CN104587331A - Preparation method of traditional Chinese medicine preparation for preventing and treating sunburn skin injury - Google Patents
Preparation method of traditional Chinese medicine preparation for preventing and treating sunburn skin injury Download PDFInfo
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- CN104587331A CN104587331A CN201510057773.8A CN201510057773A CN104587331A CN 104587331 A CN104587331 A CN 104587331A CN 201510057773 A CN201510057773 A CN 201510057773A CN 104587331 A CN104587331 A CN 104587331A
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Abstract
The invention relates to a preparation method of a traditional Chinese medicine preparation for preventing and treating sunburn skin injury. The traditional Chinese medicine preparation is prepared from the following raw materials in percentage by weight: 9% of a traditional Chinese medicine extract, 3% of monoglyceride, 10% of stearic acid, 10% of glycerinum, 3% of honey, 2% of vitamin C and the balance of deionized water. The traditional Chinese medicine preparation prepared by virtue of the preparation method is low in ultraviolet transmittance, has an intermediate anti-ultraviolet effect, has no stimulation to skin and is wide in application prospect.
Description
Technical field
The invention belongs to Chinese medicine technical field, particularly, relate to a kind of preparation method of preventing and treating solaris skin injury Chinese medicine preparation.
Background technology
Continuous worsening in recent years due to natural ecological environment, the degree aggravation that ozone layer is destroyed, the ultraviolet arriving earth surface is increased, and the health threat caused the mankind is also increasing, and the uitraviolet intensity contained in sunlight is very high, ultraviolet easy penetrating skin surface, ultraviolet radiation can not only produce melanin, makes skin darkening, makes the possibility of skin ageing in addition, after skin accepts ultraviolet overexposure, meeting lesional epidermis cell; Activation Tyrosinase, accelerates pigment synthesis, destroys the moisture-keeping functions of skin, makes skin become dry, make the elastic fibers in skin corium impaired, microgroove is produced, under strong illumination, also can cause skin inflammation, burn, when having abnormal case, then can become pigmentosa skin carcinoma etc.
In brown color after skin shines, show that skin enters self-protection state.Thickening of skin is the performance of skin self-protection with melanic generation.But melanin can only partially absorb UV-B, play buffer action, make skin injury-free, but without the function absorbing ultraviolet light,long wave.
Research shows, external sunscreen is the solar lentigines dermopathic most direct approach of prevention and main policies, commercially available whitening, sun-proof class cosmetics are not only expensive and also disputable in safety, and it contains certain chemical addition agent, has side effect to skin, the anaphylaxiss such as very possible appearance is red and swollen, trace is itched, more can put on the skin more dry and more dry, sudden and violent skin of even tanning severely, and the many unification of effect, take effect slow, and with rear easy recurrence.
Chinese herbal medicine is applied to cosmetics long history, and people just know and to paint the fingernails with Flos Impatientis in ancient times, pencil one's eyebrows, with the oils and fats skin protection of animal by Indigo Naturalis.In the contemporary society of uphold nature, with action temperature with there is again the Chinese herbal medicine extract of certain effect for natural additive, be applied in cosmetics the highest priority having become many cosmetics research and development organizations.This kind of cosmetics now pour in Cosmetic Market like the mushrooms after rain and are the cognition of consumers in general institute gradually, therefore research and develop the focus of attention of this area of developing that to take natural Chinese medicinal herb as the external sunscreen of main component be always.
Summary of the invention
The object of the invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease, has no side effect, safe ready, cheap natural cosmetics and preparation method thereof.Its objective is to effectively prevent and treat solaris skin injury, and a series of skin problems that sunburn occurs, the defects such as the cosmetics safety overcoming prior art is poor, pigmentation is expensive.
Chinese medicine is used for the history that cosmetic sunscreen has more than one thousand years, of long standing and well established, theoretical abundant, " Ling Shu Miraculous Pivot or Divine Axis pathogen cacosplanchnia shape ": " its vim and vigour all go up walks sky key in face for the twelve regular channels, 365 networks.", scripture shows, the complexion of people is relevant to QI and blood.Have in " General Treatise on the Cause and Symptoms of Diseases ": " dark complexion chap person, or internal organs have phlegm retention, or skin is by ailment said due to cold or exposure, all makes qi and blood disorder, and to raw black chap, the vital organs of the human body 12 menses, all go up in face, the trip of husband's blood, all flourish the exterior and the interior.People or phlegm retention waterlogging possession, or space between skin and muscles wind-engaging is got along well to vim and vigour, puckery or turbid, can not be flourish in skin, side becomes raw black." traditional Chinese medical science thinks: the vital organs of the human body of people directly have influence on face.Lung: main breathing a surname sends out, outer conjunction fur; Occur that mottle is relevant with lung-heat.The heart: main heart arteries and veins, mind, " in face, it fills at blood vessels in its China ".Insufficiency of heart-QI, deficiency of heart-YANG, deficiency of heart-blood, flaming up of heart-fire, stagnation of heart-blood, deficiency of heart-blood, heat attacking the pericardium, causes lusterless complexion.Kidney: the kidney being the origin of congenital constitution.Kidney storing essence, main water liquid, main, the raw marrow of main bone.Insufficiency of kidney-YANG, deficiency of the kidney yin, deficiency of kidney-essence, cause deficient in energy, makings is low.
Present inventor is according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, from motherland's medical treasure-house, filter out benefiting QI and nourishing blood, heat clearing and damp drying, the natural Chinese medicine of effect of eliminating fire and detoxication, antiinflammatory, antiallergic, by theory of Chinese medical science prescription, has the effect of taking stopgap measures and effecting a permanent cure to sunburn.
For achieving the above object, the technical solution used in the present invention is as follows:
Prevent and treat a preparation method for the Chinese medicine preparation of solaris skin injury, described preparation is prepared by the raw material of following weight proportioning and obtains:
Chinese medicine extract 9%, monoglyceride 3%, stearic acid 10%, glycerol 10%, Mel 3%, vitamin C 2%, surplus are deionized water, and the percentage ratio sum of raw material is 100%.
The preparation method of described preparation is:
Glycerol, stearic acid, monoglyceride are placed in container and mix, stir 1 hour, then Chinese medicine extract, vitamin C, Mel, deionized water is added, with homogenizing blender with 2000 revs/min, stir and obtain milky substance in 5 minutes, then, in incapsulating, packaging warehouse-in, every capsules loads 0.5g.
Described Chinese medicine extract is prepared from by following raw material:
The Radix Astragali, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Poria, Fructus Cnidii, Radix Glycyrrhizae, Cortex Moutan, Herba Hedyotidis Diffusae, Flos Lonicerae, the Rhizoma Atractylodis Macrocephalae,
Folium Ginkgo, Semen Armeniacae Amarum, the Radix Stemonae, the Flos Sophorae Immaturus, Herba Taraxaci, Semen Persicae, Radix Aconiti Lateralis Preparata, Semen Coicis, Rhizoma Coptidis, Flos Farfarae.
Preferably, described Chinese medicine extract is prepared from by the raw material of following weight parts:
The Radix Astragali 35 parts, the Radix Angelicae Dahuricae 35 parts, Radix Angelicae Sinensis 35 parts, 35 parts, Poria, Fructus Cnidii 30 parts,
30 parts, Radix Glycyrrhizae, Cortex Moutan 30 parts, Herba Hedyotidis Diffusae 25 parts, Flos Lonicerae 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts,
Folium Ginkgo 20 parts, 20 parts, Semen Armeniacae Amarum, the Radix Stemonae 20 parts, the Flos Sophorae Immaturus 15 parts, Herba Taraxaci 15 parts,
10 parts, Semen Persicae, Radix Aconiti Lateralis Preparata 10 parts, Semen Coicis 10 parts, Rhizoma Coptidis 8 parts, Flos Farfarae 5 parts.
The preparation method of described Chinese medicine extract is as follows:
(1) according to parts by weight weighting raw materials;
(2) get the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Fructus Cnidii, Radix Glycyrrhizae, Cortex Moutan, Herba Hedyotidis Diffusae, Folium Ginkgo, Radix Aconiti Lateralis Preparata, Flos Farfarae add 3 times of weight 90% alcohol dipping 24 hours; reflux, extract, twice; each 1 hour; merge extractive liquid; be condensed into the clear paste that density is 1.2 g/ml, crushed after being dried obtains complex A;
(3) get residual components water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour; Second time extracts the water adding 2 times of weight, and extraction time is 1 hour; Filter, merging filtrate, be concentrated into the clear paste that density is 1.2 g/ml, crushed after being dried obtains complex B;
(4) mixed complex A and complex B obtains the Chinese medicine extract of the application.
The present invention is based on the differential diagnosis of diseases of motherland's medical science and the dialectical principle combined, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical tune, its Effective Component of Chinese Medicine all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, reliably evident in efficacy through clinical practice, mild in medicine property and, there is not toxic and side effects, have a extensive future.
Usage and dosage: be coated with usage outward, gets 1 capsules uniform application in face, cervical region, hand.
Beneficial effect of the present invention:
(1) multiplex natural cosmetics of the present invention all adopts natural material, and not chemosynthesis, to skin fanout free region, safety is higher, and preparation method is fairly simple, and production cost is lower.
(2) the present invention's anti-sunburn preparation, there is the effect of anti-sunburn, moisturizing, use very convenient, cheap, eliminate the cumbersome process smearing multiple cosmetics every day.
Detailed description of the invention
Embodiment 1
Prevent and treat a preparation method for the Chinese medicine preparation of solaris skin injury, it is prepared by the raw material of following weight proportioning and obtains:
Chinese medicine extract 9%, monoglyceride 3%, stearic acid 10%, glycerol 10%, Mel 3%, vitamin C 2%, surplus are deionized water, and the percentage ratio sum of raw material is 100%.
The preparation method of described preparation is:
Glycerol, stearic acid, monoglyceride are placed in container and mix, stir 1 hour, then Chinese medicine extract, vitamin C, Mel, deionized water is added, with homogenizing blender with 2000 revs/min, stir and obtain milky substance in 5 minutes, then, in incapsulating, packaging warehouse-in, every capsules loads 0.5g.
Described Chinese medicine extract is prepared from by the raw material of following weight parts:
The Radix Astragali 35 parts, the Radix Angelicae Dahuricae 35 parts, Radix Angelicae Sinensis 35 parts, 35 parts, Poria, Fructus Cnidii 30 parts,
30 parts, Radix Glycyrrhizae, Cortex Moutan 30 parts, Herba Hedyotidis Diffusae 25 parts, Flos Lonicerae 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts,
Folium Ginkgo 20 parts, 20 parts, Semen Armeniacae Amarum, the Radix Stemonae 20 parts, the Flos Sophorae Immaturus 15 parts, Herba Taraxaci 15 parts,
10 parts, Semen Persicae, Radix Aconiti Lateralis Preparata 10 parts, Semen Coicis 10 parts, Rhizoma Coptidis 8 parts, Flos Farfarae 5 parts.
The preparation method of described Chinese medicine extract is as follows:
(1) according to parts by weight weighting raw materials;
(2) get the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Fructus Cnidii, Radix Glycyrrhizae, Cortex Moutan, Herba Hedyotidis Diffusae, Folium Ginkgo, Radix Aconiti Lateralis Preparata, Flos Farfarae add 3 times of weight 90% alcohol dipping 24 hours; reflux, extract, twice; each 1 hour; merge extractive liquid; be condensed into the clear paste that density is 1.2 g/ml, crushed after being dried obtains complex A;
(3) get residual components water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour; Second time extracts the water adding 2 times of weight, and extraction time is 1 hour; Filter, merging filtrate, be concentrated into the clear paste that density is 1.2 g/ml, crushed after being dried obtains complex B;
(4) mixed complex A and complex B obtains the Chinese medicine extract of the application.
Embodiment 2
Effect experiment therapeutical effect is verified:
Get SD rat 30, body weight at about 120g, male and female half and half.Rat shaves hair with electronic hairclipper at back before ultraviolet radiation.Experimental animal divides into groups: 1. blank group: after ultraviolet radiation damage, without any process; 2. matched group (Commercial sunscreens emulsifiable paste): after ultraviolet radiation damage, smear Commercial sunscreens emulsifiable paste, every day three times, dosage is 0.5g/ time.3. emulsifiable paste group of the present invention: after ultraviolet radiation damage, smear the preparation of the embodiment of the present invention 1, every day three times, dosage is 0.5g/ time.Record skin scab forming time and wound healing time.The result sees the following form 1:
Table 1
| Group | Number of cases | Scab forming time (my god) | Healing time (my god) |
| Blank group | 10 | 0.81±0.17 | 14.25±1.12 |
| Matched group | 10 | 0.79±0.16 | 13.37±1.34 |
| Of the present invention group | 10 | 0.56±0.11 | 9.68±1.21 |
As can be seen from the above table, compared with blank group and matched group, the scab forming time of of the present invention group and the equal significance of healing time shorten (P < 0.05), the scab forming time of matched group and healing time and without there was no significant difference between blank group of any process.Show that emulsifiable paste of the present invention has sunburn and significantly treat repair.
The anti-sunburn preparation security research of the present invention
Cosmetics of the present invention belong to external preparation, carry out safety research to it.Adopt the anti-sunburn preparation of embodiment 1.
Be fixed in fixed bin by tested rabbit, be applied on the plucked skin in right side with this given the test agent 0.5g, application area is (2.5 × 2.5) cm
2, smear every day once, smear 14d continuously.From the 2nd day, answer cropping before smearing at every turn, remove residual sample with warm water, observed result after 1h, check plot, left side is smeared 0.5mL normal saline and is contrasted, and marks by skin wound repair standards of grading, calculate every only tested rabbit integral mean value every day, judge skin stimulus intensity.Experimental result shows: animal subject back is all without red and swollen, and fester, blister phenomenon, is as good as with blank group skin, shows product nonirritant of the present invention, safe and reliable.
The sun-proof potency assay in invention formulation UVA district
Method: utilize dual-beam ultraviolet/visible spectrophotometer, quartz cell adhesive tape is coated with sample, quartz plate adhesive tape is coated with sample difference working sample absorbance and light transmittance, the sun-proof usefulness in overall merit Qi UVA district.
Experiment content:
1. absorbance measurement
Connect ultraviolet spectrophotometer instrument power source preheating 15min, setting determined wavelength is: 350nm, 360nm, 370nm, 380nm, 390nm, be placed in sample arm and reference light paths by the unloaded quartz cell posting adhesive tape, demodulating apparatus zero point; Testing sample pond is placed in sample arm, another quartz cell posting adhesive tape is placed in reference light paths, measure the ultraviolet light absorption angle value A of 5 wavelength, measured value is calculated arithmetic mean of instantaneous value, sequentially determining 5 parallel sample, then by A1 ~ A5, ask arithmetic mean of instantaneous value, be the ultraviolet light absorption angle value of sample, the sunscreen products formulated according to QB/T2410-1998, at the evaluation criteria of UVA district ultraviolet spectrophotometry, makes evaluation to test result;
Deliberated index is as follows: 0.5<A value <1.0 has minimum protection ultraviolet light effect; 1.1<A value <1.5 has medium protection ultraviolet light effect; 1.6<A value <2.0 has high protectiving ultraviolet radiation response; A value >2.1 has complete protectiving ultraviolet radiation response.The absorbance values of experimental result display finished product group is 1.237, shows to have medium protection ultraviolet effect.The results are shown in Table 2.
Table 2: finished dosage form is in UVA district ultraviolet absorptivity measurement result
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, all minor variations that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should protection scope of the present invention be thought.
Claims (4)
1. prevent and treat a preparation method for solaris skin injury Chinese medicine preparation, it is characterized in that, the preparation method of described preparation comprises the steps:
Take off according to weight proportion and state raw material: Chinese medicine extract 9%, monoglyceride 3%, stearic acid 10%, glycerol 10%, Mel 3%, vitamin C 2%, surplus are deionized water;
Glycerol, stearic acid and monoglyceride are placed in container mix, stir 1 hour, then add Chinese medicine extract, vitamin C, Mel and deionized water, with homogenizing blender with 2000 revs/min, stir 5 minutes and get final product;
Described Chinese medicine extract is prepared from by following raw material medicaments: the Radix Astragali, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Poria, Fructus Cnidii, Radix Glycyrrhizae, Cortex Moutan, Herba Hedyotidis Diffusae, Flos Lonicerae, the Rhizoma Atractylodis Macrocephalae, Folium Ginkgo, Semen Armeniacae Amarum, the Radix Stemonae, the Flos Sophorae Immaturus, Herba Taraxaci, Semen Persicae, Radix Aconiti Lateralis Preparata, Semen Coicis, Rhizoma Coptidis, Flos Farfarae.
2. method according to claim 1, is characterized in that, described Chinese medicine extract is prepared from by the crude drug of following weight parts:
The Radix Astragali 35 parts, the Radix Angelicae Dahuricae 35 parts, Radix Angelicae Sinensis 35 parts, 35 parts, Poria, Fructus Cnidii 30 parts,
30 parts, Radix Glycyrrhizae, Cortex Moutan 30 parts, Herba Hedyotidis Diffusae 25 parts, Flos Lonicerae 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts,
Folium Ginkgo 20 parts, 20 parts, Semen Armeniacae Amarum, the Radix Stemonae 20 parts, the Flos Sophorae Immaturus 15 parts, Herba Taraxaci 15 parts,
10 parts, Semen Persicae, Radix Aconiti Lateralis Preparata 10 parts, Semen Coicis 10 parts, Rhizoma Coptidis 8 parts, Flos Farfarae 5 parts.
3. the method described in claim 1 or 2, is characterized in that, the preparation method of described Chinese medicine extract comprises the steps:
(1) according to weight portion weighting raw materials;
(2) Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Fructus Cnidii, Radix Glycyrrhizae, Cortex Moutan, Herba Hedyotidis Diffusae, Folium Ginkgo, Radix Aconiti Lateralis Preparata, Flos Farfarae is got, mixing, add 3 times of weight 90% alcohol dipping 24 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, be condensed into the clear paste that density is 1.2 g/ml, crushed after being dried obtains complex A;
(3) get surplus stock medicine, by water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour; Second time extracts the water adding 2 times of weight, and extraction time is 1 hour; Filter, merging filtrate, be concentrated into the clear paste that density is 1.2 g/ml, crushed after being dried obtains complex B;
(4) complex A and complex B is mixed and get final product.
4. method described in claim 1-3 is used for sun-proof purposes.
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| CN107260634A (en) * | 2017-06-30 | 2017-10-20 | 合肥卓畅农业科技有限公司 | A kind of green Chinese nti-freckle suncream and preparation method thereof |
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| CN107260634A (en) * | 2017-06-30 | 2017-10-20 | 合肥卓畅农业科技有限公司 | A kind of green Chinese nti-freckle suncream and preparation method thereof |
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