CN102869258A - 用于pten基因缺失相关疾病的治疗的聚（adp-核糖）聚合酶（parp）的二氢吡啶并酞嗪酮抑制剂 - Google Patents

用于pten基因缺失相关疾病的治疗的聚（adp-核糖）聚合酶（parp）的二氢吡啶并酞嗪酮抑制剂 Download PDF

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CN102869258A
CN102869258A CN201180017703XA CN201180017703A CN102869258A CN 102869258 A CN102869258 A CN 102869258A CN 201180017703X A CN201180017703X A CN 201180017703XA CN 201180017703 A CN201180017703 A CN 201180017703A CN 102869258 A CN102869258 A CN 102869258A
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phenyl
ketone
pyrido
phthalazines
dihydro
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丹尼尔·楚
王兵
冯英
沈宇乔
伦纳德·埃德温·波斯特
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Biomarin Pharmaceutical Inc
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Biomarin Pharmaceutical Inc
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CN201180017703XA 2010-02-03 2011-02-03 用于pten基因缺失相关疾病的治疗的聚（adp-核糖）聚合酶（parp）的二氢吡啶并酞嗪酮抑制剂 Pending CN102869258A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710081268.6A CN106943406A (zh) 2010-02-03 2011-02-03 用于pten基因缺失相关疾病的治疗的聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30117410P 2010-02-03 2010-02-03
US61/301,174 2010-02-03
PCT/US2011/023532 WO2011097334A1 (en) 2010-02-03 2011-02-03 Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency

Related Child Applications (1)

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CN201710081268.6A Division CN106943406A (zh) 2010-02-03 2011-02-03 用于pten基因缺失相关疾病的治疗的聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

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CN102869258A true CN102869258A (zh) 2013-01-09

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CN201180017703XA Pending CN102869258A (zh) 2010-02-03 2011-02-03 用于pten基因缺失相关疾病的治疗的聚（adp-核糖）聚合酶（parp）的二氢吡啶并酞嗪酮抑制剂
CN201710081268.6A Pending CN106943406A (zh) 2010-02-03 2011-02-03 用于pten基因缺失相关疾病的治疗的聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂

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US (4) US8541403B2 (enExample)
EP (1) EP2531033A4 (enExample)
JP (5) JP5883397B2 (enExample)
CN (2) CN102869258A (enExample)
AU (3) AU2011212928B2 (enExample)
CA (1) CA2787844C (enExample)
WO (1) WO2011097334A1 (enExample)

Cited By (4)

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WO2016188307A1 (zh) * 2015-05-25 2016-12-01 苏州康润医药有限公司 氮杂非那烯-3-酮的衍生物、其制备方法及其作为parp抑制剂的应用
CN110382468A (zh) * 2017-02-25 2019-10-25 苏州开拓药业股份有限公司 具有聚(adp-核糖)聚合酶(parp)抑制活性的二氢吡啶并二氮杂萘酮化合物及其用途
WO2022022664A1 (zh) * 2020-07-31 2022-02-03 正大天晴药业集团股份有限公司 用作parp抑制剂的吲哚并七元酰肟类似物的结晶及其制备方法
CN114430775A (zh) * 2019-10-01 2022-05-03 德雷克塞尔大学 Rad52的喹啉抑制剂和使用方法

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CN110382468B (zh) * 2017-02-25 2023-03-24 苏州开拓药业股份有限公司 具有聚(adp-核糖)聚合酶(parp)抑制活性的二氢吡啶并二氮杂萘酮化合物及其用途
CN114430775A (zh) * 2019-10-01 2022-05-03 德雷克塞尔大学 Rad52的喹啉抑制剂和使用方法
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