CN102875573B - 一种头孢克肟化合物及其药物组合物 - Google Patents
一种头孢克肟化合物及其药物组合物 Download PDFInfo
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- CN102875573B CN102875573B CN 201210389728 CN201210389728A CN102875573B CN 102875573 B CN102875573 B CN 102875573B CN 201210389728 CN201210389728 CN 201210389728 CN 201210389728 A CN201210389728 A CN 201210389728A CN 102875573 B CN102875573 B CN 102875573B
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- isopropylcarbinol
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- 239000013078 crystal Substances 0.000 claims abstract description 129
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 48
- 239000000243 solution Substances 0.000 claims description 43
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Landscapes
- Cephalosporin Compounds (AREA)
Abstract
Description
对比例1 | 对比例2 | 对比例3 | 对比例4 | |
溶解度(20℃)mg/L | 53.78 | 54.67 | 54.25 | 53.69 |
对比例5 | 对比例6 | 对比例7 | 对比例8 | |
溶解度(20℃)mg/L | 55.10 | 55.01 | 54.78 | 53.59 |
实施例1 | 对比例18 | 对比例19 | 对比例20 | |
步骤1中,甲醇、丙酮的体积比 | 5:2 | 5:1 | 5:4 | 1:1 |
步骤2中,异丁醇水溶液体积百分比浓度 | 1% | 1% | 1% | 1% |
纯度(HPLC) | 99.98% | 99.32% | 99.42% | 99.24% |
收率 | 99.2% | 94.3% | 92.4% | 91.8% |
实施例1 | 对比例21 | 对比例22 | 对比例23 | |
步骤1中,甲醇、丙酮的体积比 | 5:2 | 5:2 | 5:2 | 1:2 |
步骤2中,异丁醇水溶液体积百分比浓度 | 1% | 5% | 6% | 8% |
纯度(HPLC) | 99.98% | 99.57% | 99.32% | 99.16% |
收率 | 99.2% | 99.1% | 98.6% | 97.9% |
Claims (15)
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Families Citing this family (6)
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CN103193798B (zh) * | 2013-04-18 | 2014-04-02 | 四川省惠达药业有限公司 | 一种头孢克肟化合物及其药物组合物 |
CN103622916B (zh) * | 2013-12-19 | 2015-04-08 | 石家庄市华新药业有限责任公司 | 一种头孢克肟干混悬制剂及其制备方法 |
CN105078902A (zh) * | 2015-09-24 | 2015-11-25 | 青岛华之草医药科技有限公司 | 一种治疗细菌感染的药物盐酸头孢他美酯组合物颗粒剂 |
CN105496984B (zh) * | 2015-12-18 | 2019-01-11 | 石药集团欧意药业有限公司 | 一种质量稳定的头孢克肟胶囊及其制备方法 |
CN106798732A (zh) * | 2016-07-19 | 2017-06-06 | 四川赛卓药业股份有限公司 | 一种头孢克肟分散片及制备方法 |
CN107312019B (zh) * | 2017-06-16 | 2019-06-25 | 成都倍特药业有限公司 | 一种头孢克肟及其结晶方法 |
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CN101544660A (zh) * | 2009-05-07 | 2009-09-30 | 郑仙锋 | 一种头孢克肟化合物及其制法 |
CN102268018A (zh) * | 2010-06-03 | 2011-12-07 | 广州白云山制药股份有限公司广州白云山化学制药厂 | 头孢克肟的结晶方法 |
CN101863907B (zh) * | 2010-07-07 | 2012-05-23 | 福建省福抗药业股份有限公司 | 一种头孢哌酮钠的结晶方法 |
CN102079751B (zh) * | 2010-12-10 | 2012-06-06 | 湖北楚阳科技股份有限公司 | 头孢克肟三水合物的制备方法 |
CN102311452B (zh) * | 2011-09-22 | 2013-07-03 | 山东罗欣药业股份有限公司 | 头孢克肟晶体、其制备方法及含有该晶体的片剂组合物 |
CN102516262A (zh) * | 2011-12-20 | 2012-06-27 | 浙江国邦药业有限公司 | 一种头孢克肟三水合物的结晶方法 |
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