CN101933892B - New application of kaempferol extractive and sunscreen cosmetic containing kaempferol extractive - Google Patents
New application of kaempferol extractive and sunscreen cosmetic containing kaempferol extractive Download PDFInfo
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- CN101933892B CN101933892B CN2010102630500A CN201010263050A CN101933892B CN 101933892 B CN101933892 B CN 101933892B CN 2010102630500 A CN2010102630500 A CN 2010102630500A CN 201010263050 A CN201010263050 A CN 201010263050A CN 101933892 B CN101933892 B CN 101933892B
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Abstract
The invention discloses a new application of kaempferol extractive and a sunscreen cosmetic containing kaempferol extractive, belonging to the technical field of Chinese traditional medicine and cosmetic, wherein kaempferol extractive has strong ultraviolet absorption in UV-B range, has strong absorption strength, can effectively absorb ultraviolet of sunlight so as to prevent human skin from sun red, sunburn and tanning, can heal photosensitive dermatitis, and can be used as sun screening component of sunscreen cosmetic to be combined with variable sun screening agents to prepare sunscreen skin-care cosmetic. The produced cosmetic has high sunscreen index and is safer than chemical sun screening agent, and has small possibility of allergy effectively. Kaempferol is special medicinal and edible plant at south area, having wide source and plantation in Guangdong, Guangxi and Yunnan.
Description
Technical field
The present invention relates to Chinese medicine and cosmetic field, be specifically related to the new application of medicinal plants Rhizoma Kaempferiae extract in sun care preparations and the sun care preparations that comprises the Rhizoma Kaempferiae extract.
Background technology
In recent years, because of the random discharging of gases such as freon, atmospheric ozone layer is thin day by day, and the uitraviolet intensity that arrives ground increases day by day, and ultraviolet is also more and more heavier to the injury of human body.Ultraviolet is a section of solar radiation, and wavelength is at 230-400nm, and wavelength basis is divided into UV-A (320nm-400nm), UV-B (290nm-320nm) and UV-C (200nm-290nm); Can arrive the very UV-A of low dosage and the UV-B of minimum dosage of having only of the earth; And UV-C has arrived not earth surface, and is wherein maximum to the injury of biology with UV-B again, is solar radiation causes the photo bio effect to skin main wave band; Cause skin erythema, also the Diazolidinyl Urea cancerous cell.
Receive people's attention day by day along with ultraviolet presents problems such as rising trend to the sickness rate of the harm of human body and skin carcinoma in the whole world, the research of substance having sun-screening function has caused the concern of countries in the world.As long as sunscreen at present commonly used has following classification:
1. ultraviolet light screener
In sunscreen, add some inorganic particulates, process the physics sunscreen like titanium dioxide, zinc oxide etc.These tiny particles can form the barrier layer at skin surface, through reflection, scatters ultraviolet skin are played a protective role.Advantage is that stability is high, safety is good.Shortcoming be transparent feel poor, be prone to use and too much can stop up pore, influence sweat gland secretion, even cause dermatosis etc. at be white in color layer and coming off of skin surface deposition, and screening agent do not have Absorption to ultraviolet, just blocks effect.
2. UV absorbent
This type sunscreen is in sunscreen, to add a certain amount of ultra-violet absorption material and play anti-sunlight function.The molecular energy of these absorbent absorbs ultraviolet energy, discharges with forms such as heat energy or visible lights, thereby reduces the injury to skin.Advantage is that the product transparency of processing is high, good absorbing effect.Shortcoming is that skin is had certain zest, possibly cause inflammation, side effect such as allergy.Low, the easy prescription of chemistry sunscreen price; Sales volume is bigger on market; Mainly comprise para-amino benzoic acid derivant, o-aminobenzoa derivant, cinnamate derivative, salicylic acid esters, Benzophenones chemical compound, camphor derivatives, methane Derivatives etc.; Above-mentioned substance all has certain zest to skin, has potential safety hazard.
3. natural sun-prevention agent
The natural sun-prevention agent is extracted from natural plants, and the natural sun-prevention agent can effectively absorb ultraviolet, remove oxygen-derived free radicals.China is present, extracting solution such as Aloe, Fructus Cucumidis sativi is applied in the sunscreen product.
In addition, some Chinese herbal medicine sunscreen also belong to a kind of of natural sun-prevention agent.But the report to the sun-proof performance study of Chinese medicine extract is less; The Chinese medicine with anti-sunlight function of generally acknowledging at present is Radix Scutellariae and Flos Sophorae, and they have anti-sunlight function (what Seeley, Fu Qing preferably at UV-B and UV-A section respectively; Zhao Guilan; Deng. the development and the performance evaluation of rutin-baicalin sunscreen cream. northwest pharmaceutical journal, 1998,13 (6): 257; Lu Yongxiang. the Chinese medicine Flos Sophorae Immaturus is in the developmental research of beauty treatment aspect sun-proof. the aesthstic beauty treatment of Chinese medicine magazine, 1996,5 (1): 39).The somebody find hydrolysate (Guo Dafa, Zhang Yankun, Liu Guozhong. the development of natural sun-prevention skin protection solar oil. daily chemical industry; 1993; 2:5), Oleum Hippophae (bend to inspire. ultra-violet absorption composition and sunscreen cream in the Oleum Hippophae. Fructus Hippophae, 2003,13 (2): 34) with Aloe (seal is praised fine horse. the preparation and the pharmacodynamic study of a kind of reed mentioned in ancient books reed gel sunscreen. daily chemical industry; 1997,5:16) also have an anti-sunlight function.Not domestic not the appearing in the newspapers of sun-proof performance of other Chinese herbal medicine.
Rhizoma Kaempferiae is zingiberaceous plant Rhizoma Kaempferiae (Kaempferia galanga L.) rhizome, has another name called that husky Rhizoma Zingiberis Recens, Rhizoma Kaempferiae, three a kind of apples, three rely, the mountain is peppery etc., is south of the Five Ridges regional characteristic medical material; Have the circulation of qi promoting warming middle-JIAO, the pain relieving effect that helps digestion, be the perennial perennial root herbaceous plant of Zingiberaceae, acrid in the mouth is peppery, but is different from Rhizoma Zingiberis Recens flavor; Fragrant odour is like Camphora, and main taste compound is Borneolum Syntheticum, eucalyptol, kaempferol, kaempferide etc., originates in the torrid areas; With the rhizome hyoscine, be famous Chinese medicine, be non-staple foodstuff condiment commonly used again.At present both at home and abroad mainly concentrate on the physiological and pharmacological effect of contained chemical composition analysis evaluation of quintessence oil in the method for distilling of quintessence oil in the husky Rhizoma Zingiberis Recens (for activity of husky Rhizoma Zingiberis Recens or effective ingredient), the husky Rhizoma Zingiberis Recens and various compositions or in the application aspect the food additive, but also do not see the correlational study of its anti-sunlight function about the research of husky Rhizoma Zingiberis Recens.
Because the Chinese medicine sunscreen has performance gentleness, advantage such as inexpensive, efficient; And the Chinese medicine decapacitation with anti-sunlight function absorbs outside the ultraviolet; Solar dermatitis, skin protection jade-like stone face and freckle removing and whitening effect are treated in also having concurrently of having, and therefore develop potential Chinese medicine sunscreen with good sun-proof result and have broad application prospects.
Summary of the invention
The object of the present invention is to provide a kind of new application of Rhizoma Kaempferiae extract.
For realizing above-mentioned purpose, the present invention has taked following technical scheme:
The application of Rhizoma Kaempferiae extract in sun care preparations.
Another object of the present invention is to provide a kind of sun care preparations.Taked following technical scheme:
A kind of sun care preparations comprises the Rhizoma Kaempferiae extract as sun-prevention component.
This sun care preparations also comprises acceptable adjuvant on the cosmetics, is prepared into frost, cream, breast or liquid.
The weight percentage that the Rhizoma Kaempferiae extract accounts for sun care preparations is 0.5-7.5%.
Aforesaid Rhizoma Kaempferiae extract is to get through any preparation in following three kinds of method for preparinies:
(1) solvent method: Rhizoma Kaempferiae is ground into fine powder, uses volume to reflux or supersound extraction 1-3 time as fine powder weight 3-10 lipotropy organic solvent doubly, merge extractive liquid,, concentrating under reduced pressure promptly gets;
(2) extraction: Rhizoma Kaempferiae is ground into fine powder, uses volume to reflux or supersound extraction 1-3 time, merge extractive liquid, as fine powder weight 3-10 hydrophilic organic solvent doubly; Be evaporated to the extractum shape; Use water dissolution extractum, the reuse volumetric usage is extractum weight 1-4 lipotropy organic solvent extraction doubly 1-5 time, merges the lipotropy organic layer; Concentrating under reduced pressure promptly gets;
(3) supercritical carbon dioxide extraction method: Rhizoma Kaempferiae is ground into fine powder, is positioned in the supercritical carbon dioxide extraction still, under certain extraction conditions, extract, promptly get.
(1) and lipotropy organic solvent described in (2) be normal hexane, cyclohexane extraction, petroleum ether, ether, ethyl acetate, chloroform or benzene; (2) hydrophilic organic solvent described in is methanol, ethanol, propanol or the acetone of volumetric concentration 20-100%.
(1) and the temperature of reflux, extract, described in (2) be 25-80 ℃, each time of extracting is 0.5-5h; (1) and the temperature of supersound extraction described in (2) be room temperature to 45 ℃, each time of extracting is 10-30min.
(3) extraction conditions described in is: extraction temperature 20-60 ℃, extracting pressure 15-40Mpa, 20-50 ℃ of extraction-container temperature, pressure 6-10Mpa, flow 15-30L/h, condensate temperature 3-10 ℃, extraction time 2-6h
When the preparation sun care preparations, need carry out the evaluation of clinical efficacy to cosmetics with to sun-prevention component.The present invention has adopted dilution transmitance method and SPF method mensuration Rhizoma Kaempferiae extract and the sun-proof result of the sun care preparations processed.Mensuration result shows: the average absorption of uv of Rhizoma Kaempferiae extract all＞95%, prompting has good ultraviolet absorption effect; Is 12-25 with the Rhizoma Kaempferiae extract as the SPF of the cosmetics of sun-prevention component.
Compared with present technology the present invention has the following advantages:
1. the Rhizoma Kaempferiae extract has very strong uv absorption in the UV-B district, and absorption intensity big (Fig. 1) can absorb the ultraviolet in the sunlight effectively; Preventing that human body skin shines red, sunburn, tanned, also is the medicine of light sensation dermatitis, can be used as the sun-prevention component of sun care preparations; Composite with multiple sunscreen, preparation sun-proof skin care cosmetics, the cosmetics SPF that makes is high; And compare with chemical sunscreen, safety is better, is not easy to cause allergic reaction.
2. raw material is easy to get, and Rhizoma Kaempferiae is a southern area characteristic medicinal and edible plant, in Guangdong, there are a large amount of plantations on ground such as Guangxi, Yunnan.
Description of drawings
Fig. 1 is the uv absorption spectra of Rhizoma Kaempferiae extract.
The specific embodiment
Below through embodiment the present invention is further specified.Following examples adopt dilution transmitance method or SPF method to measure the Rhizoma Kaempferiae extract and the sun-proof result of the sun care preparations processed.
Dilution transmitance method:
This method is that sun-prevention component is dissolved or dispersed in the solvent, measures the method for transmitance and absorbance.Though this method has certain difference with the state that sunscreen applies on skin, because method is simple, can measure a lot of samples, still feasible as initial evaluation, also be the evaluation methodology that the insider uses always except that the SPF method.
Becoming every milliliter to be equivalent to crude drug 0.5mg with 50% ethanol dilution the Rhizoma Kaempferiae extract, is blank with 50% ethanol, in the 280-320nm wave-length coverage, scans, and measures the light transmittance under each wavelength, asks its average transmittance.Average absorption of uv (%)=100%-average transmittance.Absorption of uv is 80% above person, and can think has anti-sunlight function; Absorption of uv can think that 90% above person anti-sunlight function is stronger.
The SPF method:
The appraisal procedure to UVB section ultraviolet protection efficient of relatively generally acknowledging at present, is as evaluation criteria with sun protection factor (SPF).The present invention measures with reference to " cosmetics health standard 2007 editions ": SPF=(using the minimal erythema dose of sun care preparations protecting skin)/(the not minimal erythema dose of protecting skin); Minimal erythema dose: cause skin erythema, its scope reaches point of irradiation edge needed ultraviolet radiation lowest dose level (J/m
2) or the shortest time (second).With the compound method that the Rhizoma Kaempferiae extract is pressed sun care preparations, process sun care preparations with certain adjuvant, measure the SPF of each sun care preparations.
Embodiment 1
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with petroleum ether (60 ℃-90 ℃) heating and refluxing extraction 1 time, 60 ℃ of temperature, solvent load is 500ml, filter, the 490ml that must filtrate, 50 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 5.2g.
Adopting dilution transmitance method to record its average absorption of uv is 95.8%.
Embodiment 2
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with petroleum ether (60 ℃-90 ℃) heating and refluxing extraction 2 times, 75 ℃ of temperature, each solvent load is 500ml, filter, the 975ml that must filtrate, 50 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 6.5g.
Adopting dilution transmitance method to record its average absorption of uv is 96.2%.
Embodiment 3
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with chloroform heating and refluxing extraction 2 times, 56 ℃ of temperature, each solvent load is 300ml, filter, the 585ml that must filtrate, 45 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 6.8g.
Adopting dilution transmitance method to record its average absorption of uv is 96.4%.
Embodiment 4
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with normal hexane heating and refluxing extraction 3 times, 25 ℃ of temperature, each solvent load is 600ml, filter, the 1750ml that must filtrate, 45 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 6.4g.
Adopting dilution transmitance method to record its average absorption of uv is 94.4%.
Embodiment 5
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with ethyl acetate heating and refluxing extraction 1 time, 80 ℃ of temperature, each solvent load is 800ml, filter, the 785ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 5g.
Adopting dilution transmitance method to record its average absorption of uv is 96.3%.
Embodiment 6
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with petroleum ether heating and refluxing extraction 3 times, 80 ℃ of temperature, each solvent load is 800ml, filter, the 2380ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 8g.
Adopting dilution transmitance method to record its average absorption of uv is 99.5%.
Embodiment 7
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with petroleum ether supersound extraction 1 time, 25 ℃ of temperature, each solvent load is 400ml, filter, the 390ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 5.3g.
Adopting dilution transmitance method to record its average absorption of uv is 97.5%.
Embodiment 8
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with petroleum ether supersound extraction 3 times, 45 ℃ of temperature, each solvent load is 500ml, filter, the 1485ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 7.6g.
Adopting dilution transmitance method to record its average absorption of uv is 98.2%.
Embodiment 9
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with cyclohexane extraction supersound extraction 2 times, 30 ℃ of temperature, each solvent load is 800ml, filter, the 1590ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 7.4g.
Adopting dilution transmitance method to record its average absorption of uv is 98.3%.
Embodiment 10
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with ether supersound extraction 2 times, 32 ℃ of temperature, each solvent load is 300ml, filter, the 590ml that must filtrate, 25 ℃ of concentrating under reduced pressure filtratings, the Rhizoma Kaempferiae extract, be yellow oily extractum 6.4g.
Adopting dilution transmitance method to record its average absorption of uv is 96.8%.
Embodiment 11
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with methanol heating and refluxing extraction 1 time, 25 ℃ of temperature; Each solvent load is 300ml, filters the 290ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get petroleum ether layer with 300ml petroleum ether extraction 1 time; 55 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow yellow oily extractum 5.4g.
Adopting dilution transmitance method to record its average absorption of uv is 96.5%.
Embodiment 12
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with methanol heating and refluxing extraction 3 times, 70 ℃ of temperature; Each solvent load is 500ml, filters the 1490ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get petroleum ether layer with 600ml petroleum ether extraction 2 times; 55 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow yellow oily extractum 7.4g.
Adopting dilution transmitance method to record its average absorption of uv is 98.5%.
Embodiment 13
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with dehydrated alcohol heating and refluxing extraction 2 times, 80 ℃ of temperature; Each solvent load is 600ml, filters the 1180ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get the normal hexane layer with 900ml n-hexane extraction 3 times; 55 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow oily extractum 7.2g.
Adopting dilution transmitance method to record its average absorption of uv is 98.1%.
Embodiment 14
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, extract 3 times 60 ℃ of temperature with 40% alcohol heating reflux; Each solvent load is 800ml, filters the 2370ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get petroleum ether layer with 1200ml petroleum ether extraction 4 times; 60 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow oily extractum 6.9g.
Adopting dilution transmitance method to record its average absorption of uv is 98.3%.
Embodiment 15
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with 80% ethanol ultrasonic extraction 2 times, 25 ℃ of temperature; Each solvent load is 200ml, filters the 375ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get the normal hexane layer with 300ml n-hexane extraction 5 times; 55 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow oily extractum 5.2g.
Adopting dilution transmitance method to record its average absorption of uv is 96.7%.
Embodiment 16
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with 20% ethanol ultrasonic extraction 3 times, 40 ℃ of temperature; Each solvent load is 400ml, filters the 1175ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get chloroform layer with 600ml chloroform extraction 4 times; 50 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow oily extractum 4.3g.
Adopting dilution transmitance method to record its average absorption of uv is 95.2%.
Embodiment 17
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with acetone supersound extraction 1 time, 30 ℃ of temperature; Each solvent load is 800ml, filters the 790ml that must filtrate, 40 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get the cyclohexane extraction layer with 900ml cyclohexane extraction extraction 3 times; 65 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow oily extractum 4.0g.
Adopting dilution transmitance method to record its average absorption of uv is 94.5%.
Embodiment 18
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, with methanol supersound extraction 2 times, 35 ℃ of temperature; Each solvent load is 500ml, filters the 990ml that must filtrate, 60 ℃ of concentrating under reduced pressure filtratings; This concentrate is used the 300ml deionized water dissolving,, get the cyclohexane extraction layer with 300ml cyclohexane extraction extraction 3 times; 65 ℃ of concentrating under reduced pressure get the Rhizoma Kaempferiae extract, are yellow oily extractum 5.2g.
Adopting dilution transmitance method to record its average absorption of uv is 96.3%
Embodiment 19
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, be put in in the supercritical carbon dioxide extraction still 20 ℃ of extraction kettle temperature; Extraction kettle pressure 40Mpa, 20 ℃ of extraction-container temperature, extraction-container pressure 6Mpa, 10 ℃ of condensate temperatures; Flow 15L/h, extraction time 2h gets Rhizoma Kaempferiae extract 6g.
Adopting dilution transmitance method to record its average absorption of uv is 98.3%.
Embodiment 20
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, be put in in the supercritical carbon dioxide extraction still 40 ℃ of extraction kettle temperature; Extraction kettle pressure 25Mpa, 30 ℃ of extraction-container temperature, extraction-container pressure 8Mpa, 5 ℃ of condensate temperatures; Flow 25L/h, extraction time 4h gets Rhizoma Kaempferiae extract 8.6g.
Adopting dilution transmitance method to record its average absorption of uv is 99.3%.
Embodiment 21
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, be put in in the supercritical carbon dioxide extraction still 60 ℃ of extraction kettle temperature; Extraction kettle pressure 15Mpa, 50 ℃ of extraction-container temperature, extraction-container pressure 10Mpa, 8 ℃ of condensate temperatures; Flow 20L/h, extraction time 3h gets Rhizoma Kaempferiae extract 8.1g.
Adopting dilution transmitance method to record its average absorption of uv is 98.8%.
Embodiment 22
The Rhizoma Kaempferiae pulverizing medicinal materials is got 100g, is put in in the supercritical carbon dioxide extraction extraction kettle 60 ℃ of extraction kettle temperature; Extraction kettle pressure 15Mpa, 50 ℃ of extraction-container temperature, extraction-container pressure 10Mpa, 8 ℃ of condensate temperatures; Flow 20L/h, extraction time 3h gets Rhizoma Kaempferiae extract 7.6g.
Adopting dilution transmitance method to record its average absorption of uv is 98.8%.
Embodiment 23
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, be put in in the supercritical carbon dioxide extraction still 50 ℃ of extraction kettle temperature; Extraction kettle pressure 35Mpa, 40 ℃ of extraction-container temperature, extraction-container pressure 6Mpa, 3 ℃ of condensate temperatures; Flow 25L/h, extraction time 5h gets Rhizoma Kaempferiae extract 10.0g.
Adopting dilution transmitance method to record its average absorption of uv is 99.9%.
Embodiment 24
With the Rhizoma Kaempferiae pulverizing medicinal materials, get 100g, be put in in the supercritical carbon dioxide extraction still 30 ℃ of extraction kettle temperature; Extraction kettle pressure 20Mpa, 25 ℃ of extraction-container temperature, extraction-container pressure 7Mpa, 8 ℃ of condensate temperatures; Flow 20L/h, extraction time 6h gets Rhizoma Kaempferiae extract 9.3g.
Adopting dilution transmitance method to record its average absorption of uv is 99.3%.
Following examples 25-29 prepares various cosmetics for being sun-prevention component with Rhizoma Kaempferiae extract of the present invention.
Embodiment 25 comprises the cosmetics of Rhizoma Kaempferiae extract
Prescription: (below be weight percentage)
The A component
Glyceryl monostearate 5%
Octadecanol 2.5%
Vaseline 6%
Antiseptic 0.5%
The B component
Liquid paraffin 6%
Glycerol 3.5%
Rhizoma Kaempferiae extract (embodiment 1) 0.5%
VE 0.2％
Emulsifying agent TW
800.2%
The C component
Propylene glycol 4.0%
Polyethylene Glycol 3.5%
Essence 0.4%
The deionized water surplus
Method for preparing: each raw material blending of A component is heated to 70 ℃, adds the B component behind each material dissolution, be warming up to 95 ℃, keep certain hour; Be cooled to 65 ℃, mix, stir with the C component except that essence that is warming up to 65 ℃; Keep 65 ℃ of 10min, be cooled to 45 ℃, add essence; Stir, be cooled to room temperature, promptly get.
The SPF SPF of prepared cosmetics is 12 among this embodiment.
Embodiment 26 comprises the cosmetics of Rhizoma Kaempferiae extract
Prescription: (below be weight percentage)
The A component
Glyceryl monostearate 5%
Octadecanol 2.5%
Vaseline 6%
Antiseptic 0.5%
The B component
Liquid paraffin 6%
Glycerol 3.5%
Rhizoma Kaempferiae extract (embodiment 12) 2%
VE 0.5％
Emulsifying agent TW80 0.6%
The C component
Propylene glycol 4.0%
Polyethylene Glycol 3.5%
Essence 0.3%
The deionized water surplus
Method for preparing: each raw material blending of A component is heated to 70 ℃, and the dissolving back adds the B component, is warming up to 95 ℃, keeps certain hour; Be cooled to 65 ℃, mix, stir with the C component except that essence that is warming up to 65 ℃; Keep 65 ℃ of 10min, be cooled to 45 ℃, add essence; Stir, be cooled to room temperature, promptly get.
The SPF SPF of prepared cosmetics is 18 among this embodiment.
Embodiment 27 comprises the cosmetics of Rhizoma Kaempferiae extract
Prescription: (below be weight percentage)
The A component
Liquid paraffin 5%
Octadecanol 8%
Stearic acid 6%
Sodium lauryl sulfate 0.6%
Methyl hydroxybenzoate 0.2%
The B component
Glycerol 6%
Rhizoma Kaempferiae extract (embodiment 14) 3%
Essence 0.5%
Propylparaben 0.2%
The deionized water surplus
Method for preparing: with being heated to dissolving about 80 ℃ behind A, each raw material blending of B two components respectively, while stirring the B component is joined in the A component then, restir adds deionized water.Continue to be stirred to fast complete emulsifying, cooling promptly gets.
Cosmetics prepared among this embodiment are sunscreen cream, are the fine and smooth pastes of milk yellow, and its SPF is 20.
Embodiment 28 comprises the cosmetics of Rhizoma Kaempferiae extract
Prescription: (below be weight percentage)
The A component
Stearic acid 2.0%
Liquid paraffin 13%
Octadecanol 5%
Dimethicone 4%
Polyoxyethylene 20 sorbitan monooleate 5%
Rhizoma Kaempferiae extract (embodiment 19) 6%
The B component
Glycerol 4%
Propylene glycol 5%
Triethanolamine 1.5%
The C component
Vitamin e acetate 0.2%
Ethyl hydroxybenzoate 0.3%
Essence 1%
The deionized water surplus
Method for preparing: each raw material blending of A component is heated to 70 ℃, stirring and dissolving, the B component is soluble in water, be warming up to 90 ℃; Insulation 20min is cooled to 73 ℃ then, the B component is slowly added the A component, after stirring; Be cooled to 45 ℃, add the C component, stir discharging during room temperature.
The SPF SPF of prepared cosmetics is 25 among this embodiment.
Embodiment 29 comprises the cosmetics of Rhizoma Kaempferiae extract
Prescription: (below be weight percentage)
The A component
Liquid paraffin 5%
Octadecanol 8%
Stearic acid 6%
Sodium lauryl sulfate 0.6%
Methyl hydroxybenzoate 0.2%
The B component
Glycerol 6%
Rhizoma Kaempferiae extract (embodiment 23) 5%
Essence 0.5%
Propylparaben 0.2%
The deionized water surplus
Method for preparing: A, each raw material of B two components are heated to dissolving about 80 ℃ respectively, while stirring the B component are joined in the A component, restir adds deionized water.Continue to be stirred to fast complete emulsifying, cooling promptly gets.
Cosmetics prepared among this embodiment are sunscreen cream, are the fine and smooth pastes of milk yellow, and its SPF is 24.
More than be to the specifying of possible embodiments of the present invention, but this embodiment is not in order to limiting claim of the present invention, does not allly break away from equivalence of the present invention and implement or change, all should be contained in the claim of the present invention.
Claims (3)
1. a sun care preparations that contains the Rhizoma Kaempferiae liposoluble extract is characterized in that, said sun care preparations comprises the Rhizoma Kaempferiae liposoluble extract as sun-prevention component; The method for preparing of said Rhizoma Kaempferiae liposoluble extract is: Rhizoma Kaempferiae is ground into fine powder; The ratio that uses volume and fine powder weight is 8: 1 times petroleum ether heating and refluxing extraction 3 times, 80 ℃ of temperature, merge extractive liquid; 60 ℃ of concentrating under reduced pressure promptly get said Rhizoma Kaempferiae liposoluble extract.
2. sun care preparations according to claim 1 is characterized in that, the weight percentage that said Rhizoma Kaempferiae liposoluble extract accounts for sun care preparations is 0.5-7.5%.
3. sun care preparations according to claim 1 is characterized in that, said sun care preparations is frost, cream, breast.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102630500A CN101933892B (en) | 2010-08-24 | 2010-08-24 | New application of kaempferol extractive and sunscreen cosmetic containing kaempferol extractive |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102630500A CN101933892B (en) | 2010-08-24 | 2010-08-24 | New application of kaempferol extractive and sunscreen cosmetic containing kaempferol extractive |
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| Publication Number | Publication Date |
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| CN101933892A CN101933892A (en) | 2011-01-05 |
| CN101933892B true CN101933892B (en) | 2012-06-06 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102961319B (en) * | 2012-12-21 | 2014-08-27 | 上海相宜本草化妆品股份有限公司 | Skin care composition containing natural sunscreen components and preparation method of skin care composition |
| CN104523463B (en) * | 2014-09-30 | 2017-08-04 | 海南师范大学 | A kind of pineapple leaves extract and its application in suncream is prepared |
| CN105213269A (en) * | 2015-10-29 | 2016-01-06 | 桂林华诺威基因药业有限公司 | A kind of sunscreen cream |
| CN105193678A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen and after-sun repairing skin care composition |
| CN105193679A (en) * | 2015-10-29 | 2015-12-30 | 桂林华诺威基因药业有限公司 | Sunscreen composition |
| CN107397715A (en) * | 2017-07-29 | 2017-11-28 | 杭州伊瑟奇生物科技有限公司 | Biological sunlight breast |
| CN108159328B (en) * | 2018-01-23 | 2020-10-23 | 四川农业大学 | Kaempferia galanga extract with antiviral effect and preparation method thereof |
| CN109453075B (en) * | 2018-09-19 | 2021-05-14 | 厦门娜其尔日化股份有限公司 | Application of five-pear and wrestle extract |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101756831A (en) * | 2008-11-24 | 2010-06-30 | 陈静 | Glycerin and kaempferia galanga sun cream |
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Address after: Nanshan District science and Technology Park in Shenzhen City, Guangdong province 518000 Ke Feng Lu No. 2 SDGI building 7 room 702 Applicant after: Shenzhen AESTHETIC Biological Technology Co., Ltd. Co-applicant after: Sun Yat-sen University Co-applicant after: AESTHETIC Technology (Beijing) Co., Ltd. Co-applicant after: Youlika Natural Drug Co., Ltd., Zhongshan City Address before: Nanshan District science and Technology Park in Shenzhen City, Guangdong province 518000 Ke Feng Lu No. 2 SDGI building 7 room 702 Applicant before: Aesthetica Biotechnology (Shenzhen) Co., Ltd. Co-applicant before: Sun Yat-sen University Co-applicant before: AESTHETIC Technology (Beijing) Co., Ltd. Co-applicant before: Youlika Natural Drug Co., Ltd., Zhongshan City |
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