-10-01 | 사노피 바이오테크놀로지 | Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| NZ630178A (en) | 2012-09-07 | 2017-06-30 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| WO2015013668A1 (en) * | 2013-07-26 | 2015-01-29 | Ke Zhang | Anti-immunoglobulin e antibodies and methods of use thereof |
| EP3100048B1 (en) | 2014-01-29 | 2021-05-05 | Cytiva Sweden AB | Method and system for interaction analysis |
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