CN102860961A - Eye pad essence containing peony root extracts and preparation method for eye pad essence - Google Patents
Eye pad essence containing peony root extracts and preparation method for eye pad essence Download PDFInfo
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- CN102860961A CN102860961A CN2012103592401A CN201210359240A CN102860961A CN 102860961 A CN102860961 A CN 102860961A CN 2012103592401 A CN2012103592401 A CN 2012103592401A CN 201210359240 A CN201210359240 A CN 201210359240A CN 102860961 A CN102860961 A CN 102860961A
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- 239000000284 extract Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 241000736199 Paeonia Species 0.000 title abstract 3
- 235000006484 Paeonia officinalis Nutrition 0.000 title abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 230000000694 effects Effects 0.000 claims abstract description 17
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000008719 thickening Effects 0.000 claims abstract description 15
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 8
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 8
- 229960000458 allantoin Drugs 0.000 claims abstract description 8
- 230000003266 anti-allergic effect Effects 0.000 claims abstract description 8
- 240000005001 Paeonia suffruticosa Species 0.000 claims description 25
- 235000003889 Paeonia suffruticosa Nutrition 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 21
- 238000001816 cooling Methods 0.000 claims description 14
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- 238000011105 stabilization Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 11
- 239000000470 constituent Substances 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- 229960001631 carbomer Drugs 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 7
- 230000003020 moisturizing effect Effects 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 206010030113 Oedema Diseases 0.000 abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 4
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- 230000017531 blood circulation Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 abstract 2
- 229920001503 Glucan Polymers 0.000 abstract 1
- 241000208680 Hamamelis mollis Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 1
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- 229960003237 betaine Drugs 0.000 abstract 1
- 230000001914 calming effect Effects 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 abstract 1
- 210000000744 eyelid Anatomy 0.000 abstract 1
- 238000005562 fading Methods 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
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- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 229940118846 witch hazel Drugs 0.000 abstract 1
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 description 14
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 description 7
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 235000002673 Dioscorea communis Nutrition 0.000 description 5
- 241000544230 Dioscorea communis Species 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- 208000035753 Periorbital contusion Diseases 0.000 description 5
- IRLNKOAURQPXIQ-WWWUCTDISA-N Apiopaeonoside Natural products O=C(C)c1c(O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO[C@H]3[C@H](O)[C@@](O)(CO)CO3)O2)cc(OC)cc1 IRLNKOAURQPXIQ-WWWUCTDISA-N 0.000 description 4
- IDZZECHGWAZTIB-NYBIBFQCSA-N Paeonolide Chemical compound COC1=CC=C(C(C)=O)C(O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]3[C@@H]([C@@H](O)[C@@H](O)CO3)O)O2)O)=C1 IDZZECHGWAZTIB-NYBIBFQCSA-N 0.000 description 4
- IDZZECHGWAZTIB-WPQJODJHSA-N Paeonolide Natural products O=C(C)c1c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]3[C@@H](O)[C@H](O)[C@@H](O)CO3)O2)cc(OC)cc1 IDZZECHGWAZTIB-WPQJODJHSA-N 0.000 description 4
- IDZZECHGWAZTIB-UHFFFAOYSA-N affinoside Natural products COC1=CC=C(C(C)=O)C(OC2C(C(O)C(O)C(COC3C(C(O)C(O)CO3)O)O2)O)=C1 IDZZECHGWAZTIB-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 208000003464 asthenopia Diseases 0.000 description 3
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- 238000012360 testing method Methods 0.000 description 3
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
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- 238000004458 analytical method Methods 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 206010016334 Feeling hot Diseases 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
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- 238000004140 cleaning Methods 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
- -1 iron ion Chemical class 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229940023462 paste product Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses eye pad essence containing peony root extracts and a preparation method for the eye pad essence. The essence comprises a moisture component containing water, 1,3-butanediol, glycerol and glycine betaine, a thickening and stabilizing component, an anti-allergic component containing allantoin and dipotassium glycyrrhizinate, am effect activating component containing sodium hyaluronate, oat glucan, witch hazel extracts and the peony root extracts, a neutralizing component and a preservative component. The eye pad essence is natural and safe, relieves fatigue of eyes of users, and has obvious effects of promoting blood circulation to remove blood stasis, diminishing inflammation and calming, fading dark eye circles, eliminating edema and eyelid punch and replenishing moisture.
Description
[technical field]
The present invention relates to a kind of eye mask of using the root of Paeonia suffruticosa Ardr. extract and paste essence and preparation method thereof, belong to the essence technical field.
[background technology]
" the eyes are the windows of the mind " such saying is just arranged since ancient times, and the fact also the way it goes.Because the appearance of microgroove, eyes leak out the secret at age the earliest.Not having enough sleep to produce eye pouch, and fatigue can cause black eye, and sobbing can make inflamed eyes, and insobriety can make eyes edema ┄ ┄ eye part skin can really be difficult to take care of.
And the eye mask of existing dispel eye pouch, black eye, edema subsides essence is of a great variety, but the problems such as mostly powerful not obvious, non-natural effect component, effect be single, can't make consumer admire, and along with the attention of people to health-preserving, essence also more and more trends towards using the natural effect component of Chinese herbal medicine.
[summary of the invention]
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of safe, effective and stable, the eye mask that can effectively solve the application root of Paeonia suffruticosa Ardr. extract of the problems such as eye eye pouch, black eye, edema, dry microgroove pastes essence.
Another object of the present invention is in order to provide a kind of this eye mask to paste the preparation method of essence.
The present invention to achieve these goals, by the following technical solutions:
A kind of eye mask of using the root of Paeonia suffruticosa Ardr. extract pastes essence, it is characterized in that percentage composition comprises following component by weight:
A, moisturizing component
B, thickening stabilization component 0.1～0.5%
C, antiallergic component
Allantoin 0.1～0.5%
Glycyrrhizic acid dipotassium 0.1～0.5%
D, effect active constituent
E, in and component 0.1～0.5%
F, anticorrosion component 0.1～0.5%.
Paeonia suffruticosa have the title of China's " national flower ",, in " name garden, Luoyang note " Paeonia suffruticosa is called " flower king " as the history in existing several thousand of ornamental flower, and Paeonia suffruticosa is called " Luoyang is colored " etc. in " florilegium ".Paeonia suffruticosa sees the middle product of classifying as in the Shennong's Herbal the earliest as drug use in the medicine book, have the medicinal history in more than 2000 year in China.The research in its modern times was first appeared in 1887, but until the 1950's, the research of moutan root bark (another name root of Paeonia suffruticosa Ardr.) is just having greater advance aspect chemistry and the pharmacology, particularly after the fifties, research progressively deeply, separate a large amount of chemical compositions, and carried out pharmacodynamics, metabolism and toxicologic study, for clinical drug effect and the safe medication of Cortex Moutan provides strong foundation.
The effect of Chinese crude drug moutan root bark: heat clearing away, removing heat from blood, and blood, repercussive.
Analysis by modern chemistry and pharmacology aspect: contain paeonol, paeonolide, paeonolide (paeonolide ten arabinose), paeoniflorin in the moutan root bark.Still contain volatile oil 0.15～0.4% and plant sterol etc.And efficacy component is mainly paeonol, paeonolide and paeoniflorin.
Clinical confirmation pharmacological action has: antibacterial, antiinflammatory, anticoagulation, analgesic, convulsion, inhibition central action; And cardiovascular system, immunity all there is facilitation.
Aforesaid a kind of eye mask of using the root of Paeonia suffruticosa Ardr. extract pastes essence, it is characterized in that described thickening stabilization component is carbomer.
Aforesaid a kind of eye mask of using the root of Paeonia suffruticosa Ardr. extract pastes essence, it is characterized in that described in and component be triethanolamine.
The method that a kind of eye mask for preparing above-mentioned application root of Paeonia suffruticosa Ardr. extract pastes essence is characterized in that may further comprise the steps:
(1) with B with the glycerol of A in mutually mutually all the other components of rear adding A that are uniformly dispersed, be heated to 80～90 ℃, add again the C phase, insulation 5～15min, rear cooling stirs;
(2) be cooled to 45～55 ℃, add the D phase, stir, continue cooling;
(3) be cooled to 35～45 ℃, add E phase, F phase again, stir, filtration gets final product.
The present invention has following advantage with respect to prior art:
1, take from the Chinese quintessence of Chinese culture, there is medicinal history in several thousand in the natral plant ingredients source, and product is natural, safe, effective;
2, without adding: product adds essence, pigment etc. anything but;
3, the directed extraction of modern plant extract technology has bioactive function composition, selects the essence, and keeps away its waste matter;
4, alleviate eye fatigue, have blood circulation promoting and blood stasis dispelling, antiinflammatory is calm, Vitamin K, the effect of the edema that disappears, eye pouch and additional moisture content.
[specific embodiment]
The invention will be further described below in conjunction with specific embodiment:
Embodiment 1:
The eye mask that the present invention uses the root of Paeonia suffruticosa Ardr. extract pastes essence, its by weight percentage composition comprise following component:
A, moisturizing component
B, thickening stabilization component 0.5%
C, antiallergic component
Allantoin 0.5%
Glycyrrhizic acid dipotassium 0.5%
D, effect active constituent
E, in and component 0.5%
F, anticorrosion component 0.5%;
Wherein said thickening stabilization component is carbomer;
In wherein said and component be triethanolamine.
The preparation of present embodiment realizes by following steps:
(1) with B with the glycerol of A in mutually mutually all the other components of rear adding A that are uniformly dispersed, be heated to 80 ℃, add again the C phase, insulation 5min, rear cooling stirs;
(2) be cooled to 45 ℃, add the D phase, stir, continue cooling;
(3) be cooled to 35 ℃, add E phase, F phase again, stir, filtration gets final product.Embodiment 2:
The eye mask that the present invention uses the root of Paeonia suffruticosa Ardr. extract pastes essence, its by weight percentage composition comprise following component:
A, moisturizing component
B, thickening stabilization component 0.2%
C, antiallergic component
Allantoin 0.2%
Glycyrrhizic acid dipotassium 0.2%
D, effect active constituent
E, in and component 0.2%
F, anticorrosion component 0.2%;
Wherein said thickening stabilization component is carbomer;
In wherein said and component be triethanolamine.
The preparation of present embodiment realizes by following steps:
(1) with B with the glycerol of A in mutually mutually all the other components of rear adding A that are uniformly dispersed, be heated to 82 ℃, add again the C phase, insulation 10min, rear cooling stirs;
(2) be cooled to 48 ℃, add the D phase, stir, continue cooling;
(3) be cooled to 38 ℃, add E phase, F phase again, stir, filtration gets final product.
Embodiment 3:
The eye mask that the present invention uses the root of Paeonia suffruticosa Ardr. extract pastes essence, its by weight percentage composition comprise following component:
A, moisturizing component
B, thickening stabilization component 0.3%
C, antiallergic component
Allantoin 0.3%
Glycyrrhizic acid dipotassium 0.3%
D, effect active constituent
E, in and component 0.3%
F, anticorrosion component 0.3%;
Wherein said thickening stabilization component is carbomer;
In wherein said and component be triethanolamine.
The preparation of present embodiment realizes by following steps:
(1) with B with the glycerol of A in mutually mutually all the other components of rear adding A that are uniformly dispersed, be heated to 85 ℃, add again the C phase, insulation 10min, rear cooling stirs;
(2) be cooled to 50 ℃, add the D phase, stir, continue cooling;
(3) be cooled to 40 ℃, add E phase, F phase again, stir, filtration gets final product.
Embodiment 4:
The eye mask that the present invention uses the root of Paeonia suffruticosa Ardr. extract pastes essence, its by weight percentage composition comprise following component:
A, moisturizing component
B, thickening stabilization component 0.4%
C, antiallergic component
Allantoin 0.4%
Glycyrrhizic acid dipotassium 0.4%
D, effect active constituent
E, in and component 0.4%
F, anticorrosion component 0.4%;
Wherein said thickening stabilization component is carbomer;
In wherein said and component be triethanolamine.
The preparation of present embodiment realizes by following steps:
(1) with B with the glycerol of A in mutually mutually all the other components of rear adding A that are uniformly dispersed, be heated to 88 ℃, add again the C phase, insulation 10min, rear cooling stirs;
(2) be cooled to 53 ℃, add the D phase, stir, continue cooling;
(3) be cooled to 43 ℃, add E phase, F phase again, stir, filtration gets final product.
Embodiment 5:
The eye mask that the present invention uses the root of Paeonia suffruticosa Ardr. extract pastes essence, its by weight percentage composition comprise following component:
A, moisturizing component
B, thickening stabilization component 0.1%
C, antiallergic component
Allantoin 0.1%
Glycyrrhizic acid dipotassium 0.1%
D, effect active constituent
E, in and component 0.1%
F, anticorrosion component 0.1%;
Wherein said thickening stabilization component is carbomer;
In wherein said and component be triethanolamine.
The preparation of present embodiment realizes by following steps:
(1) with B with the glycerol of A in mutually mutually all the other components of rear adding A that are uniformly dispersed, be heated to 85 ℃, add again the C phase, insulation 10min, rear cooling stirs;
(2) be cooled to 50 ℃, add the D phase, stir, continue cooling;
(3) be cooled to 40 ℃, add E phase, F phase again, stir, filtration gets final product.
The eye mask of the application root of Paeonia suffruticosa Ardr. extract of embodiment 1 to embodiment 5 is pasted essence do some testing performance indexes, its test is as follows:
1. outward appearance: the faint yellow transparent viscous liquid that has
2.pH value: 4.0-7.0
3. abnormal smells from the patient: characteristic odor
4. heat-resistant stability investigation (48 ℃ * 24H): qualified
Cold-resistant study on the stability (15 ℃ * 24H): qualified.
Water can be deionized water or RO water or distilled water among the above embodiment, and the content of water can change to satisfy whole component content sums according to the variation of other component contents be absolutely.
Application process of the present invention is that the Paeonia suffruticosa essence is soaked the non-woven fabrics eye patch, and every pair of eye patch soaks and contains elite 5-10g, and using method is: behind the cleaning eye, film is affixed on eye, applies and took off in 15-20 minute; 2-4 time weekly, or apply ointment or plaster during the eyestrain.
Efficacy test method of the present invention is as follows:
One, product test
1, method of testing:
Get 1 of embodiment 3 eye sticker and be affixed on the right eye angle 15-20 minute, the blank experiment is not pasted or is done at the left eye angle.By experimenter oneself impression and canthus, left and right sides range estimation contrast effect.
2, object of study:
First group of crowd: choose 20 people from office and quality testing department:
Second group of crowd: choose 20 people from workshop and other department of factory:
3, effect feedback:
First group of crowd:
Second group of crowd:
Wherein Paeonia suffruticosa clear concept degree is referred to sensuously experience and obviously be different from common eye sticker from abnormal smells from the patient, use.
Allow first group of crowd and second group of crowd respectively the eye mask of embodiment 1, embodiment 2 on probation, embodiment 4, embodiment 5 paste product, result on trial is close with embodiment 3, just because of the increase and decrease of effect active constituent content, effective percentage is slightly corresponding slightly to be increased and decreased.
4, interpretation of result:
1.: all experimenters to the Paeonia suffruticosa concept analyse quite clearly, understandable, also very fast acceptance approval.
2.: the slight fever sense is arranged in the product use procedure, have few part not accept the sensation of heat, but most of can acceptance.
3.: to invigorate blood circulation, calm, black eye, edema all have certain result of use.
Therefore as can be known, application product of the present invention is applicable to black eye, eye pouch, edema, dry hydropenia and eye fatigue person.
Two, lecture experiment:
Ferric chloride alcoholic solution with 2% drips in essence of the present invention (can add 5 times of water dilutions), can be observed solution and becomes purple cyan.
Proof: contain a large amount of paeonol compositions in the prescription, paeonol is that the drug effect in the moutan root bark represents composition.
Principle: ferric ion generates three paeonols with the phenolic hydroxyl group complex reaction in the paeonol and closes ferrum, shows violet complex.
Purple be a kind of coordination compound (being again complex), the oxygen atom that ferrum can be used as transition elements in the hydroxyl of central atom paeonol provides lone pair electrons and ferrum to form coordinate bond.One
As be 6 paeonol molecules and an iron ion coordination, namely the ligancy of ferrum is 6.
Claims (4)
1. an eye mask of using the root of Paeonia suffruticosa Ardr. extract pastes essence, it is characterized in that percentage composition comprises following component by weight:
A, moisturizing component
B, thickening stabilization component 0.1～0.5%
C, antiallergic component
Allantoin 0.1～0.5%
Glycyrrhizic acid dipotassium 0.1～0.5%
D, effect active constituent
E, in and component 0.1～0.5%
F, anticorrosion component 0.1～0.5%.
2. a kind of eye mask of using the root of Paeonia suffruticosa Ardr. extract according to claim 1 pastes essence, it is characterized in that described thickening stabilization component is carbomer.
3. a kind of eye mask of using the root of Paeonia suffruticosa Ardr. extract according to claim 1 pastes essence, it is characterized in that described in and component be triethanolamine.
4. method that the eye mask for preparing the described application root of Paeonia suffruticosa Ardr. of claim 1 extract pastes essence is characterized in that may further comprise the steps:
(1) with B with the glycerol of A in mutually mutually all the other components of rear adding A that are uniformly dispersed, be heated to 80～90 ℃, add again the C phase, insulation 5～15min, rear cooling stirs;
(2) be cooled to 45～55 ℃, add the D phase, stir, continue cooling;
(3) be cooled to 35～45 ℃, add E phase, F phase again, stir, filtration gets final product.
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Effective date of registration: 20170606 Address after: 510000, No. 2, A zone, industrial road, Taihe village, Zhenlong, Baiyun District, Guangzhou, Guangdong Patentee after: Guangzhou sunshine Cosmetics Co., Ltd. Address before: 510000, Guangdong, Guangzhou Province, Baiyun District, long Cheng Park, Xia Industrial Avenue, West A District No. 2, Guangzhou City Ao Cosmetics Co., Ltd. Patentee before: Peng Zaihui |
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