CN101978996A - Traditional Chinese medicinal composition for preventing and treating sunburn and preparation method of cream thereof and cream thereof - Google Patents
Traditional Chinese medicinal composition for preventing and treating sunburn and preparation method of cream thereof and cream thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for preventing and treating sunburn, a preparation method of cream thereof and cream thereof. The traditional Chinese medicinal composition comprises raw material components including seabuckthorn oil, coptis and baikal skullcap root according to a weight ratio of 200-400:30:30. The preparation method comprises the following steps of: preparing an oil phase from the seabuckthorn oil, a fat-soluble excipient and a fat-soluble emulsifier according to a ratio; proportioning the baikal skullcap root, the coptis, the fat-soluble excipient, the fat-soluble emulsifier and distilled water; crushing the baikal skullcap root and the coptis, adding a part of distilled water to soak the crushed materials, and performing ultrasonic extraction under the heating condition and filtering, and obtaining filtrate; adding other components in an aqueous phase and rest distilled water into the filtrate, and fully mixing to prepare an aqueous phase; and heating the oil phase and the aqueous phase on a water bath kettle respectively, and slowly pouring the aqueous phase into the oil phase with stirring for emulsification and thus, obtaining the traditional Chinese medicinal cream for preventing and treating sunburn. The prepared traditional Chinese medicinal cream has the combined functions of preventing and treating sunburn and is lower in cost.
Description
Technical field
The present invention relates to have concurrently Chinese medicine composition and preparation thereof sun-proof and treatment sunburn effect.
Background technology
The ultraviolet of solar irradiation is useful to health, but human body tans by the sun under burning sun heavy dose of contact ultraviolet for a long time, skin rubefaction, blackout and damage can take place, and then can damage the human immune system, quicken skin ageing, cause various dermatosiss, even produce skin carcinoma.For this reason, people have just produced sunscreen various in style, wherein also have much to contain Chinese medicinal ingredients or Chinese medicine extract.For example, it is exactly a kind of sunscreen that contains Chinese medicine extract that notification number CN100577140C, name are called " a kind of nanometer baicalin emulsion cosmetics ", and these cosmetics are that 0.10 ‰～10.00 ‰ baicalin (Chinese medicine extract) is formed with surfactant, oil, essence and distilled water by mass percent.These cosmetics not only possess sun-proof and effect skin whitening, and certain effect is also being arranged aspect the auxiliary treatment acne.Yet, for the skin of having tanned severely, because these goods are a kind of cosmetics and do not have therapeutical effect substantially after all.And can play (comprising Chinese medicine) other topical drugs of therapeutical effect at present to the skin of having tanned severely, spread upon them on the skin after, can not play sun-proof effect, influence is attractive in appearance mostly again.Also promptly in existing cosmetics and medicine, lack and take into account product sun-proof and treatment sunburn double effects.
Summary of the invention
First purpose of the present invention is that a kind of Chinese medicine composition sun-proof and treatment sunburn effect that has concurrently is provided.
Second purpose of the present invention is on the basis of realizing first goal of the invention, to provide a kind of preparation method sun-proof and the traditional Chinese medicine emulsifiable paste agent for the treatment of the sunburn effect that has concurrently.
The 3rd purpose of the present invention is on the basis of realizing second goal of the invention, to provide a kind of traditional Chinese medicine emulsifiable paste agent sun-proof and treatment sunburn effect that has concurrently.
Realize the technical scheme of first goal of the invention, it is a kind of like this Chinese medicine composition sun-proof and treatment sunburn effect that has concurrently, aspect same as the prior art is, include the water-soluble extract of Radix Scutellariae in this Chinese medicine composition, its improvements are to also have water-soluble extract and the Oleum Hippophae of Rhizoma Coptidis in this Chinese medicine composition; Wherein, Rhizoma Coptidis equates that with the former survival dose of Radix Scutellariae the former medicine weight ratio of each component is Oleum Hippophae: Rhizoma Coptidis: Radix Scutellariae=200～400: 30: 30.
Realize the technical scheme of second goal of the invention, it is a kind of like this preparation method sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste that has concurrently, medicinal former medicine in this method is the medicinal former medicine of realizing in the sun-proof Chinese medicine composition with treatment sunburn effect of having concurrently of first goal of the invention, and its preparation process is as follows:
1. fully mix behind Oleum Hippophae and fat-soluble excipient and the fat-soluble emulsifier heating and melting, with the preparation oil phase; The weight ratio of its component is Oleum Hippophae: fat-soluble excipient: fat-soluble emulsifier=200～400: 250～350: 40～80;
When 2. being 200～400g with the consumption of Oleum Hippophae in the described oil phase as benchmark, use Radix Scutellariae: Rhizoma Coptidis: water soluble excipient: water soluble emulsifier=20～40g: 20～40g: 80～125g: 10～15g, and join sufficient distilled water by total amount 1000g, to prepare the preparation water;
3. with step 2. the Radix Scutellariae and the Rhizoma Coptidis powder of described proportional quantity be broken into powder, and be added in the distilled water of 1/4～1/3 consumption and soaked at least 1 hour, the supersound extraction time is no less than 40min under 60 ℃ of conditions then; Refilter, get filtrate;
4. in gained filtrate, add other components and the residue distilled water of aqueous phase, and fully mix water;
5. respectively described oil phase and water are placed and be heated to 78～82 ℃ on the water-bath, while stirring water is gently poured into emulsifying in the oil phase then, obtain having concurrently sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste.
Realizing the technical scheme of the 3rd goal of the invention, is a kind of like this traditional Chinese medicine emulsifiable paste sun-proof and treatment sunburn effect that has concurrently, and this traditional Chinese medicine emulsifiable paste is according to realizing that the sun-proof preparation method with treatment sunburn effect traditional Chinese medicine emulsifiable paste of having concurrently of second goal of the invention is prepared.
The root that the former medicine Radix Scutellariae of Chinese medicine among the present invention is a Labiatae herbaceous plant Radix Scutellariae has and can " let out lung-fire and expelling pathogenic factors from muscles heat ", lets out the effect of fire, heat clearing away and dampness by it, so its water-soluble extract can reach damp and hot removes, the purpose of the cleer and peaceful skin care of blood poison.(230～350nm) sections have uv absorption effect preferably to main component baicalin in the water-soluble extract of Radix Scutellariae at UVB.Because baicalin itself is exactly a kind of good antiallergic raw material, so baicalin is the sunscreen product of sunscreen there is not the sensitization problem in skin, and it can also reduce the zest of other components.To the skin of having tanned severely, baicalin also has good repair.In addition, baicalin has significant antioxidant role, can suppress the generation of lipid peroxide, removes free radical, can protect Skin Cell not to be subjected to the influence of oxygen-derived free radicals over oxidation, thereby the Skin Cell life-span that prolongs strengthens antidotal ability.
Rhizoma Coptidis is the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall, and heat clearing and damp drying is arranged, the effect of eliminating fire and detoxication.The water-soluble extract of Rhizoma Coptidis all has stronger ultra-violet absorption effect in ultraviolet three districts, near 100%, slightly is lower than Radix Scutellariae in the UVB district in the UVC district, also near 90%, has the sun-proof ability of wide spectrum preferably in the UVA district.In addition, the active effect of Rhizoma Coptidis tool restraint of tyrosinase, but dispelling speckles and whitening face such as easily extract, consumption is few, the extracting solution color is shallow when effective sun-proof concentration at advantage, and not appearing in the newspapers has any bad toxic and side effects to skin histology, has the value of very high extraction natural sun-prevention agent.
Fructus Hippophae is very precious medicine food dual purpose plant, for " Chinese pharmacopoeia is recorded kind.Oleum Hippophae is the vegetable oil in the hippophae rhamnoides seed, contains unsaturated fatty acid and abundant vitamin E, aminoacid, palmitoleic acid, trailing plants b element, class kind of bioactive ingredients surplus trailing plants b element, sitosterol and vitamin A, B, C, the E etc. 40 recklessly recklessly.V in the Oleum Hippophae
E, V
A, V
ASource, flavone compound and other active component be easily by skin absorbs, not only can absorb the ultraviolet energy of consumption that looses, and eliminates or gently change photic skin injury, and the photic skin injury that has taken place had repair and the healing effect.Can also eliminate the multiple deleterious oxygen radical that skin natural aging and light urge in the ageing process being produced, delaying decrepitude of skin, the various The symptoms of aging of lightization, these ultra-violet absorption compositions are than inorganic ultraviolet scattering diluent, especially do not have anaphylaxis, nonirritant, no cumulative potentiality injury than organic uv absorbers, but have good skin protection to support the effect of skin skin moistening.
With Radix Scutellariae, Rhizoma Coptidis, three kinds of drug combinations of Oleum Hippophae, make sun-proof emulsifiable paste, the irradiation that can protect UVA, UVB, UVC effectively reaches the sun-proof purpose of wide spectrum on the one hand, can remove free radical, prolong the Skin Cell life-span.Compared with prior art, by the inventive method prepared go out have traditional Chinese medicine emulsifiable paste sun-proof and treatment sunburn effect concurrently, also possess the skin of having tanned severely is played anti-inflammatory analgesic, antibacterial bacteriostatic, protects from infection, promotes the therapeutic effect of tissue repair healing of tanning severely, and can shorten wound healing time.Promptly bring into play protection and therapeutical effect jointly by water-soluble extract in Radix Scutellariae, the Rhizoma Coptidis and the oily matter in the Oleum Hippophae.
From the method that realizes second goal of the invention as can be known, realize that the sun-proof traditional Chinese medicine emulsifiable paste with treatment sunburn effect of having concurrently of the 3rd goal of the invention is Water-In-Oil (W/O) type, so, the flushing of sweat can also be reduced to this traditional Chinese medicine emulsifiable paste.
Compared with prior art,, all in preparation water process, directly extract, therefore, compare, also provide cost savings with directly selecting baicalin and Rhizoma Coptidis extract for use from Radix Scutellariae and Rhizoma Coptidis owing to Radix Scutellariae and Rhizoma Coptidis extract among the present invention.
The present invention is further illustrated below in conjunction with accompanying drawing.
Description of drawings
Light transmittance comparison diagram in Fig. 1---200～400nm scope
The specific embodiment
One, have Chinese medicine composition sun-proof and treatment sunburn effect concurrently, it includes the water-soluble extract of Radix Scutellariae, in Chinese medicine composition of the present invention, also has water-soluble extract and the Oleum Hippophae of Rhizoma Coptidis.Wherein, Rhizoma Coptidis equates that with the former survival dose of Radix Scutellariae the former medicine weight ratio of each component is Oleum Hippophae: Rhizoma Coptidis: Radix Scutellariae=200～400: 30: 30.
Further, the former medicine weight ratio of each component is got Oleum Hippophae in this Chinese medicine composition: Rhizoma Coptidis: Radix Scutellariae=250～350: 30: 30.
Two, have preparation method sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste concurrently, the medicinal former medicine in the inventive method is the medicinal former medicine in the above-mentioned Chinese medicine composition that has sun-proof and treatment sunburn effect concurrently, and its preparation process is as follows:
1. fully mix behind Oleum Hippophae and fat-soluble excipient and the fat-soluble emulsifier heating and melting, with the preparation oil phase; The weight ratio of its component is Oleum Hippophae: fat-soluble excipient: fat-soluble emulsifier=200～400: 250～350: 40～80;
When 2. being 200～400g with the consumption of Oleum Hippophae in the described oil phase as benchmark, use Radix Scutellariae: Rhizoma Coptidis: water soluble excipient: water soluble emulsifier=20～40g: 20～40g: 80～125g: 10～15g, and join sufficient distilled water by total amount 1000g, to prepare the preparation water;
3. 2. the Radix Scutellariae and the Rhizoma Coptidis powder of described proportional quantity are broken into powder with step, and be added in the distilled water of 1/4～1/3 consumption and soaked at least 1 hour, the supersound extraction time is no less than 40min and (those skilled in the art know that under 60 ℃ of conditions then, extraction time should be to spend to extract water solubility extract in Radix Scutellariae and the Rhizoma Coptidis to greatest extent, not lose time again obviously, so in the checking example, no longer is described the concrete time); Refilter, get filtrate;
4. in gained filtrate, add other components and the residue distilled water of aqueous phase, and fully mix water;
5. respectively described oil phase and water are placed and be heated to 78～82 ℃ on the water-bath and (those skilled in the art know that, it is to go up lower deviation that this temperature range should be understood to, 80 ℃ of average out to), while stirring water is gently poured into emulsifying in the oil phase then, obtain having concurrently sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste.
Further, the present invention's preparation has concurrently in the method for sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste, described fat-soluble excipient comprises one or both the mixture (in most of the cases, with wherein monoglyceride, vaseline, Cera Flava and/or liquid paraffin) in stearic acid, hexadecanol, octadecanol, monoglyceride, vaseline, lanoline, vegetable oil, Cera Flava and the liquid paraffin; Arlacel-60), one or both the mixture in sorbitan monooleate, anhydrous sorbitol tristearate and the sorbitan trioleate is (in most of the cases, with wherein sorbitan monostearate, glyceryl monostearate and/or sorbitan monooleate described fat-soluble emulsifier comprises glyceryl monostearate, sorbitan monostearate (trade name:.)。
Further say, the present invention's preparation has concurrently in the method for sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste, described water soluble excipient comprises one or both the mixture (in most of the cases, with wherein glycerol and/or ethyl hydroxybenzoate) in ethanol, glycerol, propylene glycol, micromolecule Polyethylene Glycol, ethyl hydroxybenzoate, benzoic acid and the sorbic acid; Tween 80), one or both the mixture (in most of the cases, with wherein polyoxyethylene 20 sorbitan monooleate, polyoxyethylene 20 sorbitan monostearate and/or polyoxyethylene castor oil glycerin ether) in polyoxyethylene 20 sorbitan monostearate, polyoxyethylene castor oil glycerin ether, polyoxyethylene monostearate and the polyoxyethylene laurel ether described water soluble emulsifier comprises polyoxyethylene 20 sorbitan monooleate (trade name:.
Specify: have concurrently in the method for sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste in the present invention's preparation, except that the component and proportioning of its Central Plains medicine (being crude drug), concrete fat-soluble excipient and fat-soluble emulsifier, concrete water soluble excipient and water soluble emulsifier and proportioning thereof, and they are combined be prepared into the step of water-in-oil type traditional Chinese medicine emulsifiable paste, basically all belong to prior art, for those skilled in the art, can prepare too by limited routine test several times at the most.What in several places, front note said " in most of the cases ",, be meant according to factors such as raw material sources, price and even customs selected with wherein.So, in the checking example that this description will disclose,, all only choose wherein minority and be representative for example for concrete fat-soluble excipient and fat-soluble emulsifier, concrete water soluble excipient and water soluble emulsifier and proportioning thereof.
Three, have traditional Chinese medicine emulsifiable paste sun-proof and treatment sunburn effect concurrently, traditional Chinese medicine emulsifiable paste of the present invention is that to have sun-proof method with treatment sunburn effect traditional Chinese medicine emulsifiable paste concurrently according to above-mentioned preparation prepared.
Passed through verification experimental verification by the present invention.At first according to this has component and proportioning thereof sun-proof and the Chinese medicine composition for the treatment of the sunburn effect concurrently in the specific embodiment, prepare several groups with the preparation method described in the specific embodiment and have traditional Chinese medicine emulsifiable paste sun-proof and treatment sunburn effect concurrently, carried out mouse test and external sun-proof result during checking respectively relatively.
The method of mouse test is: get 80 of kunming mices, male and female half and half are divided into vaseline group, (stochastic buying) commercially available sun-proof emulsifiable paste group and emulsifiable paste group of the present invention, 10 every group at random with mice.In mouse right ear separate application vaseline, commercially available sun-proof emulsifiable paste and emulsifiable paste of the present invention, dosage is 0.3g/.Be horizontally fixed on mice on the brandreth and place, shone 6 hours, cause the skin lesion mouse model apart from uviol lamp vertical dimension 10cm place.Mice is put to death in the cervical vertebra dislocation, cuts left and right sides auricle and removes the wide residual medicine of auris dextra, and card punch is laid the left and right ear of animal respectively, weighs with analytical balance, calculates the ear swelling rate.Swelling rate=auris dextra sheet weight/left auricle weight * 100%.Checking the results are shown in following table:
From above-mentioned checking example as can be seen; swelling rate with the matched group of the vaseline of Isodose coating is higher than each medicine group and commercially available sun-proof emulsifiable paste group (P＜0.05); there was no significant difference between each medicine group; but all be better than commercially available sun-proof emulsifiable paste a little, show that this Chinese medicine composition has significant protective effect to this model ultraviolet radiation damage.
The method of external sun-proof result comparison is: the even respectively equivalent of vaseline, commercially available sun-proof emulsifiable paste and emulsifiable paste of the present invention (test group 1 in the mouse test) is applied to the cuvette inwall, in 200～400nm wave-length coverage, scan, determine the light transmittance under each wavelength and make comparisons.Fig. 1 is the light transmittance comparison diagram in this 200～400nm scope, A, B, C are respectively vaseline, contrast the UV scanning curve with commercially available sun-proof emulsifiable paste and emulsifiable paste of the present invention among the figure, from the comparison of three UV scanning curves, commercially available as can be seen sun-proof emulsifiable paste centering ripple and long wave ultraviolet have obviously assimilation effect.But emulsifiable paste light transmittance of the present invention is minimum, uv absorption the strongest (being better than vaseline, commercially available sun-proof emulsifiable paste), and the ultraviolet light in 200～400nm scope all has good absorption.
The therapeutical effect checking:
Get 30 of SD rats, body weight about 120g, male and female half and half.Rat is shaved hair with electronic hairclipper at the back before ultraviolet radiation.Experimental animal grouping: 1. blank group: after the ultraviolet radiation damage, without any processing; 2. commercially available sun-proof emulsifiable paste group: after the ultraviolet radiation damage, smear commercially available sun-proof emulsifiable paste, every day three times, dosage is 0.6g/ time.3. emulsifiable paste group of the present invention (the test group 2 used emulsifiable pastes in the mouse test): after the ultraviolet radiation damage, smear emulsifiable paste of the present invention, every day three times, dosage is 0.6g/ time.Record skin incrustation time and wound healing time.Checking the results are shown in following table:
| Group | Number of animals (only) | The incrustation time (my god) | Healing time (my god) |
| Blank group | 10 | 0.75±0.15 | 13.61±1.34 |
| Commercially available sun-proof emulsifiable paste group | 10 | 0.79±0.19 | 14.23±1.11 |
| Emulsifiable paste group of the present invention | 10 | 0.53±0.12 | 9.72±1.16 |
As can be seen from the above table, compare with blank group and commercially available sun-proof emulsifiable paste group, the equal significance of the incrustation time of emulsifiable paste group of the present invention and healing time shortens (P＜0.05), the incrustation time of commercially available sun-proof emulsifiable paste group and healing time and without there was no significant difference between the blank group of any processing.Show that emulsifiable paste of the present invention has the obvious treatment repair to sunburn.
Claims (6)
1. have Chinese medicine composition sun-proof and treatment sunburn effect concurrently, include the water-soluble extract of Radix Scutellariae in this Chinese medicine composition, it is characterized in that also having water-soluble extract and the Oleum Hippophae of Rhizoma Coptidis in this Chinese medicine composition; Wherein, Rhizoma Coptidis equates that with the former survival dose of Radix Scutellariae the former medicine weight ratio of each component is Oleum Hippophae: Rhizoma Coptidis: Radix Scutellariae=200～400: 30: 30.
2. have preparation method sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste concurrently, it is characterized in that, the medicinal former medicine in this method is the medicinal former medicine in the described Chinese medicine composition that has sun-proof and treatment sunburn effect concurrently of claim 1, and its preparation process is as follows:
1. fully mix behind Oleum Hippophae and fat-soluble excipient and the fat-soluble emulsifier heating and melting, with the preparation oil phase; The weight ratio of its component is Oleum Hippophae: fat-soluble excipient: fat-soluble emulsifier=200～400: 250～350: 40～80;
When 2. being 200～400g with the consumption of Oleum Hippophae in the described oil phase as benchmark, use Radix Scutellariae: Rhizoma Coptidis: water soluble excipient: water soluble emulsifier=20～40g: 20～40g: 80～125g: 10～15g, and join sufficient distilled water by total amount 1000g, to prepare the preparation water;
3. with step 2. the Radix Scutellariae and the Rhizoma Coptidis powder of described proportional quantity be broken into powder, and be added in the distilled water of 1/4～1/3 consumption and soaked at least 1 hour, the supersound extraction time is no less than 40min under 60 ℃ of conditions then; Refilter, get filtrate;
4. in gained filtrate, add other components and the residue distilled water of aqueous phase, and fully mix water;
5. respectively described oil phase and water are placed and be heated to 78～82 ℃ on the water-bath, while stirring water is gently poured into emulsifying in the oil phase then, obtain having concurrently sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste.
3. described preparation has method sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste concurrently according to claim 2, it is characterized in that described fat-soluble excipient comprises one or both the mixture in stearic acid, hexadecanol, octadecanol, monoglyceride, vaseline, lanoline, vegetable oil, Cera Flava and the liquid paraffin; Described fat-soluble emulsifier comprises one or both the mixture in glyceryl monostearate, sorbitan monostearate, sorbitan monooleate, anhydrous sorbitol tristearate and the sorbitan trioleate.
4. have method sun-proof and treatment sunburn effect traditional Chinese medicine emulsifiable paste concurrently according to claim 2 or 3 described preparations, it is characterized in that described water soluble excipient comprises one or both the mixture in ethanol, glycerol, propylene glycol, micromolecule Polyethylene Glycol, ethyl hydroxybenzoate, benzoic acid and the sorbic acid; Described water soluble emulsifier comprises one or both the mixture in polyoxyethylene 20 sorbitan monooleate, polyoxyethylene 20 sorbitan monostearate, polyoxyethylene castor oil glycerin ether, polyoxyethylene monostearate and the polyoxyethylene laurel ether.
5. have traditional Chinese medicine emulsifiable paste sun-proof and treatment sunburn effect concurrently, it is characterized in that, this traditional Chinese medicine emulsifiable paste is that to have sun-proof method with treatment sunburn effect traditional Chinese medicine emulsifiable paste concurrently according to claim 2 or 3 described preparations prepared.
6. have traditional Chinese medicine emulsifiable paste sun-proof and treatment sunburn effect concurrently, it is characterized in that, this traditional Chinese medicine emulsifiable paste is that to have sun-proof method with treatment sunburn effect traditional Chinese medicine emulsifiable paste concurrently according to the described preparation of claim 4 prepared.
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