CA2787844C - Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency - Google Patents
Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency Download PDFInfo
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- CA2787844C CA2787844C CA2787844A CA2787844A CA2787844C CA 2787844 C CA2787844 C CA 2787844C CA 2787844 A CA2787844 A CA 2787844A CA 2787844 A CA2787844 A CA 2787844A CA 2787844 C CA2787844 C CA 2787844C
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- cancer
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- pyrido
- dihydro
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
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- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30117410P | 2010-02-03 | 2010-02-03 | |
| US61/301,174 | 2010-02-03 | ||
| PCT/US2011/023532 WO2011097334A1 (en) | 2010-02-03 | 2011-02-03 | Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency |
Publications (2)
| Publication Number | Publication Date |
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| CA2787844A1 CA2787844A1 (en) | 2011-08-11 |
| CA2787844C true CA2787844C (en) | 2019-08-27 |
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| Country | Link |
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| JP (5) | JP5883397B2 (enExample) |
| CN (2) | CN102869258A (enExample) |
| AU (3) | AU2011212928B2 (enExample) |
| CA (1) | CA2787844C (enExample) |
| WO (1) | WO2011097334A1 (enExample) |
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| PT2767537T (pt) | 2008-08-06 | 2017-07-17 | Medivation Technologies Inc | Inibidores de di-hidropiridoftalazinona de poli(adp-ribose)polimerase (parp) |
| US8541403B2 (en) * | 2010-02-03 | 2013-09-24 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency |
| ES2606174T3 (es) * | 2010-02-08 | 2017-03-23 | Medivation Technologies, Inc. | Procesos de síntesis de derivados de dihidropiridoftalazinona |
| PT2630146T (pt) | 2010-10-21 | 2020-07-20 | Medivation Tech Llc | Sal tosilato de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-di-hidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalino |
| WO2013028495A1 (en) * | 2011-08-19 | 2013-02-28 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma |
| US11261466B2 (en) | 2015-03-02 | 2022-03-01 | Sinai Health System | Homologous recombination factors |
| CN104945406B (zh) | 2015-05-25 | 2017-10-10 | 苏州康润医药有限公司 | 氮杂非那烯‑3‑酮的衍生物、其制备方法及其作为parp抑制剂的应用 |
| HK1255034A1 (zh) | 2015-07-01 | 2019-08-02 | Crinetics Pharmaceuticals, Inc. | 生长抑素调节剂及其用途 |
| CN108883115A (zh) * | 2015-10-26 | 2018-11-23 | 麦迪韦逊科技有限责任公司 | 用parp抑制剂治疗小细胞肺癌 |
| WO2018153279A1 (en) * | 2017-02-25 | 2018-08-30 | Suzhou Kintor Pharmaceuticals, Inc. | Dihydropyridophthalazinone compounds as inhibitors of poly (adp-ribose) polymerase (parp) for treatment of diseases and method of use thereof |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| JP2020536887A (ja) | 2017-10-13 | 2020-12-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｐａｒｐ阻害剤およびｐｄ−１系結合アンタゴニストの組合せ |
| TW201938165A (zh) | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | 治療癌症的方法及組合療法 |
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| US20220388980A1 (en) * | 2019-10-01 | 2022-12-08 | Drexel University | Quinoline inhibitors of rad52 and methods of use |
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| CA3175848A1 (en) | 2020-03-11 | 2021-09-16 | Purdue Research Foundation | Compounds with immunomodulatory activity and therapeutic uses thereof |
| US20230331739A1 (en) * | 2020-07-31 | 2023-10-19 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Indolo heptamyl oxime analog crystal as parp inhibitor and method for preparing same |
| KR20230107647A (ko) | 2020-11-13 | 2023-07-17 | 화이자 인코포레이티드 | 탈라조파립 연질 젤라틴 캡슐 투여 형태 |
| CA3203814A1 (en) | 2020-12-07 | 2022-06-16 | Pfizer Inc. | Methods of identifying a tumor that is sensitive to treatment with talazoparib and methods of treatment thereof |
| BR112023018906A2 (pt) | 2021-03-24 | 2023-10-10 | Astellas Pharma Inc | Combinação de talazoparib e um antiandrógeno para o tratamento de câncer de próstata metastático sensível à castração com mutação no gene ddr |
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| TWI883565B (zh) | 2022-10-02 | 2025-05-11 | 美商輝瑞大藥廠 | 用於治療轉移性去勢抵抗性前列腺癌之他拉唑帕尼及恩雜魯胺之組合 |
| TW202425976A (zh) | 2022-12-17 | 2024-07-01 | 美商輝瑞大藥廠 | 用於治療轉移性去勢抵抗性前列腺癌之他拉唑帕尼及恩雜魯胺之組合 |
| WO2025210510A1 (en) | 2024-04-04 | 2025-10-09 | Pfizer Inc. | Tmprss2-erg and rb1 as predictive biomarkers for treatment with a parp inhibitor |
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2011
- 2011-02-03 US US13/020,619 patent/US8541403B2/en not_active Expired - Fee Related
- 2011-02-03 EP EP11740322.0A patent/EP2531033A4/en not_active Withdrawn
- 2011-02-03 CA CA2787844A patent/CA2787844C/en not_active Expired - Fee Related
- 2011-02-03 CN CN201180017703XA patent/CN102869258A/zh active Pending
- 2011-02-03 JP JP2012552070A patent/JP5883397B2/ja not_active Expired - Fee Related
- 2011-02-03 CN CN201710081268.6A patent/CN106943406A/zh active Pending
- 2011-02-03 AU AU2011212928A patent/AU2011212928B2/en not_active Ceased
- 2011-02-03 WO PCT/US2011/023532 patent/WO2011097334A1/en not_active Ceased
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2013
- 2013-08-21 US US13/972,166 patent/US9018201B2/en not_active Expired - Fee Related
-
2015
- 2015-03-27 US US14/671,944 patent/US20150209363A1/en not_active Abandoned
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2016
- 2016-02-05 JP JP2016020358A patent/JP2016128492A/ja not_active Withdrawn
- 2016-09-22 AU AU2016231573A patent/AU2016231573A1/en not_active Abandoned
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2017
- 2017-06-20 JP JP2017120148A patent/JP2017197565A/ja active Pending
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2018
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- 2018-08-03 US US16/054,899 patent/US10493078B2/en not_active Expired - Fee Related
- 2018-09-27 JP JP2018182009A patent/JP2019011356A/ja not_active Withdrawn
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2020
- 2020-07-09 JP JP2020118694A patent/JP2020176136A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20110190288A1 (en) | 2011-08-04 |
| US20140066429A1 (en) | 2014-03-06 |
| CN102869258A (zh) | 2013-01-09 |
| EP2531033A4 (en) | 2013-07-31 |
| US10493078B2 (en) | 2019-12-03 |
| JP2017197565A (ja) | 2017-11-02 |
| JP2016128492A (ja) | 2016-07-14 |
| CN106943406A (zh) | 2017-07-14 |
| US20190070189A1 (en) | 2019-03-07 |
| US8541403B2 (en) | 2013-09-24 |
| AU2011212928A1 (en) | 2012-08-09 |
| US20150209363A1 (en) | 2015-07-30 |
| AU2016231573A1 (en) | 2016-10-20 |
| WO2011097334A1 (en) | 2011-08-11 |
| AU2011212928B2 (en) | 2016-06-23 |
| CA2787844A1 (en) | 2011-08-11 |
| JP2019011356A (ja) | 2019-01-24 |
| EP2531033A1 (en) | 2012-12-12 |
| JP2020176136A (ja) | 2020-10-29 |
| AU2018206826A1 (en) | 2018-08-09 |
| JP2013518892A (ja) | 2013-05-23 |
| US9018201B2 (en) | 2015-04-28 |
| JP5883397B2 (ja) | 2016-03-15 |
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